Apr 14, 2014 - Advanced .... Andersen, J.B., Marquardt, J.U., Kleiner, D.E., Raggi, C., Kitade, M., Seo, D., Akita, H., Durkin, M.E., and Thorgeirsson, S.S. (2013).
SnapShot: Hepatocellular Carcinoma Jens U. Marquardt1 and Snorri S. Thorgeirsson2 Department of Medicine I, Johannes Gutenberg University of Mainz, 55131 Mainz, Germany 2 Laboratory of Experimental Carcinogenesis, CCR/NCI/NIH, Bethesda, MD 20892, USA
1
CLINICAL PROGRESSION OF LIVER CANCER
UNIFOCAL HCC
CELL TYPES OF ORIGIN FOR HCC Stemness
Arterial Phase
Stem cell
Bulk tumor cells Aggresive phenotype
Cancer stem cell Bipotential progenitor
Venous Phase
50 μm
Healthy liver
Chronic injury
Cirrhosis
PROGNOSTIC CLASSIFICATION
Molecular features
Clinical/ Morphological features
Favorable Outcome
Contrast MRI imaging illustrating typical hyperenhancement (wash-in) in the arterial phase followed by wash-out in the venous phase.
HCC
BCLC STAGING & THERAPY
Poor Outcome
ECOG 0–1 Well-preserved liver function
Poor liver function Poor differentiation CK19 positive
