(A) WT-âOPTN and M98K do not differ in their interaction with Rab8A. Yeast strain cotransformed with RAB8A (upper panel) or activated RAB8A (Q67L-âRAB8A) ...
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Supplemental Material to: Kapil Sirohi, Madhavi Latha Somaraju Chalasani, Cherukuri Sudhakar, Asha Kumari, Vegesna Radha and Ghanshyam Swarup M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells Autophagy 2013; 9(4) http://dx.doi.org/10.4161/auto.23458 www.landesbioscience.com/journals/autophagy/article/23458
Figure S1. Characterization of cell death induced by M98K variant of OPTN. (A) Effect of coexpression of dominant negative caspase 9 (CASP9S) and mutant caspase 1 (mCASP1) on M98K-‐induced cell death. Upper panel, data represent extent of cell death quantitated as described in materials and methods. n=6, ***, P
