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Supplementary Material (ESI) - Royal Society of Chemistry
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Supplementary Material (ESI) - Royal Society of Chemistry
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Slope
Y
-
intercept
r2. Nominal conc. (nM). 50 100 200 300 400 500. Measured conc. (nM) 49 102 201 305 407 489. Recovery (%). 98 102 99 102 102 102. 1.24.
Supplementary Material (ESI) for Journal of Analytical Atomic Spectrometry This journal is © The Royal Society of Chemistry 2008 Electronic Supplementary Data Table S1. Data on calibration curve. a Linear regression parameters
Calibration standard curve
a
Nominal conc. (nM)
50
100
200
300
400
500
Measured conc. (nM)
49
102
201
305
407
489
Recovery (%)
98
102
99
102
102
102
Slope
Y-intercept
r2
1.24
2.10
0.9974
All measured data values are expressed as mean of 3 repeats with coefficient of
variation of ≤ 10%
Table S2. Intra- and inter-assay recovery and precision. a Oxaliplatin conc. (nM) % Recovery Precision (%C.V.) Intra-assay
Inter-assay
a
50
101
7.12
200
107
4.35
500
106
5.22
50
102
3.30
200
104
5.65
500
103
4.39
All measured data values are expressed as mean of ≥ 5 repeats with coefficient of
variation of ≤ 10%.
Supplementary Material (ESI) for Journal of Analytical Atomic Spectrometry This journal is © The Royal Society of Chemistry 2008 Table S3. Stability of oxaliplatin in MDP under different conditions. All data values are expressed as mean ± standard deviation of 3 repeats. Recovery (%) of oxaliplatin after indicated time On Ice
Time (h)
At -80 °C
2
4
109 ± 7
112 ± 3.7
1
4
9
90
104 ± 4.1
110 ± 6.9
111 ± 4.6
98 ± 1.3
Time (day)
Fig. S1. HPLC-ICP-MS chromatogram of stability samples of MDP containing oxaliplatin stored on ice for 4 h (A) and at -80ºC for 90 days (B).
3.2
A
2.4
1.6
8
0
0
B
OP
Abundance (cps×10 4 )
Abundance (cps×10 4 )
3.2
5
10
15
Time (min)
20
OP
2.4
1.6
8
0 0
5
10
Time (min)
15
20
Supplementary Material (ESI) for Journal of Analytical Atomic Spectrometry This journal is © The Royal Society of Chemistry 2008 Fig. S2. Analysis of plasma from colorectal cancer patients showing concentrations of oxaliplatin during and after a 2-h infusion (A), and a chromatogram of 1-h postinfusion sample (B). 6.0
B
A
8
A b u n d a n c e (c p s × 1 0 3 )
C o n cen tr atio n (µ M )
10
6 4 2
4.5 OP 3.0
1.5
2-h infusion
0 0
1
2
Time (hours)
3
4
0 0
5
10
Time (min)
15
20
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