CLINICAL RESEARCH e-ISSN 1643-3750 © Med Sci Monit, 2016; 22: 3605-3613 DOI: 10.12659/MSM.900992
Specific Features of Executive Dysfunction in Alzheimer-Type Mild Dementia Based on Computerized Cambridge Neuropsychological Test Automated Battery (CANTAB) Test Results
Received: 2016.08.10 Accepted: 2016.09.07 Published: 2016.10.08
Authors’ ABCDEF Contribution: Jurgita Kuzmickienė Study Design A ABCDEF Gintaras Kaubrys Data Collection B Statistical Analysis C Data Interpretation D Manuscript Preparation E Literature Search F Funds Collection G
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Department of Neurology and Neurosurgery, Center for Neurology, Vilnius University, Vilnius, Lithuania
Gintaras Kaubrys, e-mail:
[email protected] Departmental sources
The primary manifestation of Alzheimer’s disease (AD) is decline in memory. Dysexecutive symptoms have tremendous impact on functional activities and quality of life. Data regarding frontal-executive dysfunction in mild AD are controversial. The aim of this study was to assess the presence and specific features of executive dysfunction in mild AD based on Cambridge Neuropsychological Test Automated Battery (CANTAB) results. Fifty newly diagnosed, treatment-naïve, mild, late-onset AD patients (MMSE ³20, AD group) and 25 control subjects (CG group) were recruited in this prospective, cross-sectional study. The CANTAB tests CRT, SOC, PAL, SWM were used for in-depth cognitive assessment. Comparisons were performed using the t test or Mann‑Whitney U test, as appropriate. Correlations were evaluated by Pearson r or Spearman R. Statistical significance was set at p
