SuppFig-2 Significant genes in TaDk4TG - Plos

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trichorhinophalangeal syndrome I (human). 3.32548. Flg filaggrin. 3.26728. Serpinb3c serine (or cysteine) peptidase inhibitor, clade B, member 3C. 3.06105.
Gli1 Tmem16e Ptch2 Ptch1 Lef1 Scube1 Cxcr4 Tcf7 Rgs2 Id3 Gprasp2 ND6 3110082D06Rik Rhpn2 OTTMUSG00000003947 Sphkap E030049G20Rik Agrp Col8a1 6430704M03Rik Itgbl1 Dkk4

2.96841

2.94604

2.93823

2.37934

2.28

1.73363

1.71949

1.67796

1.58511

1.55928

1.55348

1.52913

1.52651

1.51829

1.50677

0.63035

0.59259

0.5918

0.57492

0.56103

0.48527

0.05291

Full Name

dickkopf homolog 4 (Xenopus laevis)

integrin, beta-like 1

RIKEN cDNA 6430704M03 gene

collagen, type VIII, alpha 1

agouti related protein

RIKEN cDNA E030049G20 gene

SPHK1 interactor, AKAP domain containing

predicted gene, OTTMUSG00000003947

rhophilin, Rho GTPase binding protein 2

RIKEN cDNA 3110082D06 gene

NADH dehydrogenase subunit 6

G protein-coupled receptor associated sorting protein 2

inhibitor of DNA binding 3

regulator of G-protein signaling 2

transcription factor 7, T-cell specific

chemokine (C-X-C motif) receptor 4

signal peptide, CUB domain, EGF-like 1

lymphoid enhancer binding factor 1

patched homolog 1

patched homolog 2

transmembrane protein 16E

GLI-Kruppel family member GLI1

leucine-rich repeat-containing G protein-coupled receptor 6

dickkopf homolog 1 (Xenopus laevis)

sonic hedgehog

A030013N09Rik 1100001G20Rik AW121567 Dkk1 Fgf20

11.01398

10.78177

5.34283

5.22339

59.79099

16.6657

Gene Symbol Shh

FoldChange (Ta/TaDk4TG)

fibroblast growth factor 20

dickkopf homolog 1 (Xenopus laevis)

expressed sequence AW121567

RIKEN cDNA 1100001G20 gene

RIKEN cDNA A030013N09 gene

sonic hedgehog

Full Name

The full list of differentially expressed genes between Ta and TaDk4TG skin at E17.5

Dkk1 Lgr6

3.84644

27.56013

4.6255

Gene Symbol Shh

FoldChange (Ta/TaDk4TG)

Fig S2 Cui-Fig S2 The full list of differentially expressed genes between Ta and TaDk4TG skin at E16.5

Serpinb3c Ndph Flg2 Spink3 Krt79 Cnnm1 Tcf7 Lef1 2610307P16Rik Slc45a2 Cxcr4 Alox12e A330094K24Rik Nsg2 Etv4 Sostdc1 Srcs3 A430010J10Rik Rhpn2 Has3 Zfp64 Plau Hhip I830077J02Rik

3.26728

3.06105

3.01533

2.89009

2.54031

2.48165

2.42795

2.4038

2.31573

2.31315

2.31203

2.3092

2.30675

2.29725

2.27821

2.19262

2.18861

2.14246

2.12471

2.06175

2.00515

1.99457

1.9548

1.95286

Gli1

3.98576

Flg

Edar

4.16365

3.32548

Mup2

4.32188

Trps1

Ptch2

4.41451

3.70205

Slco4a1

4.44522

Clec12b

Padi1

4.46346

Lhx2

Ptch1

4.95162

3.84563

Galnt9

5.081

3.8796

Hes5

5.17881

RIKEN cDNA I830077J02 gene

Hedgehog-interacting protein

plasminogen activator, urokinase

zinc finger protein 64

hyaluronan synthase 3

rhophilin, Rho GTPase binding protein 2

RIKEN cDNA A430010J10 gene

v-src suppressed transcript 3

sclerostin domain containing 1

ets variant gene 4 (E1A enhancer binding protein, E1AF)

neuron specific gene family member 2

RIKEN cDNA A330094K24 gene

arachidonate lipoxygenase, epidermal

chemokine (C-X-C motif) receptor 4

solute carrier family 45, member 2

RIKEN cDNA 2610307P16 gene

lymphoid enhancer binding factor 1

transcription factor 7, T-cell specific

cyclin M1

keratin 79

serine peptidase inhibitor, Kazal type 3

filaggrin family member 2

Norrie disease homolog

serine (or cysteine) peptidase inhibitor, clade B, member 3C

filaggrin

trichorhinophalangeal syndrome I (human)

LIM homeobox protein 2

C-type lectin domain family 12, member B

GLI-Kruppel family member GLI1

ectodysplasin-A receptor

major urinary protein 2

patched homolog 2

solute carrier organic anion transporter family, member 4a1

peptidyl arginine deiminase, type I

patched homolog 1

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9

hairy and enhancer of split 5 (Drosophila)

Nkd1 Rtp4 Slc22a4 Gem Col23a1 Grasp Lypd1 Mlana A730089K16Rik Ovol2 Cdh3 Chst2 Amdhd1 2310015K22Rik Mmp3 D630040I23Rik 2010300C02Rik Loxl4 2900022M12Rik Rac3 Sox4 Slc24a5 Ell3 Gabrp Egfl6 A430107O13Rik Hist3h2ba Tpbg 3110043A19Rik EG236749 Lrp4 Efnb3 Glis1 Slitrk6 Lamc2

1.86165

1.84241

1.82414

1.81865

1.80932

1.79447

1.79026

1.77244

1.76397

1.76164

1.74863

1.74705

1.74002

1.71647

1.71238

1.71204

1.70802

1.70405

1.69401

1.69388

1.69205

1.69154

1.67769

1.66987

1.66809

1.66639

1.64445

1.64164

1.63627

1.62904

1.6271

1.62576

1.6245

1.62433

4933417O08Rik

1.8817

1.8687

Kcnh3

1.90941

potassium voltage-gated channel, subfamily H (eag-related), member 3

laminin, gamma 2

SLIT and NTRK-like family, member 6

GLIS family zinc finger 1

ephrin B3

low density lipoprotein receptor-related protein 4

predicted gene, EG236749

RIKEN cDNA 3110043A19 gene

trophoblast glycoprotein

histone cluster 3, H2ba

RIKEN cDNA A430107O13 gene

EGF-like-domain, multiple 6

gamma-aminobutyric acid (GABA-A) receptor, pi

elongation factor RNA polymerase II-like 3

solute carrier family 24, member 5

SRY-box containing gene 4

RAS-related C3 botulinum substrate 3

RIKEN cDNA 2900022M12 gene

lysyl oxidase-like 4

RIKEN cDNA 2010300C02 gene

RIKEN cDNA D630040I23 gene

matrix metallopeptidase 3

RIKEN cDNA 2310015K22 gene

amidohydrolase domain containing 1

carbohydrate sulfotransferase 2

cadherin 3

ovo-like 2 (Drosophila)

RIKEN cDNA A730089K16 gene

melan-A

Ly6/Plaur domain containing 1

GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein

collagen, type XXIII, alpha 1

GTP binding protein (gene overexpressed in skeletal muscle)

solute carrier family 22 (organic cation transporter), member 4

receptor transporter protein 4

naked cuticle 1 homolog (Drosophila)

RIKEN cDNA 4933417O08 gene

2010010I01Rik Cbr2 S100a4 Pitx2 Kcnj4 Pgbd5 Rasl11b 6330514A18Rik Hs3st6 LOC230628 Rgs2 Wif1 Sh3rf2 Lama5 Cpne8 Sox21 Cacna1g Ovol1 Cpsf4l Abr Esr1 Smox Mycl1 Iqcd Cthrc1 Snca Sgk1 Larp2 Gsta4 Slc24a3 Anxa3 Sned1 Cfh Csrp2 Rasd1 Gpr111 Slc4a8

1.62325

1.62319

1.62138

1.62138

1.60289

1.59697

1.59168

1.58993

1.58678

1.58566

1.57204

1.5585

1.55522

1.53956

1.53213

1.52077

1.51411

1.51177

1.51176

1.50936

1.50716

1.50445

1.50064

1.50027

0.66062

0.65447

0.64137

0.63009

0.62868

0.62443

0.61669

0.6023

0.59123

0.59087

0.58258

0.58174

0.57106

solute carrier family 4 (anion exchanger), member 8

G protein-coupled receptor 111

RAS, dexamethasone-induced 1

cysteine and glycine-rich protein 2

complement component factor h

sushi, nidogen and EGF-like domains 1

annexin A3

solute carrier family 24 (sodium/potassium/calcium exchanger), member 3

glutathione S-transferase, alpha 4

La ribonucleoprotein domain family, member 2

serum/glucocorticoid regulated kinase 1

synuclein, alpha

collagen triple helix repeat containing 1

IQ motif containing D

v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)

spermine oxidase

estrogen receptor 1 (alpha)

active BCR-related gene

cleavage and polyadenylation specific factor 4-like

OVO homolog-like 1 (Drosophila)

calcium channel, voltage-dependent, T type, alpha 1G subunit

SRY-box containing gene 21

copine VIII

laminin, alpha 5

SH3 domain containing ring finger 2

Wnt inhibitory factor 1

regulator of G-protein signaling 2

similar to C05G5.5

heparan sulfate (glucosamine) 3-O-sulfotransferase 6

RIKEN cDNA 6330514A18 gene

RAS-like, family 11, member B

piggyBac transposable element derived 5

potassium inwardly-rectifying channel, subfamily J, member 4

paired-like homeodomain transcription factor 2

S100 calcium binding protein A4

carbonyl reductase 2

RIKEN cDNA 2010010I01 gene

Atp1b1 Krt19 Gpx3 3110079O15Rik C130073F10Rik Lce3f 2300002M23Rik Dkk4 Saa1 Col2a1 Fetub 2310057N15Rik EG546672 2310034C09Rik 4930553J12Rik EG433047 Krtap13

0.28452

0.08519

0.0789

0.07081

0.0645

0.06245

0.05194

0.02967

0.02438

0.0168

0.00245

0.00212

0.00193

0.00185

0.00154

0.00112

1110017D15Rik

0.38408

0.32948

Cadps

0.41628

Sgk2

Slc39a8

0.43477

AA467197

C430042M11Rik

0.43757

0.3321

BC038167

0.4605

0.35727

Mx1

0.4605

Apol7a

Car2

0.48313

0.36671

Grid2

0.50143

Tubb3

Srd5a2l2

0.50632

Scgn

Ramp3

0.53037

0.37594

Tgfa

0.53392

0.3789

EG244911

0.54534

keratin associated protein 13

predicted gene, EG433047

RIKEN cDNA 4930553J12 gene

RIKEN cDNA 2310034C09 gene

predicted gene, EG546672

RIKEN cDNA 2310057N15 gene

fetuin beta

collagen, type II, alpha 1

serum amyloid A 1

dickkopf homolog 4 (Xenopus laevis)

RIKEN cDNA 2300002M23 gene

late cornified envelope 3F

RIKEN cDNA C130073F10 gene

RIKEN cDNA 3110079O15 gene

glutathione peroxidase 3

keratin 19

ATPase, Na+/K+ transporting, beta 1 polypeptide

serum/glucocorticoid regulated kinase 2

expressed sequence AA467197

apolipoprotein L 7a

secretagogin, EF-hand calcium binding protein

tubulin, beta 3

RIKEN cDNA 1110017D15 gene

Ca2+-dependent secretion activator

solute carrier family 39 (metal ion transporter), member 8

RIKEN cDNA C430042M11 gene

cDNA sequence BC038167

myxovirus (influenza virus) resistance 1

carbonic anhydrase 2

glutamate receptor, ionotropic, delta 2

steroid 5 alpha-reductase 2-like 2

receptor (calcitonin) activity modifying protein 3

transforming growth factor alpha

predicted gene, EG244911