www.landesbioscience.com/journals/rnabiology/article/22343 ..... 2619511 Turl=http://rnajournal.cshlp.org/content/17/6/991. abstract laccessdate= }}.
Landes Bioscience
www.landesbioscience.com
Supplemental Material to: Walter N. Moss, Lumbini I. Dela-Moss, Salvatore F. Priore and Douglas H. Turner The influenza A segment 7 mRNA 3′ splice site pseudoknot/hairpin family 2012; 9(11) http://dx.doi.org/10.4161/rna.22343 www.landesbioscience.com/journals/rnabiology/article/22343
# STOCKHOLM 1.0 #=GF ID FluA_3PSS #=GF AC RFxxxxx #=GF DE Influenza A 3' splice site structured region #=GF AU Moss WN #=GF GA x #=GF NC x #=GF TC x #=GF SE PMID: #=GF SS Published; PMID: #=GF TP Cis-reg; #=GF BM x #=GF BM x #=GF RN [1] #=GF RM #=GF RT #=GF RT #=GF RT #=GF RA #=GF RL #=GF CC This family is for the 3' structured spliced site of the influenza A #=GF CC virus. Two alternative conformations have been characterized where #=GF CC the splice site is can be buried in secondary structure or open in #=GF CC a loop. This region is also a known binding site for the SF2/ASF #=GF CC exonic splicing enhancer. #=GF WK http://en.wikipedia.org/wiki/xxxxx #=GF SQ 590 DQ997307 GGUCUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG CY005563 GGUCUGAAGGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAGAUG CY077930 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAGCGGAUGGGGGUGCAGAUG CY002313 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUACCAGAAACGAAUGGGGGUGCAGAUG CY014128 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGGAUGGGGGUGCAGAUG CY071104 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGAAUGGGUGUGCAGAUG GQ369831 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAAGGGGGUGCAGAUG CY038413 GGUUUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGGUUGCAGAUG CY079429 GGUCUAAAAGAUGAUCUCCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG CY022798 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAAAGGAUGGGAGUGCAAUUG AF216735 GGUCAGAAAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAAGUG DQ376671 GGUCUGAGAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAAAGGAUGGGAGUGCAAAUG DQ351860 GAUCUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAACCGGAUGGGAGUGCAAAUG CY027308 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAGCGAAUGGGAGUGCAGAUG GQ923390 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGGGUGCAGAUG CY045320 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGACCUACCAGAAACGGAUGGGAGUGCAAAUG EU478796 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGGGUGCAGAUG CY081088 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAGAGAAUGGGAGUGCAGAUG DQ320958 GGUCUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGAGUGCAGAUG CY037986 GGUCUGAAGGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGGGUGCAGAUG CY003409 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAGCGAAUGGGGGUGCAGAUG AY059509 GGUCUGAAAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAAAUG CY015161 GGUCUAAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAAAUG CY085321 GGCUUAAAGGAUGAUCUUCUUGAAAAUUUACAGGCCUACCAGAAGCGAAUGGGGGUGCAAAUG DQ376678 GGUCUGAGAGAUGAUCUUCUCGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GU086108 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAAAAACGAAUGGGGGUGCAAAUG EU871922 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGGAUGGGAGUGCAGAUG CY063639 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGAAUGGGAGUACAGAUG GQ229311 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG EU871837 GGCCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GU050555 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGGAAGGGGUUGCAGAUG CY076014 GGUCUGAAAGACGACCUUCUUGAAAAUUUGCAGACCUACCAGAAGCGGAUGGGAGUGCAGAUG DQ997086 GGUCUGAGAGACAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG GQ161131 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGAGUGCAAAUA FJ461595 GGUCUCAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAACGGAUGGGAGUGCAAAUG GQ404606 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGAGUGCAGAUG CY085865 GGUUUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAAAUA AJ278648 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGGGUGCAGAUG GU186494 GGUCUAAAAGAUGAUCUUCUCGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG HM144887 GGCCUGAAAGAUGAUCUUCUUGAAAACUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG EF155052 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGAGUGCAGCUG GU053016 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGUGUGCAAAUG CY085593 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGAAUGGGGGUGCAGAUG EF605598 GGUCUGAGAGAUAAUCUUCUUGAAAACUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG CY009597 GGUCUGAAAAAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGAGUGCAAAUG CY077945 GGUCUGAAAGAUGAUCUCCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGGGUGCAGAUG CY061664 GGUCUGAAGGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUA EU478849 GGUCUGAAAGAUGACCUUCUUGAAAAUUUACAGGCCUAUCAGAAACGGAUGGGAGUGCAGAUA AB586838 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGUUUACCAGAAACGGAUGGGAAUGCAAAUG CY015485 GGUCUAAAAGAUGAUCUUCUUGAAAACUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG M63517 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG EU597926 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGGGUACAGAUG GU052756 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGAGUGCAAAUG CY001430 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAGACGAAUGGGGGUGCAGAUG CY069304 GGUUUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAGAUG GU593047 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGAAUGGGAGUCCCGACG EU794506 GGUUUGAAAGAUGAUCUCCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAUUG CY045248 GGUUUGAAAGAUGAUCUUCUUGAAAACUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG AF509057 GGUUUGAAAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAAAUA DQ376688 GGUUUGAGAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG AY241593 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG CY078003 GGUUUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG EF063509 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGGUUGCAGAUG CY015104 GGUCUAAAAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG HM172137 GGUCUUAGAGACAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG CY003385 GGUCUGAAAAAUGAUCUCCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGGGUGCAGAUG CY006045 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAGCGAAUGGGAGUGCAGAUG CY041283 GGUCUAAAAGAUGAUCUCCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG
EU532035 DQ997489 GU052668 AF250492 DQ226101 GU086020 EF154989 DQ320966 CY031572 CY028252 HM060050 GQ475623 EU086320 CY021494 AF523497 CY067577 GU053346 DQ186984 EF362419 AB538492 AJ298947 DQ376689 CY004440 CY067473 CY022374 CY037096 GU351861 EU743087 GU186762 HM780479 CY061696 AY210065 DQ997445 AY724263 HQ014835 GU051683 EU258944 AY075029 CY080580 EU478830 EU794530 EU794522 GU051080 DQ376672 CY076166 GU220602 GQ227382 EU598107 EF124057 GU050160 CY064122 CY004451 GU086028 GQ385925 HM172124 GU052714 GU186657 CY009445 DQ997384 CY073455 CY087190 CY060932 GU049866 EU662948 CY018016 EU597969 CY029983 CY028276 GU052015 AJ458339 EU743190 DQ376685 CY007572 DQ226100 GQ404584 AY221535 CY083538 GU052136 AB434355 CY032382 CY045312 GQ229295 CY051128 CY005044 AB498025 DQ376677 GU135936 EU735835 GU051937 EU716552 GQ414927 CY020830 CY031389 CY084668 GU050883 HM998925
GGUCUGAAAGAUGAUCUUAUUGAAAAUUUGCAGGCCUACCAAAAACGGAUGGGAGUGCAAAUG GGUCUGAAAGAUGAUCUUAUUGAAAAUUUGCAGGCCUACCAAAAACGGAUGGGGGUGCAGAUG GGUCUAAGAGAUGAUCUUCUUGAAAAUUUACAGGCCUACCAGAAGCGGAUGGGAGUGCAAAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUUCCAGAAACGGAUGGGAGUGCAAAUG GGCCUGAAAGAUGAUCUUAUUGAAAAUUUGCAGGCAUACCAAAAGCGGAUGGGGGUGCAGAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUCUACAGGCCUAUCAGAAACGAAUGGGAGUGCAAAUG GGCCUAAAAGAUGAUCUUAUUGAAAAUUUACAGGCAUACCAGAAACGGAUGGGGGUGCAGAUG GGUCUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUACAGAUG GGUCUGAAAAAUGAUCUCCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGAGUACAGAUG GGCCUGAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG GGUCUAAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUAAAAAAUGAUCUCCUUGAUAAUUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG GGCCUGAAAGAUGAUCUUAUUGAAAAUUUACAGGCAUACCAGAAACGGAUGGGGGUGCAGAUG GGUCUGAAAGACGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAAAAAAGGAUGGGAGUGCAAAUG GGUUUGAGAGAUGAUCUCCUUGAAAAUUUACAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUAAAAGAUGAUCUUCUUGGAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG GGUCUGAAAGAUGACCUUCUUGAAAACUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUA GGUCUGAGAGAUAAUCUUCUUGAAAAUUUGCAGACCUACCAGAAACGAAUGGGAGUGCAGAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAAAAAUGAUCUUUUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG GGUCUGAGAGAUGAUCUUCUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGACCUACCAGAAACGAAUGGGAGUGCAAAUG GGUUUGAAAGAUGAUCUCCUUGAAAAUUUACAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUAAAAGAUGAUCUCCUUGAAAAUUUACAGGCCUAUCAGAAGCGAAUGGGGGUGCAGAUG GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAAAGGAUGGGAGUGCAACUG GGUCUAAAAGAUGAUUUGCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGCCUAAAAGAUGAUCUUCUUGGAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGGGUGCAGAUG GGUCUGAAAGAUGACCUUCUUGAAAUUUUGCAGGCCUACCAGAAGCGAAUGGGAGUGCAGGUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGACA GGUCUAAAAAAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG GGUCUGAAAGAUGAUCUUAUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGGGUGCAGAUG GGUCUGAAAAAUGAUCUUCUUGAAUAUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAUAUG GGUCUGAAGGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAAGGAUGAUCUUCUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGAGUGCAGAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAAAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAAGUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUACAAAUG GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGUCUACCAGAAACGGAUGGGAGUGCAGAUA GGUUUGAAAGAUGAUCUCCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAACUG GGUUUGAAAGAUGAUCUCCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUACAAAUG GGUCUGAAGGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGAAUGGGAGUGCAAAUG GGUCUGAGAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAAAAAAGGAUGGGAGUGCAAAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGACCUACCAGAAACGGAUGGGAGUGCAGAUG GGUCUGAAAGAUGAUCUCCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGAGUGCAACUG GGUCUAAGAGAUGAUCUUCUUGAAAAUUUACAGACCUAUCAGAAACGAAUGGGGGUGCAGAUG GGUUUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG GGGCUAAGGGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAACCGGAUGGGAGUGCAGAUG GGCUUGAAAGAUGACCUCCUUGAAAAUUUGCAGGCAUACCAGAAGCGGAUGGGAGUGCAGAUG GGUCUAAAAGAUGAUCAUCUUGAAAAUCUACAGGCCUAUCAGAAACGAAUGGGAGUGCAAAUG GGUCUAAGAGACGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAGAUG GGUUUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGAGUGCAGAUG GGUUUAAGAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAGAGAUAAUCUUCUUGAAAACUUGCAGGCCUACCAGAAACGAAUGGGAGUACAGAUG GGUCUGAAAAAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG GGUCUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGGAUGGGAGUGCAGAUG GGUCUAAAAGAUGACCUUAUUGAAAAUUUGCAGGCUUACCAGAAGCGGAUGGGAGUGCAACUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGAAUGGGAGUGCAGAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAAAGGAUGGGAGUGCAGAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAAAGGAUGGGAGUGCAAAUA GGUCUAAAAGAUGAUCUUCUUGGAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUACCAGAAGCGAAUGGGGGUGCAGAUG GGUCUAAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG GGUCUAAAGGAUGAUCUUCUUGAAAAUUUGCAGGCAUACCAGAAACGAAUGGGAGUGCAGAUG GGUCUGAAAAAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGAGUGCAGAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAGCGAAUGGGGGUGCAGAUG GGUUUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAAAGAUGAUCUUCUUGAAAACUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAGAUG GGCCUAAGAGAUGAUCUUAUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGGGUGCAGAUG GGUCUGAAAAAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG GGUCUGAAAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAAAAACGAAUGGGAGUGCAAAUG GGUCUGAAAGAUGACCUCCUUGAAAAUUUGCAGGCCUACCAGAAGCGAAUGGGAGUGCAGAUG GGUCUAAAAGAUGAUCUCAUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGGGUGCAGAUG GGUUUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUA GGUUUGAAAGAUGAUCUUCUUGUAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGAGUGCAGAUG GGUCUAAAGGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGGGUGCAAAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGAAUGGGAGUGCAAAUG GGGCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAGAGAUAACCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG GGUCUGAGAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUAAAGGAUGAUCUUCUUGAAAACUUACAGGCCUUUCAGAAACGAAUGGGAGUGCAAAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAAAAAUGAUCUCCUUGAAAAUUUACAGGUCUAUCAGAAACGAAUGGGGGUGCAGAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAAAUG GGUCUGAAAAAUGAUCUCCUUGAUAAUUUGCAGGCCUAUCAAAAACGAAUGGGGGUGCAGAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAGCGAAUGGGGGUUCAGAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAACCGGAUGGGAGUGCAGAUG GGUCUAAAGGAUGACCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGAGUGCAACUG
CY003545 GGUCUAAAAGAUGAUCUUCUUGAAAAAUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAGAUG GQ475952 GGUCUGAAAAAUGAUCUCCUUGAAAAUUUACAGGCCUAUCAGAAACGGAUGGGGGUGCAGAUG AJ291398 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGAGUGCAGAUG CY076750 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAGAUG DQ849011 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAGGUG GU051090 GGUCUGAAGAAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG EU049989 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAAAUG CY085841 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGUAUGGGAGUGCAGAUA GU367328 GGUCUAAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGAAUGGGAGUGCAGAUG CY012569 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGGUUGCAGAUG CY037917 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAAAAACGGAUGGGAGUGCAGAUA GU051498 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGGUG AM920745 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUA CY067705 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCAUACCAGAAGCGAAUGGGAGUGCAAAUG CY034839 GGUCUAAGAGAUGAUCUCCUUGGAAAUUUGCAGGCCUAUCAGAAAAGGAUGGGAGUGCAAAUG EU697235 GGUCUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUA CY005539 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAAAAACGGAUGGGAGUGCAGAUG CY005414 GGUCUAAAGGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAAAUG GQ921325 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGUAGUGCAAAUG CY080318 GGUCUGAAAGAUGACCUUCUUGAAAUUUUGCAGGCCUACCAGAAGCGAAUGGGAGUGCACAUG GU050099 GGUCUAAAGGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG CY024811 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG CY061856 GGUUUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAACGGAUGGGAGUGCAAAUG CY031644 GGUCUGAGAGACGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAAAGGAUGGGAGUGCAACUG FJ750570 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGACCUACCAGAAACGGAUGGGAGUGCAGAUG CY075958 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCUUACCAGAAACGAAUGGGAGUGCAAAUG DQ064404 GGUCUGAAAGAUGAUCUUAUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGGGUGCAGAUG CY024943 GGUUUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAAAAACGAAUGGGGGUGCAGAUG FJ798779 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUA FJ654298 GGUCUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGACACGAAUGGGAGUGCAGAUG CY021574 GGUCUGAAAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGAAUGGGAGUGCAAAUG EU532034 GGUCUGAAAGAUGAUCUUAUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGGGUACAGAUG GU051426 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAAAAGCGGAUGGGAGUGCAAAUG M33045 GGUCUGAAAAAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGGGUGCAGAUG AB538495 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAAAUG CY087099 GGUCUAAAAGAUGAUCUUCUUGAAAAUCUACAGGCCUAUCAGAAACGAAUGGGGGUGCAAAUG EU882860 GGUCUAAAAGAUGACCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGAGUGCAACUG CY078099 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAAAAACGGAUGGGAGUGCAGAUG GQ476100 GGUCUGAAAAGUGAUCUCCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG AF359560 GGUCUGAAAGAUAAUCUUCUUGAAAAUUUGCAGGCCCACCAGAAACGAAUGGGAGUGCAAAUG CY032398 GGUUUGAAAAAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAAAUG CY021198 GGUCUAAAGGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAAAAACGGAUGGGAGUGCAAAUG CY086907 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGUCUACCAGAAGCGAAUGGGAGUGCAGAUG M63535 GGUUUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAGCGAAUGGGGGUGCAGAUG HM142741 GGCCUGAAAGAUGAUCUUAUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGAGUGCAGAUG CY022478 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAAAUG HM172123 GGUGUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGAGUGCAGAUG GU052900 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAGACGGAUGGGAGUGCAAAUG HM114572 GGUCUAAGAGAUAAUCUUCUUGAUAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG FJ417400 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAGAUG M63536 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAAAAACGGAUGGGAGUGCAAAUG CY085753 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGAGUGCAGAUA CY026460 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAGCGAAUGGGGGUGCAAAUG HM370057 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGGUUGCAAAUG CY080232 GGUCUAAAAGAUGAUCUCCUUGAAAAUUUGCAGGCAUACCAGAAACGAAUGGGAGUGCAGAUG HQ454980 GGUCUGAAAGAUGAUCUUCUUGAAAACUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG GQ404645 GGUCUGAAAGAUGACCUUCUUGAAAAUUUACAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG EU597908 GGUCUAAGAGAUGAUCUUCUUGACAAUUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAGAUG M23920 GGUCUAAAAAGUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG CY018926 GGUCUAAGAGAUGAUCUCCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAGAUG CY044270 GGUCUAAAAGAUAAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG GU052276 GGUAUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GQ923526 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUACAGAUG HQ214343 GGUCUAAGAGAUGAUCUUCUUGAAAAAUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAGAUG AY241599 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGGAUGGGAGUGCAAAUG GQ404621 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUACCAGAAACGGAUGGGGGUGCAGAUG CY066680 GGUCUGAAGGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGAAUGGGAGUGCAGAUG CY022606 GGUCUAAAGGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGGAUGGGAGUGCAGAUG CY077009 GGUCUGAAGGAUGAUCUCCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG CY078426 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGAAUGGGGGUGCAGAUG GQ923206 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAGCGGAUGGGAGUGCAGAUG EU743079 GGUCUAAAAAAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAAAUG EF597299 GGCCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG HQ622813 GGCCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGGUUGCAGAUG CY025102 GGUCUAAAGGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG EU742889 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCAUAUCAGAAACGGAGGGGAGUGCAAAUG M19374 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG CY075926 GGUCUAAAGGAUGAUCUUCUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGAGUGCAAAUG GQ404626 GGUCUGAAAGAUGACCUUCUCGAAAAUUUACAGGCCUACCAAAAGCGAAUGGGAGUGCAGAUG GU083624 GGUCUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAAAAACGAAUGGGAGUGCAGAUG CY084234 GGUCUGAAAGAUGAUCUCCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG GQ923550 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUA AY210264 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAAAGAAUGGGGGUGCAGAUG GU086060 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGCCCUACCAGAAGCGGAUGGGAGUGCAGAUA EU743065 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAGACGGAUGGGAGUGCAAAUG CY076726 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAAAAACGGAUGGGGUUGCAGAUG HM998917 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAACCGGAUGGGAGUGCAACUG AY856865 GGUCUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAACCGGAUGGGAGUGCAAAUG EU597989 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGAGUACAGAUG CY063268 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGUAUGGGAGUGCAGAUG M63525 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGGGUGCAGAUU DQ021697 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGGAUGGGAGUGCAGAUG CY004243 GGUCUGAAAGAUAAUCUUCUUGAAACUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAAAUG AF251430 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUACAGACCUAUCAGAAACGGAUGGGAGUGCAAAUG CY031221 GGUCUAAGAGACGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAAAGGAUGGGAGUGCAACUG GU064952 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGUUUGCAAAUG
AF156461 GGUUUGAAAGAUGAUCUUAUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGGGUGCAGAUG CY020846 GGUCUGAAAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GU050548 GGUCUAAAAGAUGAUCUUCUUGAAAAUCUGCAGGCCUAUCAGAAACGGAUGGGAAUGCAAAUG EU478807 GGUCUGAAAGAUGACCUUCUUGAAAAUUUACAGGCAUACCAGAAGCGGAUGGGAGUGCAAAUA GU272001 GGUCUGAGGGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG CY038405 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAGCGGAUGGGAUUACAGAUG DQ226104 GGCCUAAAAGAUGACCUUAUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGGGUGCAGAUG CY029874 GGUCUAAAGGAUGACCUUCUUGAAAAUUUGCAGGCAUACCAGAAACGAAUGGGAGUGCAGAUG CY014592 GGCCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG AB441171 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGAAUGGGAGUGCAGAUG EU743218 GGUCUGAGAGAUAAUCUUCUUGAAAAUUUACAGGCCUACCAGAAGCGGAUGGGAGUGCAGAUG GQ161107 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUA GU186603 GGUCUAAAAGAUGAUCUUCUUGAAAUUUUGCAGGCAUACCAGAAACGGAUGGGAGUGCAAAUG AF523496 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAAGCCUACCACAAACCGAUGGGAGUGCAAAUG DQ485219 GGCCUGAAAGAUGAUCUUAUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGGGUGCAGAUG GQ257382 GGUCUGAAGGAUGAUCUUCUUGAAAAUUUGCAGACCUACCAGAAACGGAUGGGAGUGCAGAUG CY081064 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUAUCAGAAGCGAAUGGGAGUGCAGAUG CY044661 GGUCUGAAAAAUGAUCUCCUUGAAAAUUUACAGGCCUACCAGAAACGAAUGGGGGUGCAGAUG CY025270 GGUCUGAGAAAUGAUCUCCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGAGUGCAGAUG GU052058 GGUCUGAAAGAUAACCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAAAUG DQ256384 GGACUAAGGGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG CY013169 GGUCUAAAAGACGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAGAUG CY066296 GGUCUGAAAGAUGACCUUCUUGAAAAUUUACAGGCAUACCAGAAGCGAAUGGGAGUGCAGAUG CY071336 GGUCUGAAAGAUGACCUUCUUGAUAAUUUGCAGGCCUACCAGAAGCGAAUGGGAGUGCAGAUG CY045781 GGUCUGAAAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAAAAACGAAUGGGAGUGCAGAUG AY241611 GGUCAAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAGACGGAUGGGAGUGCAAAUG HQ664934 GGUCUAAGAGGUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAGAUG CY085585 GGUCUAAAAGACGAUCUUCUUGAAAAUUUACAGGCCUACCAGAAGCGAAUGGGGGUGCAAAUG CY005896 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAAAUG DQ064405 GGUCUGAAAGAUGAUCUUAUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGGGUGCAAAUG CY020590 CGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG CY078123 GGUCUGAAAGAUGAUCUUCUUGAAAACUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAAAUG EF597277 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGAGUGCAAAUG CY066192 GGUCUGAGAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGAAUGGGAGUGCAGAUG GU272009 GGUCUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG EF492259 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGAAUGGGGUUGCAGAUG CY019403 GGUCUGAGAGAUAAUCUUCUUGAUAAUUUACAGGCCUACCAGAAACGAAUGGGAGUGCAAAUG CY010853 GGUCUGAAAAAUGAUCUCCUUGAAAAUUUGCAGGCCUAUCAAAAACGAAUGGGGGUGCAGAUG AY210048 GGUUUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG DQ666926 GGUCUAAAGGAUGAUCUUCUUGAAAAUUUACAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG DQ064406 GGUCUGAAGGAUGAUCUUAUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGGGUGCAGAUG CY030150 GGUUUGAAAAAUGAUCUCCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG EU743419 GGUCUAAAAAAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG CY028805 GGUUUGAAAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG CY015040 GGUCUGAAAGAUGAUCUUCUUGAAAACUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG DQ280220 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGAGUGCAGAUG HQ221641 GGUCUGAAAGAAGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGGGUGCAAAUG GU052637 GGGCUAAGGGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG CY077694 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG CY026284 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAGCGAAUGGGGGUGCAGAUG CY053870 GGUCUGAAAGAUGAUCUUCUUGAAAACUUGCAGGCCUAUCAGAAACGGAUGGGAGUGCAGAUG CY085004 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAACGACUGGGGGUGCAAAUG EF620903 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUACCAGAGACGGAUGGGAGUGCAAAUG CY036832 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAGAUG DQ997290 GGUCUGAGAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG GU053136 GGUCUGAAAAAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG DQ226098 GGACUGAAAGAUGAUCUUAUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGGGUGCAGAUG CY025486 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAAAAACGAAUGGGAGUGCAGAUG AJ410570 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAAAAACGGAUGGGGGUGCAGAUG HQ606474 GGUUUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGAAUGGGAGUGCAGAUG CY070147 GGUUUAAGAGAUGACCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAGAUG CY083235 GGUCUGAAAGAUGCCCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGAAUGGGAGUGCAGAUG DQ226103 GGCCUAAAAGAUGACCUUAUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGAGUGCAGAUG GQ373132 GGUCUAAAAGAUGAUCUUAUUGAAAACUUGCAGGCUUACCAGAAACGGAUGGGAGUGCAACUG FN429083 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGGAUGGGAGUGCAAAUA GU053164 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG AY377926 GGUCUAAAAGAUGACCUUCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUUGGAGUGCAGAUG CY028789 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG CY031339 GGUCUGAAAAAUGAUCUCCUUGAUAAUUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG CY080922 GGUCUGAAAAAUGAUCUCCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG DQ376684 GGUCUGAGAGAUGACCUUCUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGAGUGCAAAUG CY008693 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCUUAUCAGAAGCGAAUGGGGGUGCAGAUG Z26862 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAAAAACGGAUGGGAGUGCAGAUG AB586790 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGAGUGCAAAUG CY066808 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAAAAGCGAAUGGGAGUGCAGAUG EU835747 GGCCUGAAGGAUGAUCUUAUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGAGUGCAGAUG AF474051 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGAGUGCAAAUG AF073203 GGCCUAAAAGAUGAUCUUCUUGGAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGCGCAAAUG FJ534567 GGUCUAAGAGAUAAUCUCCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG HM157260 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCAUACCAGAAGCGAAUGGGAGUGCAGAUG CY078468 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGAGUGCAGAUG CY061656 GGUUUAAAAGAUGACCUUCUUGAAAAUUUACAGGCCUAUCAGAAACGGAUGGGAGUGCAAAUG DQ064399 GGCCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGGGUGCAGAUG CY020350 GGUCUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCUUACCAGAAACGAAUGGGAGUGCAGAUG GU050280 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGAUUGCAGAUG CY040259 GGUCUGAAAAAUGAUCUCCUUGAAAAUUUACAGGCCUAUCAGAAACGGAUGGGGGUGCAAAUG CY045773 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUA GU135921 GGUCUAAAGGAUGAUCUUCUUGAAAACUUACAGGCCUAUCAGAAACGAAUGGGAGUGCAAAUG EF124187 GGUCUGAGAGAUAACCUUCUUGAAAAUUUACAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG L37797 GGUCUGAAAGAUGAUCUCCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG GU050183 GGUCUGAAAGACGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGGGUGCAAAUG AY377931 GGUCUAAAAGAUGACCUUCUUGUAAAUUUACAGGCCUAUCAGAAACGAAUGGGAGUGCAGAUG CY079493 GGUCUAAAGGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUU GU052330 GGUUUGAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG AB434299 GGCCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUA CY061305 GGUCUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCAUACCAGAAACGAAUGGGAGUGCAGAUG
CY053822 CY085625 CY085633 DQ376666 CY079317 HM060055 GU051383 AB538497 AY747612 GQ206306 EF492267 AY210266 HQ734203 GQ923566 AB507267 CY062804 AB434371 GU086052 FJ200429 AB546170 DQ997512 CY086001 CY021550 CY004259 AF073196 CY067593 EU050031 HM172163 CY016676 AY300964 GQ373122 CY079132 DQ376658 CY006108 FJ610082 EU050073 EF492250 DQ997329 CY004444 GU186518 GQ229359 GU052748 AB441990 CY009373 EU478838 CY028284 CY045554 AB434291 EU478840 EU597992 CY026292 CY050581 CY013312 CY040969 EU743136 AF250487 HM440148 CY009893 CY006396 CY061640 AB434411 HQ014827 DQ366309 EU871861 CY084556 CY067569 CY045570 EU050014 HM172134 CY025398 CY087139 GQ475721 CY087174 CY062295 HM172129 GU049952 CY077766 GU396097 HM060045 CY036992 CY077263 CY031363 DQ186980 CY077836 AB434419 CY085617 CY067713 CY068202 CY077625 CY085353 CY027292 DQ997552 GU053514 HQ221640 AY210058 CY006220
GGUCUGAAAGACGAUCUUCUUGAAAAUUUGCAGACCUACCAGAAGCGGAUGGGAGUGCAGAUG GGUUUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGGAUGGGAGUGCAAAUG GGUCUAAAAGAUGAUCUCCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGACUGCAAAUG GGUCUGAGAGAUGAUCUUCUUGAAAAUUUACAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGGAUGGGAAUGCAGAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAGCGAAUGGGAGUGCAAAUG GGUCUAAAAGAUGAUCUUCUUGAAAACUUACAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG GGUCUGAAAGACGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAGAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG GGCCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUUCCAGAAACGGAUGGGGUUGCAGAUG GGUCUAAAAGACGAUCUUAUUGAAAAUUUGCAGGCUUACCAAAAACGAAUGGGGUUGCAGAUG GGUCUAAAAGAUGAUCUUCUUGAAAACUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUACCAAAAACGGAUGGGAGUGCAAAUG GGUCUAAAAGAUGAUCUUCUUGAAAACUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG GGUCUGAGAGAUGAUCUUCUUGAAAAUUUGCAGGCAUACCAGAAGCGGAUGGGAGUGCAAAUG GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGAAUGGGAGUGCAGAUG GGUCUGAAAGAUGAUCUUCUUGAAAACUUGCAGGCCUACCAAAAACGGAUGGGAGUGCAGAUA GGUCUAAAGGAUGAUCUUCUUGAAAAUCUACAGGCCUAUCAGAAACGAAUGGGAGUGCAAAUG CGUUUGAAAGAUGAUCUCCUUGAAAAUUUGCAGGUCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAAAGAUGAUCUUCUUGGAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAAAGAUGAUCUUAUUGAAAAUUUGCAGGCCUACCUGAAACGGAUGGGGGUGCAGAUG GGUUUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGAGUGCAAAUG CGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGGGUGCAAAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGACUGGGAGUGCAAAUG GGUUUGAAAGACGAUCUCCUUGAAAAUUUACAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAAAGAUGAUCUUAUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAGAGACAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGCUG GGUCUGAAAAACGAUCUCCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGGAUGGGAGUGCAAAUG GGUCUAAAAGAUGAUCUUAUUGAAAACUUGCAGGCUUACCAGAAACGGAUGGGAGUGCAGCUG GGUCUAAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAAAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGAGUACAAAUG GGUCUUAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGAGUGCAACUG GGUCUAAAAGACGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGCAUGGGGUUGCAGAUG GGUCUGAAAGAUGAUCUUAUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG GGUUUGAAAGAUGACCUCCUUGAAAAUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAGAUG GGUCUAAAAGAUGAUCUUCUCGAAAAUUUGCAGGCCUAUCAGAAACGGAUGGGAGUGCAGAUG GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGGCUUACCAAAAACGGAUGGGAGUGCAAAUA GGACUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAGAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUA GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUA GGUCUGAAGGAUGACCUUCUUGAAAAUUUGCAGGCAUACCAGAAACGAAUGGGAGUGCAGAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUACCAGAAGCGGAUGGGAGUGCAAAUG GGUUUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUU GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAAAAACGAAUGGGAGUGCAGAUA GGUCUAAGAGAUGAUCUUCUUGAUAAUUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAGAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAGCGAAUGGGAGUGCAGAUG GGUUUAAGGGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAGAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGAGUGCAGAUG GGUUUGAAAAAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUCUGCAGGCUUACCAGAAACGGAUGGGAGUGCAAAUG GGUUUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAAAUG GGUUUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUA GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAAAAGCGAAUGGGAGUACAGAUG GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAGAUA GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAGCGAAUGGGGGUGCAGAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGGGUGCAAAUG GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCCUACCAAAAACGGAUGGGGGUGCAGAUG GGUCUGAAGGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAAAAGCGAAUGGGGGUGCAGAUG GGUUUGAAAGAUGAUCUCCUUGAAAACUUACAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGAGUGCAAAUG GGUCUAAGAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGAGUGCAGAUG GGUCUGAGAGACAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGGGUGCAGAUG GGUCUGAAAAAUGAUCUCCUUGAAAAUUUACAGGCCUAUCAAAAACGAAUGGGAGUGCAGAUG GGUCUAAAGGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGUGUGCAAAUG GGUCUGAAAAAUGAUCUCCUUGAAAAUUUACAGGCCUAUCAGAACCGAAUGGGGGUGCAGAUG GGUCUAAAAGAUGACCUUAUUGAAAAUUUGCAGGCUUACCAGAAGCGGAUGGGAGUGCAAUUG GGUUUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAGAUA GGUCUGAGAGAUAAUCUUCUUGAAAAUGUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG GGUCUGAAAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAAAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAAAAACGAAUGGGAGUGCAGAUG GGUUUGAAAGAUGAUCUCCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAAAGAAUGGGAGUGCAAAUG GGUCUAAGAGAUGACCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAGAUG GGUCUGAAGGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUGAAAAAUGAUCUCCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGAAUGGGGGUGCAGAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAGCGAAUGGGGGUGCAAAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAGCGAAUGGGGGUGCAGAUG GGUCUAAAAGAUGAUCUCCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGGGUGCAAAUG GGUCUGAAGGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAAAUG GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACAAAUGGGGGUGCAGAUG GGCCUGAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGGGUGCAAAUG GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGGGUGCAGAUG GGUCUGAGAGAUGAUCUUAUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG GGUCUGAAAGAAGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GGUCUAAAAAAUGAUCUUCUUGAAAACUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG GGUCUAAAAGAUGAUCUUCUCGAAAAUUUGCAGGCCUAUCAAAAACGAAUGGGGGUGCAGAUG
CY004555 GGUCUAAAAGAUGAUCUUCUUGAAAAUCUGCAGGCAUACCAGAAACGGAUGGGAGUGCAAAUG CY056980 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGAAUGGGAGUGCAAAUG EU478825 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGAGUGCAAAUA HM223587 GGUCUAAAAGAUGAUCUUCUUGAAAAUCUACAGGCCUAUCAGAAACGAAUGGGAGUGCAAGUG CY077728 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAAAAACGAAUGGGGGUGCAGAUG CY027508 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAACGGAUGGGAGUGCAGAUG GQ475967 GGUCUGAAAAAUGAUCUCCUUGAAAAUUUACAGGCCUAUCAGAAACGAUUGGGGGUGCAGAUG GQ404613 CGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG CY061020 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAUCGAAUGGGAGUGCAGAUG CY036896 GGUCUGAAAGAUAACCUUCUCGAAAAUUUACAGGCCUACCAAAAGCGAAUGGGAGUGCAGAUG GQ907303 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAGCGGAUGGGAGUGCAGAUG GQ475797 GGUCUGAAAGAUGAUCUCCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG FJ384746 GGUUUGAAAGAUGAUCUUAUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGGGUGCAGAUG EU597921 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCACAAACGAAUGGGGGUGCAGAUG CY063321 GGUCUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAAAAACGAAUGGGAGUGCAAAUG CY028693 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAGAUG CY001785 GGUCUAAGAGAUGAUCUUCUUGAAAACUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG CY043897 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGAGUGCAAAUG CY010141 GGUCUGAAAAAUGAUCUCCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUU CY078604 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAAAGGAUGGGAGUGCAGAUG EU478811 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGAGUGCAGAUA HM144788 GGUCUGAAAGAUGAUCUUCUCGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG DQ666934 GGUCUAAAAGAUGAUCUUCUUGAUAAUUUACAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG M55481 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAGACGAAUGGGGGUGCAGAUG HM172132 GGACUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG CY079559 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGAGUGCAGAUG DQ280204 GGUCUAAAAGACGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG AB285097 GGUCUGAAGGAUGAUCUUCUUGAAAACUUGCAGGCCUAUCAGAAACGAAUGGGAGUGCAAAUG CY079477 GGUCUGAAAGAUGAUCUUCUUGUAAAUUUGCAGGCCUACCAAAAACGGAUGGGAGUGCAAAUG EU835750 GGCCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGAGUGCAACUG HM114548 GGUCUAAGAGAUAAUCUUCUUGAAAAUCUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG GQ229335 GGUUUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAACGGAUGGGAGUACAAAUG CY064186 GGUCUAAAGGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAGAUG AF509065 GGUCUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAAAGAAUGGGAGUGCAGAUG DQ366317 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCCUACCAAAAACGGAUGGGGGUGCAAAUG HM172136 GGUCUGAGAGACAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG CY016061 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGGAUGGGGGUGCAGAUG DQ492943 GGUCUGAGAGAUAAUCUUCUCGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG CY028813 GGUUUGAAAGAUGAUCUUCUUGAUAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GQ122494 GGUCUGAGAGAUAAUCUUCUUGAAAAUUUACAGGCCUACCAGAAACGAAUGGGAGUGCAAAUG CY050773 GGUCUGAAAAAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG CY076825 GGUCUAAAAGACGAUCUUCUUGAAAAUUUGCAGACCUACCAGAAGCGGAUGGGAGUGCAGAUG GU052923 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAAGGGAGUGCAAAUG DQ914817 GGUCUGAGAGACGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG FJ610128 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGAGUGCAAAUA EU597959 GGUCUAAGAGAUGACCUUCUUGAAAAUUUGCAGACCUACCAGAAACGAAUGGGGGUGCAGAUG EF492258 GGUCUAAAAGACGAUCUUAUUAAAAAUUUGCAGGCUUACCAGAAACGAAUGGGGUUGCAGAUG DQ376674 GGUCUGAGAGAUGAUCUUCUUGAAAAUUUACAGGCCUACCAGAAAAGGAUGGGAGUGCAAAUG CY038680 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGUGUGCAGAUG CY077127 GGUCUGAAGGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGGAUGGGAGUGCAGAUG HM144893 GGUCUGAAAGACGAUCUCCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG AY130766 GGUCUGAAAGACGAUCUUAUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGGGUGCAGAUG DQ997425 GGUCUGAGAGAUGAUCUUAUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGGGUGCAGAUG CY062500 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAGAUG CY043388 GGUCUAAAAAAUGAUCUCCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG CY077001 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG GQ148826 GGUCUAAAAGACGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGAAUGGGGUUGCAGAUG CY041898 GGUCUAAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAAAAACGGAUGGGAGUGCAGAUG EU049998 GGUUUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGAGUGCAAAUG AB434347 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUA CY039392 GGUCUGAAAGAUGACCUUCUCGAAAAUUUACAGGCCUAUCAAAAGCGGAUGGGAGUGCAGAUG CY003713 GGUCUAAAGGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAGAUG CY005732 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCUUACCAGAAACGGAUGGGAGUGCAGAUG CY008989 GGUUUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG EU716499 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAAAAACGAAUGGGGGUGCAGAUG HM114596 GGUCUAAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAAAUG EU478808 GGUCUGAAAGAUGACCUUCUUGAAAAUUUACAGGCCUACCAGAAGCGGAUGGGAGUGCAAAUA CY078668 GGUCUAAAGGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAAAUG HM144844 GGUCUGAAAGAUGAUCUGCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GQ148829 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUACCACAAACGGAUGGGGUUGCAGAUG AF255373 GGUCUAAAAGAUGAUCUCAUUGAAAAUUUGCAGGCUUACCAAAAACGGAUGGGGGUGCAGAUG CY036800 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAAAAACGAAUGGGGGUGCAGAUG GU052246 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAACGGAUGGGAGUGCAAAUG CY026652 GGUUUGAAAAAUGAUCUCCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGAGUGCAGAUG CY034271 GGUCUAAGAGACGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAAAGGAUGGGAGUGCAACUG CY057711 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG CY086962 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCUUACCAAAAACGGAUGGGAGUGCAGAUA EU478841 GGUCUGAAAGAUGACCUUCUUGAAAAUUUACAGGCCUACCAGAAACGGAUGGGAGUGCAGAUA CY015677 GGCCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAGCGAAUGGGGGUGCAGAUG CY005376 GGUCUAAAAGAUGAUCUUCUUGAAAAUCUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG CY044805 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAGAUA EU676309 GGUCUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGUCUACCAGAAACGAAUGGGAGUGCAGAUG CY009325 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGGGUGCAGAUA DQ997472 GGUCUGAAAGAUGAUCUUAUUGAAAAUUUGCAGGCAUACCAGAAACGGAUGGGGGUGCAGAUG HM172145 GGUCUGAGAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGAAUGGGAGUGCAGAUG GQ404577 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGGAUGGGGGUGCAGAUG EF155007 GGCCUGAAAGAUGAUCUUAUUGACAAAUUGCAGGCAUACCAGAAACGGAUGGGGGUGCAGAUG CY081317 GGUCUAAAAGAUGAUCUUCUCGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG GU051347 GGUCUAAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG CY038560 GGCCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAGAUG HM060056 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAAAAACGGAUGGGAGUGCAAAUG CY031652 GGUCUAAGGGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAAAGGAUGGGAGUGCAACUG CY084812 GGCCUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAGCGAAUGGGGGUGCAGAUG L25831 GGUCUGAAAGAUGAUCUCCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUA CY003561 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG CY077653 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGAAUGGGAGUACAAAUG
CY085665 GGUUUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGGAUGGGAGUGCAAAUA AY221537 GGUUUGAAAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAAAUG GQ404587 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAAAAGCGAAUGGGGGUGCAGAUG EU651887 GGUCUGAGAGAUAAUCUCCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG DQ849006 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGAGUGCAGAUG CY041355 GGUCUGAAAGAUGAUCUUCUUGAAAAUCUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG EU516314 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGGAUGCAGAUG CY045472 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAAAUG CY006588 GGUCUAAGAGAUGAUCUUCUUGAAAACUUGCAGACCUAUCAGAAACGAAUGGGAGUGCAGAUG CY019435 GGUCUGAGAGAUAAUCUUCUUGAAAAUUUACAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG DQ064393 GGUCUUAAAGAUGAUCUUAUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUG FJ538950 GGUCUGAGGGACAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG CY002569 GGUCUUAAAAAUGAUCUCCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG AB434379 GGUCUGAAGGAUGACCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAAAUA CY064066 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG CY009813 GGUCUAAAAAAUGAUCUCCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG CY014954 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUACCAGAAGCGGAUGGGAGUGCAAAUG GU051966 GGUCUAAAAGAUAAUCUUAUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG EU716541 GGUCUGAAAAAUGAUCUCCUUGAAAAUCUACAGGCCUAUCAGAAACGAAUGGGGGUGCAGAUG CY038445 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCUUAUCAGAAACGGAUGGGAUUGCAGAUG EU053144 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCAUACCAGAAAAGGAUGGGAGUGCAAAUA AY241588 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGAAUGGGAGUGCAAAUG CY087131 GGUCUAAAAGACGAUCUUCUUGAAAAUUUACAGGCCUACCAGAAACGAAUGGGGGUGCAAAUG EU258938 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUACAGGCCUAUCAGAAGCGGAUGGGAGUGCAAAUG CY037472 GGUCUGAAAAAUGAUCUCCUUGAAAAUUUACAGGCCUAUCAGAAACGAAUGGGAGUGCAGAUG CY078131 GGUCUAAAAGAUGAUCUUCUCGAAAAUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAGAUG EU049987 GGUCUAAAAGAUGAUCUUAUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG GU051086 GGUUUGAAAGAUGACCUCCUUGAAAAUUUGCAGGCAUACCAGAAGCGGAUGGGAGUGCAGAUG CY012705 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUACAGACCUAUCAGAAACGAAUGGGAGUGCAGAUG EU662949 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAAAGGAUGGGAGUGCAAAUG DQ997259 GGUCUGAAAGAUAAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAGAUG M38299 GGUCUGAAAGAUGAUCUCCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGCUG CY032946 GGUUUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGAAUGGGAGUGCAAAUG Z26859 GGUCUGAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGGGUGCAGAUA GU052645 GGACUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG CY004081 GGUCUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUACCAGAAGCGGAUGGGAGUGCAAAUG CY012921 GGUCUAAGAGAUGAUCUUCUUGAAAAUUUGCAGACCUAUCAGAAACGAAUGGGGGUGCAAAUG CY037955 GGUCUGAAAGAUGACCUCCUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAGAUA EF155003 GGUCUAAAAGAUGAUCUUAUUGACGAUUUGCAGGGCUACCAGAAACGGAUGGGAGUGCAAAUG M55477 GGUUUAAAAGAUGAUCUUCUUGAAAAUUUGCAGGCCUAUCAGAAGCGAAUGGGGGUGCAGAUG GQ229271 GGUCUGAAAGAUGACCUUCUUGAAAAUUUGCAGGCCUAUCAGAAACGGAUGGGAGUGCAGAUG EF154991 AGAUUGAAAGAUGAUCUUAUUGAAAAUUUGCAGGCCUACCAGAAACGGAUGGGAGUGCAAAUG #=GC SS_alt1 AAAA.......BBBBBBBaaaa.....BBBBBBB. #=GC SS_alt2 ............ //
{{User sandbox}} {{Infobox rfam | Name = Influenza A Segment 7 Splice Site | image = | width = 226px | caption = The consensus secondary structures of the Influenza A segment 7 3' splice site family of RNA motifs | Symbol = IAVS7SS | AltSymbols = | Rfam = | RNA_type = [[Cis-reg]] | Tax_domain = [[Orthomyxoviridae]]; | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} The 3' splice site of the [[influenza A ]] virus can adopt two different types of RNA [[secondary structure|structure]]: a [[pseudoknot]] and a [[hairpin]]. This structured region was first discovered in a bioinformatics survey of influenza A based on thermodynamic folding free energy and amino acid codon suppression.{{cite journal |author=Moss WN, Priore SF, and Turner DH |title=Identification of potential conserved RNA secondary structure throughout influenza A coding regions |journal=RNA | volume=17 |issue=6 |pages=991-1011 |year=2011 |month=June |pmid=21536710 |doi=10.1261/rna. 2619511 |url=http://rnajournal.cshlp.org/content/17/6/991.abstract |accessdate= }} Initial models of the [[secondary structure]] were based on computational methods for [[Nucleic acid structure prediction]]. The hairpin conformation was predicted using RNAalifold,{{cite journal |author=Berhart SH, , Hofacker IL, Will S, Gruber AR, and Stadler, PF |title=RNAalifold: improved consensus structure prediction for RNA alignments |journal=BMC Bioinformatics |volume=9 |issue= |pages=474 |year=2008 | month=November |pmid= |doi=10.1186/1471-2105-9-474 |url=http://www.biomedcentral.com/ 1471-2105/9/474 |accessdate= }} while the pseudoknot was predicted with DotKnot.{{cite journal |author=Sperschneider J, and Datta A | title=DotKnot: pseudoknot prediction using the probability dot plot under a refined energy model. |journal=Nucleic Acids Res. |volume=38 |issue=7 |pages=e103 |year=2010 |month=November | pmid=20123730 |doi=10.1093/nar/gkq021 |url=http://http://nar.oxfordjournals.org/content/ 38/7/e103.long |accessdate= }} Segment 7 encodes the [[M1 protein]] and the smaller [[M2 proton channel]] protein, which is produced by [[RNA splicing]]. M2 protein is critical to the virus: it forms the [[ion channel]]s that allow for acidification of the virion that stimulates in un-coating. The 3' splice site region used to produce M2 was experimentally probed with structuresensitive chemicals and enzymes and was found to adopt both the hairpin and pseudoknot conformations in solution. Each conformation places important splicing regulatory sites in
different structural environments, which has implications for the modulation of splicing of the segment 7 transcript. For example, the splice site, [[polypyrimidine tract]], branch point, and [[ASF/SF2]] exonic enhancer binding sites are expected to be more accessible in the hairpin conformation and less accessible in the pseudoknot (Figure 1). [[File:IAVS7SS_Fig.tif|thumb|right|x240px|Figure 1. Cartoon of the influenza segment 7 transcript showing the open reading frames for M1 and the spliced M2 proteins. Below left is the hairpin conformation while below right is the pseudoknot. The branch point is annotated in purple, the polypyrimidine tract in blue, the 3' splice site with a red arrow and the SF2/ASF exonic enhancer site in orange]]By shifting the equilibrium between the pseudoknot and hairpin it may be possible to reduce or enhance M2 splicing, respectively. '''A Potentially Shared Mechanism''' This putative mechanism may also be one that is common to spliced influenza transcripts. A similarly placed, but structurally distinct, [[influenza virus pseudoknot]]/hairpin was also described in the 3' splice site of segment 8 transcripts, which encode the NP and, by splicing, NEP proteins.{{cite journal |author=Gultyaev AP, Heus HA, Olsthoorn RC |title=An RNA conformational shift in recent H5N1 influenza A viruses | journal=Bioinformatics |volume=23 |issue=3 |pages=272ñ6 |year=2007 |month=February | pmid=17090581 |doi=10.1093/bioinformatics/btl559 |url= |accessdate=2010-07-13}} These structures form a family of structured RNAs shared between influenza A and [[influenza B]] {{cite journal |author=Gultyaev AP, Olsthoorn RC |title=A family of non-classical pseudoknots in influenza A and B viruses |journal=RNA Biol | volume=7 |issue=2 |pages=125ñ9 |year=2010 |month=March |pmid=20200490 |doi= |url=http:// www.landesbioscience.com/journals/rna/abstract.php?id=11287 |accessdate=2010-07-13}} '''Host Species Specific Structural Stability''' The 3' splice site structures in influenza A segment 7 show host-species specific trends in structural stability. The greatest number of structurally stabilizing mutations occur in avian specific strains, while the most structurally destabilizing mutations occurred in human strains: swine fell in between. This general trend in stability: avian, swine, human, roughly follows the temperatures at which the influenza virus reproduces within each host species. The temperatures of the avian gut and the swine and human lung are 42, 37, and 34 degrees Celsius, respectively. This observation is a local instance of a global trend in influenza A coding sequences, where avian, swine, and human strains show different stability.{{cite journal |author=Priore SF, Moss WN, and Turner DH |title=Influenza A Virus Coding Regions Exhibit Host-Specific Global Ordered RNA Structure |journal=PLoS One |volume=7 |issue=4 |pages=e35989 |year=2012 |month=June |pmid= |doi=10.1371/journal.pone.0035989|url=http://www.plosone.org/article/info%3Adoi %2F10.1371%2Fjournal.pone.0035989|accessdate= }} It may be the case that RNA structure is more stable in hosts where the replication temperature is high in order to preserve functional structures or important structural equilibria. ==See Also== * [[pseudoknot]] * [[Non-coding RNA]] * [[Nucleic acid secondary structure]] ==References== {{reflist|2}} ==External links== *{{Rfam|id=|name= }}
*[http://pseudobaseplusplus.utep.edu/ PseudoBase++] - Database of RNA pseudoknot secondary structures *[http://rna.chem.rochester.edu/ Turner Lab]
[[Category:Cis-regulatory RNA elements]]
