Chinese Journal of Clinical Oncology [SpringerLink] DOI 10.1007/s11805-007-0009-8
Apr. 2007, Vol. 4, No. 2
P 1~6 Bin Cai et al.
Studies of Differentially-Expressed Genes in Human Endometrial Cancer of Various Differentiated Grades
Bin Cai1 David Hogg2 Guangzhong Lu3 Ling Liu1,2 Xiaowei Xi1 Wei Xu1 Huifang Lu1 Yongbin Yang1 Xiaoping Wan1
Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated First People’s Hospital, Shanghai 200080, China. 2 Departments of Medicine and Medical Biophysics, University of Toronto, Toronto, Canada. 3 Department of Pathology, Shanghai Jiao Tong University Affiliated First People’s Hospital, Shanghai 200080, China. 1
Correspondence to: Xiaoping Wan E-mail:
[email protected]
This work was supported by a grant from the National Natural Science Foundation of China (No.30371481), the Natural Science Foundation of Shanghai (No. 06ZR14053) and the Key Project of the Shanghai Health Bureau (No.2005ZD002).
Received January 3, 2007; accepted January 16, 2007. CJCO http://www.cjco.cn E-mail:
[email protected] Tel(Fax):86-22-2352 2919
To study the gene expression profiles of human endometrial cancers at various differentia0ted grade levels and to identify the genes related to differentiation of the endometrial cancers. METHODS cDNA microarray technology was used to analyze the differentially-expressed genes among different differentiated grades of 32 cases of endometrial cancer. Hierarchical cluster analysis (HCA) for the gene expression profiles of the cases was employed. RESULTS The tissue samples were grouped based on the various differentiated tumor grades with 33 differentiation-related genes identified out (P
