Suppl Fig 2 - Nature

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1.2. 102. 103. 104. HeLa/Pgp-1. Pgp-1. eEF2. 1. 2. Supplemental Figure 2. 19-. 20-. 21-. Weight (g). 18-. 17-. Vehicle. Hipp. Day 0 Day 6 Day 0 Day 6. 16-. 22-
B

22212019181716-

250-

10050-

1.2

M D R1 a/

eL

a

H

H

eL

2

F

0.8 0.6 0.4 0.2 103

Drug [nM]

104

Dxr Hipp HeLa Dxr Hipp HeLa/Pgp-1

1.2 Relative Cell Viability

1.0

0

eEF2

CD4

CD11b

Ly-6G

Dxr Sil HeLa Dxr Sil HeLa/Pgp-1

102

Vehicle Hipp AST

Pgp-1 1

B220

% PE+ Cells

Vehicle Hipp

E

Relative Cell Viability

Vehicle Hipp ALT

D

60 50 40 30 20 10

0

Serum [U/L]

150-

Day 0 Day 6 Day 0 Day 6 Vehicle Hipp

C

35030025020015010050-

200-

Serum [U/L]

Weight (g)

A

Supplemental Figure 2

1.0 0.8 0.6 0.4 0.2 0

0

102 103 Drug [nM]

104