Mar 1, 2016 - Effects of latrunculin A (1) and sunitinib on the endothelial colony forming cells. (ECFCs) in angiogenesis assays. (a) Concentration response ...
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Supplementary Materials: Discovery of Novel Antiangiogenic Marine Natural Product Scaffolds Hassan Y. Ebrahim and Khalid A. El Sayed * Macrolides 21
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Latrunculin A (1) 2 3 4 5 6 7 8 9 10 11 12 Latrunculin H (13)
Figure S1. Chemical structures of marine natural products (MNPs) library members accepted in Eli Lilly angiogenic screening assays.
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(f) Figure S2. In silico molecular descriptors of compounds 1‐38 calculated by Eli Lillyʹs bioinformatics system. (a) Molecular weight. (b) cLogP. (c) Polar surface area. (d) Number of H‐bond donors. (e) Number of H‐bond acceptors. (f) Number of rotatable bonds.
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(b) Figure S3. Effects of latrunculin A (1) and sunitinib on the endothelial colony forming cells (ECFCs) in angiogenesis assays. (a) Concentration response curve of latrunculin A (i) and sunitinib (ii) treatments on endothelial colony forming cells (ECFCs) CD31 tube area. (b) Concentration response curve of latrunculin A (i) and sunitinib (ii) treatments on endothelial colony forming cells (ECFCs) CD31 nuclei area.