images and diagnosis Spinal glioblastoma multiforme Ahmed Salem
a,*
, Amer Alshorbaji b, Abdelatief Almousa
a
a Medical Oncology Department, King Hussein Cancer Center, Al-Jubeiha, Amman 11941, Jordan, Amman, Jordan
b
King Hussein Medical City,
* Corresponding author. Address: Radiation Oncology Department, King Hussein Cancer Center, Al-Jubeiha, Amman 11941, Jordan. Tel.: +962 799 615458; fax: +962 6 535 3001 Æ
[email protected] Æ Accepted for publication 30 June 2013 Hematol Oncol Stem Cell Ther 2013; xx(xx): xxx–xxx ª 2013 King Faisal Specialist Hospital & Research Centre. Published by Elsevier Ltd. All rights reserved. DOI: http://dx.doi.org/10.1016/j.hemonc.2013.06.006
A
22-years-old female presented with low back pain radiating to the left lower extremity in addition to significant left lower extremity muscle weakness. Magnetic Resonance Imaging (MRI) of the lumbar spine revealed an oval-shaped, smooth, moderately enhancing intramedullary mass lesion at the level of D11/D12 (Figures 1 and 2). She subsequently underwent open surgical biopsy. Histopathology revealed glioblastoma multiforme (WHO grade IV) (Figures 3 and 4). MRI of the brain and entire spine failed to exhibit any additional focal
Figure 2. Transverse MRI showing the lesion.
Figure 1. Sagittal MRI showing the lesion.
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Figure 3. Pathological specimen showing hypercellular, atypical cells with mitotic figures and perivascular proliferation.
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images and diagnosis
SPINAL GBM MULTIFORME
lesions. Due to inoperability, she received external beam radiation therapy in the form of 5040 cGy over 28 fractions.
CONFLICT OF INTEREST None declared.
Figure 4. The specimen stained positive for glial fibrillary acidic protein confirming the glial origin of the tumor.
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