1. Supplemental table 1. Methodological Quality Assessment by the Newcastle-Ottawa Scale. Studies. Selection. Comparability. Exposure. Total quality score.
Supplemental table 1. Methodological Quality Assessment by the Newcastle-Ottawa Scale Selection Comparability The case Cases and Controls Cases and definition is Represen controls Studies Community with no controls with adequate with tativeness with Controls history of comparable independent of cases comparable disease age validation gender Akkus et al, 2004 1 1 0 1 0 1 Chen and Zou et al, 2007
Similar non-respons e rate for both groups
Total quality score
1
Exposure Same method of ascertainment for cases and controls 1
1
7
Ascertain ment of outcome
1 1
1 1
0 0
1 1
0 1
0 1
1 1
1 1
1 1
6 8
1
1
0
1
0
0
1
1
1
6
Hao al, 2015
1
1
0
1
1
1
1
1
1
8
Jin et al, 2004
1
1
0
0
0
0
1
1
1
5
Kilkens et al, 2013
1
1
0
1
1
1
1
1
1
8
Li and Chen et al, 2015
1
1
0
0
1
1
1
1
1
7
Li et al, 2015 Liu et al, 2013
1 1
1 1
0 0
1 0
1 1
1 1
1 1
1 1
1 1
8 7
Mao et al, 2010
1
1
0
1
0
0
1
1
1
6
Mu et al, 2003
1
1
0
0
0
0
1
1
1
5
Shi et al, 2012
1
1
0
1
1
1
1
1
8
Shi and Zhang et al, 2012
1
1
0
1
0
0
1
1
1
6
Song et al, 2015
1
1
0
0
1
1
1
1
1
7
Tian et al, 2011
1
0
0
1
1
1
1
1
1
7
Tosic-Golubovic et al, 2010
1
1
1
0
1
1
1
1
1
8
Wan et al, 2005
1
1
0
0
0
1
1
1
1
6
Wang et al, 2012
1
1
0
1
0
0
1
1
1
6
Wang et al, 2014
1
1
0
1
1
1
1
1
1
8
Xu et al, 2012
1
1
0
1
1
1
1
1
1
8
Chen and Wang et al, 2007 Gonçalves de Medeiros et al, 2012
1
1
Xu et al, 2014
1
1
0
0
0
0
1
1
1
5
Xu et al, 2017
1
1
0
1
1
1
1
1
1
8
Zhang et al, 2007
1
0
0
1
0
0
1
1
1
5
2
Supplemental figure 1. Funnel plot Funnel Plot of Standard Error by Std diff in means 0.0
Standard Error
0.2
0.4
0.6
0.8 -7
-6
-5
-4
-3
-2
-1
0
Std diff in means
3
1
2
3
4
5
6
7
Supplemental figure 2. Depression symptoms of IBS patients: forest plot of HAMD factors
4
Supplemental figure 3. Forest plot of depressive symptoms in patients with different IBS subtypes vs. healthy controls
5
Supplemental figure 4. Forest plot of depressive symptoms in refractory of IBS patients vs. healthy controls
6
Supplemental figure 5. Forest plot of depressive symptoms in IBS patients using different diagnostic criteria
7
Supplemental figure 6. Forest plot of depressive symptoms assessed by different HAMD versions in IBS patients
8
Supplemental figure 7. Forest plot of depressive symptoms of IBS patients from different sources
9
Supplemental figure 8. Forest plot of depressive sympotms in IBS patients in different countries
10
