Stereotactic Radiosurgery for Intracranial Chondrosarcoma. Aditya K. Iyer BA, MEng; Hideyuki Kano MD PhD; Douglas Kondziolka MD MSc FRCS(C) FACS; ...
Stereotactic Radiosurgery for Intracranial Chondrosarcoma Aditya K. Iyer BA, MEng; Hideyuki Kano MD PhD; Douglas Kondziolka MD MSc FRCS(C) FACS; Ajay Niranjan MD MBA; John Flickinger MD; L. Dade Lunsford MD University of Pittsburgh, School of Medicine University of Pittsburgh, Department of Neurological Surgery
Introduction To evaluate the role of stereotactic radiosurgery (SRS) in the management of intracranial chondrosarcoma. Methods We reviewed the outcomes of 22 consecutive patients (9 males) who underwent Gamma knife SRS between 1987 and 2010 for an intracranial chondrosarcoma. The median patient age was 42 years (range 15-75). Fifteen patients had at least one prior craniotomy and 3 had prior fractionated radiation therapy (RT). The median tumor volume and margin dose was 8.0cc and 15 Gy respectively. Seventeen patients had at least one cranial nerve deficit, most commonly diplopia related to an abducens nerve palsy (n=9).
Patient Survival after SRS
The improvement rate of cranial nerve deficits ranged from 0 to 100% for different nerves. The deterioration rate of cranial nerve deficits after SRS ranged from 0 to 29%.
Kaplan-Meier estimate of overall survival after SRS. The median survival after SRS was 75.4 months. Progression-free Survival
Results At a median follow up of 75 months (range, 3-168 months), seven patients (32%) died of tumor progression. The overall survival after SRS was 76%, 70% and 56% at 3, 5 and 10 years, respectively and the median survival after SRS was 75.4 months. Factors associated with longer survival included younger age (< 40 years, p=0.05), a shorter interval (
