sSNV Cellular Prevalences Mean Cluster Cellular ... - PLOS

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SMARCA4. TNFRSF14. CREEBP. EZH2. SMARCA4. TNFRSF14. SGK1. SGK1. Timetotransformation:2.84y. Treatmentbetweensamples: -Radiation. T1 T2. 1. 3.
sSNV Cellular Prevalences

Mean Cluster Cellular Prevalences

Clonal Phylogenies

BCL6 EZH2 KMT2D STAT3

3

Clonal Prevalences

sSNV Cellular Prevalences

Mean Cluster Cellular Prevalences

Clonal Phylogenies

BCL6 MEF2C TNFRSF14

BCL6 EZH2 KMT2D STAT3

2 1

Clonal Prevalences

BCL6 MEF2C TNFRSF14

1

3

2

Time to transformation: 1.45y Treatment between samples: - Observation - Chlorambucil + Prednisone

4 Time to transformation: 7.65y Treatment between samples: - Observation

BCL6 CARD11 CREEBP FOXO1

1

3

BCL6 CARD11 CREEBP FOXO1

2

4

B2M

IRF4

1

STAT3

Time to transformation: 0.99y Treatment between samples: - Cyclophosphamide + Prednisone - R-CHOP

2

4

STAT3 BCL6 HIST1H1B TNFRSF14

6 4

EZH2

HIST1H1E

BCL6 HIST1H1B TNFRSF14

4

7

HIST1H1E

5

2

EZH2

3

ATP6V1B2 EP300 FAS TNFAIP3 Time to transformation: 0.85y Treatment between samples: - R-CVP BCL6

SGK1

B2M

3 IRF4

Time to transformation: 0.70y Treatment between samples: - Observation

1

5

ATP6V1B2 EP300 2 FAS TNFAIP3

6

BCL6

7

3

Time to transformation: 3.00y Treatment between samples: - R-CVP + R maintenance

1

CREEBP EZH2 SMARCA4 TNFRSF14

1

CREEBP EZH2 SMARCA4 TNFRSF14

2

SGK1

1 CCND3 CIITA CREBBP DTX1 IL4R KLHL6

HIST1H1B

4 Time to transformation: 2.84y Treatment between samples: - Radiation

Time to transformation: 5.05y Treatment between samples: - Observation

3

B2M BCL7A CREBBP EBF1 EZH2 EP300 GNA13 MEF2B TNFRSF14 ZFP36L1

Time to transformation: 0.78y Treatment between samples: - Observation

DTX1

CCND3 CIITA CREBBP DTX1 IL4R KLHL6

HIST1H1B

3

6

2

5

IRF8 SGK1 ZFP36L1

IRF8 SGK1 ZFP36L1

4

DTX1

T1 T2 B2M BCL7A CREBBP EBF1 EP300

2

1

EZH2 GNA13 MEF2B TNFRSF14 ZFP36L1

3

CARD11

4

CARD11

T1 T2