Supplementary File 8

Correlation prognostic miRNAs and other transcripts (Boston dataset) miRNA

hsa-‐miR-‐323-‐3p

Correlation

0.693 0.579 0.555 0.536 0.437 0.421 0.385 0.384 0.382 0.381 0.375 0.364 0.354 -‐0.354 -‐0.341 0.326

p-value

2.00E-‐06 0.0001753 0.0003633 0.0006223 0.0068449 0.0094436 0.0185031 0.0189887 0.0197998 0.0199426 0.0220378 0.0270083 0.0315423 0.0317575 0.0390169 0.0486735

Gene Name

SNORD113-‐8 SNORD114-‐13 SNORD113-‐3 SNORD113-‐9 SNORD113-‐2 C14ORF79 MEG3 SNORD114-‐1 JAG2 TRAF3 SCARNA13 EVL EML1 SNHG10 LGMN SNORD112

miRNA

hsa-‐miR-‐487b

Correlation

0.533 0.515 0.494 0.486 0.478 0.473 0.457 0.422 0.417 0.406 0.401 0.396 -‐0.392 0.383 -‐0.378 0.373 0.358 -‐0.356 -‐0.354 -‐0.35 -‐0.349 -‐0.343 0.34 0.34 0.337 -‐0.334 0.331 -‐0.328 0.326 0.325

p-value

0.0006756 0.0011147 0.0018979 0.0023221 0.0027725 0.0031087 0.0044855 0.009257 0.01033 0.0126551 0.0137914 0.0151538 0.0164407 0.0191895 0.0209991 0.0230511 0.0294499 0.0306338 0.031421 0.0334383 0.0344163 0.0375604 0.0396491 0.0397558 0.0416714 0.0434224 0.045108 0.0474125 0.049201 0.0496291

Gene Name

SNORD113-‐3 SNORD113-‐9 MEG3 SNORD113-‐8 EVL DICER1 SNORD113-‐2 SNORD114-‐13 SNORD112 SNORD114-‐1 C14ORF79 EML1 LGMN PSMC1 SNHG10 CCNK SNORD113-‐6 SLC25A29 ASPG PRIMA1 AK7 MIR342 HSP90AA1 ANKRD9 HSP90AA1 MIR410 BTBD7 OTUB2 PSMC1 INF2

miRNA

hsa-‐miR-‐329

Correlation

0.537 0.508 0.506 0.49 0.451 0.435 0.426 0.412 0.409 -‐0.39 0.385 -‐0.385 0.379 0.364 0.357 0.346 0.344 0.342 0.328

p-value

0.0006151 0.0013412 0.0013956 0.0020922 0.0050755 0.0071487 0.0084941 0.0111836 0.0119495 0.0170369 0.0186977 0.0187435 0.0207123 0.0266679 0.0300959 0.0357472 0.0368084 0.037975 0.0475161

Gene Name

SNORD113-‐8 SNORD113-‐3 SNORD113-‐9 SNORD113-‐2 SNORD114-‐13 C14ORF79 MEG3 SNORD112 INF2 SNHG10 DICER1 LGMN EVL EML1 CDCA4 SERPINA3 HSP90AA1 CCNK EML1

miRNA


Correlation

0.521 0.511 0.5 0.484 0.459 -‐0.448 -‐0.439 -‐0.431 0.425 -‐0.423 -‐0.413 0.409 -‐0.395 0.392 -‐0.385 -‐0.385 0.384 0.38 0.375 0.372 -‐0.369 0.367 0.363 -‐0.362 -‐0.361 0.358 -‐0.357 0.344 0.34 -‐0.34 0.337 -‐0.337 0.335 0.331 0.331

p-value

0.0009493 0.0012182 0.0016382 0.0023956 0.0042397 0.0053901 0.0065781 0.0077528 0.0087851 0.0090745 0.0110765 0.0119981 0.015482 0.0165335 0.0184908 0.0187135 0.0190453 0.0203728 0.0221269 0.0234147 0.0244508 0.0253585 0.0273051 0.0278871 0.0280067 0.029841 0.0302175 0.0372959 0.0394008 0.0395773 0.0413137 0.0413449 0.0429616 0.0452889 0.0454561

Gene Name

SNORD113-‐3 SNORD113-‐8 SNORD113-‐9 DICER1 SNORD113-‐2 LGMN SNHG10 PRIMA1 MEG3 MIR342 ASPG SNORD114-‐13 C14ORF177 CCNK AK7 OTUB2 C14ORF79 EVL AKT1 PSMC1 SMEK1 PSMC1 HSP90AA1 TDP1 MIR541 PAPOLA MIR376A2 INF2 EML1 SNORD114-‐31 SNORD112 SLC25A29 ANKRD9 PPP1R13B EML1

miRNA

hsa-‐miR-‐376a*

Correlation

0.723 0.657 0.59 0.513 0.498 0.497 0.348 0.342 0.331

p-value

4.00E-‐07 9.90E-‐06 0.0001209 0.0011789 0.001707 0.0017707 0.0349416 0.0383881 0.0455883

Gene Name

SNORD113-‐8 SNORD114-‐13 SNORD113-‐3 MEG3 SNORD113-‐9 SNORD114-‐1 SNORD113-‐2 JAG2 TRAF3

miRNA

hsa-‐miR-‐379*

Correlation

0.675 0.599 0.522 0.506 0.486 0.477 0.433 0.429 0.418 0.393 0.385 -‐0.383 0.379 -‐0.375 0.367 0.364 0.352 0.35 0.346

p-value

4.70E-‐06 9.09E-‐05 0.0009254 0.0013881 0.0022661 0.0028296 0.0073705 0.008043 0.0100604 0.016038 0.01869 0.0194189 0.0206948 0.0221269 0.025632 0.0265785 0.032577 0.0334934 0.0358201

Gene Name

SNORD114-‐13 SNORD113-‐8 C14ORF79 SNORD113-‐3 MEG3 SNORD113-‐9 SNORD113-‐2 EML1 INF2 SCARNA13 SNORD112 SNHG10 CDCA4 LGMN JAG2 DICER1 BTBD7 CCNK SNORD114-‐1

miRNA

hsa-‐miR-‐382

Correlation

0.574 0.531 0.493 0.482 0.468 0.452 0.427 0.424 0.381 0.377 -‐0.371

p-value

0.0002044 0.0007282 0.0019144 0.0025448 0.0034909 0.0049602 0.0083962 0.0088495 0.020146 0.0212962 0.0238953

Gene Name

SNORD113-‐2 SNORD113-‐9 SNORD112 SNORD113-‐8 SNORD113-‐3 SNORD114-‐13 C14ORF79 JAG2 SNORD113-‐5 MEG3 MOAP1

miRNA

hsa-‐miR-‐410

Correlation

0.679 0.614 0.594 0.566 0.536 0.481 0.458 0.424 0.421 0.416 0.384 0.364 0.35 0.343 -‐0.34 0.328

p-value

3.80E-‐06 5.39E-‐05 0.0001078 0.0002622 0.0006275 0.0026071 0.0043746 0.0088811 0.0095369 0.0104882 0.0189902 0.0268405 0.0335462 0.0374421 0.0393322 0.0474464

Gene Name

SNORD113-‐8 SNORD113-‐3 SNORD113-‐9 MEG3 SNORD114-‐1 SNORD112 SNORD113-‐2 TRAF3 DICER1 SNORD114-‐13 CCNK BTBD7 SNORD114-‐4 C14ORF79 SNHG10 HSP90AA1

miRNA

hsa-‐miR-‐411*

Correlation

0.631 0.6 0.566 0.556 0.467 0.465 0.434 0.403 0.397 0.395 0.393 -‐0.377 -‐0.364 -‐0.353 0.352 0.348 0.348 0.344 0.343 -‐0.337 0.335 0.335 -‐0.334 -‐0.328 -‐0.328 -‐0.325

p-value

2.80E-‐05 8.57E-‐05 0.0002628 0.0003538 0.0035609 0.0037058 0.0073429 0.0132993 0.0150115 0.0155883 0.016015 0.0214286 0.0269842 0.0322207 0.0325825 0.0347913 0.0350254 0.0368407 0.0377019 0.0415382 0.042724 0.0427413 0.0432588 0.0471357 0.0478552 0.0499044

Gene Name

SNORD114-‐13 SNORD113-‐8 SNORD113-‐9 C14ORF79 SNORD113-‐3 JAG2 BTBD7 INF2 MEG3 EML1 SNORD112 LGMN MIR342 MIR376A2 DICER1 SCARNA13 C14ORF102 AKT1 SNORD113-‐2 SNHG10 SNORD114-‐1 CCNK C14ORF177 CCDC88C TDP1 ASPG

miRNA

hsa-‐miR-‐432

Correlation

0.679 0.655 0.593 0.526 0.504 0.494 0.431 0.431 0.427 0.421 0.414 0.411 0.394 0.393 0.388 0.375 0.352 0.347 -‐0.342 0.342 0.332

p-value

3.80E-‐06 1.08E-‐05 0.0001109 0.0008231 0.0014843 0.0019129 0.0076969 0.007735 0.0083209 0.0094831 0.0107923 0.0114186 0.0157982 0.0161404 0.0176882 0.0222573 0.0328499 0.0351333 0.0380081 0.038149 0.0450095

Gene Name

SNORD113-‐9 SNORD112 SNORD113-‐2 SNORD113-‐8 SNORD113-‐3 MEG3 C14ORF79 JAG2 EIF5 DICER1 MIR494 EML1 TNFAIP2 CCNK EIF5 SERPINA3 BTBD7 HSP90AA1 PRIMA1 INF2 EVL

miRNA


Correlation

0.541 0.494 0.494 0.461 0.435 0.427 0.401 0.391 0.366 -‐0.333

p-value

0.0005465 0.0018866 0.0018872 0.0040978 0.0071428 0.0083488 0.0138669 0.0166082 0.0259731 0.0440437

Gene Name

SNORD114-‐13 SNORD113-‐9 SNORD113-‐8 SNORD113-‐2 SNORD113-‐3 JAG2 C14ORF79 INF2 EML1 LGMN

miRNA

hsa-‐miR-‐487a

Correlation

0.71 0.611 0.591 0.567 0.5 0.455 0.451 0.436 0.434 0.42 0.396 0.382 0.379 0.378 0.361 0.34 0.329

p-value

9.00E-‐07 5.98E-‐05 0.0001174 0.0002552 0.0016121 0.0046736 0.0050674 0.0069089 0.0072278 0.0096417 0.0153847 0.0195747 0.0207831 0.0212432 0.0281357 0.0398216 0.0466853

Gene Name

SNORD113-‐8 SNORD114-‐13 SNORD113-‐9 SNORD113-‐3 MEG3 SNORD113-‐2 SNORD114-‐1 BTBD7 C14ORF79 SNORD112 TRAF3 CCNK JAG2 SCARNA13 SNORD114-‐4 DICER1 EML1

miRNA

hsa-‐miR-‐493*

Correlation

0.56 0.53 0.517 -‐0.497 0.474 0.468 0.468 0.468 0.458 -‐0.454 0.449 0.445 0.444 -‐0.443 0.443 0.441 -‐0.43 0.42 -‐0.419 -‐0.418 -‐0.412 0.412 0.412 0.41 -‐0.405 -‐0.402 0.397 -‐0.397 0.392 -‐0.387 -‐0.385 0.373 -‐0.371 -‐0.368 0.365 -‐0.363 -‐0.359 -‐0.358 -‐0.358 0.356 -‐0.354

p-value

0.0003113 0.0007403 0.0010459 0.0017354 0.0030716 0.0034912 0.0034924 0.0035276 0.0043701 0.0047951 0.005345 0.0058167 0.0059324 0.006042 0.006057 0.0063246 0.007934 0.0096938 0.0098269 0.0100715 0.011205 0.0112656 0.0112701 0.0118087 0.0129999 0.0135206 0.0150197 0.015092 0.0165528 0.0180619 0.0186201 0.0228063 0.023933 0.0250945 0.0264623 0.0273747 0.0290981 0.029719 0.0298529 0.0303229 0.0314951

Gene Name

C14ORF79 EVL AKT1 LGMN INF2 SNORD113-‐9 ANKRD9 HSP90AA1 PAPOLA TDP1 JAG2 IFI27 CDCA4 MIR381 CRIP2 DICER1 SLC25A29 CCNK CLMN OTUB2 MIR376A2 WDR20 PSMC1 WARS JAG2 MIR342 EML1 AK7 C14ORF102 AMN MIR541 SETD3 MIR655 UBR7 C14ORF159 PRIMA1 MIR376A1 MIR410 C14ORF177 BAG5 CLMN

-‐0.348 0.348 -‐0.347 0.343 0.341 0.334 0.329 0.328 -‐0.327 -‐0.325

0.0348383 0.0349767 0.0353646 0.0376467 0.0386759 0.0430875 0.0466885 0.0478342 0.0481088 0.0495456

SERPINA1 CRIP1 AKT1 PSMC1 BTBD7 C14ORF80 SERPINA1 IFI27L2 SNHG10 SNORD113-‐1

miRNA

hsa-‐miR-‐495

Correlation

0.562 0.546 0.539 0.497 0.488 0.474 0.44 0.427 0.424 0.418 0.411 0.408 -‐0.406 -‐0.402 0.402 0.381 -‐0.381 0.377 -‐0.369 0.364 0.363 0.36 0.34 0.338 -‐0.337 -‐0.337 -‐0.334

p-value

0.0002929 0.0004708 0.0005777 0.0017543 0.0021939 0.0030203 0.00649 0.0083825 0.0089313 0.0101369 0.0114544 0.0122652 0.0127722 0.013539 0.0136631 0.0199184 0.0201075 0.0215124 0.0245998 0.0268863 0.0273872 0.0287214 0.0394014 0.0405357 0.0411147 0.0415408 0.0430172

Gene Name

SNORD113-‐8 SNORD113-‐9 SNORD113-‐3 SNORD114-‐13 C14ORF79 MEG3 SNORD113-‐2 DICER1 INF2 SNORD112 SERPINA3 EML1 ASPG LGMN CCNK SCARNA13 SNHG10 BTBD7 PRIMA1 AKT1 EVL JAG2 ANKRD9 TDP1 C14ORF177 AK7 MIR342

miRNA

hsa-‐miR-‐539

Correlation

0.669 0.621 0.533 0.508 0.493 0.488 0.486 0.434 0.42 0.418 0.414 0.38 0.379 -‐0.363 0.36 -‐0.342 -‐0.339 0.338 0.335 0.331 -‐0.327 -‐0.326 0.325

p-value

6.10E-‐06 4.17E-‐05 0.0006876 0.0013401 0.0019512 0.0021964 0.0023157 0.0072619 0.0096672 0.0101196 0.0108214 0.0203812 0.0205879 0.0272598 0.0283913 0.0382094 0.0399925 0.041025 0.0426591 0.0455958 0.0481072 0.0489475 0.0498515

Gene Name

SNORD114-‐13 SNORD113-‐8 SNORD113-‐3 SNORD113-‐9 MEG3 SNORD114-‐1 BTBD7 C14ORF79 SCARNA13 CCNK DICER1 BAG5 TRAF3 ASPG TDP1 PRIMA1 UBR7 EML1 CRIP2 SERPINA3 C14ORF177 MIR342 SNORD113-‐2

miRNA

hsa-‐miR-‐655

Correlation

0.615 0.555 0.484 0.45 -‐0.435 0.428 0.427 -‐0.405 0.367 0.366 0.362 0.357 0.356 0.356 -‐0.333 -‐0.332

p-value

5.13E-‐05 0.0003632 0.00238 0.0052048 0.0071371 0.0081995 0.0084141 0.0129053 0.0254946 0.0260105 0.0277783 0.0299656 0.0304341 0.0305881 0.0443046 0.0450306

Gene Name

SNORD114-‐13 SNORD113-‐8 SNORD113-‐3 MEG3 SNHG10 C14ORF79 SNORD113-‐9 LGMN DICER1 SNORD114-‐1 SNORD113-‐2 EML1 CCNK SCARNA13 ASPG PRIMA1

miRNA

hsa-‐miR-‐656

Correlation

0.606 0.537 0.506 0.486 0.455 0.432 0.405 0.373 0.371 0.343 0.332

p-value

7.17E-‐05 0.00061 0.0013971 0.0022884 0.0046914 0.0076107 0.012972 0.0231257 0.0237479 0.0379339 0.044658

Gene Name

SNORD114-‐13 MEG3 SNORD113-‐3 SNORD113-‐8 SNORD113-‐2 C14ORF79 SNORD113-‐9 SNORD112 SNORD114-‐1 EML1 INF2

miRNA

hsa-‐miR-‐889

Correlation

0.482 0.477 0.438 0.437 0.425 0.419 0.386 -‐0.38 -‐0.376 0.375 -‐0.368 -‐0.363 -‐0.362 0.362 0.361 -‐0.358 -‐0.352 -‐0.351 0.347 -‐0.345 -‐0.343 -‐0.342 0.342 -‐0.341 -‐0.337 -‐0.337 0.335 0.332 0.331 0.329 0.328 -‐0.325

p-value

0.0024987 0.002848 0.006722 0.006876 0.0088066 0.0097632 0.0183409 0.0203329 0.0219733 0.0221473 0.0251128 0.0273933 0.0275965 0.027852 0.0282498 0.0296487 0.0324125 0.0330537 0.0354015 0.0367474 0.0374524 0.0381421 0.0385832 0.0389143 0.0411654 0.0416175 0.0425453 0.0444696 0.0456143 0.0468032 0.0474426 0.0493697

Gene Name

SNORD114-‐13 SNORD113-‐9 SNORD113-‐2 SNORD113-‐8 C14ORF79 AKT1 INF2 ASPG MIR541 SNORD113-‐3 MIR342 CCDC88C AK7 EVL CDCA4 JAG2 SLC25A29 AMN PAPOLA OTUB2 MIR376A2 LGMN WDR20 PRIMA1 C14ORF177 TDP1 SERPINA1 DICER1 HSP90AA1 SERPINA3 PSMC1 CINP