Supplemental Table 1. Microarray Expression Data of DU145 ... - PLOS

Supplemental Table 1 DU145 Microarray Expression (all samples)

Drafahl et al.

Supplemental Table 1. Microarray Expression Data of DU145 Cells. Samples: DU145 cells collected 1.5 h after treatments: 1) Mock; 2) FGF19; 3) TNFalpha; 4) FGF19 + TNFalpha. Duplicate samples collected; analyzed on 8 chips; grouped in 4 treatments for analysis. Analysis: Analysis in GeneSpringGX: 1148 out of 24,220 probesets satisfy corrected p-value cut-off of 0.015 using Oneway ANOVA Asymtotic p-value computation. Of these, 307 shown here satisfy fold-change cut-off of 2.0 in at least one condition pair, using Sample 1 [Mock] as the control condition. Transcript Cluster ID refers to Affymetrix GeneChip Human Gene 1.0 ST Array Human (cat# 901085). Information on Probesets is available at http://media.affymetrix.com in the file HuGene-1_0-v1.na30.hg19.transcript.csv.zip Transcript Cluster ID 7899016 7899455 7900922 7901054 7901110 7901175 7901993 7903786 7905085 7905881 7905929 7907349 7908347 7909839 7912706 7914094 7914603 7915504 7917503 7917514 7917516 7917530 7917532 7918725 7919589 7919612 7919614 7919747 7919749 7920341 7920401 7921621 7921916 7922229 7923753 7924029 7925531 7926875 7926900 7928308 7928489 7930074 7933043 7933228 7933707 7938301 7938396 7938702 7939341 7939374 7939434 7941104 7941136 7941621 7942168 7942596 7942824 7943367 7943715

Fold change [FGF] vs [Mock] 2.2608542 2.4446414 2.4944987 1.388867 2.5400648 2.0707376 1.8517549 1.1968074 2.517727 2.302976 1.5475854 1.6761777 4.075566 2.7696972 2.0000284 1.696644 1.5476654 2.3806021 1.3665904 1.167309 1.598253 1.3760818 1.1760712 1.9282532 2.6767964 2.9894493 2.525579 2.5292373 1.9127309 1.8830367 2.2361987 2.1513727 2.0903435 1.0442609 1.0844691 2.2568316 1.9845777 1.2828289 1.0720813 3.459583 4.4900985 1.1109186 2.5032167 1.917342 1.9599841 1.9903129 1.124111 1.431981 1.511618 3.2268572 1.8220451 2.0251718 2.0646636 2.5391202 2.4605563 2.6515155 2.386951 3.324317 1.6618454

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Fold change Regulation [TNF] vs [Mock] [TNF] vs [Mock] 1.0809926 down 1.0935985 up 1.0960414 down 2.6486068 up 1.0070043 down 1.1713148 down 1.5409014 up 2.0255053 up 1.0637678 up 1.0349579 down 6.4375386 up 1.6105281 up 1.0819963 up 1.1232837 up 1.6192496 up 1.1571207 up 2.0616717 up 1.0994763 down 2.4800422 up 2.9382727 up 3.344233 up 3.8510222 up 2.625148 up 1.0030944 down 1.0022985 up 1.039097 down 1.0614165 up 2.0141478 up 1.8552912 up 1.0794905 down 1.0271832 up 1.1806052 up 1.1108546 up 2.8259149 up 1.9498838 up 2.1320176 up 1.0760733 up 3.7852602 up 2.2228436 up 1.1017288 up 1.0820185 up 2.3015468 up 1.0227156 up 1.0587547 up 1.159282 down 1.2492743 down 2.1464915 up 1.7606944 up 1.4451082 up 1.3541443 up 1.1878307 up 1.0550069 down 1.038632 up 1.0836924 up 1.1311376 down 1.2202382 down 1.105973 down 2.5973916 up 2.2585733 up

1

Fold change Regulation [Both] vs [Mock] [Both] vs [Mock] 2.4445314 down 2.7450182 up 2.3818767 down 1.3617798 up 2.459696 down 2.3878517 down 2.5022717 up 1.981951 up 2.3968148 down 2.1298664 down 2.7592466 up 2.1089993 up 4.1298833 up 2.6691685 up 1.4111823 down 2.0586839 up 2.191194 up 2.534039 down 3.297532 up 2.6458046 up 3.9458985 up 5.3077455 up 2.2186656 up 2.057421 up 2.5396922 down 2.8355222 down 2.400456 down 3.0402343 up 2.7877865 up 2.010113 up 2.2903645 down 2.6016772 up 1.8315898 up 1.6793075 up 2.0491138 up 1.1297443 down 2.0994337 up 3.3536305 up 2.4233856 up 2.9193566 down 4.404106 up 1.4743282 up 2.3368337 up 2.0620441 up 2.203837 down 2.086512 down 1.8625218 up 2.232552 up 2.0299945 up 3.5108619 up 2.0116203 up 2.0994446 down 2.078328 down 2.4729493 down 2.6599412 down 2.8673735 down 2.3018968 down 7.6375036 up 2.316999 up

Supplemental Table 1 DU145 Microarray Expression (all samples)

7943890 7945283 7945521 7948565 7949603 7950248 7952986 7953508 7954029 7954104 7955589 7956908 7957298 7958019 7959146 7962579 7966150 7966996 7968484 7968883 7970507 7971620 7972826 7974335 7975121 7975602 7976451 7976567 7976648 7977046 7977507 7978644 7979269 7981111 7982248 7982269 7982507 7982753 7983828 7986411 7987025 7987135 7987572 7987772 7989132 7989661 7989849 7989883 7992021 7994659 7996516 7998664 8000998 8001547 8002266 8003332 8003401 8004167 8004271 8004905 8005166 8005399 8005471 8005547 8005553 8005683 8005736 8006690 8007212 8008052 8008297 8009727 8013035 8013323

2.6156194 2.028868 2.1493819 2.2612264 2.4510283 1.7940098 3.0668278 2.2922707 1.6652582 2.029076 1.0269986 2.0496678 1.9047928 1.2645311 2.6179366 1.538658 1.7506326 2.2771075 2.3353126 1.7834044 2.0206625 1.9085242 1.470991 2.487498 2.199798 2.355822 1.7626507 1.0485333 1.9178782 1.5271263 2.4097528 1.0085242 1.1420517 1.8125315 2.3360312 2.3082364 2.1315823 1.7968625 2.005136 1.8784914 2.3072028 2.6541104 2.2362099 1.9356287 2.071413 1.9704598 1.6664084 1.3052235 1.7426167 2.2853608 1.9245323 2.1429653 2.066618 2.3900156 2.1820292 2.7644083 2.3409479 3.0913694 2.5635955 1.208083 2.0766997 1.8979347 2.4255216 6.352794 6.3538485 1.4666522 2.0540016 1.9775531 1.2380027 1.8143865 2.0400062 2.0826 2.1016817 6.3511243

Drafahl et al.

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1.4511335 1.3203614 1.069956 1.0257081 1.1628865 1.0211515 1.5682039 1.1503038 1.3198634 1.0617579 2.7261426 2.2404115 1.7775489 2.2547336 1.2201854 1.8048514 1.7266798 1.093994 1.1211064 1.8554488 1.0425197 1.0317934 2.217695 1.6206765 1.1052421 1.0838075 2.389506 2.4624784 1.0598499 3.1619003 1.1299441 2.804837 2.468517 1.1805418 1.0115979 1.0486037 1.1567513 1.1162198 1.0144621 1.0884192 1.0488248 1.1063641 1.1875457 1.0899607 1.0722613 1.0682566 1.5956157 2.176453 1.1341977 1.1347035 1.0466641 1.0067971 1.1965871 1.1624962 1.1211561 1.0412112 1.0219353 1.2374643 1.0959291 2.1330562 1.0122373 1.0922496 1.093034 1.09853 1.099 1.1979381 1.122374 1.0493935 3.2527473 1.242577 1.1738588 1.0671111 1.070621 1.0990334

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2.4573867 2.133306 2.254094 2.525728 2.5776012 2.002605 4.2659307 2.0646195 2.321711 1.9319618 1.7611876 4.430343 2.7833207 2.3101542 2.474122 2.2970684 2.3066595 2.2975233 2.2901547 2.2668862 1.7563987 2.037839 1.2803427 3.1684723 2.3142388 2.5195658 3.9482453 1.9107491 2.1269221 1.6030178 2.345211 2.6916158 2.1813076 2.097866 2.0646968 2.0020556 2.123176 2.0254605 1.7416393 2.0557804 2.00032 2.1349857 2.689146 2.0403447 1.8068324 2.1547027 2.2690988 2.6824837 2.0554652 2.2948787 2.0166407 2.0501835 2.026479 2.7758002 2.2714992 2.8171442 2.4409983 3.0261133 2.6843307 1.4593081 2.290905 2.013154 2.3599038 4.0271854 4.0294127 2.4819431 1.9565161 2.060545 2.6420288 2.074978 1.9259623 2.2856803 1.842002 4.02931

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Supplemental Table 1 DU145 Microarray Expression (all samples)

8013325 8013329 8014197 8017651 8018975 8020025 8021727 8023401 8024089 8025395 8025601 8025612 8027117 8027368 8027884 8027996 8028908 8030128 8030171 8032718 8032863 8032909 8033257 8034021 8034034 8034416 8034631 8034920 8035600 8036207 8036318 8037301 8041168 8041204 8042144 8044333 8044450 8047606 8048717 8048864 8049073 8051443 8051583 8052669 8053406 8053741 8054519 8055208 8056285 8056977 8058201 8058390 8058477 8058914 8059111 8060949 8063345 8064388 8064502 8064978 8065596 8065855 8066697 8067040 8068238 8068460 8069057 8070194 8070720 8071737 8074969 8076209 8077786 8078300

6.351667 6.3491282 1.4563494 1.3719014 2.5436165 1.8253485 2.1405797 1.8243015 2.7726822 2.4366035 1.1610497 1.1124451 2.086925 2.1467955 2.6170576 2.3961644 1.4524866 1.2058955 1.9898623 2.1748054 2.2743945 2.5588176 1.3112069 2.1243675 2.1524968 1.9804751 1.9437693 2.6601653 1.9375521 1.1327382 2.0876863 1.25914 2.033217 2.1416798 1.8483477 1.8436674 2.3124166 1.9721545 1.1523522 2.008242 2.703198 1.9234077 2.4936876 1.9956686 2.0131967 2.5041878 1.8440013 1.9858154 1.510869 1.7429456 2.3484 1.7030606 1.1293082 2.3439815 2.1503854 1.904496 1.9794463 1.1951004 2.193757 1.1098151 2.387699 2.2653863 2.458562 1.9787192 1.5279917 1.9296855 2.6664457 2.0045133 1.0423127 2.7539003 2.0567482 1.9536283 1.168828 1.729967

Drafahl et al.

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1.098883 1.0988333 1.9991854 1.9937439 1.0248704 1.0100636 1.0042708 1.114739 1.1032242 1.0967386 3.4296024 3.111842 1.0410175 1.1795384 1.1684384 1.0146303 2.8098178 2.021642 1.04835 1.0316616 1.0570076 1.0892628 2.3351917 1.0924027 1.0921302 1.032919 1.0017105 1.037962 1.0327528 2.3366854 1.0142809 2.496095 1.2942848 1.0080991 2.2133129 1.1324173 1.0266119 1.1950548 3.93398 20.377653 1.1918703 1.018277 1.999008 1.4312721 1.0350666 1.0295722 1.1300061 1.2216893 1.5096546 1.382266 1.0676371 1.9540936 2.8967788 1.063061 1.1258776 1.0096996 1.2107245 2.267441 1.0455247 2.1242259 1.3158562 1.2135451 1.2414794 1.1510756 2.0454378 1.1401004 1.088534 1.2685838 2.06424 1.1042078 1.1674533 1.1084241 2.5607796 1.2361484

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4.02888 4.027393 3.0008686 2.1026475 2.5447247 2.169608 2.2040265 2.0873282 2.759471 2.3431013 2.6978254 1.4781314 2.0646763 1.8845503 3.403731 3.1090896 1.2585241 1.6624088 2.049528 1.87891 2.3511078 2.719951 2.6158745 2.05077 2.044694 2.043322 2.0745587 2.7285044 2.1491556 1.6327901 1.9493417 1.1884428 2.143209 2.0482297 3.182102 2.0276656 2.2341766 2.033575 3.1351802 18.77999 2.828992 2.0088701 2.0392249 2.5892189 2.065407 2.205934 2.0267556 2.177338 2.086879 2.157843 2.015425 3.3529017 2.5349073 2.2140217 2.3653705 2.0315578 2.1896925 1.2797167 2.0931487 1.6428797 2.3994694 2.4632945 2.1945846 2.3025212 2.3863633 2.0098007 2.84374 2.0577865 1.5587813 2.6744292 2.1489017 2.0020297 1.5831003 2.1334038

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Supplemental Table 1 DU145 Microarray Expression (all samples)

8080781 8081386 8082350 8083792 8084878 8087576 8088128 8091723 8093126 8094599 8095187 8095680 8095697 8095868 8097461 8097468 8098690 8098758 8099850 8100003 8100977 8100994 8102362 8103911 8104926 8110022 8111812 8112274 8112668 8113709 8114006 8114010 8115831 8116227 8116910 8116983 8116992 8117594 8118007 8118345 8118634 8119088 8121884 8122265 8123148 8123315 8124388 8124498 8124531 8126066 8126658 8126666 8127502 8129953 8130556 8131666 8131803 8133030 8133345 8134339 8135967 8136983 8143629 8145259 8145795 8146788 8147079 8147206 8148728 8151401 8151549 8151816 8154233 8155250

2.3361084 1.276441 2.0047944 2.0868323 2.3524845 2.2458987 1.7982833 1.1514354 2.196205 1.4787436 2.1469867 1.7124621 1.4072051 1.924822 1.0874869 1.5473449 1.0746492 3.0247314 2.096833 2.6092296 1.4884754 1.47793 1.0985043 1.8260171 2.126884 2.0412261 1.9009086 1.2903603 1.5968981 1.4863268 2.2371616 1.2329897 2.1827073 1.553573 1.8413328 1.0514922 1.0636276 2.3129609 2.4401696 1.1542864 2.0405197 1.0806347 2.8794725 1.4765267 2.0290387 1.6602969 2.3168983 2.5198102 2.6456537 2.4061582 2.9006386 1.4438196 2.0399754 2.2557268 1.4069401 1.2694384 1.2556094 2.048913 2.3527908 1.9480876 2.0706067 2.266387 2.2727401 2.0203755 12.270263 2.5862873 2.1299953 1.2451265 2.9833493 2.1500995 1.8844202 1.2920676 1.4356257 2.170658

Drafahl et al.

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1.0402596 3.7740483 1.037563 1.2191485 1.121406 1.1597097 1.1919836 2.1972134 1.0564064 1.7595485 1.471999 4.275438 4.810818 2.3237202 2.0903218 1.7545134 2.689937 1.0620939 1.7529854 1.3821673 1.8118126 2.7908084 2.9115393 1.2546285 1.1960171 1.0610658 1.1688567 2.500476 1.6458184 2.248343 1.0745023 6.85351 1.0006156 1.3229613 2.373097 2.888179 1.9691668 1.1213775 1.1209488 2.388828 1.0145099 2.3368418 2.296197 9.642801 1.0798239 1.2701585 1.3381572 1.2123121 1.4648201 1.0757681 1.1597369 2.2188869 1.2295152 3.160131 3.5534508 2.5857184 3.4094114 1.0109047 1.0515833 1.1676682 1.2532215 1.1545 1.1597842 1.0772828 1.2416594 1.0239607 1.0613607 2.3153667 1.0713997 1.0319717 1.0681638 1.5235186 1.9324012 1.118608

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1.8495088 3.5164177 2.0723724 2.176073 2.0166926 2.251189 2.1717465 1.871209 2.059674 2.6896172 2.9328854 5.6811523 5.812699 3.76869 1.8540576 3.391624 2.2798815 2.9699917 2.5725706 2.6088207 2.4600766 3.3017724 2.8650837 2.5477805 1.2585322 2.0997744 2.1001616 2.1461499 2.9795928 2.3264732 1.9061667 5.52027 2.1346173 2.019612 3.3137841 2.3649936 2.1072226 2.4374418 2.4752946 1.3842418 2.0696998 1.1447896 5.080227 8.653875 2.0732186 2.0312552 2.4078984 2.360135 3.4596224 2.4923935 2.7057288 1.1237485 2.4513066 4.3018303 2.1185637 2.6026847 3.4316628 2.1020977 2.3386137 2.0625093 1.9676554 2.3133092 2.440964 2.0203438 10.261096 2.3743205 2.1301715 2.5529838 2.9632113 2.1340044 2.0102491 2.0517359 2.4501698 2.240621

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Supplemental Table 1 DU145 Microarray Expression (all samples)

8158684 8159337 8159609 8159642 8160835 8160953 8161024 8161526 8163930 8164428 8167790 8168691 8170882 8171024 8172088 8172358 8172905 8173673 8174893 8176566 8177885 8178115 8178244 8178676 8179205 8179827

2.564328 2.6434324 1.9586276 2.287777 2.280975 2.014237 4.0678344 1.1098498 2.6951709 2.5133436 2.1549838 2.0594351 2.1394508 2.723695 1.7000552 2.0651014 2.5166852 2.367521 2.0969703 2.9333315 2.4394307 1.141997 2.0859368 2.0922308 2.438852 2.0064256

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4.386171 1.1418958 1.1788433 1.0769913 1.1827819 1.0072609 1.1375593 3.330245 1.1293191 1.1026566 1.1276081 1.0690289 1.0332601 1.0095226 1.4742575 1.0647056 1.0118152 1.0148996 1.0632219 1.0705352 1.1227775 2.4205186 1.0207036 1.0672346 1.1211872 1.0132763

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9.893243 2.583625 2.0851092 2.2771919 2.4184878 2.1262584 4.36047 1.5501455 2.70201 2.5356393 2.1596563 2.1869152 2.0882452 2.7475665 2.5048892 2.1897547 2.452382 2.2483373 2.1444426 2.3578038 2.469719 1.3821541 2.113231 2.2846334 2.4728563 1.9728495

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