Southeast Asian Medicinal Plants as a Potential Source of ...

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Hindawi Evidence-Based Complementary and Alternative Medicine Volume 2017, Article ID 7185649, 39 pages https://doi.org/10.1155/2017/7185649

Review Article Southeast Asian Medicinal Plants as a Potential Source of Antituberculosis Agent Shuaibu Babaji Sanusi, Mohd Fadzelly Abu Bakar, Maryati Mohamed, Siti Fatimah Sabran, and Muhammad Murtala Mainasara Centre of Research for Sustainable Uses of Natural Resources (CoR-SUNR), Faculty of Science, Technology and Human Development, Universiti Tun Hussein Onn Malaysia (UTHM), 86400 Parit Raja, Batu Pahat, Johor, Malaysia Correspondence should be addressed to Mohd Fadzelly Abu Bakar; [email protected] Received 24 January 2017; Revised 23 April 2017; Accepted 18 May 2017; Published 3 July 2017 Academic Editor: Ghee T. Tan Copyright Β© 2017 Shuaibu Babaji Sanusi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Despite all of the control strategies, tuberculosis (TB) is still a major cause of death globally and one-third of the world’s population is infected with TB. The drugs used for TB treatment have drawbacks of causing adverse side effects and emergence of resistance strains. Plant-derived medicines have since been used in traditional medical system for the treatment of numerous ailments worldwide. There were nine major review publications on antimycobacteria from plants in the last 17 years. However, none is focused on Southeast Asian medicinal plants. Hence, this review is aimed at highlighting the medicinal plants of Southeast Asian origin evaluated for anti-TB. This review is based on literatures published in various electronic database. A total of 132 plants species representing 45 families and 107 genera were reviewed; 27 species representing 20.5% exhibited most significant in vitro anti-TB activity (crude extracts and/or bioactive compounds 0–100 πœ‡g/ml from 90% ethanolic extract [47]. Methanolic extract of whole plant exhibited inhibition against Asthma, pneumonia, fever Babadaton Whole plant: 80% methanol H37Rv at the MIC 1600 πœ‡g/ml in TEMA [48]. [49, 50].

Gilinggilingan

Akar saga

Not stated

Local name Part used: extract/active compound Activity

Table 1: Southeast Asian medicinal plants screened for anti-TB.

Evidence-Based Complementary and Alternative Medicine 5

Zingiberaceae

Zingiberaceae

Alpinia zerumbet (Pers.) B. L. Burtt & R. M. Sm.

Aloaceae

Aloe vera L.

Alpinia purpurata K. Schum.

Liliaceae

Allium odorum L.

Zingiberaceae

Meliaceae

Aglaia erythrosperma Pannell

Alpinia galanga (L.) Sw.

Family

Scientific name

Leaves: 80% methanol

The extract showed inhibition against H37Rv strain at the MIC 1600 πœ‡g/ml [48].

Leaves: 80% methanol

Rhizomes: methanol

At 100 πœ‡g/ml, the methanolic extract of rhizomes showed 80% inhibition against H37Rv [58].

Leave: methanol/compounds 𝛽-sitosteryl-𝛽-D-galactoside (1), At 100 πœ‡g/ml, the methanolic extract of leaves showed 90% Luyang pula 𝛽-sitosteryl-3-O-6σΈ€  -palmityl-𝛽-D- inhibition against H37 Rv. glucoside (2), kumatakenin (3) were All isolated compounds 1, 2, 3 showed MIC > 128 πœ‡g/ml [58]. isolated from the extract

Khaa, Lengkuas,

The crude chloroform, methanol, water extract of the rhizomes exhibited activity against H37Ra strain at MIC of 0.12, 1000, and 1000 πœ‡g/ml, respectively. The MIC value for the isolated compound (1) was 0.024 πœ‡g/ml [41].

The extract was active against H37Rv strain at MIC 1600 πœ‡g/ml [48]. The extract showed activity against H37Rv strain at the MIC of 1600 πœ‡g/ml [48].

Compounds 3, 4,7 showed anti-TB activity against H37Ra strain with the MIC of 25 πœ‡g/ml which is better than compounds 1, 2, 6,8 with the MIC value of 50 πœ‡g/ml, while compound 5 showed weaker activity (MIC, >200 πœ‡g/ml) [51].

Rhizome: chloroform methanol water Compound 1σΈ€  acetoxychavicol acetate (1) was isolated from chloroform extract of rhizome

Lidah buaya Leaves: 80% methanol

Kucai

Fruits and leaves: 95%/cabraleadiol (1), cabraleahydroxylactone (2), ethyl eichlerianoate (3), eichlerialactone (4), aglinin A (5), cabralealactone (6), aglaialactone (7), flavagline (8) were isolated from the extract

Local name Part used: extract/active compound Activity

Table 1: Continued.

Common cold [59].

Cough [59].

TB, bronchitis, pain in chest, whooping cough, asthma, sore throat [54–57].

Asthma, bronchitis [53].

Asthma, cough [52].

Nil.

Traditional uses (references)

6 Evidence-Based Complementary and Alternative Medicine

Lamiaceae

Annonaceae

Annona muricata L.

Paku gajah

Marattiaceae

Leaves: 80% methanol

The extract exhibited activity against H37Rv strain at the MIC of 400 πœ‡g/ml [48].

Aerial part: hexane and EtOAc/pimaric acid (1), 9𝛼-13𝛼Chroomuay epidioxyabiet-8(14)-en-18-oic acid 1, 2, 3 all showed anti-TB activity at MIC, 50 πœ‡g/ml [65]. (2), 15-hydrooxydehydroabietic acid (3) were isolated from the extract The extract at concentration of 5 mg/ml showed 82.1% Sirsak Leaves: aqueous inhibition against H37Rv and 50.0% against MDR strain [62].

Hempedu Bumi

Acanthaceae

Anisochilus harmandii Doan ex Suddee & A. J. Paton

Bayam

Dita

Leaves: methanol/19,20E-vallesamine (1), a mixture of angustilobine B N4 -oxide Only 4 exhibited activity at MIC of 100 πœ‡g/ml, against, while all (2), N4 -methyl angustilobine B (3), other compounds like 1, 2, 3, 5,6 showed activity with 20S-tubotaiwine (4), >128 πœ‡g/ml [60]. 6,7-seco-angustilobine B (5), (+)-manilamine (6) were obtained from the extract Methanolic extract of whole plant exhibited inhibition against Whole plant: 80% methanol H37Rv strain at the MIC 1600 πœ‡g/ml in TEMA [48]. At 5 mg/ml the extract exhibited 100.0% inhibition against Herbs: aqueous H37Rv and 93.7% against MDR strain [62].

Local name Part used: extract/active compound Activity

Amaranthaceae

Apocynaceae

Alstonia scholaris (L.) R. Brown

Amaranthus tricolor L. Andrographis paniculata Nees Angiopteris evecta (J. R. Forst.) Hoffm.

Family

Scientific name

Table 1: Continued.

Asthma, cough [66, 67].

Nil.

Cough, fever [64].

Leprosy, sore throat [63].

Cough [61].

Fever [60].

Traditional uses (references)

Evidence-Based Complementary and Alternative Medicine 7

Moraceae

Oxalidaceae

Artocarpus rigidus subsp. Rigidus

Averrhoa bilimbi L.

Annonaceae

Anomianthus dulcis (Dunal) J. Sinclair

Moraceae

Annonaceae

Annona reticulata L.

Artocarpus lakoocha Roxb.

Family

Scientific name

Belimbing masam

Tampang

Ma-Haad

Num Wua

Kantaloht (peurak)

Fruits, leaves: 80% methanol

Stem bark: 80% ethanol, dichloromethane and water/(2S)-5hydroxy-6,7-dimethoxyflavanone (1), 9-methoxyliriodenine (4), Liriodenine (5) were isolated from the extract Roots: dichloromethane/Lakoochins A (1) and B (2) were isolated from the extract Root bark: flavonoid 7-demethylartonol E (1), chromone artorigidusin (2), xanthone artonol B (3), flavonoid artonin F (4), flavonoid cycloartobiloxanthone (5), xanthone artoindonesianin C (6), all isolated from n-hexane, chloroform, methanol extracts

90% ethanol

Asthma, cough [73].

Sore throat [71].

Fever [69].

Cough, high fever [44, 68].

Traditional uses (references)

The methanol extracts of both fruit and leaves exhibited Whooping cough and fever inhibition against H37Rv at the MIC 1600 πœ‡g/ml in TEMA [48]. [74].

All the isolated compounds showed activity again H37Ra in MABA with compound 4 being the most active compound (MIC 6.25 πœ‡g/ml). This was followed by compounds 2 and 6 (MIC 12.5 πœ‡g/ml) and compounds 5, 1,3 with the MIC of 25, 50, 100 πœ‡g/ml, respectively [72].

Compound 1 and 2 showed anti-TB activity against H37Ra strain with the MICs of 12.5 and 50 πœ‡g/ml, respectively [70].

Compounds (5), (1), (4) demonstrated anti-TB activity against H37Ra using MABA with the MIC values of 100, 200, 200 πœ‡g/ml, respectively [69].

The crude extract exhibited activity at the MIC of 49.17 πœ‡g/ml against H37Rv [44].

Local name Part used: extract/active compound Activity

Table 1: Continued.

8 Evidence-Based Complementary and Alternative Medicine

Family

Acanthaceae

Asteraceae

Zingiberaceae

Asteraceae

Solanaceae

Scientific name

Barleria lupulina Lindl.

Blumea balsamifera DC.

Boesenbergia pandurata (Roxb.) Schltr.

Camchaya calcarea Kitamura

Capsicum annum L. Cili

Krachai

Sembung utan

Sa-letpangpon

Fruit: 80% methanol

Whole plant: dichloromethane/goyazensolides (1), lychnophorolides A (2), centratherin or lychnophorolides B (3), isogoyazensolides (4), isocentratherin (5), 5-epiisogoyazensolides (7), 5-epi-isocentratherin (8), 1(10),E,4Z,11(13)-germacratriene12,6-olide-15-oic acid (9), caffeic acid methyl ester (10) were isolated from the extract

Rhizome: chloroform methanol water

Not stated

Stem: chloroform methanol water

Leaves: chloroform methanol water

The extract showed activity against H37Rv strain at the MIC of 1600 πœ‡g/ml [48].

Compound 4 was the most active against H37Ra strain with MIC value of 1.5 πœ‡g/ml, followed by compounds 1, 2, 5, 7,8 with the same MIC value of 3.1 πœ‡g/ml. Compounds 3, 9,10 showed less activities with the MIC values of 6.2, 50, and 25 πœ‡g/ml, respectively [79].

Chloroform, methanol, water extract of leaves all exhibited activity against H37Ra strain at the MIC of 1000 πœ‡g/ml. Chloroform extract of stem exhibited inhibition at MIC of 500 πœ‡g/ml against H37Ra strain while methanol and water extract showed activities at 1000 πœ‡g/ml [41]. At 500 πœ‡g/ml, the extract exhibited 96.0 and 82.0% inhibition against H37Rv and MDR, respectively, in LRP assay [38]. Both methanol and water extracts of rhizome exhibited inhibitory activity in MABA against H37Ra strain at the MIC of 62.5 πœ‡g/ml, while chloroform extract showed activity at 1000 πœ‡g/ml MIC [41].

Local name Part used: extract/active compound Activity

Table 1: Continued.

Cough, anorexia, asthma, sore throat [80].

Nil.

Cough [78].

Cough [77].

Cough, fever [75, 76].

Traditional uses (references)

Evidence-Based Complementary and Alternative Medicine 9

Apiaceae

Meliaceae

Asteraceae

Chisocheton penduliflorus Planch. ex Hiern

Chromolaena odorata (L.) R. M. King & H. Rob. Agonoi

Pegaga

Kabu

Bombacaceae

Centella asiatica (L.) Urb.

Kemunting cina

Kruai pa

Wood and leaves: 95% methanol/cabraleadiol (1), allo-aromadendrane-10𝛽, 14-diol (2), allo-aromadendrane-10𝛼, 14-diol (3) eichlerialactone (4), cabraleahydroxylactone (5), cabralealactone (6), allo-aromadendrane-10𝛽,13,14-triol (7) were isolated from the extract Flowers: isosakuranetin (1), 4σΈ€  hydroxy-5,6,7-trimethoxyflavanone (2), acacetin (3), luteolin (4), all isolated from chloroform extract

Herbs: aqueous

Whole plant: 80% methanol

Fruit: 80% methanol

Leaves: 80% methanol

Nil.

Cough [87].

The compounds isolated exhibited activities against H37Ra at different MIC values (πœ‡g/ml) 174.8 (1), 606.0 (2), 704.2 (3), 699.3 (4) [86].

TB, leprosy, asthma [84].

Bronchitis, fever [83].

Asthma, TB [82].

Fever [81].

Traditional uses (references)

Compound 4 showed good anti-TB activity against H37Ra with the MIC value of 25 πœ‡g/ml, better than 1, 2, 5, 6,7 with the MICs of 50 πœ‡g/ml, while compound 3 showed weaker activity (MIC, 100 πœ‡g/ml) [85].

The extract exhibited anti-TB activity against H37Rv strain at the MIC of 1600 πœ‡g/ml [48]. The extract showed activity against H37Rv strain at the MIC of 1600 πœ‡g/ml [48]. 78.5 and 50.0% inhibition were observed at 5 mg/ml concentration against H37Rv and MDR, respectively [62].

The extract was active against H37Rv at MIC 1600 πœ‡g/ml [48].

Stem bark: hexane and dichloromethane/bioactive compounds, Caseargrewiin A (1), Caseargrewiin B (2), Caseargrewiin C (3), Caseargrewiin D (4), rel(2S,5R,6R,8S,9S,10R,18S,19R)-18,19diacetoxy-18,19-epoxy-6-methoxy- 1, 2, 4, 5,6 all exhibited good anti-TB activity against H37Ra strain with MICs of 12.5 πœ‡g/ml while 3 showed moderate activity 2-(2-methylbutanoyloxy)clerodawith MIC of 25 πœ‡g/ml [81]. 3,13(16),14-triene (5) and rel-(2S,5R,6R,8S,9S,10R,18S,19R)18,19-diacetoxy-18,19-epoxy-6hydroxy-2-(2methylbutanoyloxy)cleroda3,13(16),14-triene (6) were isolated from the extract

Local name Part used: extract/active compound Activity

Apocynaceae

Flacourtiaceae

Casearia grewiifolia Vent.

Catharanthus roseus (L.) G. Don Ceiba pentandra (L.) Gaertn.

Family

Scientific name

Table 1: Continued.

10 Evidence-Based Complementary and Alternative Medicine

Clausena guillauminii Tanaka Clausena harmandiana (Pierre) Guillaumin

Clausena excavate Burm. f.

Citrus aurantiifolia (Christm.) Swingle Citrus microcarpa Bunge

Scientific name

Rutaceae

Rutaceae

Rutaceae

Song Fa

Sun Soak

Limau kasturi Leaves: 80% methanol

Rutaceae

Fruits and flowers: 90% ethanol

Dentatin (1), nordentatin (2), clausenidin (3), O-methylated clausenidin (4), 3-formylcarbazole (5), mukonal (6), 3-methoxycarbonylcarbazole (7), 2-hydroxy-formyl-7methoxycarbazole (8), clauszoline (9); compounds 1, 2, 6, 7, 8,9 where isolated from the chloroform extract of rhizomes; compound 3 was isolated from crude hexane extract of rhizome. Methylation of compound 3 gave rise to compound 4; compound 10 was isolated from crude chloroform extract of the root Roots: acetone/fluroclausine A (1) and heptazoline (2) were obtained from the extract

Limau nipis Not stated

TB [92].

Cough [94].

Cough [94].

Using the green fluorescent protein microplate assay (GFPMA), both 1 and 2 exhibited anti-TB activity against H37Ra strain with the same IC50 value of 25 πœ‡g/ml [93]. MICs of 83.1 to >100 πœ‡g/ml were observed when 90% ethanolic extract of fruits and flowers was tested against H37Rv in MABA [47].

Cough [90].

Traditional uses (references) Sore throats, bronchitis, asthma [88, 89].

Compounds 1, 4,7, isolated, were more active against H37Ra with MIC of 50 πœ‡g/ml; this is followed by 2, 5, 8,9 with MIC of 100 πœ‡g/ml, while compounds 3 and 6 are with MIC of 200 πœ‡g/ml [91].

In LRP assay, extract at 500 πœ‡g/ml showed 98.0% inhibition against H37Rv strain and 36.0% against MDR strain [38]. The extract exhibited anti-TB activity against H37Rv strain at the MIC of 1600 πœ‡g/ml in TEMA [48].

Local name Part used: extract/active compound Activity

Rutaceae

Family

Table 1: Continued.

Evidence-Based Complementary and Alternative Medicine 11

Leguminosae

Cucurbitaceae

Clitoria ternatea L.

Coccinia grandis (L.) Voigt

Boraginaceae

Costaceae

Cordia globifera W. W. Smith

Costus speciosus (J. Koenig) Sm.

Combretaceae

Colocasieae

Lamiaceae

Verbenaceae

Clerodendrum indicum (L.) Kuntze

Coleus atropurpureus L. Benth Colocasia esculenta (L.) Schott Combretum griffithii Van Heurck & M¨ull. Arg.

Family

Scientific name Flowers: 80% methanol

The extract exhibited anti-TB activity against H37Rv strain at the MIC of 1600 πœ‡g/ml [48].

Cough, asthma [95].

Traditional uses (references)

Bunga kelentik

Whole plant: 80% methanol

At MIC = 1600 πœ‡g/ml, the extract showed anti-TB activity Asthma, leprosy, TB [96]. against H37Rv strain [48]. In MABA, chloroform, methanol, water extract of leaves all Phak Asthma, cough, bronchitis Leaves: chloroform methanol water exhibited activity against H37Ra strain at the MIC of 1000 πœ‡g/ml tamlueng [97, 98]. [41]. σΈ€  σΈ€  Compound 2 ,5 -dimethyl The isolate was active against H37Rv strain at the MIC of Bronchitis, TB [99]. Piladang benzopelargonolactone was isolated 200 πœ‡g/ml [99]. from the chloroform fraction of leaf The methanol extract of leaves showed activity against H37Rv Asthma, coughing with Keladi cina Leaf: 80% methanol strain with the MIC value 1600 πœ‡g/ml [48]. sputum [100]. Stem: methanol/1-(2-hydroxy-41 exhibited anti-TB activity against H37Ra strain with the MIC methoxyphenyl)-3-(4-hydroxy-3Khamin Coughing, leprosy [102]. of 3.13 πœ‡g/mL [101]. methoxyphenyl)propane (1) were khruea isolated from the extract Root: dichloromethane/Globiferin (1), cordiachrome B (2), Compounds 1, 2,3 displayed good activity (MIC, 6.2, 12.5, cordiachrome C (3), cordiaquinol C 1.5 πœ‡g/ml resp.) using MABA against H37 Ra, followed by 5, 6,7 Sak Hin Cough [104]. (4), alliodorin (5), elaeagin (6), (MIC, 12.5 πœ‡g/ml) and then 4 with MIC of 25 πœ‡g/ml [103]. cordiachromene (7) were isolated from the extract The methanol extract of Stem and flowers exhibited anti-TB Setawar halia Stem and flowers: 80% methanol Asthma, bronchitis [105]. activity against H37Rv strain with the MIC value 800 πœ‡g/ml [48].

Bunga pagoda

Local name Part used: extract/active compound Activity

Table 1: Continued.

12 Evidence-Based Complementary and Alternative Medicine

Family

Euphorbiaceae

Zingiberaceae

Scientific name

Croton kongensis Gagnep.

Curcuma aeruginosa Roxb.

Leaves: crude dichloromethane extract. ent-8,9-seco-7𝛼,11𝛽-diacetoxykaura8(14),16-dien-9,15-dione (1), ent-8,9-seco-8,14-epoxy-7𝛼hydroxy-11𝛽-acetoxy-16-kauren9,15-dione (2), ent-8,9-seco-7𝛼-hydroxy-11𝛽acetoxykaura-8(14),16-dien-9,15dione (3), all were isolated from dichloromethane extract of leaves Whole plants, leaves: ethanol, ethyl acetate, methylene chloride, Plao Ngeon, n-Hexane/ent-1𝛽,7𝛼,14𝛽Kh sΛ†am bc triacetoxykaur-16-en-15-one (1), bα»™ ent-7𝛼,18-dihydroxykaur-16-en-15one (2), ent-16(S)-18-acetoxy-7𝛼hydroxykaur-15-one (3), ent-18-acetoxy-7𝛼-hydroxykaur-16en-15-one (4), ent-1𝛽,14𝛽-diacetoxy-7𝛼hydroxykaur-16-en-15-one (5), ent-1𝛽-acetoxy-7𝛼,14𝛽dihydroxykaur-16-en-15-one (6), ent-7𝛼,14𝛽-dihydroxykaur-16-en15-one (7) were all isolated from ethanol, ethyl acetate, methylene extract of whole plants and leaves Waan Rhizomes: water/essential oil mahaamek Using GFPMA, essential oil showed weaker anti-TB activity against H37Ra strain with 2500 πœ‡g/ml MIC value [109].

The activities against H37Ra strain were observed at the MIC of 25–50, >50, 6.25–12.5, 12.5–25 πœ‡g/ml from ethanol, ethyl acetate, methylene chloride, n-Hexane crude extracts of whole plants and leave using microtiter resazurin assay. Isolated compound 1 exhibited the highest activity with MIC values of 0.78, 1.56, 3.12–12.5 πœ‡g/ml against H37Ra, H37Rv, other resistant strains of M. tb screened. Both compounds 2 and 3 exhibited MIC at 1.56 πœ‡g/ml. Compounds 4, 5, 6,7 on the other hand showed MIC value 3.12–6.25 against H37Ra and H37Rv and other resistant strains of M. tb [108].

Dichloromethane crude extract exhibited activity against H37Ra strain with the MIC value 12.5 πœ‡g/ml in MABA. The isolated compounds 2 and 3 showed better activity with the MIC value 6.25 πœ‡g/ml than compound 1 with 25.0 πœ‡g/ml MIC [106].

Local name Part used: extract/active compound Activity

Table 1: Continued.

Dyspepsia [109].

Leprosy, weight loss [107].

Traditional uses (references)

Evidence-Based Complementary and Alternative Medicine 13

Family

Leguminosae

Annonaceae

Leguminosae

Leguminosae

Scientific name

Dalbergia parviflora Roxb.

Dasymaschalon dasymaschalum (Blume) I. M. Turner

Dendrolobium lanceolatum (Dunn) Schindl.

Derris indica L

KradukKhiat

Buu ngong

Sak Kee

Stem: hexane, ethyl acetate, methanol/Flavanone (1), dalparvone (2), dalparvinene (6) were isolated from the extract Leaves: ethyl acetate/3𝛽-hydroxy-21-O-acetyl-24methylenecycloartane (1) was obtained from the extract Root: hexane and dichloromethane/Flavanones 1 (1), flavanones (2), flavan (3), dibenzocycloheptene derivative (4), 4σΈ€  -hydroxy-7,8-(2σΈ€ σΈ€  ,2σΈ€ σΈ€  dimethylpyran)flavan (5) isolated from the extract. Root and stem: dichloromethane extract/3-methoxy-(3σΈ€ σΈ€  ,4σΈ€ σΈ€  -dihydro3σΈ€ σΈ€  ,4σΈ€ σΈ€  -diacetoxy)-2σΈ€ σΈ€  ,2σΈ€ σΈ€  dimethylpyrano-(7,8:5σΈ€ σΈ€  ,6σΈ€ σΈ€  )-flavone (1), 2σΈ€  -methoxy-4σΈ€  ,5σΈ€  methylenedioxyfurano [7,8:4σΈ€ σΈ€  ,5σΈ€ σΈ€  ]-flavone (2), 8,4σΈ€  -dimethoxy-7-O-𝛾,𝛾dimethylally-lisoflavone (3), 3,4-methylenedioxy-10-methoxy-7oxo[2]benzopyrano[4,3b]benzopyran (4), desmethoxy kanugin (5), karanjin (6), lacheolatin B (7), pongachromene (8), 3,7-dimethoxyflavone (9), pachycarin D (10), maackiain (11), medicarpin (12) karanjachromene (13), pinnatin (14) isolated from this extract

Nil.

Nil.

Bronchitis and whooping cough [23].

Compound 1 exhibited highest activity against H37Ra strain with MIC of 6.3 πœ‡g/ml, followed by 2 (MIC, 12.5 πœ‡g/ml) and then 3 and 5 with MICs of 25 πœ‡g/ml [112].

4, 13,14 (6.25, 12.5, 12.5 πœ‡g/ml, resp.) showed stronger activity compared to 1, 5, 7, 9, 10 (25, 50, 50, 50, 50 πœ‡g/ml resp.) that showed moderate activity, with 3, 8, 10,12 (100, 100, 200, 100 πœ‡g/ml resp.) showing weaker activity against H37Ra strain using MABA [113].

Expectorant [110].

Traditional uses (references)

Compound 1 displayed activity against H37Ra strain with the MIC value of 50 πœ‡g/ml [111].

Using GFPMA, compound 1 exhibited good anti-TB activity against H37Ra strain with the MIC of 12.5 πœ‡g/ml, while compounds 2 and 6 showed activity with the MICs of 50 πœ‡g/ml [110].

Local name Part used: extract/active compound Activity

Table 1: Continued.

14 Evidence-Based Complementary and Alternative Medicine

Eclipta prostrata (L.) L. Kra-meng

Tako Na

Ebenaceae

Asteraceae

Kluai ruesi

Nom ngua

Chan

Nil.

Compound 2 exhibited good (MIC = 6.25 πœ‡g/ml) anti-TB activity against H37Ra, followed by compound 4 (MIC = 50 πœ‡g/ml). Compounds 1 and 3 showed weak activity (MICs β‰₯ 200 πœ‡g/ml) [115].

Asthma and TB [117].

Nil.

Nil.

Fever [114].

Traditional uses (references)

1 and 2 exhibited moderate to weak anti-TB activity against H37Ra strain with MIC of 25 and 200 πœ‡g/ml, respectively [114].

Diospyrin isolated showed activity against H37Ra in MABA with the MIC of 6.25 πœ‡g/ml [116]. Betulinaldehyde exhibited inhibitory activity in microbroth dilution assay against H37Ra with the MIC of 25 πœ‡g/ml [116]. Water, chloroform, methanol extracts of whole plant exhibited Whole plant: chloroform methanol inhibition in MABA against H37Ra strain at the MICs of 62.5, water 125, 1000 πœ‡g/ml respectively [41].

Betulinic acid (1) and 2-oxo-3𝛽,19𝛼dihydroxy-24-nor-urs-12-en-28-oic acid (2) Fruits: dichloromethane/palmarumycins JC1 (1), palmarumycins JC2 (2), isodiospyrin (3), isodiospyrol A (4) were isolated from the extract Diospyrin, isolated from dichloromethane extract of wood Betulinaldehyde, obtained from dichloromethane extract of wood

Local name Part used: extract/active compound Activity

Ebenaceae

Ebenaceae

Diospyros ehretioides Wall. ex G. Don

Diospyros glandulosa Lace Diospyros rhodocalyx Kurz

Ebenaceae

Family

Diospyros decandra Lour.

Scientific name

Table 1: Continued.

Evidence-Based Complementary and Alternative Medicine 15

Leguminosae

Zingiberaceae

Etlingera elatior (Jack) R. M. Sm.

Fabaceae

Leguminosae

Family

Erythrina subumbrans Merr.

Erythrina fusca Lour.

Eriosema chinense Vogel

Scientific name

All compounds 1, 2, 3, 4 exhibited anti-TB activity against H37Ra with the MICs of 12.5 πœ‡g/ml [122].

Nil.

Cough [122].

Antibacterial [120].

Compounds 1, 2, 3,4 demonstrated anti-TB activity against H37Ra with MICs of 100, 50, 50, 25 πœ‡g/ml, respectively [119].

Compound 1 showed activity against H37Ra strain with 50 πœ‡g/ml MIC value [121].

Nil.

Traditional uses (references)

Crude hexane extract showed anti-TB activity against H37Ra strain with the MIC value of 50 πœ‡g/ml using MABA. Compounds 10, 11, 12,13 demonstrated good anti-TB activity against H37Ra strain with the same MIC value of 12.5 πœ‡g/ml. Compounds 1, 8,9 exhibited moderate activity with the same MIC value of 25 πœ‡g/ml. Compounds 2 and 6 showed activity at MIC values of 50 and 100 πœ‡g/ml, respectively [118].

At 100 πœ‡g/ml, the methanolic extract of rhizomes showed 86% Rhizomes: methanol/Stigmasterol inhibition against H37Rv. Bunga kantan (1) and 𝛽-sitosterol (2) were isolated The isolated compounds 1 and 2 exhibited MIC > 128 πœ‡g/ml from the extract [58].

Roots: hexane, dichloromethane, methanol/Khonklonginol A (1), B (2), F (6), H (8), lupinifolinol (9), Toon dehydrolupinifolinol (10), flemichin Khonklong D (11), eriosemaone A (12), lupinifolin (13) were obtained from the extract Stem bark: hexane and ethyl acetate/sandwicensin (1), Thong long erythrisenegalone (2), lonchocarpol A (3), lupinifolin (4) were isolated from the extract Bark: n-hexane, dichloromethane and methanol/1-methoxyerythrabyssin II (1) was isolated from the extract Stem: n-hexane and dichloromethane/erystagallin A (1), erycristagallin (2), 5-hydroxysophoranone (3), erysubin F (4) were isolated from the extract

Local name Part used: extract/active compound Activity

Table 1: Continued.

16 Evidence-Based Complementary and Alternative Medicine

Fabaceae

Annonaceae

Flemingia strobilifera (L.) W. T. Aiton

Friesodielsia discolor (Craib) D. Das

Clusiacea

Moraceae

Ficus carica L.

Garcinia mangostana L.

Rutaceae

(Bignoniaceae)

Fernandoa adenophylla (Wall. Ex G. Don) Steenis

Feroniella lucida Swingle

Zingiberaceae

Family

Etlingera pavieana (Pierre ex Gagnep.) R. M. Sm.

Scientific name

Fruits and flowers: 90% ethanol

Mangkhud

Serengan

Ara

Leave: dichloromethane and ethyl acetate/3σΈ€  -formyl-2σΈ€  ,4σΈ€  -dihydroxy6σΈ€  -methoxychalcone (1) was isolated from the extract Fruits: 𝛼-mangostin (1), 𝛽-mangostin (2), 𝛾-mangostin (3), garcinone D (4), mangostenol (5), garcinone B (6), mangostanin (7), mangostanol (8), mangostenone A (9), tovophyllin B (10), demethylcalabaxanthone (11), trapezifolixanthone (12), mangostinone (13) all isolated from chloroform, methanol extract

Leaves: 80% methanol

Leaves: 80% methanol

90% ethanol Sung (mak)/kohk Fruits and flowers: 90% ethanol sung

Khae Pa

Rhizomes: dichloromethane/(E)((E)-3-(4-methoxyphenyl)allyl)3(4-hydroxyphenyl)acrylate (1) was isolated from the crude extract

Compounds isolated showed activities against H37Ra in microbroth dilution at different MIC values (πœ‡g/ml) 6.25 (1), 6.25 (2), 25 (3), 25 (4), 100 (5), 6.25 (6), 25 (7), 200 (8), 25 (9) 25 (10), 12.5 (11), 12.5 (12), 200 (13) [129].

Compound 1 exhibited anti-TB activity against H37Ra strain with 6.25 πœ‡g/ml MIC value [128].

At MIC = 1600 πœ‡g/ml, the extract showed anti-TB activity against H37Rv strain [48].

The extract showed inhibition against H37Rv at MIC value 91.54 πœ‡g/ml in MABA [44]. In MABA, 90% ethanolic extract of fruits and flowers exhibited activity against H37Rv strain with MIC ranging from 90.4 to >100 πœ‡g/ml [44]. There was anti-TB activity against H37Rv strain at 1600 πœ‡g/ml [48].

In microbroth dilution assay, the extract exhibited inhibition at MIC of 79.7 to >100 πœ‡g/ml [47].

Compound 1 demonstrated anti-TB activity with the MIC value of 50.00 πœ‡g/ml [123].

Local name Part used: extract/active compound Activity

Table 1: Continued.

Fever [130].

Nil.

TB [127].

Asthma, cough [126].

Cough, TB [44, 125].

Skin diseases [124].

Fever and cough [123].

Traditional uses (references)

Evidence-Based Complementary and Alternative Medicine 17

Gynura divaricata (L.) DC. Gynura pseudochina (L.) D.C. var. hispida Thv. Haplophragma adenophyllum (Wall. ex G. Don) Dop

Goniothalamus laoticus (Finet & Gagnep.) Bˆan

Glycosmis pentaphylla (Retz.) DC. Goniothalamus gitingensis Elmer

Scientific name

Bignoniaceae

Asteraceae

Asteraceae

Annonaceae

Annonaceae

Rutaceae

Family

In microbroth dilution, the isolated compound 4 showed the best activity against H37Ra with MIC of 12.5 πœ‡g/ml, followed by compounds 2 and 3 both with the MIC of 6.25 πœ‡g/ml, and then compound 1 with 100 πœ‡g/ml [133].

1 showed anti-TB with the MIC of 16 πœ‡g/ml [132].

The 90% ethanol extracts of fruits and flowers exhibited activities against H37Rv strain with the MIC of 93.5 to >100 πœ‡g/ml in MABA [47].

Cold [134].

Nil.

Cough [131].

Traditional uses (references)

Kay pa

90% ethanol

In MABA, the MIC of 83.25 πœ‡g/ml was observed against H37Rv [44].

Cough [44].

The essential oil showed inhibitory effect against H37Ra strain Bronchitis and pulmonary with the MIC value of 50 πœ‡g/ml [135]. TB [135]. At the MIC of 200 πœ‡g/ml, chloroform extract of whole plant Asthma, fever, AIDS Waan Whole plant: chloroform methanol exhibited activity against H37Ra strain while both methanol and [136, 137]. water extracts exhibited activity at 1000 πœ‡g/ml MIC, respectively Mahaakaan water [41].

Leaves/Liriodenine (1) was isolated from the extract Flowers: goniotriol (1), (+)-altholactone (2), howiininA (3) Khao-Lam- and an aporphine alkaloid; (βˆ’)-nordicentrine (4), all isolated dong from n-hexane, ethyl acetate, methanol extracts Leaves: hexane, dichloromethane, methanol/essential oil

Xom Xeuan Fruits and flowers: 90% ethanol

Local name Part used: extract/active compound Activity

Table 1: Continued.

18 Evidence-Based Complementary and Alternative Medicine

Lamiaceae

Oleaceae

Jasminum sambac (L.) Aiton

Euphorbiaceae

Malvaceae

Boraginaceae

Zingiberaceae

Family

Hyptis suaveolens (L.) Poit.

Hymenocardia wallichii Tul

Heliotropium indicum Linn. Hibiscus rosa-sinensis L.

Hedychium ellipticum Buch.-Ham. ex Sm.

Scientific name

Melor

Maeng luk kha

Bunga raya

Leaves: 80% methanol

Stem: dichloromethane, methanol, hexane/Squalene were isolated from the extract Whole plant: hexane, chloroform and methanol/8𝛼,9𝛼-epoxysuaveolic acid (2), suaveolic acid (4), suaveolol (5) were isolated from the extract

Leaves: 80% methanol

Yaa Nguang Leaves: water Chaang

Fever and respiratory tract infections [143].

Cough, Leprosy [144].

At MIC = 1600 πœ‡g/ml, the crude extract showed inhibition against H37Rv strain [48].

Nil.

Cough, leprosy, bronchial catarrh [141].

Compounds 2, 4, 5 displayed weak anti-TB activities (MIC 100–200 πœ‡g/ml) against H37Ra strain using MABA [143].

Squalene displayed anti-TB activity against H37Ra strain with the MIC value of 100 πœ‡g/ml [142].

The crude extract showed activity against H37Ra strain using MABA with the MIC of 20.8 πœ‡g/ml [140]. The extract exhibited anti-TB activity against H37Rv strain at the MIC of 1600 πœ‡g/ml [48].

Asthma [140].

Bronchitis [139].

Rhizomes: n-hexane and dichloromethane/Coronarin E (1) and 16-Hydroxylabda-8(17),11,13trien-15,16-olide (7) were isolated from the extract

Compounds 1 and 7 exhibited good anti-TB activity against H37Ra strain using GFPMA with the MIC value of 12.5 and 6. 25 πœ‡g/ml, respectively [138].

Traditional uses (references)

Local name Part used: extract/active compound Activity

Table 1: Continued.

Evidence-Based Complementary and Alternative Medicine 19

Zingiberaceae

Verbenaceae

Sapindaceae

Kaempferia marginata Carey

Lantana camara L.

Lepisanthes rubiginosa (Roxb.) Leenh. Mertajam

Leaves: 80% methanol

Not stated

Kembang telek

Not stated

Tup mup

Kencur

Zingiberaceae

In broth microdilution assay, the extract showed inhibition against H37Rv strain at 1600 πœ‡g/ml [48].

At 500 πœ‡g/ml, the extract exhibited 94.0 and 79.0% inhibition against H37Rv and MDR, respectively, in LRP assay [38].

Compounds sandaracopimaradien-1𝛼-ol and 2𝛼-acetoxysandaracopimaradien-1𝛼-ol exhibited ant-TB activity against H37Ra strain with the MIC values of 25 and 50 πœ‡g/ml, respectively. Compounds 2, 3, 6, sandaracopimaradien-1𝛼,2𝛼-diol were less active (MICs of > 100 πœ‡g/ml) [150].

The extract exhibited anti-TB activity against H37Rv strain at the MIC of 1600 πœ‡g/ml [48]. In LRP assay, the extract at 500 πœ‡g/ml exhibited 69.0% inhibition against both H37Rv and MDR strain [38].

Caniojane exhibited anti-TB activity against H37Ra strain using MABA with 25 πœ‡g/ml MIC value [146].

Roots: dichloromethane and ethanol/caniojane were isolated from the extract Leaves: 80% methanol

The extract showed in vitro activity against H37Rv strain at the MIC of 1600 πœ‡g/ml [48].

Leaves: 80% methanol

Whole plant: dichloromethane and/(1R,2S,5S,9S,10S,11R,13R)-1,2,11trihydroxy-pimara-8(14),15-diene (2), (1S,5S,7R,9R,10S,11R,13R)-1,7,11-trihydroxypimara-8(14),15-diene (3), (1R,2S,5S,7S,9R,10S,13R)-1,2dihydroxypimara-8(14),15diene-7-one (6), sandaracopimaradien-1𝛼-ol,2𝛼acetoxysandaracopimaradien-1𝛼-ol, sandaracopimaradien-1𝛼,2𝛼-diol were isolated from the extract

Urat sugi

Euphorbiaceae

Jatropha integerrima Jacq.

Jarak

Local name Part used: extract/active compound Activity

Acanthaceae

Euphorbiaceae

Jatropha curcas L.

Justicia gendarussa Burm. f. Kaempferia galangal L.

Family

Scientific name

Table 1: Continued.

TB [153].

TB, leprosy, asthma [151, 152].

Fever [150].

Asthma, cough [149].

Respiratory disorders [148].

Styptic [147].

Leprosy [145].

Traditional uses (references)

20 Evidence-Based Complementary and Alternative Medicine

Morinda citrifolia Linn.

Momordica charantia L.

Rubiaceae

Cucurbitaceae

Noni

Ampalaya

Leaves: ethanol/2,4-bis(2phenylpropan-2-yl)phenol (1) isolated from the extract Leaves: ethanol and hexane/(E)-phytol (1), cycloartenol (2), stigmasta-4-en-3-one (3), stigmasta-4-22-dien-3-one (4), 𝛽-sitosterol (5), stigmasterol (6), campesta-6,22-dien-5𝛼,8𝛼epidioxy-3𝛽-ol (7) were isolated from the extract

Sa Mat Khao Fruits and flowers: 90% ethanol

At 100 πœ‡g/ml, the crude extract of ethanol and hexane fractions displayed 89 and 95% inhibition, respectively, against H37Rv strain. 2 : 1 mixture of compounds 3 and 4 exhibited good activity (MIC = 2 πœ‡g/ml) against H37Rv strain followed by 7 (MIC = 2.5 πœ‡g/ml) and then 1 and 6 (MICs = 32 πœ‡g/ml). Compound 2 and 5 were less active with MIC values of 64 and 128 πœ‡g/ml, respectively [159].

Respiratory infection [159].

Leprosy [158].

Cough, fever [156].

The activity against H37Rv strain in MABA was observed at the MIC of 45.7 to >100 πœ‡g/ml from 90% ethanolic extract [47]. Compound 1 exhibited anti-TB activity against H37Rv strain MIC value of 14 πœ‡g/ml using MABA [157].

Nil.

Expectorant [155].

TB [48].

Traditional uses (references)

The extract of fruits and flowers exhibited activities at MIC ranging between 0.05 and 11.9 πœ‡g/ml in MABA against H37Rv [47].

Both compounds 1 and 2 showed activities against H37Ra in MABA at the MIC = 200 πœ‡g/ml [154].

Flavones nevadensin (1) and isothymusin (2), all were isolated from chloroform extract of aerial part

Rutaceae

Prod Ka yaeng

In TEMA, the extract showed inhibition against H37Rv strain at 1600 πœ‡g/ml [48].

Leaves: 80% methanol

Tin Tang Tia Fruits and flowers: 90% ethanol

Scrophulariaceae

Limnophila geoffrayi Bonati

Palas tikus

Local name Part used: extract/active compound Activity

Annonaceae

Arecaceae

Licuala spinosa Thunb.

Marsypopetalum modestum (Pierre) B. Xue Micromelum minutum Wight & Arn.

Family

Scientific name

Table 1: Continued.

Evidence-Based Complementary and Alternative Medicine 21

Rutaceae

Murraya paniculata (L.) Jack

Pedilanthus tithymaloides (L.) Poit.

Euphorbiaceae

Passifloraceae

Lamiaceae

Moraceae

Morus alba L.

Orthosiphon stamineus Benth. Passiflora foetida L.

Family

Scientific name Merbatu

Leaves and fruit: 80% methanol

In broth microdilution assay, the extract showed inhibition against H37Rv strain at 1600 πœ‡g/ml [48]. Chloroform extract of leaves at the MIC of 250 πœ‡g/ml showed Kaeo Leaves: chloroform methanol water activity against H37Ra strain while both methanol and water extracts exhibited activity at 1000 πœ‡g/ml MIC, respectively [41]. Misai Leaves: hexane, chloroform, ethyl The hexane, chloroform, ethyl acetate extracts of leaves Kuching acetate exhibited activity with the MICs of 25.00, 3.12, 6.25 πœ‡g/ml [164]. Letup-letup Whole plant: 80% methanol There was inhibition against H37Rv at MIC = 1600 πœ‡g/ml [48]. Leaves: methanol, water, hexane/1𝛼,13𝛽,14𝛼-trihydroxy3𝛽,7𝛽-dibenzoyloxy-9𝛽,15𝛽diacetoxyjatropha-5,11E-diene (1), 1𝛼,7𝛽,13𝛽,14𝛼-tetrahydroxy-3𝛽benzoyloxy-9𝛽,15𝛽diacetoxyjatropha-5,11E-diene (2), 1𝛼,8𝛽,9𝛽,14𝛼,15𝛽-pentaacetoxy-3𝛽- Compound 1 showed stronger (12.5 πœ‡g/ml) activity compared to benzoyloxy-7-oxojatropha-5,12Sa yaek 2, 3, 4, and 5 (100, 50, 100, and 50 πœ‡g/ml resp.) against H37Ra in diene (3), MABA [167]. 7,8𝛽,9𝛽,14𝛼,15𝛽-pentaacetoxy-3𝛽benzoyloxy-1𝛼,5𝛽dihydroxyjatropha-6(7),12-diene (4), 1𝛼,7,8𝛽,9𝛽,14𝛼,15𝛽hexaacetoxy-3𝛽-benzoyloxy-5𝛽hydroxyjatropha-6(7),12-diene (5) were obtained from the extract

Local name Part used: extract/active compound Activity

Table 1: Continued.

Nil.

Cough [166].

Loss of weigh [165].

Cough, asthma, expectorant [161–163].

Cough [160].

Traditional uses (references)

22 Evidence-Based Complementary and Alternative Medicine

Piperaceae

Euphorbiaceae

Phyllanthus acidus (L.) Skeels

Piper betle L.

Phytolaccaceae

Family

Petiveria alliacea L.

Scientific name

Plu, Daun sirih

Cermai

Singawalang

Leaves:chloroform methanol water

Leaves: 80% methanol

Not stated

96% ethanol: leaves

The ethanolic extract of leaves exhibited activity against drug sensitive and resistant strains of H37Rv at the MIC of 1280 πœ‡g/ml [168]. At 500 πœ‡g/ml, the extract exhibited 98.0 and 76.0% inhibition against H37Rv and MDR, respectively, in LRP assay [38]. The extract exhibited anti-TB activity against H37Rv strain at the MIC = 1600 πœ‡g/ml [48]. Chloroform extract of leaves was more active against H37Ra strain with MIC value 62.5 πœ‡g/ml than the methanol and water extract both with activity at MIC of 1000 πœ‡g/ml [41].

Local name Part used: extract/active compound Activity

Table 1: Continued.

Asthma, leprosy cough, dyspnea, bronchitis [171–173].

Cough [170].

Antibacterial [169].

Traditional uses (references)

Evidence-Based Complementary and Alternative Medicine 23

Piperaceae

Piperaceae

Piperaceae

Araceae

Piper nigrum L.

Piper sarmentosum Roxb.

Pistia stratiotes L.

Family

Piper chaba Hunter

Scientific name Fruit: chloroform, methanol, water; compound Piperine (1) was isolated from chloroform crude extract of fruit Stem: n-hexane/chabamide (1) was isolated from the extract

Inhibition against H37Ra strain was observed at MIC (πœ‡g/ml) of 16, 25, 1000 with respect to the chloroform, methanol, water extract of fruit in MABA. Compound 1 isolated exhibited Dee plee activity at MIC of 50 πœ‡g/ml [41]. Compound 1 exhibited anti-TB activity with the MIC value of 12.5 πœ‡g/ml against H37Ra strain [175]. The extract exhibited anti-TB activity against H37Rv strain at Fruit: 80% methanol the MIC of 1600 πœ‡g/ml [48]. Lada hitam Ethyl acetate, n-hexane, water extract fraction of leaves Leaves: ethyl acetate n-hexane water exhibited inhibition against H37Rv strain using TEMA at the MIC values of 25, 50, 100 πœ‡g/ml, respectively [176]. At the MIC = 800 πœ‡g/ml, the extract showed inhibition against Whole plant: 80% methanol H37Rv strain [48]. The methanol extract of leaves showed more activity against MTB (MIC 12.5 πœ‡g/ml) in TEMA than both petroleum ether Leaves: petroleum ether, and Chloroform extracts (MIC 25 πœ‡g/ml). The ethyl acetate and Chloroform, methanol chloroform fractions of methanol extract exhibited MICs at 3.12 πœ‡g/ml [179]. The aqueous and ethanol extracts of leaves exhibited anti-TB activity MIC/MBC 12.5 πœ‡g/ml. Methanolic extract was Leaves: aqueous, ethanol Kadok, fractionated with ethyl acetate; the fraction of ethyl acetate Cha-plu exhibited anti-TB activity with MIC/MBC 3.12 πœ‡g/ml [180]. Fruits: hexane and methanol/pellitorine (1), Compounds 1 and 11 were more active (MICs = 25 πœ‡g/ml) guineensine (2), brachystamide B (3), sarmentine (4), brachyamide B against H37Ra strain followed by 2, 4, 5 (MICs = 50 πœ‡g/ml); then 3 and 8 showed weaker activities with the MIC values of (5), sarmentosine (8), 1-(3,4-methylenedioxyphenyl)-1E- 100 and 200 πœ‡g/ml, respectively [181]. tetradecene (11) were isolated from the extract The inhibition against H37Rv was observed at the MIC of Water lettuce Whole plant: 80% methanol 1600 πœ‡g/ml [48].

Local name Part used: extract/active compound Activity

Table 1: Continued.

Leprosy, TB [182].

Cough [178].

Asthma, bronchitis, TB, sore throat [176, 177].

Asthma [174].

Traditional uses (references)

24 Evidence-Based Complementary and Alternative Medicine

Annonaceae

Lamiaceae

Polyalthia debilis (Piere) Finet & ganep

Premna odorata Blanco

Annonaceae

Commelinaceae

Annonaceae

Polyalthia cerasoides (Roxb.) Benth. ex Bedd

Rhoeo spathacea (Sw.) Stearn Rollinia mucosa (Jacq.) Baill.

Asteraceae

Family

Pluchea indica (L.) Less.

Scientific name

Leaves: aqueous

In TEMA, the extracts of flowers and leaves showed inhibitory activities against H37Rv strain at the MIC of 800 πœ‡g/ml each [48]. The extract showed 100% inhibition against H37Rv and MDR at 5 mg/ml [62].

Root: hexane, EtOAc, MeOH/Bidebiline E (1), Isolated compounds 1, 2,3 showed anti-TB activity against octadeca-9,11,13-triynoic acid (2), Sai den H37Ra strain with MICs of 6.25 πœ‡g/ml [184]. 𝛼-humulene (3) were isolated from the extract Compounds 1, 2, 3 showed moderate anti-TB activity against Root: methanol/Debilisone B (1), Kon Krok H37Ra strain with MIC values of 25.0, 12.5, 25.0 πœ‡g/ml, Debilisone C (2), Debilisone E (3) respectively [185]. Leaves: methanol and Crude methanolic extract showed inhibition against H37Rv dichloromethane/1-heneicosyl strain with >128 πœ‡g/ml MIC. Compound 1 showed good anti-TB Alagaw formate (1) was isolated from the activity (8 πœ‡g/ml) [187]. extract At 5 mg/ml, the extract exhibited 100% inhibition against H37Rv Nil Leaves: 80% methanol and MDR [62]. Fruits and flowers extract were active at MIC ranging between Khanthaloht Fruits and flowers: 90% ethanol 43.9 and 75.2 πœ‡g/ml in MABA [47].

Beluntas

Flower Leaves: 80% methanol

Local name Part used: extract/active compound Activity

Table 1: Continued.

Nil.

TB, asthma [188].

TB [187].

TB [186].

Fever [184].

TB [183].

Traditional uses (references)

Evidence-Based Complementary and Alternative Medicine 25

Rubiaceae

Euphorbiaceae

Selaginellaceae

Leguminosae

Solanaceae

Sapium indicum L.

Selaginella plana (Desv. ex Poir.) Hieron.

Sesbania grandiflora (L.) Poir.

Solanum spirale Roxb.

Family

Rothmannia wittii (Craib) Bremek.

Scientific name

Pak dit

Geti

Fruit: water

Root: methanol/isovestitol (1), medicarpin (2), sativan (3), betulinic acid (4)

Fruit: 80% methanol

Paka merak Whole plant: 80% methanol

Muk Mo

Bark and fruits: n-Hexane and ethyl acetate/A compound 6𝛽-hydroxy-10-O-acetylgenipin (1) was isolated from the extract Fruit: hexane/compounds 12-(2-N-methylaminobenzoyl)4𝛽,5,20-trideoxyphorbol-13-acetate (1), 12-(2-N-methylaminoben-zoyl)4𝛼,5,20-trideoxyphorbol-13-acetate (2), sapintoxin A (3), 𝛼- saponine (4), sapintoxin C (5), 12-(2-N-methylaminobenzoyl)4𝛼,20-dideoxy-5-hydroxyphorbol13-acetate (6) sapintoxin B (7), 12-(2σΈ€  -N-methylaminobenzoyl)-4𝛼deoxy-5,20-dihydroxyphorbol-13acetate (8), 12-(2-methylaminobenzoyl)-4deoxyphorbaldehyde-13-acetae (9) were isolated from extract

The extract exhibited inhibition against H37Rv strain at the MIC of 1600 πœ‡g/ml [48]. The methanol crude extract exhibited anti-TB activity against H37Rv with MIC value of 625 πœ‡g/ml. Isolated compounds 1-3 exhibited MIC of 50 πœ‡g/ml while compound 4 showed activity at MIC of 100 πœ‡g/ml [193]. Essential oil extracted showed anti-TB activity against H37Ra strain with MIC value of 50 πœ‡g/ml [194].

Fevers and colds [194].

Sore throat [192].

Coughing and asthma [48].

Fever [191].

Compound 3 (MIC, 3.12 πœ‡g/ml) was the most active compound against H37 Ra using MABA, followed by 7 (MIC, 12.5 πœ‡g/ml) and then followed by 5, 8,9 (MIC, 25 πœ‡g/ml). Compound 1 showed moderate activity (MIC, 50 πœ‡g/ml) while 2, 4,6 showed weak activity (200, >200, >200 MIC, πœ‡g/ml, respectively) [190].

In in vitro assay, the extract showed activity against H37Rv at 1600 πœ‡g/ml MIC [48].

Fever [189].

Traditional uses (references)

Compound 1 displayed activity against H37 Ra using MABA with MIC value of 12.50 πœ‡g/ml [189].

Local name Part used: extract/active compound Activity

Table 1: Continued.

26 Evidence-Based Complementary and Alternative Medicine

Family

Solanaceae

Asteraceae

Anacardiaceae

Apocynaceae

Menispermaceae

Menispermaceae

Euphorbiaceae

Scientific name

Solanum torvum Sw.

Spilanthes acmella (L.) Murray

Spondias pinnata (L.f.) Kurz

Tabernaemontana coronaria (L.) Willd.

Tiliacora triandra (Colebr.) Diels

Tinospora crispa (L.) Hook. F. & Thomson

Trigonostemon reidioides (Kurz) Craib

Among the tested compounds, 12 and 14 were the two most active compounds against H37Ra strain with the MICs of 3.84 πœ‡M, followed by 13, with the MIC of 3.91 πœ‡M. Compounds 11 and 10 were active and moderately active with the MICs of 7.86 and 15.72 πœ‡M, respectively. Compounds 1, 2, 3, 7, 8, 9 exhibited weak activity with MICs of 183.57, 168.71, 88.55, 83.79, 72.58, 38.30 πœ‡M, respectively [203].

Root: n-hexane, EtOAc, MeOH/Compounds trigonoreidon A (1), trigonoreidon B (2), trigonoreidon C (3), trigonostemon Lot Thanong C (7), spruceanol (8), trigonostemone (9), rediocide A (10), rediocide B (11), rediocide C (12), rediocide F (13), rediocide G (14) were isolated from the extract

Compounds 1, 2, 3,4 demonstrated anti-TB activity against MDR-MTB strains with the MIC values ranging from 0.7 to 6.2 πœ‡g/ml [199].

Roots: tiliacorinine (1), 2σΈ€  -nortiliacorinine (2), tiliacorine (3), 13σΈ€  -bromo-tiliacorinine (4) were isolated from the extract

In microbroth dilution assay, the extract exhibited inhibition at MIC of 2.43 to 96.2 πœ‡g/ml [47].

At the MIC of 800 πœ‡g/ml, the extract showed inhibition against H37Rv strain [48].

Leaves: 80% methanol

Kheuah Khao Fruits and flowers: 90% ethanol Ho

Ya-nang

Jasmine

Loloh cemcem

Raan

Terung pipit Fruit: 80% methanol

There was inhibition at the MIC of 1600 πœ‡g/mL against H37Ra strain [48]. The chloroform, methanol, water extract of whole plant Whole plant: chloroform methanol exhibited inhibition in MABA, against H37Ra strain at the MIC water of 500, 1000, 1000 πœ‡g/ml, respectively [41]. The extracts were active against MDR strain of Chloroform, 80% ethanol. Lowenstein-Jensen medium with 100% inhibition at concentration of 100 mg/ml [198].

Local name Part used: extract/active compound Activity

Table 1: Continued.

Asthma [203].

Coughs, asthma leprosy [201, 202].

Fever [200].

TB [48].

Chronic cough [198].

TB, cough, sore throats [196, 197].

Cough [195].

Traditional uses (references)

Evidence-Based Complementary and Alternative Medicine 27

Annonaceae

Annonaceae

Annonaceae

Verbenaceae

Apocynaceae

Uvaria rufa Blume

Uvaria valderramensis Cabuang, Exconde & Alejandro

Vitex trifolia L.

Voacanga globosa Merr.

Family

Uvaria microcarpa Champ. ex Benth.

Scientific name

Bayag-usa

Phi sua

Usog

Mak Phii Phouan, Susung kalabaw

The extract showed inhibition at MIC ranging from 43.2 to >100 πœ‡g/ml against H37Rv [47]. The activity against H37Rv strain was observed at the MIC Fruits and flowers: 90% ethanol ranging from 33.1 to >100 πœ‡g/ml in MABA [47]. Methanol, ethyl acetate, n-butanol All three extracts showed inhibition in MIC value >128 πœ‡g/ml in MABA. Kaempferol (1), quercitrin (2) isolated from methanolic extract of Mixture of 1 and 2 exhibited activities against H37Rv with MIC of 64 πœ‡g/ml using microplate Alamar Blue assay [205]. leave Leaves: dichloromethane and Compound 1 showed better activity (10 πœ‡g/ml) while 2 and 3 methanol/valderramenols A (1), exhibited lesser activity (32 πœ‡g/ml) against H37Rv using MABA grandiuvarone (2), andreticuline (3) [206]. isolated from the extract The extract showed inhibition at MIC value of 8.02 πœ‡g/ml 90% ethanol against H37Rv [44]. In in vitro assays, 90% ethanolic fruit and flower extract Fruits and flowers: 90% ethanol exhibited activity against H37Rv strain at the MIC ranging from 77.6 to >100 πœ‡g/ml [47]. 1 demonstrated potent anti-TB activity against H37Rv strain as Leaves: dichloromethane and demonstrated in MABA (MIC = 4 πœ‡g/ml) and low-oxygen methane/Globospiramine (1) was recovery assay (MIC = 5.2 πœ‡g/ml) [208]. isolated from the extract

Phii Phouan Fruits and flowers: 90% ethanol

Local name Part used: extract/active compound Activity

Table 1: Continued.

TB [209].

Asthma, cough [44, 207].

TB [204].

Nil.

Traditional uses (references)

28 Evidence-Based Complementary and Alternative Medicine

Family

Zingiberaceae

Zingiberaceae

Rhamnaceae

Rhamnaceae

Scientific name

Zingiber officinale Roscoe

Zingiber zerumbet (L.) Roscoe ex Sm.

Ziziphus mauritiana Lam.

Ziziphus oenoplia (L.) Mill.

Traditional uses (references)

In TEMA, the extract of methanol showed inhibition against Rhizome: 80% methanol/6-shogaol H37Rv strain at the MIC of 1600 πœ‡g/ml [48]. At 100 πœ‡g/ml, the Cough, asthma [210]. Halia, Luya (1) and 6-gingerol (2) were isolated methanolic extract of rhizomes showed 61% inhibition against H37Rv. The isolated compound 2 (MIC 33 πœ‡g/ml) showed more from the extract activity than 1 (MIC 64 πœ‡g/ml) [58]. Leprosy, cough, asthma, In MABA, the chloroform, methanol, water extract of rhizome Rhizome: chloroform methanol chest pain, loss of appetite exhibited inhibition against H37Ra strain at the MIC of 125, Haeo dam water [211, 212]. 1000, 1000 πœ‡g/ml, respectively [41]. Root: mauritine M (1) and Isolated compounds exhibited activities against H37Ra at the Asthma, bronchitis Phut-sa nummularines H (2), all isolated MIC 72.8 πœ‡g/ml (1) and 4.5 πœ‡g/ml (2) [213]. [214, 215]. from ethanol extracts Root: hexane, ethyl acetate and Ziziphine N and Q showed weak anti-TB activity against H37Ra Asthma, fever [217]. methanol/Ziziphine N and Q were strain with the same MIC value of 200 πœ‡g/ml [216]. isolated from the extract

Local name Part used: extract/active compound Activity

Table 1: Continued.

Evidence-Based Complementary and Alternative Medicine 29

30 showing MIC values of 50 πœ‡g/ml) were obtained. 1σΈ€  Acetoxychavicol acetate isolated from Alpinia galanga (L.) Sw. exhibited MIC value of 0.024 πœ‡g/ml. Pimaric acid, 9𝛼13𝛼-epidioxyabiet-8 (14)-en-18-oic acid, and 15-hydrooxydehydroabietic acid obtained from Anisochilus harmandii Doan ex Suddee & A. J. Paton all showed MIC value of 50 πœ‡g/ml. Lakoochins A and B isolated from Artocarpus lakoocha Roxb. showed MICs of 12.5 and 50 πœ‡g/ml, respectively. Flavonoid artonin F, chromone artorigidusin, xanthone artoindonesianin C, flavonoid cycloartobiloxanthone, and flavonoid 7-demethylartonol E isolated from Artocarpus rigidus Wall. showed MIC values of 6.25, 12.5, 12.5, 25, and 50 πœ‡g/ml, respectively. Active compounds obtained from Camchaya calcarea Kitamura are isogoyazensolides (MIC, 1.5 πœ‡g/ml), goyazensolides, lychnophorolides A, isocentratherin, isogoyazensolides and 5-epi-isocentratherin (with the same MIC value of 3.1 πœ‡g/ml), lychnophorolides B, 1(10),E,4Z,11(13)-germacratriene-12,6-olide-15-oic acid, and caffeic acid methyl ester (MICs, 6.2, 50, and 25 πœ‡g/ml resp.). Caseargrewiin A, Caseargrewiin B, Caseargrewiin D, rel(2S,5R,6R,8S,9S,10R,18S,19R)-18,19-diacetoxy-18,19-epoxy-6methoxy-2-(2-methylbutanoyloxy)cleroda-3,13(16),14-triene, and rel-(2S,5R,6R,8S,9S,10R,18S,19R)-18,19-diacetoxy-18,19epoxy-6-hydroxy-2-(2-methylbutanoyloxy)cleroda-3,13(16), 14-triene (all showing MIC value of 12.5 πœ‡g/ml) and Caseargrewiin C (showing MIC of 25 πœ‡g/ml) were isolated from Casearia grewiifolia Vent. Cabraleadiol, allo-aromadendrane-10𝛽, 14-diol, cabraleahydroxylactone, cabralealactone, allo-aromadendrane-10𝛽, 13, 14-triol (all displaying MICs of 50 πœ‡g/ml), and eichlerialactone (MIC, 25 πœ‡g/ml) were obtained from Chisocheton penduliflorus Planch. ex Hiern. Fluroclausine A and heptazoline isolated from Clausena guillauminii Tanaka all showed MIC of 25 πœ‡g/ml. Dentatin, O-methylated clausenidin, and 3-methoxycarbonylcarbazole isolated from Clausena excavata Burm. f. all showed MIC value of 50 πœ‡g/ml. 1-(2-Hydroxy-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)propane isolated from Combretum griffithii Van Heurck & MΒ¨ull. Arg. showed MIC of 3.13 πœ‡g/ml. Globiferin, cordiachrome B, cordiachrome C (showing MICs of 6.2, 12.5, and 1.5 πœ‡g/ml resp.), alliodorin, elaeagin, cordiachromene (same MIC value of 12.5 πœ‡g/ml), and cordiaquinol C (MIC, 25 πœ‡g/ml) were isolated from Cordia globifera W. W. Smith. The bioactive compounds of Croton kongensis Gagnep., ent1𝛽,7𝛼,14𝛽-triacetoxykaur-16-en-15-one (MICs, 0.78, 1.56, and 3.12–12.5 πœ‡g/ml), ent-7𝛼,18-dihydroxykaur-16-en-15-one (MIC, 1.56 πœ‡g/ml), and ent-16(S)-18-acetoxy-7𝛼-hydroxykaur-15-one exhibited MIC of 1.56 πœ‡g/ml. Furthermore, ent18-acetoxy-7𝛼-hydroxykaur-16-en-15-one, ent-1𝛽,14𝛽-diacetoxy-7𝛼-hydroxykaur-16-en-15-one, ent-1𝛽-acetoxy-7𝛼,14 𝛽dihydroxykaur-16-en-15-one, and ent-7𝛼,14𝛽-dihydroxykaur-16-en-15-one showed MIC values ranging from 3.12 to 6.25 πœ‡g/ml. Other active compounds isolated from Croton kongensis are ent-8,9-seco-8,14-epoxy-7𝛼-hydroxy-11𝛽-acetoxy-16-kauren-9,15-dione (MIC, 6.25 πœ‡g/ml), ent-8,9-seco7𝛼-hydroxy-11𝛽-acetoxykaura-8(14),16-dien-9,15-dione (MIC, 6.25 πœ‡g/ml), and ent-8,9-seco-7𝛼,11𝛽-diacetoxykaura-8(14), 16-dien-9,15-dione (MIC, 25.0 πœ‡g/ml). Flavanone, dalparvone, and dalparvinene isolated from Dalbergia parviflora

Evidence-Based Complementary and Alternative Medicine Roxb. showed MIC values of 12.5, 50, and 50 πœ‡g/ml respectively. 3𝛽-hydroxy-21-O-acetyl-24-methylenecycloartane from Dasymaschalon dasymaschalum (Blume) I. M. Turner exhibited MIC of 50 πœ‡g/ml. Bioactive compounds isolated from Dendrolobium lanceolatum (Dunn) Schindl., Flavanones 1, flavanones, flavan, and 4σΈ€  -hydroxy-7,8-(2σΈ€ σΈ€  ,2σΈ€ σΈ€  dimethylpyran)flavan, exhibited MICs of 6.3, 12.5, 25, and 25 πœ‡g/ml, respectively. Compounds 3,4-methylenedioxy-10methoxy-7-oxo[2]benzopyrano[4,3-b]benzopyran, karanjachromene, pinnatin, 3-methoxy-(3σΈ€ σΈ€  ,4σΈ€ σΈ€  -dihydro-3σΈ€ σΈ€  ,4σΈ€ σΈ€  diacetoxy)-2σΈ€ σΈ€  ,2σΈ€ σΈ€  -dimethylpyrano-(7,8 : 5σΈ€ σΈ€  ,6σΈ€ σΈ€  )-flavone, desmethoxy kanugin, lacheolatin B, 3,7-dimethoxyflavone, and pachycarin D (showing MIC values of 6.25, 12.5, 12.5, 25, 50, 50, 50, and 50 πœ‡g/ml, resp.) were isolated from Derris indica L. Betulinic acid from Diospyros decandra Lour., showing MIC of 25 πœ‡g/ml. From Diospyros ehretioides Wall. ex G. Don, palmarumycins JC2 (MIC, 6.25 πœ‡g/ml) and isodiospyrol A (MIC, 50 πœ‡g/ml) were isolated. Diospyrin, isolated from Diospyros glandulosa Lace, showed MIC value of 6.25 πœ‡g/ml. Betulinaldehyde isolated from Diospyros rhodocalyx Kurz exhibited MIC value of 25 πœ‡g/ml. Dehydrolupinifolinol (MIC, 12.5 πœ‡g/ml), flemichin D (MIC, 12.5 πœ‡g/ml), eriosemaone A (MIC, 12.5 πœ‡g/ml), lupinifolin (MIC, 12.5 πœ‡g/ml), Khonklonginol A (MIC, 25 πœ‡g/ml), Khonklonginol H (MIC, 25 πœ‡g/ml), lupinifolinol (MIC, 25 πœ‡g/ml), and Khonklonginol B (MIC, 50 πœ‡g/ml) were isolated from Eriosema chinense Vogel. From Erythrina fusca Lour., erythrisenegalone (50 πœ‡g/ml MIC), lonchocarpol A (50 πœ‡g/ml MIC), and lupinifolin (25 πœ‡g/ml MIC) were isolated. Bioactive compounds erystagallin A, erycristagallin, 5-hydroxysophoranone, erysubin F (all showing MICs of 12.5 πœ‡g/ml), and 1-methoxyerythrabyssin II (showing MICs of 50 πœ‡g/ml) were obtained from Erythrina subumbrans Merr. (E)-((E)-3-(4-methoxyphenyl)allyl)3-(4-hydroxyphenyl)acrylate from Etlingera pavieana (Pierre ex Gagnep.) R. M. Sm., exhibited MICs of 50 πœ‡g/ml. 3σΈ€  -formyl-2σΈ€  ,4σΈ€  dihydroxy-6σΈ€  -methoxychalcone, a bioactive compound from Friesodielsia discolor (Craib) D. Das, showed MICs of 6.25 πœ‡g/ml. From Garcinia mangostana L., 𝛼-mangostin (MIC, 6.25 πœ‡g/ml), 𝛽-mangostin (MIC, 6.25 πœ‡g/ml), 𝛾mangostin (MIC, 25 πœ‡g/ml), garcinone D (MIC, 25 πœ‡g/ml), garcinone B (MIC, 6.25 πœ‡g/ml), mangostanin (MIC, 25 πœ‡g/ ml), mangostenone A (MIC, 25 πœ‡g/ml), tovophyllin B (MIC, 25 πœ‡g/ml), demethylcalabaxanthone (MIC, 12.5 πœ‡g/ml), and trapezifolixanthone (MIC, 12.5 πœ‡g/ml) were identified as active compounds. Active compound Liriodenine isolated from Goniothalamus gitingensis Elmer exhibited MIC of 16 πœ‡g/ml. Active compounds (+)-altholactone (MIC, 6.25 πœ‡g/ ml), howiininA (MIC, 6.25 πœ‡g/ml), and (βˆ’)-nordicentrine (12.5 πœ‡g/ml) were isolated from Goniothalamus laoticus (Finet & Gagnep.) BΛ†an. Coronarin E and 16-Hydroxylabda8(17),11,13-trien-15,16-olide isolated from Hedychium ellipticum Buch.-Ham. ex Sm. showed MICs of 12.5 and 6.25 πœ‡g/ml, respectively. Caniojane isolated from Jatropha integerrima Jacq. demonstrated MIC of 25 πœ‡g/ml. Bioactive compounds, sandaracopimaradien-1𝛼-ol and 2𝛼-acetoxysandaracopimaradien-1𝛼-ol isolated from Kaempferia marginata Carey, showed MICs of 25 and 50 πœ‡g/ml, respectively.

Evidence-Based Complementary and Alternative Medicine From Morinda citrifolia Linn., campesta-6,22-dien-5𝛼,8𝛼epidioxy-3𝛽-ol (2.5 πœ‡g/ml), (E)-phytol (32 πœ‡g/ml), and stigmasterol (32 πœ‡g/ml) were obtained. Active compounds 2,4bis(2-phenylpropan-2-yl)phenol isolated from Momordica charantia L. showed 14 πœ‡g/ml MIC. 1𝛼,13𝛽,14𝛼-trihydroxy3𝛽,7𝛽-dibenzoyloxy-9𝛽,15𝛽-diacetoxyjatropha-5,11E-diene and 1𝛼,8𝛽,9𝛽,14𝛼,15𝛽-pentaacetoxy-3𝛽-benzoyloxy-7-oxojatropha-5,12-diene isolated from Pedilanthus tithymaloides (L.) Poit. demonstrated 12.5 and 50 πœ‡g/ml MIC. From Piper sarmentosum Roxb., pellitorine, 1-(3,4-methylenedioxyphenyl)-1E-tetradecene, guineensine, sarmentine, and brachyamide B showed MICs of 25, 25, 50, 50, and 50 πœ‡g/ml, respectively. Bidebiline E (6.25 πœ‡g/ml), octadeca-9,11,13triynoic acid (6.25 πœ‡g/ml), and 𝛼-humulene (6.25 πœ‡g/ml) were isolated from Polyalthia cerasoides (Roxb.) Benth. ex Bedd. Debilisone B, Debilisone C, and Debilisone E isolated from Polyalthia debilis (Piere) Finet & ganep exhibited MIC values of 25, 12.5, and 25 πœ‡g/ml, respectively. 1-Heneicosyl formate and 6𝛽-hydroxy-10-O-acetylgenipin from Premna odorata Blanco and Rothmannia wittii (Craib) Bremek. showed 8 and 12.5 πœ‡g/ml MIC values, respectively. The compounds chabamide and piperine isolated from Piper chaba Hunter exhibited MIC values of 12.5 and 50 πœ‡g/ml, respectively. Bioactive compounds sapintoxin A (3.12 πœ‡g/ml), sapintoxin B (12.5 πœ‡g/ml), sapintoxin C (25 πœ‡g/ml), 12-(2σΈ€  -Nmethylaminobenzoyl)-4𝛼-deoxy-5,20-dihydroxyphorbol-13acetate (25 πœ‡g/ml), 12-(2-methylaminobenzoyl)-4-deoxyphorbaldehyde-13-acetae (25 πœ‡g/ml), and 12-(2-N-methylaminobenzoyl)-4𝛽,5,20-trideoxyphorbol-13-acetate (50 πœ‡g/ ml) were isolated from Sapium indicum L. From Sesbania grandiflora (L.) Poir., isovestitol (50 πœ‡g/ml), medicarpin (50 πœ‡g/ml), and sativan (50 πœ‡g/ml) were isolated as active compounds. Tiliacorinine, 2σΈ€  -nortiliacorinine, tiliacorine, and 13σΈ€  -bromo-tiliacorinine from Tiliacora triandra (Colebr.) Diels exhibited MIC ranging between 0.7 and 6.2 πœ‡g/ml. From Uvaria valderramensis Cabuang, Exconde & Alejandro, valderramenols A, grandiuvarone, and reticuline were isolated and showed MICs of 10, 32, and 32 πœ‡g/ml, respectively. Globospiramine obtained from Voacanga globosa Merr. exhibited 4 and 5.2 MICs. Compound nummularines H isolated from Ziziphus mauritiana Lam. exhibited MIC of 4.5 πœ‡g/ml. 6-Gingerol from Zingiber officinale Roscoe demonstrated MIC value of 33 πœ‡g/ml. Generally, some of the reviewed plant species such as Alpinia galanga, Artocarpus rigidus, Camchaya calcarea, Combretum griffithii, Cordia globifera, Croton kongensis, Dendrolobium lanceolatum, Derris indica, Diospyros glandulosa, Diospyros ehretioides, Friesodielsia discolor, Garcinia mangostana, Goniothalamus laoticus, Hedychium ellipticum, Marsypopetalum modestum, Morinda citrifolia, Orthosiphon stamineus, Piper sarmentosum, Polyalthia cerasoides, Premna odorata, Sapium indicum, Tiliacora triandra, Trigonostemon reidiodes, Voacanga globosa, Tinospora crispa, Vitex trifolia, and Ziziphus mauritiana proved to be potential source of anti-TB (crude and/or bioactive compound exhibited anti-TB activities at MIC values ranging from 0 to