Supplemental Material to

1 downloads 0 Views 430KB Size Report
GPR109B SRP9. CABYR. GPR161. GNAS. LPHN2. AGTR1. GNA12. F2RL2. SSTR2. GPR126. NMB. EDARADD DPYSL5. CD3Z. FZD1. P2RY8. FZD7. APH1B.
Landes Bioscience

www.landesbioscience.com

Supplemental Material to: Melchiorre Cervello, Dimcho Bachvarov, Nadia Lampiasi, Antonella Cusimano, Antonina Azzolina, James A. McCubrey and Giuseppe Montalto Molecular mechanisms of sorafenib action in liver cancer cells 2012; 11(15) http://dx.doi.org/10.4161/cc.21193 http://www.landesbioscience.com/journals/cc/article/21193

Supplemental Table 1. Common differentially-expressed gene groups upon treatment with in sorafenib in HepG2 and Huh7 cells A. Down-regulated genes Angiogenesis

JAG1

EPAS1

IL8

Apoptosis

IER3

EGLN3

LGALS1

Blood coagulation

PROS1 PFN2 TUBA1 PCDHB2 ITGAV KIF23 E2F2 CDKN2A ESCO2 SIL SOX9 TPM3 CDV1 RLN2

PFN1 TUBB2 KIAA1467 ITGA1 ESPL1 TFDP1 SMC1L1 HCAP-G

Cell adhesion

Cell cycle

Cell differentiation Cell growth DNA replication

Immune response

Lipid metabolism

RUVBL1 CENPE PRIM2A HMGB1 PRKDC POLA INHBB CXCL1 CD8B1 GPX3 SLC27A2 SCD UGT2B4

NRP1

TNFAIP2

H2-ALPHA K-ALPHA-1 PCDHB11 ITGB6 KIFC1 TCF19 BRIP1 MAD2L1

TUBA4 MASS1 PCDHB6 CAP1 PSMD1 PTMA BCCIP CETN2

KIF14 AMICA1 EVA1

KIF11 PLEKHH2 KITLG

KIF18A DSG3 CLDN1

TUBA6 AMIGO2 NID2

CDC45L YWHAQ RGC32 ASPM

CCNE1 TGFB1 CDC25A PARD6G

CCND1 MDK CDC7 GAS2L3

DUSP6 CCND3 SMC4L1 PRG4

AEBP1 KIAA1102 SPAG1

EBP CNN3 EMP2

CALD1 FGF19 SPRY1

AHSG KNG1 SPRY4

TNFRSF11B GDF11 MYH4 PLXND1 ID3 FST

PRDX1 EVI1 PDGFC

CASC5 DNMT3B MCM4 CXCL6 ASF1A

CENPF MCM7 NEIL3 FOS

HNRPD MCM8 EXO1 ATF7IP

ORC6L POLQ XRCC2 NASP

RAD51AP1 BLM FANCA EZH2

PSF1 CHAF1B FANCD2 HMGA2

POLD3 DUT XRCC5 HMGN2

MBL2 SERPIND1 SECTM1 CRLF1 CPT2 FADS1

HMMR MIG-6 IFITM2 MMD ACSL4 PLD1

CCR6 EPO IFITM3

PECAM1 CD83 CD24

CCL20 S100A9 ITGB1

CXCL2 CFH SRXN1

CXCL5 C4BPA GPX2

FABP5 PTDSS1

ACSL3 HSD17B7

AKR1C3 TM7SF2

MGLL FDPS

MTP UGT2B4

Metabolism (other than lipid metabolism)

Protein biosynthesis

Protein modification

RNA processing

Signal transduction

Transcription

Transport

ARG1 ALDOA PGK1 PAICS GCLM AKR1C1 FLJ16237 SLC2A9 EIF4A1 HSPCA THC2301371 SUMO1 MAP4K3 FGFR2 UCHL5 USP13 UBE2N DIAPH3 DNMT1 HNRPH3 SHC1 GPR161 NMB STMN1 LAMA4 SH3KBP1 PTRF SMAD6 POU2AF1 PHF19 MYB SCML2 TF CSE1L

LOC441046 PFKFB4 LDHB PSAT1 TDO2 VNN3 HSD17B12 GPT2 RPS27L FKBP5 THC2301753 PLOD2 BUB1B PTP4A2 LDLR TFRC UBE2E2 ICAM1 ZNF281 SYNCRIP C5 GNAS EDARADD LNK NAT8 SPRY2 EWSR1 EWSR1 NSEP1 MED31 FLJ90396 HTATIP2 SLC1A3 CYP26B1

AKR1B1 GAPDH ACLY GLULD1 KYNU VNN2 AADAC AS3MT NANOS1 FKBP14 DAG1 STYK1 PBK PPM1E ADAMTS12 CTSC USP10 TRIM8 SF3B3 NOLC1 GNG5 LPHN2 DPYSL5 PIK3R3 SMAP1L ANXA13 ZNF588 ZNF253 GTF2I PRKCBP1 ETV5 ID1 NUP153 ENST00000361789

CHST6 PDK1 ENO1 NT5E SULT1A1 CRYZ INSIG1

ME1 TPI1 AK2 GLUD2 CPOX LOC286016 GPAM

TTN AKR1B10 CTPS SLC6A6 ENPP3 COCH RDH11

GMDS HMGCS1 TYMS SLC6A14 SOD1 GSTM3 ACMSD

MAN1A1 ENO1B DPYSL2 DDAH1 PREX1 STS-1 SLC2A6

HSPB1 LOC121981 PPIA MASTL CDC2 DUSP5 HTRA3 DPP4 UBE2C C16orf28 DHX15 HNRPAB SPRED1 AGTR1 CD3Z ECT2 ECOP

FLJ13236 PPIAL4 WASF1 MAP3K8 PASK TSPAN8 NEDD8 ADAM23 UBE2N TRIM34 TARDBP HNRPA2B1 PAMCI GNA12 FZD1 RASL12 VGL-3

DARS2 LOC388817 SLC7A11 WNK4 ADRBK2 ST6GAL1 FBXO5 PCSK6 UBE2T TRIM6 SFRS9 CPSF6 GPR109B F2RL2 P2RY8 RHOA ARS2

RRBP1 PPIAL4 CAPZA1 DYRK3 EPHA2 POMGNT1 CPM ADAM28 KRT18

EIF4E THC2301132

BAT1 HNRPR SRP9 SSTR2 FZD7 CFL1 ITSN1

THOC4 SNRPB CABYR GPR126 APH1B DLG7 CDCA7

ZNF286 ETV4 NR2F1 SP100 KNTC1

ZNF257 ZNF430 NR4A2 HMG1L1 ZNF587

ZNF215 MYCBP AES ETV5 LIMD1

PSIP1 ETV1 TH1L CUTL2 ARNTL2

SALL4 NFE2L3 PAPOLA ZFHX4 PBX3

SYT12 DPYD

SLCO1B3 AOF2

SLC4A4 PYCRL

SLC39A6 CYP51A1

SLC1A7 CYP51A1

TGFBR2 PRKD3 GCNT1 LRP8 ADAM18 ADPN

SLC1A1 KCNE3 SLC36A4 MICAL2

SLC38A2 SLC12A2 MTL5 NQO1

SH3GLB1 MX1 LOC285458 CDH19 TEP1 HERC5 DLEC1 DTNBP1 AHNAK EPB41 SPRR2G

BIRC4

Cell growth

CYR61

SOCS2

DNA replication

POLI MTSS1 GBP3 GPX7 APOE SULT2A1 HSD17B1 ARG2 FLJ10986 IRS2 GABARAPL2 ACY3 RPS28

CSNK1D XCL2 IFIT2 MR1 THC2373524 SOAT2 OCA2 PPARGC1A GALT B3GALT6 SSR3 DHRSX EFTUD1

Apoptosis Cell adhesion Cell cycle

Cell differentiation

Immune response Lipid metabolism

Metabolism (other than lipid metabolism) Protein biosynthesis

GJA1 ACCN2 SORCS2 CYP4F11

ORM2 PKD2 LRP10 UQCR

B. Up-regulated genes TNFRSF14 SEMA6A

MGC27019 FZD5 EREG TAF1 LAMA3 ABLIM3 NRG1 PLA2G12B MVP

ORM1 ATP11A DNM1L CYB5-M

GJB2 COL5A2 LRP12 DKK3

RBP4 COL9A3 SRGAP2

VCP VDAC1 SLC39A4

NRG2

GDNF

BIRC3

FEM1B

PPFIBP1

CD44

IGFALS

GPR56

MLLT4

ARVCF

HDAC5 HRASLS3

SLC12A6 SASH1

BTC ALS2CR19

CABLES1 LAMP3

CDKN1C DAB2

GADD45A H41

DST ARHGAP26 FHOD3

VILL PPP1R9A DAAM1

TBCE HNMT NEBL

SPAG9 RP9 SLC39A5

SLC2A14 EFEMP1 FAM3B

ZNF313 TIMM9 TUFT1

UBE2B CGRRF1 DAF

RAD18 GSTA3 C6

ATXN3 ANKRD1 IL15

SLK CAMLG SECTM1

DNASE1 GBP3 ZNF179

IFIT1 IL7

C11orf11 PCCA SLC20A1 CREBBP PGM3 ME3 GSTA5 AGPAT3 MRPL33

CPT1A UGCG OSBPL1A BIRC7 XYLB OGDHL LOC201164 CTL2 SGNE1

SORL1 PRKAB2

HPGD PIP5K2A

PLCL2 SPTLC1

PLA1A FLJ11088

AMHR2 OGG1 OAT GSTA2 TMLHE WARS2

NEU1 MANBA SDSL GSTA1 MESP1 EIF5

SMPDL3A FUT3 CORO2A DHRS10 MCEE PPIL6

PGM2L1 SLC3A1 GABARAPL1 UAP1L1 C1orf24

Protein modification

RNA processing Signal transduction

Transcription

Transport

 

NAPG UBL3 DAPK2 ERBB3 PARP14 NEURL2 PSMB9 MKRN1

DNAJB2 TTL PRKCZ JAK1 TIPARP CLDN3 DEFB126

G1P2 SGKL PIM1 CAPN2 RNF186 LONP

HERPUD1 PINK1 TRIB1 KIAA1950 SETDB2 CRBN

FAM80B COL4A3BP FLJ22405 DPP7 PCGF5 C15orf16

STK33 GOLGA5 DUSP10 CTSB FBXO25 FBXO32

CLK4 EGFR PTP4A1 TMPRSS2 LNX2 CCNB1IP1

IKBKB PRKACB PTEN PSMB8 MID2 NEDD4L

NONO CAMKK2 GNAZ SEL1L SNX8 KLF11 SP110 ZBTB2 MAFB MLLT10 ZNF550 IPO7 CYP3A4 XCL1 MDS032 CLCN7 COLM NDRG1 ZFYVE1

CART1 TAOK3 GPR146 DVL1 RHOU IRF5 C2orf3 MAF KLF6 BHLHB3 PHF15 PIG8 CYP3A7 MTL5 SLC15A4 CLCN5 SLC6A12 AFTIPHILIN

NUDT21 GADD45B GNGT1 MYO9A RHOU ZNF449 MAFK HLF GATA5 HOXA4 C22orf1 MGC15763 CYP3A5 FNBP1L RAMP1 ATP6V1H STX3A TOMM7

CASC3 PLCE1 GNB5 CNIH3 AREG TCEA3 ZBTB8 CREB5 GLI1 MAX RFXDC1 LOC317671 ABCB7 MT2A SLC19A2 SLC22A3 ICA1 STXBP6

AUH DUSP16 GPR30 SSB3 RAB32 ZNF165 FOXP1 PAWR RRAGC RRN3 SP140 RNF14 MT1X MT2A FABP3 ATP6V1C1 SULT1C1 ATP6V0D2

SAV1 ARRB2 HS1BP3 SEMA3B ZNF206 KIAA1285 HDAC4 KLF4 AFF4 NPAS1 ERO1LB RRAGD RAB17 SLC16A6 NUDT9 IFIH1 VAT1

GPSM1 FGG RASA4

GNGT1 PDE8B HS1BP3

PRDM16 ZNF295 RORA LOC153222 NMI POU3F3 ACOX1 MCART1 RAB9A SLC12A7 ITPR3 RILP TNN

ATF3 KLF15 RARA SP100 THRB ACADSB SLC25A13 BET1 KCNE2 TRPV2 CNKSR3 NIFUN

Supplemental Table 2. Genetic networks in sorafenib-treated HCC cell linesa. a

Ntwk 1

2

3

4

5

1

A. Up-regulated networks in sorafenib-treated HepG2 cells Genes in Ingenuity Networksb Associated pathways ALP, ASNS, ATF3, ATM, BBC3, C/ebp, CEBPB, Cell Death, Gene CEBPG, CHRDL2, CIRBP, CREB5, CTH, DDIT3, Expression, EGR1, ERN1, GDF15, LCN2, LDL, MAFG, Infectious MTHFD2, NFIL3, NFkB (complex), NUPR1, Disease OSBPL6, PDGF BB, PEPCK, S100P, Sapk, SH3RF1, STC2, SYNE1, TNFRSF12A, TRIB3, UNC5B, UPP1 ANP32A, C5AR1, CBWD1, CSTA, Cyclin A, Antigen ERK1/2, FAM59A, FSH, GAS5, GCLM, GPR56, Presentation, GRB10, hCG, HIRA, HRK, IgG, IL11, IL12 Hematological (complex), IL6R, Interferon alpha, ISG20, JUN, System LGALS3, MAP2K1/2, Mek, NADPH oxidase, PP2A, Development and RAD23B, RASD1, SARS, STAT, TCF20, TGM1, Function, TPM2, VEGFA Immune Cell Trafficking 14-3-3, Akt, AMPK, ARHGAP29, DHDH, Estrogen Hematological Receptor, Focal adhesion kinase, G-protein beta, System GFPT1, GNA13, Gsk3, Hdac, HDAC10, HMOX1, Development and Insulin, Mapk, MDM4, MKNK2, NCF2, Function, Gene oxidoreductase, Pdgf, PI3K, PIK3CA, PRKAB2, Expression, PRKAR2A, PTPRH, RAB3IP, Rac, Ras, Ras Connective homolog, STX16, Vegf, VTI1A, WWOX, YAP1 Tissue Development and Function AGPAT9, ASNS, ATF4, beta-estradiol, BMI1, Amino Acid CEP290, CTH, DDIT4, E4F1, EIF4EBP1, FAM45A, Metabolism, FUT1, GARS, GDF15, GGT6, GRIN2C, IFRD1, Drug ILDR1, LCN2, MBNL2, MTHFD2, MVD, NARS, Metabolism, PLA2, PSPH, RAB31, RCAN3, SC4MOL, SELE, Small Molecule SELPLG, SLC5A5, SMG1, STC2, TARS, TGFB1 Biochemistry Actin, ARF4, ASNS, BCAT1, CCPG1, COTL1, Cell Cycle, DDX18, DTNA, EGFR, EIF2B3, GKAP1, GPC1, Reproductive HGS, HIVEP2, HK1, HKDC1, HSD17B1, ITPKA, System LAMP2, MXI1, MYC, NAV2 (includes EG:89797), Development and OSCAR, PMAIP1, retinoic acid, Retinoic acid-RAR- Function, RXR, SBDS, SCAMP1, SCAMP3, SERPINB8, Cellular SMARCA4, testosterone, TMEM49, TNXB, TRAK2 Assembly and Organization B. Up-regulated networks in sorafenib-treated Huh7 cells ANKRD1, ATF3, BBC3, BEX2, C/ebp, CEBPG, Drug CREB5, DDIT3, FGG, glutathione transferase, Metabolism, GNB5, GNGT1, GST, GSTA1, GSTA2, GSTA3, Gene Expression, GSTA5, HERPUD1, HLF (includes EG:3131), Amino Acid HSD17B14, IBTK (includes EG:25998), JUND, Metabolism MAFK, MTSS1, NFIL3, NFkB (complex), OPTN, Pias, PXR ligand-PXR-Retinoic acid-RXRα,

Scorec 52

39

27

25

20

39

2

3

4

5

1

2

3

RGS9BP, Sapk, SLC12A7, SLC3A1, TOPORS, TRIB3 26s Proteasome, C12ORF49, C2ORF3, C3ORF15, CORO2A, DPP7, hCG, HDAC4, HISTONE, Histone h4, Hsp90, KATNA1, KLHL24, MIR1, MIR124, MT1L, MTL5, NEDD4L, NOL8, NR3C1, OAT, Pka, PRKACB, RAB32, RAD18, RBM47, RRAGC, RRAGD, SAT1, SAT2, SLC15A4, Trypsin, UBE2B, Vegf, XRN1 AREG, BET1, BIN1, CYR61, DNAJB2 (includes EG:3300), EGFR ligand, ERBB, ERBB3, ERBB3 ligand, ERBB4 ligand, EREG, ERK1/2, GAS5, Gcn5l, GDNF, GOLGA2, GPER, IRS, JAK, KIF5C, KLC1, LGALS8, MST1, NRG, NRG1, NRG2, NTN4, RASD1, Shc, SLC12A6, SOCS, SOCS2, SPAG9, STAT, TRIB1

Cell Morphology, 30 Nervous System Development and Function, Cellular Function and Maintenance DNA Replication, Recombination, and Repair, Embryonic Development, Tissue Development Gene Expression, DNA Replication, Recombination, and Repair, Lipid Metabolism

ACOX1, Akt, ASAH1, Cbp/p300, CIRBP, CPT1A, CREBBP, Estrogen Receptor, GADD45A, GRB10, Growth hormone, IGFALS, KLF4, MAF, MPDZ, MXD1, N-cor, NMI, NUDT21, OGG1, PEPCK, PPARGC1A, RARA, Rxr, SEMA3B, SLC20A1, Smad2/3, STAT5a/b, SULT2A1, SWI-SNF, TCEA3, THRB, thymidine kinase, Thyroid hormone receptor, VitaminD3-VDR-RXR AFF1, AFF4, AHNAK, Alpha tubulin, CD55, Cell Death, CLCN2, CRBN, FBXO32, Fcer1, Fibrinogen, Cardiovascular & GADD45B, HDL, HSD17B1, Hsp27, Ige, IgG, Embryonic KLKB1, LAMA3, LDL, LGALS2, MAP2K1/2, Development Mek, NPC2, OSBPL6, OSBPL1A, P38 MAPK, Pak, PLC gamma, RILP, SERPINC1, SIAH1, SORL1, SPINT1, UGCG, VEGFA C. Down-regulated networks in sorafenib-treated HepG2 cells AFP, ANG, ASH1L, BNIP3L, CD3D, CHD8, DNA DHX9, DUT (includes EG:1854), FABP1, FEN1, Replication, HIST1H1A, HIST1H1B, HIST1H1T, Histone H1, Recombination, Histone h3, HP, IKK (complex), KIAA0101, and Repair, MALT1, MYBPH, NASP, NCAPD2, NCAPH, Hematologi-cal NFE2, P38 MAPK, PCNA, PLA2G2A, SGK1, Disease SHMT1, TNFRSF11A, TOP2A, Trypsin, UBE2I, UNG, ZAP70 APC, AURKA, AURKB, BIRC5, BUB1, CCNB1, Cell Cycle, CCNB2, Cdc2, CDC6, CDC20, CDC23 (includes Cancer, Genetic EG:8697), CDC25C, CDCA8, CDK2AP1, CLCN5, Disorder Cofilin, Cyclin A, Cyclin B, Cyclin E, DDX24, E2f, ERK1/2, HSP90AB1, HSPA1A, KLB, LGI1, MCM2, POLA2, PTTG1, STARD13, TCP1, TK1, TPI1, TPX2, YWHAE 14-3-3, ANKH, ASB9, BMP4, BRIP1, Calcineurin Cancer, protein(s), CENPA, CTSL2, DKK1, hCG, Histone Gastrointestinal h4, HSD17B7, IL12 (complex), IL17RB, IL1RAP, Disease, Genetic

29

27

26

51

44

36

4

5

1

2

3

4

5

Jnk, MCM3, MCM5, MCM10, Mek, MHC Class II, Disorder ORC1L, POLR2L (includes EG:5441), PRLR, RBBP4, RNA polymerase II, RPA, RPA1, RRM2, SOCS3, SPP1, ST6GAL1, TCEB2, Vegf, XRCC6 Akt, AMPK, APOM, CALR, CDCA7, CP, CSRP2, Carbohydrate CTGF, CYP8B1, DBI, DEPDC1, FXYD5, FZD2, Metabolism, Glucose Transporter, Growth hormone, HMGCS1, Small Molecule HNF4α dimer, IGFBP7, Insulin, LRP, MCM6, Biochemistry, MIR124, Mre11, NME4, PCSK9, PDGF BB, PP2A, Lipid PROS1, SCD, SLC2A1, SLC2A2, SLC2A3, Metabolism SMC1A, T3-TR-RXR, TJP2 A2M, B3GNT1, Collagen type I, Collagen(s), Genetic Disorder, COPA, CPB2, E2F7, E2F8, FGA, FGB, FGG, Hematological Fibrin, Fibrinogen, Focal adhesion kinase, Integrin, Disease, Amino ITGA3, LSP1, MBL2, Mmp, NFkB (complex), Acid Metabolism P4HA1, P4HB, Pdgf Ab, PDGFRB, SERPINA3, Stat3-Stat3, TFPI2, TMED9, TNPO3, Top2, UBE2, UBE2S, UHRF1, VSNL1, WDR34 D. Down-regulated networks in sorafenib-treated Huh7 cells AEBP1, ANXA13, CDC6, CDC7, CDC45L, DNA CDCA4, DUSP5, E2f, E2F2, E2F7, E2F8, Replication, EDARADD, LMNB2, MCM2, MCM3, MCM4, Recombination, MCM5, MCM6, MCM7, MCM10, NFkB and Repair, (complex), NUSAP1, ORC1L, ORC6L, PASK, Cancer PBK, PELI1, PGRMC1, PRR11, SKA2, SLC2A6, thymidine kinase, TNFAIP2, VOPP1, WDR34 AK2, APOM, C18ORF10, CDCA7, CLSPN, Protein CPSF6, DEPDC1, DKK1, DNA-directed DNA Synthesis, polymerase, DSCC1, EWSR1, EZH2, FUS, Cardiovascular HTATIP2, KIAA0101, LDLR, LIMCH1, MIR124, Disease, Genetic MYH4, NEDD8, NME4, PBX3, PCNA, PCSK9, Disorder PHF19, POLA2, POLQ, POLR2L (includes EG:5441), RAD51AP1, Ras, RBBP4, RNA polymerase II, RPS15A (includes EG:6210), SF3B3, YBX1 C8ORF4, Caspase, CETN2, CP110, Cytochrome c, Small Molecule DPYD, DSG3, EIF4A1, EIF4E, Eif4g, FZD2, Biochemistry, GAPDH (includes EG:2597), GPX2, GPX3, RNA PostHMGN1, HMGN2, HN1, HNRNPD, Hsp27, Hsp70, Transcriptional HSPB1, IFT57, LBR, LDHA, LDHB, NUP153, Modification NUTF2, Pkc(s), PRDX1, PSME3, SOD1, SRXN1, SUB1, TARDBP, TMPO ACLY, AFP, CAPZA1, CDK2AP1, DPP4, ERK1/2, Lipid ETV5, FDPS, Fgf, FGF19 (includes EG:9965), Metabolism, FGFR2, GC-GCR dimer, GPAM, HISTONE, Molecular HMMR, IL17R, INSIG1, ITGB6, KDM1A, MBD3 Transport, (includes EG:53615), NPAT, PLC gamma, PROM1, Nucleic Acid RBP4, SCD, SH3KBP1, SLPI, SNRPB, SPRY1, Metabolism SPRY2, SPRY4, SQLE, TPX2, UNG, WDR77 ABCD3, ATF7IP, ATPase, BAT1, BLM, BRIP1, DNA DUT (includes EG:1854), FANCD2, FANCM, Replication,

35

33

45

43

38

36

36

Fibrinogen, H2AFX, HMGA2, ICAM1, IKK (complex), IL1, KIF20B, MTTP, NfkB1-RelA, PELO, PRKDC, PRMT6, RAD51L1, RPA, RRBP1, RUVBL1, SGEF, SHMT1, SUMO1, THOC4, TOP2A, UBE2N, UBE2T, VCP, XRCC2, XRCC5 a

Recombination, and Repair, Cellular Function and Maintenance

The five top-scoring networks for each drug treatment are presented.

b

Bold genes are those identified by the microarray analysis, other genes were either not on the

expression array or excluded by our gene expression selection criteria. c

 

A score of 3 was considered significant (p < 0.001).

Supplemental Table 3. Genes, identified by clustering (the 417 gene list) that are comparatively up- or down-regulated in HepG2 cells vs Huh7 cells upon sorafenib treatment (≥2-fold, p = 0.05) A. Genes upregulated in HepG2 cells, compared to Huh7 cells P-value Genbank GeneSymbol Description 0.000407 NM_003064 SLPI Homo sapiens secretory leukocyte protease inhibitor (antileukoproteinase) (SLPI), mRNA [NM_003064] 0.00058 NM_003897 IER3 Homo sapiens immediate early response 3 (IER3), transcript variant short, mRNA [NM_003897] 0.000999 NM_014059 RGC32 Homo sapiens response gene to complement 32 (RGC32), mRNA [NM_014059] 0.00111 NM_016205 PDGFC Homo sapiens platelet derived growth factor C (PDGFC), mRNA [NM_016205] 0.00132 NM_030955 ADAMTS12 Homo sapiens a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12 (ADAMTS12), mRNA [NM_030955] 0.00163 AF090930 PRO0478 Homo sapiens clone HQ0478 PRO0478 mRNA, complete cds. [AF090930] 0.00208 NM_003931 WASF1 Homo sapiens WAS protein family, member 1 (WASF1), transcript variant 1, mRNA [NM_003931] 0.00301 NM_002211 ITGB1 Homo sapiens integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1A, mRNA [NM_002211] 0.00333 NM_006744 RBP4 Homo sapiens retinol binding protein 4, plasma (RBP4), mRNA [NM_006744] 0.00347 AK027209 FLJ23556 Homo sapiens cDNA: FLJ23556 fis, clone LNG09443. [AK027209] 0.00355 NM_175924 ILDR1 Homo sapiens immunoglobulin-like domain containing receptor 1 (ILDR1), mRNA [NM_175924] 0.00385 NM_016147 PME-1 Homo sapiens protein phosphatase methylesterase-1 (PME-1), mRNA [NM_016147] 0.00407 NM_003004 SECTM1 Homo sapiens secreted and transmembrane 1 (SECTM1), mRNA [NM_003004] 0.00425 AK022351 AK022351 Homo sapiens cDNA FLJ12289 fis, clone MAMMA1001788. [AK022351] 0.0044 ENST00000255136 Homo sapiens, clone IMAGE:4745538, mRNA. [BC039151] 0.00489 NM_206818 OSCAR Homo sapiens osteoclast-associated receptor (OSCAR), transcript variant 1, mRNA [NM_206818] 0.00498 NM_001430 EPAS1 Homo sapiens endothelial PAS domain protein 1 (EPAS1), mRNA [NM_001430] Homo sapiens aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) (AKR1C1), mRNA 0.00525 NM_001353 AKR1C1 [NM_001353] 0.00529 NM_031942 CDCA7 Homo sapiens cell division cycle associated 7 (CDCA7), transcript variant 1, mRNA [NM_031942] 0.00567 NR_001442 FER1L4 Homo sapiens fer-1-like 4 (C. elegans) (FER1L4) on chromosome 20 [NR_001442] 0.00629 NM_005213 CSTA Homo sapiens cystatin A (stefin A) (CSTA), mRNA [NM_005213] 0.00641 NM_053044 HTRA3 Homo sapiens HtrA serine peptidase 3 (HTRA3), mRNA [NM_053044] 0.0065 AK123481 AK123481 Homo sapiens cDNA FLJ41487 fis, clone BRTHA2004350. [AK123481] 0.00663 NM_032336 SLD5 Homo sapiens SLD5 homolog (SLD5), mRNA [NM_032336] 0.00716 NM_033300 LRP8 Homo sapiens low density lipoprotein receptor-related protein 8, apolipoprotein e receptor (LRP8), transcript variant 2, mRNA [NM_033300] 0.00728 AA219130 AA219130 AA219130 zq99g05.s1 Stratagene NT2 neuronal precursor 937230 Homo sapiens cDNA clone IMAGE:650168 3', mRNA sequence [AA219130] 0.00737 NM_001218 CA12 Homo sapiens carbonic anhydrase XII (CA12), transcript variant 1, mRNA [NM_001218] 0.00763 NM_002228 JUN Homo sapiens v-jun sarcoma virus 17 oncogene homolog (avian) (JUN), mRNA [NM_002228] 0.00771 NM_207505 FLJ45248 Homo sapiens FLJ45248 protein (FLJ45248), mRNA [NM_207505] 0.00825 NM_003290 TPM4 Homo sapiens tropomyosin 4 (TPM4), mRNA [NM_003290] 0.00845 NM_014632 MICAL2 Homo sapiens microtubule associated monoxygenase, calponin and LIM domain containing 2 (MICAL2), mRNA [NM_014632] 0.00849 NM_003662 PIR Homo sapiens pirin (iron-binding nuclear protein) (PIR), transcript variant 1, mRNA [NM_003662] 0.00908 AF116642 AF116642 Homo sapiens PRO1618 mRNA, complete cds. [AF116642] 0.00924 NM_206910 C6orf216 Homo sapiens chromosome 6 open reading frame 216 (C6orf216), transcript variant 3, mRNA [NM_206910] 0.00945 AF256215 ARNTL2 Homo sapiens cycle-like factor CLIF mRNA, complete cds. [AF256215] 0.00947 NM_144601 CKLFSF3 Homo sapiens chemokine-like factor super family 3 (CKLFSF3), transcript variant 1, mRNA [NM_144601] 0.0095 NM_006818 MLLT11 Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 (MLLT11), mRNA [NM_006818] 0.00977 NM_023076 C16orf28 Homo sapiens chromosome 16 open reading frame 28 (C16orf28), mRNA [NM_023076] 0.0098 NM_004695 SLC16A5 Homo sapiens solute carrier family 16 (monocarboxylic acid transporters), member 5 (SLC16A5), mRNA [NM_004695] 0.01 NM_019844 SLCO1B3 Homo sapiens solute carrier organic anion transporter family, member 1B3 (SLCO1B3), mRNA [NM_019844] 0.0101 NM_000641 IL11 Homo sapiens interleukin 11 (IL11), mRNA [NM_000641] 0.0103 NM_014045 LRP10 Homo sapiens low density lipoprotein receptor-related protein 10 (LRP10), mRNA [NM_014045] 0.0106 AK022044 AK022044 Homo sapiens cDNA FLJ11982 fis, clone HEMBB1001335. [AK022044] 0.0111 CR601458 CR601458 full-length cDNA clone CS0DJ001YJ05 of T cells (Jurkat cell line) Cot 10-normalized of Homo sapiens (human). [CR601458] 0.0112 NM_024758 AGMAT Homo sapiens agmatine ureohydrolase (agmatinase) (AGMAT), mRNA [NM_024758] 0.0114 BC020784 MGC14289 Homo sapiens similar to RIKEN cDNA 1200014N16 gene, mRNA (cDNA clone IMAGE:4773508), complete cds. [BC020784] 0.0119 NM_019067 GNL3L Homo sapiens guanine nucleotide binding protein-like 3 (nucleolar)-like (GNL3L), mRNA [NM_019067] 0.0121 BC051317 RBBP6 Homo sapiens retinoblastoma binding protein 6, mRNA (cDNA clone IMAGE:6214974), complete cds. [BC051317]

0.0123 0.0126 0.0127 0.013 0.0134 0.0135 0.0136 0.0144 0.0146 0.0146 0.0146 0.0148 0.0148 0.0153 0.0153 0.0153 0.0158 0.0158 0.016 0.016 0.016 0.0161 0.0162 0.0163 0.0164 0.0168 0.0169 0.0175 0.0176 0.0178 0.0178 0.018 0.0183 0.019 0.0192 0.0193 0.0194 0.0195 0.0195 0.0198 0.02 0.02 0.0204 0.0207 0.0208 0.0209 0.021 0.0213 0.0216 0.0221 0.0223 0.0224

NM_005117 NM_172364 NM_020239 NM_001853 NM_001266 NM_018948 NM_002133 AK074696 NM_018038 NM_032211 NM_024895 NM_001008394 BC029919 NM_002263 NM_003629 NM_004665 AL713706 NM_001046 AK092508 NM_203471 NM_006470 NM_199511 NM_003045 NM_007283 NM_144998 NM_058172 BC036263 NM_004750 NM_003557 AK098081 NM_052813 NM_016606 AK021848 NM_015881 AK021772 AK093655 NM_001673 NM_004482 NM_002203 NM_015326 NM_001003954 AF390550 NM_004454 NM_172069 AK091784 NM_014988 NM_020918 NM_139004 NM_152675 AK130891 AK124558 NM_005475

FGF19 CACNA2D4 CDC42SE1 COL9A3 CES1 MIG-6 HMOX1 AK074696 FLJ10246 LOXL4 PDZK7 EID3 SRGAP1 KIFC1 PIK3R3 VNN2 DPYSL5 SLC12A2 AK092508 LGALS14 TRIM16 URB SLC7A1 MGLL STRA13 ANTXR2 LOC23117 CRLF1 PIP5K1A AK098081 CARD9 C5orf19 AK021848 DKK3 FLJ11710 GLCCI1 ASNS GALNT3 ITGA2 SRGAP2 ANXA13 AF390550 ETV5 PLEKHH2 AK091784 KIAA1102 GPAM HFE FLJ23754 AK130891 AK124558 LNK

Homo sapiens fibroblast growth factor 19 (FGF19), mRNA [NM_005117] Homo sapiens calcium channel, voltage-dependent, alpha 2/delta subunit 4 (CACNA2D4), transcript variant 1, mRNA [NM_172364] Homo sapiens CDC42 small effector 1 (CDC42SE1), mRNA [NM_020239] Homo sapiens collagen, type IX, alpha 3 (COL9A3), mRNA [NM_001853] Homo sapiens carboxylesterase 1 (monocyte/macrophage serine esterase 1) (CES1), transcript variant 3, mRNA [NM_001266] Homo sapiens mitogen-inducible gene 6 (MIG-6), mRNA [NM_018948] Homo sapiens heme oxygenase (decycling) 1 (HMOX1), mRNA [NM_002133] Homo sapiens cDNA FLJ90215 fis, clone MAMMA1002205. [AK074696] Homo sapiens hypothetical protein FLJ10246 (FLJ10246), mRNA [NM_018038] Homo sapiens lysyl oxidase-like 4 (LOXL4), mRNA [NM_032211] Homo sapiens PDZ domain containing 7 (PDZK7), mRNA [NM_024895] Homo sapiens E1A-like inhibitor of differentiation 3 (EID3), mRNA [NM_001008394] Homo sapiens SLIT-ROBO Rho GTPase activating protein 1, mRNA (cDNA clone IMAGE:4153945), with apparent retained intron. [BC029919] Homo sapiens kinesin family member C1 (KIFC1), mRNA [NM_002263] Homo sapiens phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) (PIK3R3), mRNA [NM_003629] Homo sapiens vanin 2 (VNN2), transcript variant 1, mRNA [NM_004665] Homo sapiens mRNA; cDNA DKFZp761O1810 (from clone DKFZp761O1810). [AL713706] Homo sapiens solute carrier family 12 (sodium/potassium/chloride transporters), member 2 (SLC12A2), mRNA [NM_001046] Homo sapiens cDNA FLJ35189 fis, clone PLACE6016210. [AK092508] Homo sapiens lectin, galactoside-binding, soluble, 14 (LGALS14), transcript variant 2, mRNA [NM_203471] Homo sapiens tripartite motif-containing 16 (TRIM16), mRNA [NM_006470] Homo sapiens steroid sensitive gene 1 (URB), transcript variant 1, mRNA [NM_199511] Homo sapiens solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 (SLC7A1), mRNA [NM_003045] Homo sapiens monoglyceride lipase (MGLL), transcript variant 1, mRNA [NM_007283] Homo sapiens stimulated by retinoic acid 13 homolog (mouse) (STRA13), mRNA [NM_144998] Homo sapiens anthrax toxin receptor 2 (ANTXR2), mRNA [NM_058172] Homo sapiens KIAA0220-like protein, mRNA (cDNA clone MGC:9515 IMAGE:3903371), complete cds. [BC036263] Homo sapiens cytokine receptor-like factor 1 (CRLF1), mRNA [NM_004750] Homo sapiens phosphatidylinositol-4-phosphate 5-kinase, type I, alpha (PIP5K1A), mRNA [NM_003557] Homo sapiens cDNA FLJ40762 fis, clone TRACH2002847. [AK098081] Homo sapiens caspase recruitment domain family, member 9 (CARD9), mRNA [NM_052813] Homo sapiens chromosome 5 open reading frame 19 (C5orf19), mRNA [NM_016606] Homo sapiens cDNA FLJ11786 fis, clone HEMBA1006036. [AK021848] Homo sapiens dickkopf homolog 3 (Xenopus laevis) (DKK3), transcript variant 1, mRNA [NM_015881] Homo sapiens cDNA FLJ11710 fis, clone HEMBA1005149. [AK021772] Homo sapiens cDNA FLJ36336 fis, clone THYMU2006303. [AK093655] Homo sapiens asparagine synthetase (ASNS), transcript variant 2, mRNA [NM_001673] Homo sapiens UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) (GALNT3), mRNA [NM_004482] Homo sapiens integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) (ITGA2), mRNA [NM_002203] Homo sapiens SLIT-ROBO Rho GTPase activating protein 2 (SRGAP2), mRNA [NM_015326] Homo sapiens annexin A13 (ANXA13), transcript variant 2, mRNA [NM_001003954] Homo sapiens cervical cancer suppressor gene 5 mRNA, complete cds. [AF390550] Homo sapiens ets variant gene 5 (ets-related molecule) (ETV5), mRNA [NM_004454] Homo sapiens pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 (PLEKHH2), mRNA [NM_172069] Homo sapiens cDNA FLJ34465 fis, clone HLUNG2003061. [AK091784] Homo sapiens KIAA1102 protein (KIAA1102), mRNA [NM_014988] Homo sapiens glycerol-3-phosphate acyltransferase, mitochondrial (GPAM), mRNA [NM_020918] Homo sapiens hemochromatosis (HFE), transcript variant 4, mRNA [NM_139004] Homo sapiens hypothetical protein FLJ23754 (FLJ23754), mRNA [NM_152675] Homo sapiens cDNA FLJ27381 fis, clone UBA07680. [AK130891] Homo sapiens cDNA FLJ42567 fis, clone BRACE3007559. [AK124558] Homo sapiens lymphocyte adaptor protein (LNK), mRNA [NM_005475]

0.0224 0.0226 0.0227 0.0228 0.0229 0.023 0.0238 0.024 0.024 0.0243 0.0244 0.0244 0.0244 0.0247 0.0257 0.0259 0.0259 0.026 0.0263 0.0264 0.0265 0.0266 0.0267 0.0267 0.0268 0.0268 0.0269 0.027 0.027 0.0271 0.0276 0.0278 0.0279 0.0283 0,0285 0.0288 0.0291 0.0294 0.0294 0.0299 0.03 0.0301 0.0302 0.0309 0.0312 0.0317 0.0318 0.0319 0.0319 0.0322 0.0329 0.0332

NM_006169 NM_001004320 AK026323 NM_003311 NM_016571 NM_017860 AK024389 NM_178582 NM_182924 NM_006085 NM_006018 NM_032717 NM_000923 NM_006671 NM_019058 NM_003937 CR598364 NM_002079 NM_033380 NM_021158 NM_201553 NM_007353 BC041925 NM_000297 NM_133378 NM_004419 NM_001456 AA541413 NM_015262 NM_003029 AK074866 NM_030912 AK094156 BC022826 NM_014056 NM_002061 NM_015103 BC022205 NM_058197 NM_000433 NM_001932 NM_005194 NM_020038 AK026418 NM_014034 NM_002760 NM_001622 NM_001905 BC041417

NNMT FLJ16237 ALPK1 PHLDA2 GLULD1 ENST00000278949 C1orf56 FLJ14327 HM13 MICAL-L2 BPNT1 GPR109B MGC11324 PDE4C SLC1A7 DDIT4 KYNU CR598364 GOT1 COL4A5 TRIB3 FGL1 GNA12 SLC7A11 PKD2 TTN DUSP5 ENST00000343505 FLNA AA541413 FAM21C SHC1 TRIM11 TRIM8 LOC440668 BC022826 HIG1 GCLM PLXND1 ENST00000305954 BC022205 CDKN2A NCF2 MPP3 CEBPB ABCC3 AK026418 ASF1A PRKY AHSG CTPS BC041417

Homo sapiens nicotinamide N-methyltransferase (NNMT), mRNA [NM_006169] Homo sapiens FLJ16237 protein (FLJ16237), mRNA [NM_001004320] Homo sapiens cDNA: FLJ22670 fis, clone HSI08684. [AK026323] Homo sapiens pleckstrin homology-like domain, family A, member 2 (PHLDA2), mRNA [NM_003311] Homo sapiens glutamate-ammonia ligase (glutamine synthase) domain containing 1 (GLULD1), mRNA [NM_016571] Homo sapiens cDNA FLJ38080 fis, clone CTONG2016185. [AK095399] Homo sapiens chromosome 1 open reading frame 56 (C1orf56), mRNA [NM_017860] Homo sapiens cDNA FLJ14327 fis, clone PLACE4000250. [AK024389] Homo sapiens histocompatibility (minor) 13 (HM13), transcript variant 4, mRNA [NM_178582] Homo sapiens MICAL-like 2 (MICAL-L2), transcript variant 1, mRNA [NM_182924] Homo sapiens 3'(2'), 5'-bisphosphate nucleotidase 1 (BPNT1), mRNA [NM_006085] Homo sapiens G protein-coupled receptor 109B (GPR109B), mRNA [NM_006018] Homo sapiens hypothetical protein MGC11324 (MGC11324), mRNA [NM_032717] Homo sapiens phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila) (PDE4C), mRNA [NM_000923] Homo sapiens solute carrier family 1 (glutamate transporter), member 7 (SLC1A7), mRNA [NM_006671] Homo sapiens DNA-damage-inducible transcript 4 (DDIT4), mRNA [NM_019058] Homo sapiens kynureninase (L-kynurenine hydrolase) (KYNU), mRNA [NM_003937] full-length cDNA clone CS0CAP007YJ17 of Thymus of Homo sapiens (human). [CR598364] Homo sapiens glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) (GOT1), mRNA [NM_002079] Homo sapiens collagen, type IV, alpha 5 (Alport syndrome) (COL4A5), transcript variant 2, mRNA [NM_033380] Homo sapiens tribbles homolog 3 (Drosophila) (TRIB3), mRNA [NM_021158] Homo sapiens fibrinogen-like 1 (FGL1), transcript variant 4, mRNA [NM_201553] Homo sapiens guanine nucleotide binding protein (G protein) alpha 12 (GNA12), mRNA [NM_007353] Homo sapiens solute carrier family 7, (cationic amino acid transporter, y+ system) member 11, mRNA (cDNA clone IMAGE:5300264), partial cds. [BC041925] Homo sapiens polycystic kidney disease 2 (autosomal dominant) (PKD2), mRNA [NM_000297] Homo sapiens titin (TTN), transcript variant N2-A, mRNA [NM_133378] Homo sapiens dual specificity phosphatase 5 (DUSP5), mRNA [NM_004419] Homo sapiens mRNA for KIAA1357 protein, partial cds. [AB037778] Homo sapiens filamin A, alpha (actin binding protein 280) (FLNA), mRNA [NM_001456] AA541413 ni77g08.s1 NCI_CGAP_Pr12 Homo sapiens cDNA clone IMAGE:982910, mRNA sequence [AA541413] Homo sapiens family with sequence similarity 21, member C (FAM21C), mRNA [NM_015262] Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1 (SHC1), transcript variant 2, mRNA [NM_003029] Homo sapiens cDNA FLJ90385 fis, clone NT2RP2005247, weakly similar to ZINC-FINGER PROTEIN RFP. [AK074866] Homo sapiens tripartite motif-containing 8 (TRIM8), mRNA [NM_030912] Homo sapiens cDNA FLJ36837 fis, clone ASTRO2011422. [AK094156] Homo sapiens cDNA clone IMAGE:5441030, partial cds. [BC022826] Homo sapiens likely ortholog of mouse hypoxia induced gene 1 (HIG1), mRNA [NM_014056] Homo sapiens glutamate-cysteine ligase, modifier subunit (GCLM), mRNA [NM_002061] Homo sapiens plexin D1 (PLXND1), mRNA [NM_015103] Homo sapiens mRNA; cDNA DKFZp434A0131 (from clone DKFZp434A0131). [AL137492] Homo sapiens, clone IMAGE:5258564, mRNA. [BC022205] Homo sapiens cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) (CDKN2A), transcript variant 3, mRNA [NM_058197] Homo sapiens neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2) (NCF2), mRNA [NM_000433] Homo sapiens membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) (MPP3), mRNA [NM_001932] Homo sapiens CCAAT/enhancer binding protein (C/EBP), beta (CEBPB), mRNA [NM_005194] Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 3 (ABCC3), transcript variant MRP3B, mRNA [NM_020038] Homo sapiens cDNA: FLJ22765 fis, clone KAIA1180. [AK026418] Homo sapiens ASF1 anti-silencing function 1 homolog A (S. cerevisiae) (ASF1A), mRNA [NM_014034] Homo sapiens protein kinase, Y-linked (PRKY), mRNA [NM_002760] Homo sapiens alpha-2-HS-glycoprotein (AHSG), mRNA [NM_001622] Homo sapiens CTP synthase (CTPS), mRNA [NM_001905] Homo sapiens cDNA clone IMAGE:5286005, partial cds. [BC041417]

0.0335 0.0339 0.0344 0.0345 0.0348 0.0352 0.0352

NM_006520 NM_020739 NM_012334 NM_003280 NM_000660 NM_175850 NM_145791

TCTE1L CCPG1 MYO10 TNNC1 TGFB1 DNMT3B MGST1

0.0353 0.0355 0.0355 0.036 0.0361 0.0362 0.0364 0.037 0.037 0.0372 0.0373 0.0381 0.0381 0.0384 0.0384 0.0387 0.0393 0.0395 0.0395 0.0398 0.0399 0.0399 0.0401 0.0402 0.0402 0.0407 0.0414 0.0416 0.0416 0.0416 0.042 0.0424 0.0428 0.0432 0.0437 0.0437 0.0443 0.0448 0.0452 0.0453 0.0458 0.0461 0.0462 0.0469

NM_000158 NM_198336 BF373107 BC038559 S63912 NM_003407 NM_005628 NM_002089 NM_175839 NM_000051 NM_005241 NM_022837 NM_005980 NM_002210 NM_020800 NM_033468 NM_001001290 AK092744

GBE1 INSIG1 BF373107 BC038559 HNRPA3P1 ZFP36 SLC1A5 CXCL2 SMOX ATM EVI1 FLJ22833 S100P ITGAV WDR56 ZNF257 SLC2A9 AK092744 ENST00000341963 SMG1 NQO2 PSAT1 TNFRSF11B ENST00000310023 ARMCX3 VPS13A PORIMIN BF514799 GNG5 PSPH AV753543 EVER1 PXN DEADC1 AF086249 BCAT1 LTB4DH LOC344887 AF445027 BC047753 C18orf21 GLS BC024155 BHMT2

NM_015092 NM_000904 NM_058179 NM_002546 NM_016607 NM_033305 NM_052932 BF514799 NM_005274 NM_004577 AV753543 NM_007267 BC052611 NM_182503 AF086249 NM_005504 NM_012212 BX640843 AF445027 BC047753 NM_031446 AF158555 BC024155 NM_017614

Homo sapiens t-complex-associated-testis-expressed 1-like (TCTE1L), mRNA [NM_006520] Homo sapiens cell cycle progression 1 (CCPG1), transcript variant 2, mRNA [NM_020739] Homo sapiens myosin X (MYO10), mRNA [NM_012334] Homo sapiens troponin C, slow (TNNC1), mRNA [NM_003280] Homo sapiens transforming growth factor, beta 1 (Camurati-Engelmann disease) (TGFB1), mRNA [NM_000660] Homo sapiens DNA (cytosine-5-)-methyltransferase 3 beta (DNMT3B), transcript variant 6, mRNA [NM_175850] Homo sapiens microsomal glutathione S-transferase 1 (MGST1), transcript variant 1c, mRNA [NM_145791] Homo sapiens glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen disease, glycogen storage disease type IV) (GBE1), mRNA [NM_000158] Homo sapiens insulin induced gene 1 (INSIG1), transcript variant 2, mRNA [NM_198336] BF373107 CM2-FT0123-280700-305-C12 FT0123 Homo sapiens cDNA, mRNA sequence [BF373107] Homo sapiens, clone IMAGE:3851018, mRNA. [BC038559] D10S102=FBRNP [human, fetal brain, mRNA, 3043 nt]. [S63912] Homo sapiens zinc finger protein 36, C3H type, homolog (mouse) (ZFP36), mRNA [NM_003407] Homo sapiens solute carrier family 1 (neutral amino acid transporter), member 5 (SLC1A5), mRNA [NM_005628] Homo sapiens chemokine (C-X-C motif) ligand 2 (CXCL2), mRNA [NM_002089] Homo sapiens spermine oxidase (SMOX), transcript variant 1, mRNA [NM_175839] Homo sapiens ataxia telangiectasia mutated (includes complementation groups A, C and D) (ATM), transcript variant 1, mRNA [NM_000051] Homo sapiens ecotropic viral integration site 1 (EVI1), mRNA [NM_005241] Homo sapiens hypothetical protein FLJ22833 (FLJ22833), mRNA [NM_022837] Homo sapiens S100 calcium binding protein P (S100P), mRNA [NM_005980] Homo sapiens integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) (ITGAV), mRNA [NM_002210] Homo sapiens WD repeat domain 56 (WDR56), mRNA [NM_020800] Homo sapiens zinc finger protein 257 (ZNF257), mRNA [NM_033468] Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 9 (SLC2A9), transcript variant 2, mRNA [NM_001001290] Homo sapiens cDNA FLJ35425 fis, clone SMINT2001615, highly similar to FERRITIN LIGHT CHAIN. [AK092744] Homo sapiens, hypothetical protein DKFZp566H0824, clone IMAGE:4607730, mRNA. [BC029383] Homo sapiens PI-3-kinase-related kinase SMG-1 (SMG1), mRNA [NM_015092] Homo sapiens NAD(P)H dehydrogenase, quinone 2 (NQO2), mRNA [NM_000904] Homo sapiens phosphoserine aminotransferase 1 (PSAT1), transcript variant 1, mRNA [NM_058179] Homo sapiens tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) (TNFRSF11B), mRNA [NM_002546] Homo sapiens armadillo repeat containing, X-linked 3 (ARMCX3), transcript variant 1, mRNA [NM_016607] Homo sapiens vacuolar protein sorting 13A (yeast) (VPS13A), transcript variant A, mRNA [NM_033305] Homo sapiens pro-oncosis receptor inducing membrane injury gene (PORIMIN), mRNA [NM_052932] UI-H-BW1-anj-a-01-0-UI.s1 NCI_CGAP_Sub7 Homo sapiens cDNA clone IMAGE:3082272 3', mRNA sequence [BF514799] Homo sapiens guanine nucleotide binding protein (G protein), gamma 5 (GNG5), mRNA [NM_005274] Homo sapiens phosphoserine phosphatase (PSPH), mRNA [NM_004577] AV753543 AV753543 NPD Homo sapiens cDNA clone NPDBEC03 5', mRNA sequence [AV753543] Homo sapiens epidermodysplasia verruciformis 1 (EVER1), mRNA [NM_007267] Homo sapiens cDNA clone MGC:59724 IMAGE:6252827, complete cds. [BC052611] Homo sapiens deaminase domain containing 1 (DEADC1), mRNA [NM_182503] Homo sapiens full length insert cDNA clone ZD39G09. [AF086249] Homo sapiens branched chain aminotransferase 1, cytosolic (BCAT1), mRNA [NM_005504] Homo sapiens leukotriene B4 12-hydroxydehydrogenase (LTB4DH), mRNA [NM_012212] Homo sapiens mRNA; cDNA DKFZp686B14224 (from clone DKFZp686B14224). [BX640843] Homo sapiens clone 114 tumor rejection antigen mRNA, complete cds. [AF445027] Homo sapiens, Similar to PMS2 postmeiotic segregation increased 2 (S. cerevisiae), clone IMAGE:6193449, mRNA. [BC047753] Homo sapiens chromosome 18 open reading frame 21 (C18orf21), mRNA [NM_031446] Homo sapiens glutaminase C mRNA, complete cds. [AF158555] Homo sapiens cDNA clone IMAGE:3936053, partial cds. [BC024155] Homo sapiens betaine-homocysteine methyltransferase 2 (BHMT2), mRNA [NM_017614]

0.0471 0.0473 0.0475 0.0476 0.0483 0.0484 0.0495 0.0496 0.0499

NM_022074 NM_013411 AL833317 NM_198970 NM_014918 AK022339 BX649059 M90656 NM_017982

FLJ22794 AK2 MYCPBP AES CHSY1 AK022339 GAS2L3 GCLC SUSD4

Homo sapiens FLJ22794 protein (FLJ22794), transcript variant 1, mRNA [NM_022074] Homo sapiens adenylate kinase 2 (AK2), transcript variant AK2B, mRNA [NM_013411] Homo sapiens mRNA; cDNA DKFZp313L197 (from clone DKFZp313L197). [AL833317] Homo sapiens amino-terminal enhancer of split (AES), transcript variant 3, mRNA [NM_198970] Homo sapiens carbohydrate (chondroitin) synthase 1 (CHSY1), mRNA [NM_014918] Homo sapiens cDNA FLJ12277 fis, clone MAMMA1001711. [AK022339] Homo sapiens mRNA; cDNA DKFZp779P0730 (from clone DKFZp779P0730). [BX649059] Human gamma-glutamylcysteine synthetase (GCS) mRNA, complete cds. [M90656] Homo sapiens sushi domain containing 4 (SUSD4), mRNA [NM_017982]

P-value 0.000466 0.000619 0.000651 0.000881 0.000926 0.00101 0.00133 0.00155 0.00187 0.0021 0.00221 0.00233 0.00287 0.00292 0.003 0.00321 0.00325 0.00329 0.00339 0.00412 0.00421 0.00434 0.00439 0.00443 0.00467 0.00467 0.00483 0.00506 0.00547 0.0058 0.00611 0.00612 0.007 0.00715 0.00732 0.00736 0.00737 0.00739 0.00769 0.0077

Genbank NM_000765 NM_005952 NM_001979 NM_032121 NM_138622 NM_024786 NM_133263 NM_018245 NM_201222 NM_005949 NM_000236 AK124659 X97261 NM_175617 NM_006413 NM_030666 NM_006714 NM_024738 NM_000777 NM_138375 NM_173549 NM_003719 NM_015549 AK090515 NM_005415 NM_024861

GeneSymbol CYP3A7 MT1X EPHX2 DKFZp564K142 BCL2L11 ZDHHC11 PPARGC1B OGDHL MAGED2 MT1F LIPC NAP5 MT1L MT1E RPP30 SERPINB1 SMPDL3A FLJ21415 CYP3A5 CABLES1 FLJ39553 PDE8B PLEKHG3 LOC283663 SLC20A1 FLJ22671 ENST00000245185 LARGE BC018687 SASH1 HIST1H2AE MUC20 CR601196 IFIT1 NEU1 SULT2A1 DGAT1 AK124936 CREB5 NEDD4L

B. Genes upregulated in Huh7 cells, compared to HepG2 cells Description Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 7 (CYP3A7), mRNA [NM_000765] Homo sapiens metallothionein 1X (MT1X), mRNA [NM_005952] Homo sapiens epoxide hydrolase 2, cytoplasmic (EPHX2), mRNA [NM_001979] Homo sapiens implantation-associated protein (DKFZp564K142), mRNA [NM_032121] Homo sapiens BCL2-like 11 (apoptosis facilitator) (BCL2L11), transcript variant 2, mRNA [NM_138622] Homo sapiens zinc finger, DHHC-type containing 11 (ZDHHC11), mRNA [NM_024786] Homo sapiens peroxisome proliferative activated receptor, gamma, coactivator 1, beta (PPARGC1B), mRNA [NM_133263] Homo sapiens oxoglutarate dehydrogenase-like (OGDHL), mRNA [NM_018245] Homo sapiens melanoma antigen family D, 2 (MAGED2), transcript variant 3, mRNA [NM_201222] Homo sapiens metallothionein 1F (functional) (MT1F), mRNA [NM_005949] Homo sapiens lipase, hepatic (LIPC), mRNA [NM_000236] Homo sapiens cDNA FLJ42668 fis, clone BRAMY2020270. [AK124659] H.sapiens mRNA for metallothionein isoform 1R. [X97261] Homo sapiens metallothionein 1E (functional) (MT1E), mRNA [NM_175617] Homo sapiens ribonuclease P/MRP 30kDa subunit (RPP30), mRNA [NM_006413] Homo sapiens serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1 (SERPINB1), mRNA [NM_030666] Homo sapiens sphingomyelin phosphodiesterase, acid-like 3A (SMPDL3A), mRNA [NM_006714] Homo sapiens hypothetical protein FLJ21415 (FLJ21415), mRNA [NM_024738] Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 5 (CYP3A5), mRNA [NM_000777] Homo sapiens Cdk5 and Abl enzyme substrate 1 (CABLES1), mRNA [NM_138375] Homo sapiens hypothetical protein FLJ39553 (FLJ39553), mRNA [NM_173549] Homo sapiens phosphodiesterase 8B (PDE8B), transcript variant 1, mRNA [NM_003719] Homo sapiens pleckstrin homology domain containing, family G (with RhoGef domain) member 3 (PLEKHG3), mRNA [NM_015549] Homo sapiens cDNA FLJ33196 fis, clone ADRGL2006034. [AK090515] Homo sapiens solute carrier family 20 (phosphate transporter), member 1 (SLC20A1), mRNA [NM_005415] Homo sapiens hypothetical protein FLJ22671 (FLJ22671), mRNA [NM_024861] Homo sapiens metallothionein 2A, mRNA (cDNA clone MGC:12397 IMAGE:4051220), complete cds. [BC007034] Homo sapiens like-glycosyltransferase (LARGE), transcript variant 1, mRNA [NM_004737] Homo sapiens, clone IMAGE:4717477, mRNA. [BC018687] Homo sapiens SAM and SH3 domain containing 1 (SASH1), mRNA [NM_015278] Homo sapiens histone 1, H2ae (HIST1H2AE), mRNA [NM_021052] Homo sapiens mucin 20 (MUC20), mRNA [NM_152673] full-length cDNA clone CS0DB002YH03 of Neuroblastoma Cot 10-normalized of Homo sapiens (human). [CR601196] Homo sapiens interferon-induced protein with tetratricopeptide repeats 1 (IFIT1), transcript variant 2, mRNA [NM_001548] Homo sapiens sialidase 1 (lysosomal sialidase) (NEU1), mRNA [NM_000434] Homo sapiens sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (SULT2A1), mRNA [NM_003167] Homo sapiens diacylglycerol O-acyltransferase homolog 1 (mouse) (DGAT1), mRNA [NM_012079] Homo sapiens cDNA FLJ42946 fis, clone BRSTN2005721. [AK124936] Homo sapiens cAMP responsive element binding protein 5 (CREB5), transcript variant 1, mRNA [NM_182898] Homo sapiens neural precursor cell expressed, developmentally down-regulated 4-like (NEDD4L), mRNA [NM_015277]

NM_004737 BC018687 NM_015278 NM_021052 NM_152673 CR601196 NM_001548 NM_000434 NM_003167 NM_012079 AK124936 NM_182898 NM_015277

0.00776 0.00806 0.00833 0.00837 0.00954 0.00963 0.00979 0.0108 0.0112 0.0114 0.0114 0.0117 0.012 0.0123 0.0123 0.0124 0.0125 0.013 0.0131 0.0131 0.0136 0.0139 0.014 0.0141 0.0143 0.0143 0.0152 0.0155 0.0156

NM_080749 NM_000790 AK055625 NM_021229 NM_013261 NM_005950 NM_015900 NM_005946 NM_005223 NM_001609 NM_005953 NM_153631 NM_001876 NM_004273 NM_016608 NM_000076 BC025971 NM_005947 NM_001017927 NM_003657 NM_153229 BC060766 NM_173462 NM_031430 NM_018291 NM_001352 NM_021244 NM_001748 AK023472

NEURL2 DDC PCGF5 NTN4 PPARGC1A MT1G PLA1A MT1A DNASE1 ACADSB MT2A HOXA3 CPT1A CHST3 ARMCX1 CDKN1C MGC11257 MT1B LOC130355 BCAS1 FLJ33318 SLC2A14 PAPLN RILP FLJ10986 DBP RRAGD CAPN2 AK023472

0.0157 0.0158 0.0158 0.0159 0.0167 0.0168 0.0171 0.0174 0.0176 0.0177 0.0182 0.0183 0.0185 0.0186 0.019 0.0197 0.02 0.0201 0.0202 0.0202 0.0205 0.0207

NM_000341 NM_080661 NM_182532 NM_017644 NM_001505 NM_022168 NM_005951 NM_003389 NM_005228 NM_012216 NM_019059 NM_005675 NM_021109 NM_014178 U88357 NM_033256 AF390550 AK093969 NM_005141 NM_003578 NM_022771 NM_002200

SLC3A1 MGC15937 TMEM61 DRE1 GPR30 IFIH1 MT1H CORO2A EGFR MID2 TOMM7 DGCR6 TMSB4X STXBP6 ERBB3 PPP1R14A AF390550 C14orf65 FGB SOAT2 TBC1D15 IRF5

Homo sapiens neuralized-like 2 (Drosophila) (NEURL2), mRNA [NM_080749] Homo sapiens dopa decarboxylase (aromatic L-amino acid decarboxylase) (DDC), mRNA [NM_000790] Homo sapiens cDNA FLJ31063 fis, clone HSYRA2001105. [AK055625] Homo sapiens netrin 4 (NTN4), mRNA [NM_021229] Homo sapiens peroxisome proliferative activated receptor, gamma, coactivator 1, alpha (PPARGC1A), mRNA [NM_013261] Homo sapiens metallothionein 1G (MT1G), mRNA [NM_005950] Homo sapiens phospholipase A1 member A (PLA1A), mRNA [NM_015900] Homo sapiens metallothionein 1A (functional) (MT1A), mRNA [NM_005946] Homo sapiens deoxyribonuclease I (DNASE1), mRNA [NM_005223] Homo sapiens acyl-Coenzyme A dehydrogenase, short/branched chain (ACADSB), nuclear gene encoding mitochondrial protein, mRNA [NM_001609] Homo sapiens metallothionein 2A (MT2A), mRNA [NM_005953] Homo sapiens homeo box A3 (HOXA3), transcript variant 2, mRNA [NM_153631] Homo sapiens carnitine palmitoyltransferase 1A (liver) (CPT1A), nuclear gene encoding mitochondrial protein, mRNA [NM_001876] Homo sapiens carbohydrate (chondroitin 6) sulfotransferase 3 (CHST3), mRNA [NM_004273] Homo sapiens armadillo repeat containing, X-linked 1 (ARMCX1), mRNA [NM_016608] Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), mRNA [NM_000076] Homo sapiens cDNA clone IMAGE:4907364, partial cds. [BC025971] Homo sapiens metallothionein 1B (functional) (MT1B), mRNA [NM_005947] Homo sapiens hypothetical protein LOC130355 (LOC130355), mRNA [NM_001017927] Homo sapiens breast carcinoma amplified sequence 1 (BCAS1), mRNA [NM_003657] Homo sapiens hypothetical protein FLJ33318 (FLJ33318), mRNA [NM_153229] Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 14, mRNA (cDNA clone MGC:71510 IMAGE:5297510), complete cds. [BC060766] Homo sapiens papilin, proteoglycan-like sulfated glycoprotein (PAPLN), mRNA [NM_173462] Homo sapiens Rab interacting lysosomal protein (RILP), mRNA [NM_031430] Homo sapiens hypothetical protein FLJ10986 (FLJ10986), mRNA [NM_018291] Homo sapiens D site of albumin promoter (albumin D-box) binding protein (DBP), mRNA [NM_001352] Homo sapiens Ras-related GTP binding D (RRAGD), mRNA [NM_021244] Homo sapiens calpain 2, (m/II) large subunit (CAPN2), mRNA [NM_001748] Homo sapiens cDNA FLJ13410 fis, clone PLACE1001720. [AK023472] Homo sapiens solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1 (SLC3A1), mRNA [NM_000341] Homo sapiens similar to RIKEN cDNA 0610008P16 gene (MGC15937), mRNA [NM_080661] Homo sapiens transmembrane protein 61 (TMEM61), mRNA [NM_182532] Homo sapiens DRE1 protein (DRE1), mRNA [NM_017644] Homo sapiens G protein-coupled receptor 30 (GPR30), mRNA [NM_001505] Homo sapiens interferon induced with helicase C domain 1 (IFIH1), mRNA [NM_022168] Homo sapiens metallothionein 1H (MT1H), mRNA [NM_005951] Homo sapiens coronin, actin binding protein, 2A (CORO2A), transcript variant 1, mRNA [NM_003389] Homo sapiens epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) (EGFR), transcript variant 1, mRNA [NM_005228] Homo sapiens midline 2 (MID2), transcript variant 1, mRNA [NM_012216] Homo sapiens translocase of outer mitochondrial membrane 7 homolog (yeast) (TOMM7), mRNA [NM_019059] Homo sapiens DiGeorge syndrome critical region gene 6 (DGCR6), mRNA [NM_005675] Homo sapiens thymosin, beta 4, X-linked (TMSB4X), mRNA [NM_021109] Homo sapiens syntaxin binding protein 6 (amisyn) (STXBP6), mRNA [NM_014178] Homo sapiens clone R1 ErbB-3 R1 (c-erbB-3) mRNA, partial cds. [U88357] Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 14A (PPP1R14A), mRNA [NM_033256] Homo sapiens cervical cancer suppressor gene 5 mRNA, complete cds. [AF390550] Homo sapiens cDNA FLJ36650 fis, clone UTERU2000023. [AK093969] Homo sapiens fibrinogen beta chain (FGB), mRNA [NM_005141] Homo sapiens sterol O-acyltransferase 2 (SOAT2), mRNA [NM_003578] Homo sapiens TBC1 domain family, member 15 (TBC1D15), mRNA [NM_022771] Homo sapiens interferon regulatory factor 5 (IRF5), transcript variant 1, mRNA [NM_002200]

0.0208 0.0213 0.0214 0.0223 0.023 0.0235 0.0235 0.0236 0.0237 0.0238 0.0239 0.0245 0.0252 0.0254 0.0259 0.0259 0.0261 0.0263 0.0267 0.0268 0.0268 0.0268 0.0272 0.0276 0.028 0.0299 0.03 0.0302 0.0304 0.0307 0.031 0.0313 0.0314 0.0314 0.0316 0.0316 0.0316 0.0317 0.0317 0.0318 0.032 0.033 00332 0.0334 0.0342 0.0345 0.0346 0.0347 0.0348 0.0349 0.0354 0.0355

NM_001698 NM_016302 NM_003492 NM_002648 NM_033086 NM_021603 NM_052966 NM_006096 NM_003020 NM_138445 NM_004105 NM_178508 NM_007069 NM_016341 NM_014992 NM_003749 NM_021260 NM_000308 NM_014751 NM_004636 NM_003640 NM_001002233 NM_018660 NM_015262 NM_000300 NM_006499 BC022205 NM_207323 BG191465 NM_018291 NM_001165 NM_001007260 NM_145740 NM_005461 NM_031432 NM_002052 NM_199040 NM_020796 NM_178546 NM_003710 NM_145008 NM_052880 AK094963 NM_014391 NM_178836 NM_176825 NM_018405 NM_006989 NM_003358 NM_018490 BM979049 BF373107

AUH CRBN CXorf12 PIM1 FGD3 FXYD2 C1orf24 NDRG1 SGNE1 GPR146 EFEMP1 C6orf1 HRASLS3 PLCE1 DAAM1 IRS2 ZFYVE1 PPGB MTSS1 SEMA3B IKBKAP RAB11FIP1 ZNF395 FAM21C PLA2G2A LGALS8 BC022205 DKFZp667M2411 BG191465 FLJ10986 BIRC3 C21orf18 GSTA1 MAFB UCK1 GATA4 NUDT4 SEMA6A LOC339483 SPINT1 YPEL4 MGC17330 FLJ37644 ANKRD1 LOC201164 SULT1C1 HSA272196 RASA4 UGCG LGR4 BM979049 BF373107

Homo sapiens AU RNA binding protein/enoyl-Coenzyme A hydratase (AUH), nuclear gene encoding mitochondrial protein, mRNA [NM_001698] Homo sapiens cereblon (CRBN), mRNA [NM_016302] Homo sapiens chromosome X open reading frame 12 (CXorf12), mRNA [NM_003492] Homo sapiens pim-1 oncogene (PIM1), mRNA [NM_002648] Homo sapiens FYVE, RhoGEF and PH domain containing 3 (FGD3), mRNA [NM_033086] Homo sapiens FXYD domain containing ion transport regulator 2 (FXYD2), transcript variant b, mRNA [NM_021603] Homo sapiens chromosome 1 open reading frame 24 (C1orf24), transcript variant 2, mRNA [NM_052966] Homo sapiens N-myc downstream regulated gene 1 (NDRG1), mRNA [NM_006096] Homo sapiens secretory granule, neuroendocrine protein 1 (7B2 protein) (SGNE1), mRNA [NM_003020] Homo sapiens G protein-coupled receptor 146 (GPR146), mRNA [NM_138445] Homo sapiens EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1), transcript variant 1, mRNA [NM_004105] Homo sapiens chromosome 6 open reading frame 1 (C6orf1), transcript variant 1, mRNA [NM_178508] Homo sapiens HRAS-like suppressor 3 (HRASLS3), mRNA [NM_007069] Homo sapiens phospholipase C, epsilon 1 (PLCE1), mRNA [NM_016341] Homo sapiens dishevelled associated activator of morphogenesis 1 (DAAM1), mRNA [NM_014992] Homo sapiens insulin receptor substrate 2 (IRS2), mRNA [NM_003749] Homo sapiens zinc finger, FYVE domain containing 1 (ZFYVE1), transcript variant 1, mRNA [NM_021260] Homo sapiens protective protein for beta-galactosidase (galactosialidosis) (PPGB), mRNA [NM_000308] Homo sapiens metastasis suppressor 1 (MTSS1), mRNA [NM_014751] Homo sapiens sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B (SEMA3B), transcript variant 1, mRNA [NM_004636] Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (IKBKAP), mRNA [NM_003640] Homo sapiens RAB11 family interacting protein 1 (class I) (RAB11FIP1), transcript variant 2, mRNA [NM_001002233] Homo sapiens zinc finger protein 395 (ZNF395), mRNA [NM_018660] Homo sapiens family with sequence similarity 21, member C (FAM21C), mRNA [NM_015262] Homo sapiens phospholipase A2, group IIA (platelets, synovial fluid) (PLA2G2A), mRNA [NM_000300] Homo sapiens lectin, galactoside-binding, soluble, 8 (galectin 8) (LGALS8), transcript variant 1, mRNA [NM_006499] Homo sapiens, clone IMAGE:5258564, mRNA. [BC022205] Homo sapiens hypothetical protein DKFZp667M2411 (DKFZp667M2411), mRNA [NM_207323] RST10559 Athersys RAGE Library Homo sapiens cDNA, mRNA sequence [BG191465] Homo sapiens hypothetical protein FLJ10986 (FLJ10986), mRNA [NM_018291] Homo sapiens baculoviral IAP repeat-containing 3 (BIRC3), transcript variant 1, mRNA [NM_001165] Homo sapiens chromosome 21 open reading frame 18 (C21orf18), transcript variant 4, mRNA [NM_001007260] Homo sapiens glutathione S-transferase A1 (GSTA1), mRNA [NM_145740] Homo sapiens v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) (MAFB), mRNA [NM_005461] Homo sapiens uridine-cytidine kinase 1 (UCK1), mRNA [NM_031432] Homo sapiens GATA binding protein 4 (GATA4), mRNA [NM_002052] Homo sapiens nudix (nucleoside diphosphate linked moiety X)-type motif 4 (NUDT4), transcript variant 2, mRNA [NM_199040] Homo sapiens sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A (SEMA6A), mRNA [NM_020796] Homo sapiens hypothetical protein LOC339483 (LOC339483), mRNA [NM_178546] Homo sapiens serine protease inhibitor, Kunitz type 1 (SPINT1), transcript variant 2, mRNA [NM_003710] Homo sapiens yippee-like 4 (Drosophila) (YPEL4), mRNA [NM_145008] Homo sapiens HGFL gene (MGC17330), mRNA [NM_052880] Homo sapiens cDNA FLJ37644 fis, clone BRHIP2000239. [AK094963] Homo sapiens ankyrin repeat domain 1 (cardiac muscle) (ANKRD1), mRNA [NM_014391] Homo sapiens similar to CG12314 gene product (LOC201164), mRNA [NM_178836] Homo sapiens sulfotransferase family, cytosolic, 1C, member 1 (SULT1C1), transcript variant 2, mRNA [NM_176825] Homo sapiens hypothetical protein, clone 2746033 (HSA272196), mRNA [NM_018405] Homo sapiens RAS p21 protein activator 4 (RASA4), mRNA [NM_006989] Homo sapiens UDP-glucose ceramide glucosyltransferase (UGCG), mRNA [NM_003358] Homo sapiens leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4), mRNA [NM_018490] BM979049 UI-CF-DU1-adl-i-11-0-UI.s1 UI-CF-DU1 Homo sapiens cDNA clone UI-CF-DU1-adl-i-11-0-UI 3', mRNA sequence [BM979049] BF373107 CM2-FT0123-280700-305-C12 FT0123 Homo sapiens cDNA, mRNA sequence [BF373107]

0.0356 0.0357 0.0358 0.0365 0.0366 0.0368 0.0375 0.0377 0.0378 0.0386

BC011671 BC047362 NM_019044 NM_015696 NM_052946 NM_176870 NM_000846 BC063022 NM_133631 NM_006371

0.039 0.0391 0.0392 0.0392 0.0393 0.0393 0.0394 0.0398 0.04 0.04 0.0401 0.0401 0.0402 0.0406 0.0406 0.0408 0.0409 0.0413 0.0414 0.0417 0.0418 0.042 0.0421 0.0422 0.0423 0.0425 0.0428 0.043 0.0432 0.0432 0.0433 0.0435 0.0441 0.0441 0.0441 0.0444 0.0445 0.0448 0.0454 0.0457 0.0458

W86899 NM_022460 NM_001343 NM_024692 NM_004683 NM_173491 NM_013399 NM_002178 NM_018284 NM_007107 NM_080658 NM_005791 NM_016607 NM_006498

GNB5 BC047362 FLJ10996 GPX7 NOSTRIN MT1K GSTA2 BC063022 ROBO1 CRTAP

W86899 HS1BP3 DAB2 RSNL2 RGN LSM11 C16orf5 IGFBP6 GBP3 SSR3 ACY3 MPHOSPH10 ARMCX3 LGALS2 ENST00000310865 NM_017460 CYP3A4 NM_018022 TMEM51 BC042334 CPN2 CR615016 CR615016 NM_004684 SPARCL1 NM_022719 DGCR14 NM_004968 ICA1 NM_020165 RAD18 AK091994 LOC286044 NM_033257 DGCR6L NM_153699 GSTA5 AL833099 AL833099 NM_005336 HDLBP NM_178313 SPTBN1 NM_015071 ARHGAP26 NM_015288 PHF15 NM_001008494 RAXLX NM_002462 MX1 NM_018973 DPM3 NM_182665 RASSF5 NM_000716 C4BPB NM_014326 DAPK2 NM_003122 SPINK1 NM_032932 RAB11FIP4 NM_032601 MCEE NM_015424 CHRDL2

Homo sapiens guanine nucleotide binding protein (G protein), beta 5, mRNA (cDNA clone IMAGE:4131809), complete cds. [BC011671] Homo sapiens cDNA clone IMAGE:5315177, partial cds. [BC047362] Homo sapiens hypothetical protein FLJ10996 (FLJ10996), mRNA [NM_019044] Homo sapiens glutathione peroxidase 7 (GPX7), mRNA [NM_015696] Homo sapiens nitric oxide synthase trafficker (NOSTRIN), mRNA [NM_052946] Homo sapiens metallothionein 1K (MT1K), mRNA [NM_176870] Homo sapiens glutathione S-transferase A2 (GSTA2), mRNA [NM_000846] Homo sapiens cDNA clone IMAGE:5246259, partial cds. [BC063022] Homo sapiens roundabout, axon guidance receptor, homolog 1 (Drosophila) (ROBO1), transcript variant 2, mRNA [NM_133631] Homo sapiens cartilage associated protein (CRTAP), mRNA [NM_006371] W86899 zh60b12.s1 Soares_fetal_liver_spleen_1NFLS_S1 Homo sapiens cDNA clone IMAGE:416447 3' similar to gb:L05091 40S RIBOSOMAL PROTEIN S28 (HUMAN);, mRNA sequence [W86899] Homo sapiens HS1-binding protein 3 (HS1BP3), mRNA [NM_022460] Homo sapiens disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2), mRNA [NM_001343] Homo sapiens restin-like 2 (RSNL2), mRNA [NM_024692] Homo sapiens regucalcin (senescence marker protein-30) (RGN), transcript variant 1, mRNA [NM_004683] Homo sapiens LSM11, U7 small nuclear RNA associated (LSM11), mRNA [NM_173491] Homo sapiens chromosome 16 open reading frame 5 (C16orf5), mRNA [NM_013399] Homo sapiens insulin-like growth factor binding protein 6 (IGFBP6), mRNA [NM_002178] Homo sapiens guanylate binding protein 3 (GBP3), mRNA [NM_018284] Homo sapiens signal sequence receptor, gamma (translocon-associated protein gamma) (SSR3), mRNA [NM_007107] Homo sapiens aspartoacylase (aminocyclase) 3 (ACY3), mRNA [NM_080658] Homo sapiens M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) (MPHOSPH10), mRNA [NM_005791] Homo sapiens armadillo repeat containing, X-linked 3 (ARMCX3), transcript variant 1, mRNA [NM_016607] Homo sapiens lectin, galactoside-binding, soluble, 2 (galectin 2) (LGALS2), mRNA [NM_006498] Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 2004990. [AL389981] Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4), mRNA [NM_017460] Homo sapiens transmembrane protein 51 (TMEM51), mRNA [NM_018022] Homo sapiens, Similar to RIKEN cDNA 1300018K11 gene, clone IMAGE:5190234, mRNA, partial cds. [BC042334] full-length cDNA clone CS0DB006YM19 of Neuroblastoma Cot 10-normalized of Homo sapiens (human). [CR615016] Homo sapiens SPARC-like 1 (mast9, hevin) (SPARCL1), mRNA [NM_004684] Homo sapiens DiGeorge syndrome critical region gene 14 (DGCR14), mRNA [NM_022719] Homo sapiens islet cell autoantigen 1, 69kDa (ICA1), transcript variant 2, mRNA [NM_004968] Homo sapiens RAD18 homolog (S. cerevisiae) (RAD18), mRNA [NM_020165] Homo sapiens cDNA FLJ34675 fis, clone LIVER2001608. [AK091994] Homo sapiens DiGeorge syndrome critical region gene 6-like (DGCR6L), mRNA [NM_033257] Homo sapiens glutathione S-transferase A5 (GSTA5), mRNA [NM_153699] Homo sapiens mRNA; cDNA DKFZp313E2215 (from clone DKFZp313E2215). [AL833099] Homo sapiens high density lipoprotein binding protein (vigilin) (HDLBP), mRNA [NM_005336] Homo sapiens spectrin, beta, non-erythrocytic 1 (SPTBN1), transcript variant 2, mRNA [NM_178313] Homo sapiens Rho GTPase activating protein 26 (ARHGAP26), mRNA [NM_015071] Homo sapiens PHD finger protein 15 (PHF15), mRNA [NM_015288] Homo sapiens RAX-like homeobox (RAXLX), mRNA [NM_001008494] Homo sapiens myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) (MX1), mRNA [NM_002462] Homo sapiens dolichyl-phosphate mannosyltransferase polypeptide 3 (DPM3), transcript variant 1, mRNA [NM_018973] Homo sapiens Ras association (RalGDS/AF-6) domain family 5 (RASSF5), transcript variant 3, mRNA [NM_182665] Homo sapiens complement component 4 binding protein, beta (C4BPB), transcript variant 1, mRNA [NM_000716] Homo sapiens death-associated protein kinase 2 (DAPK2), mRNA [NM_014326] Homo sapiens serine protease inhibitor, Kazal type 1 (SPINK1), mRNA [NM_003122] Homo sapiens RAB11 family interacting protein 4 (class II) (RAB11FIP4), mRNA [NM_032932] Homo sapiens methylmalonyl CoA epimerase (MCEE), mRNA [NM_032601] Homo sapiens chordin-like 2 (CHRDL2), mRNA [NM_015424]

0.0458 0.0463 0.0463 0.0463 0.0465 0.0466 0.0466 0.0469 0.047 0.0472 0.0472 0.0473 0.048 0.0483 0.0484 0.0491 0.0495

 

NM_031446 NM_001031 NM_002126 NM_198485 NM_032795 NM_152766 NM_018295 NM_022362 NM_017633 NM_005108 NM_152840 NM_000275 BX956036 NM_024709 NM_019102 NM_005101 NM_001657

C18orf21 RPS28 HLF FAM79B RPUSD4 MGC40107 FLJ11000 MMS19L FAM46A XYLB HPS4 OCA2 BX956036 C1orf115 HOXA5 G1P2 AREG

Homo sapiens chromosome 18 open reading frame 21 (C18orf21), mRNA [NM_031446] Homo sapiens ribosomal protein S28 (RPS28), mRNA [NM_001031] Homo sapiens hepatic leukemia factor (HLF), mRNA [NM_002126] Homo sapiens family with sequence similarity 79, member B (FAM79B), mRNA [NM_198485] Homo sapiens RNA pseudouridylate synthase domain containing 4 (RPUSD4), mRNA [NM_032795] Homo sapiens hypothetical protein MGC40107 (MGC40107), mRNA [NM_152766] Homo sapiens hypothetical protein FLJ11000 (FLJ11000), mRNA [NM_018295] Homo sapiens MMS19-like (MET18 homolog, S. cerevisiae) (MMS19L), mRNA [NM_022362] Homo sapiens family with sequence similarity 46, member A (FAM46A), mRNA [NM_017633] Homo sapiens xylulokinase homolog (H. influenzae) (XYLB), mRNA [NM_005108] Homo sapiens Hermansky-Pudlak syndrome 4 (HPS4), transcript variant 3, mRNA [NM_152840] Homo sapiens oculocutaneous albinism II (pink-eye dilution homolog, mouse) (OCA2), mRNA [NM_000275] DKFZp781J1775_r1 781 (synonym: hlcc4) Homo sapiens cDNA clone DKFZp781J1775 5', mRNA sequence [BX956036] Homo sapiens chromosome 1 open reading frame 115 (C1orf115), mRNA [NM_024709] Homo sapiens homeo box A5 (HOXA5), mRNA [NM_019102] Homo sapiens interferon, alpha-inducible protein (clone IFI-15K) (G1P2), mRNA [NM_005101] Homo sapiens amphiregulin (schwannoma-derived growth factor) (AREG), mRNA [NM_001657]