Int. J. Med. Sci. 2007, 4
19 International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2007 4(1):19-27 © Ivyspring International Publisher. All rights reserved
Research Paper
Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes Naomi Brooks1, Jennifer E. Layne1, Patricia L. Gordon1 3, Ronenn Roubenoff1 2, Miriam E. Nelson1 2 4, Carmen Castaneda-Sceppa1 2 1. Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston MA, USA. 2. The Friedman School of Nutrition Science and Policy, Tufts University, Boston MA, USA. 3. Department of Physiological Nursing, University of California, San Francisco, CA, USA. 4. John Hancock Center for Physical Activity and Nutrition, Tufts University, Boston, MA, USA Correspondence to: Carmen Castaneda-Sceppa, M.D., Ph.D., Tufts University, 711 Washington St.; Boston, MA 02111. Telephone (617) 556-3081 Fax (617) 556-3083 E-mail
[email protected] Received: 2006.11.08; Accepted: 2006.12.16; Published: 2006.12.18
Hispanics are at increased risk of morbidity and mortality due to their high prevalence of diabetes and poor glycemic control. Strength training is the most effective lifestyle intervention to increase muscle mass but limited data is available in older adults with diabetes. We determined the influence of strength training on muscle quality (strength per unit of muscle mass), skeletal muscle fiber hypertrophy, and metabolic control including insulin resistance (Homeostasis Model Assessment –HOMA-IR), C-Reactive Protein (CRP), adiponectin and Free Fatty Acid (FFA) levels in Hispanic older adults. Sixty-two community-dwelling Hispanics (>55 y) with type 2 diabetes were randomized to 16 weeks of strength training plus standard care (ST group) or standard care alone (CON group). Skeletal muscle biopsies and biochemical measures were taken at baseline and 16 weeks. The ST group show improved muscle quality (mean±SE: 28±3) vs CON (-4±2, p
