Subcellular localization of anthracyclines in ... - Semantic Scholar
Recommend Documents
PtdIns3P in proteins such as the early-endosomal antigen 1. [EEA1 (Gaullier ..... (A) Schematic representation of myotubularin showing protein domains. GRAM,.
Oct 18, 1993 - Control of Cell Polarity. Michael Ziman,* Daphne Preuss,t Jon Mulholland,*. Jeanne M. O'Brien,* David Botstein,* and Douglas I. Johnson*.
including neural networks [1] and support vector machines (SVM) [2-8]. This category includes methods like P-CLASSIFIER [6] and CELLO [7,8], which utilize ...
2 (phot2), or both (Briggs and Huala, 1999; Christie and. Briggs, 2001; Briggs and Christie, 2002). ...... We are grateful to John M. Christie for his careful review of ...
FASEB J. 14, 2171â2176 (2000). Key Words: preimplantation embryos nucleus centrosome- kinetochore microtubule cell division. Alzheimer's disease is the ...
the pTEX plasmid (Kelly et al., 1992) by PCR, with EcoRI and. HindIII sites added at the ..... John Kelly for supplying the pTEX vector. This work was supported.
Aug 9, 2012 - Barinov A, Loux V, Hammani A, Nicolas P, Langella P, et al. .... Frank K, Sippl MJ (2008) High-performance signal peptide prediction based on.
Mar 6, 2013 - We conclude that Nmnat2 activity supports axon survival through a site of ... from Nmnat2 transport vesicles and that protein stability, a key ...
Aug 20, 2013 - 1 Department of Otolaryngology, University of Miami, Miller School of ..... circle), CD4+nFOXP3+ cells (black triangle) or CD4+cFOXP3+ (red.
Xylem Cells. 1,2. Kyung-Hoan Im, Daniel J. Cosgrove, and Alan M. Jones*. Department of Biology, The University of North Carolina, Chapel Hill, North Carolina.
Jun 17, 2015 - [18,19], heterodimeric CrtY cyclases [20], and CruA/CruP [21]. Though cyclic carotenoids have been detected in Synechocystis, the enzyme ...
Aug 23, 2002 - Shirley Gil-Parradoâ¡Â§Â¶, Oliver Poppâ¡, Tobias A. Knoch , Stefan Zahler**, Felix Bestvater ,. Marcel Felgenträgerâ¡ ... porter proteins. All of the ...
IgG, and Texas Red goat anti-rabbit IgG from Cappel (Westchester,. PA); Sprague Dawley male rats .... centrifuged for 10 minutes at 800 rpm (132 gav). The pellet was resus- ..... Hauri, H.-P., Yuan, L.C. and Klausner, R.D. (1990). Microtubule-.
Jan 12, 2016 - electron microscopy. Mitochondrial size were outlined with magnetic lasso and analyzed by image analysis tool in Adobe. Photoshop. Statistics.
Nov 3, 2015 - M. Carolina Gallego-Iradi1,2, Alexis M. Clare1, Hilda H. Brown1,2, Christopher Janus1,. Jada Lewis1, David R. Borchelt1,2* ... Janus C, Lewis J, Borchelt DR (2015) Subcellular. Localization of Matrin 3 ...... Buchan JR, Parker R. Eukary
3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) catalyzes the synthesis of ..... HâL). BiP gold particles were observed over structures surrounded by cytoplasm (Fig. ...... ulatory role of 1-deoxy-D-xylulose 5-phosphate synthase.
David Kryl,1 Talene Yacoubian,2 Annakaisa Haapasalo,3 Eero Castren,3 Donald Lo,2 and Philip A. Barker1 ...... For example, Ã-amyloid precursor protein and Na âK ATPase, .... Ip NY, Stitt TN, Tapley P, Klein R, Glass DJ, Fandl J, Greene LA,.
pal neurons and transfected neurons in neocortical brain slices and showed no ...... TrkB revealed that the receptor was clearly present in the PSD fraction but ...
Aug 11, 2006 - 2) was produced in three variations, pSAT1, pSAT4, ... NotI fragments into three pSATN BiFC plasmids, pSAT1, pSAT 4 and pSAT6, in which ...
Perry Miller,4 Mark Gerstein,2 G. Shirleen Roeder,1 and Michael Snyder1,2,6 ...... Uetz, P., Giot, L., Cagney, G., Mansfield, T.A., Judson, R.S.,. Knight, J.R. ...
Jan 12, 2016 - electron microscopy. Mitochondrial size were outlined with magnetic lasso and analyzed by image analysis tool in Adobe. Photoshop. Statistics.
May 21, 2009 - ihg2.helmholtz-muenchen.de/ihg/mitoprot.html), ChloroP. (Emanuelsson et al. .... using Adobe Photoshop 8.0 (Adobe Systems, San Jose, CA). The images ... were prepared by first slicing the fruit and removing the seeds.
Jun 2, 2015 - The Sigma-1 receptor (S1R) is known to play a protective role in the ... Sigma binding sites are classified into Sigma-1 (S1R) and Sigma-2 ...
Subcellular localization of anthracyclines in ... - Semantic Scholar
Aug 14, 2015 - anthracycline derivatives in cultured H9c2(2-1) rat cardiomyoblasts. The first group consisted of doxorubicin. (DOX) and two of its derivatives ...
Invest New Drugs (2015) 33:1032–1039 DOI 10.1007/s10637-015-0276-9
PRECLINICAL STUDIES
Subcellular localization of anthracyclines in cultured rat cardiomyoblasts as possible predictors of cardiotoxicity Kazimierz Studzian 1 & Krzysztof Kik 1 & Malgorzata Lukawska 2 & Irena Oszczapowicz 2 & Malgorzata Strek 1 & Leszek Szmigiero 1
Received: 14 January 2015 / Accepted: 6 August 2015 / Published online: 14 August 2015 # The Author(s) 2015. This article is published with open access at Springerlink.com
Summary In this study, we compared the cellular uptake, intracellular localization and cytotoxicity of two groups of anthracycline derivatives in cultured H9c2(2-1) rat cardiomyoblasts. The first group consisted of doxorubicin (DOX) and two of its derivatives containing a formamidino group (–N=CH–N
