Supplementary Table 1. Odds ratios for elevated HbA1câ¥6 at 45y (i) per SD of 5-year BMI change during different life periods adjusted for baseline BMI, and (ii) ...
SUPPLEMENTARY DATA
Supplementary Table 1. Odds ratios for elevated HbA1c≥6 at 45y (i) per SD of 5-year BMI change during different life periods adjusted for baseline BMI, and (ii) per SD of BMI at each age adjusted for BMI at 45y (n=7855)* HbA1c 6† BMI change between ages (y)
Odds ratio (95% CI) Adjusted for baseline BMI
Birth to 7
1.58 (1.34, 1.86)
7-11
1.50 (1.35, 1.67)
11-16
1.70 (1.46, 1.98)
16-23
2.63 (2.15, 3.21)
23-33
3.42 (2.49, 4.69)
33-45
4.17 (2.79, 6.23)
BMI (SD score) at (years)
Adjusted BMI at 45y
0
0.84 (0.73, 0.95)
7
0.94 (0.83, 1.08)
11
1.04 (0.91, 1.18)
16
1.13 (1.00, 1.28)
23
1.30 (1.12, 1.50)
33
1.43 (1.21, 1.69)
*Results estimated using multiple imputation † includes diagnosed type 2 diabetes. All models adjusted for gender, social class in childhood and at 42y, family history of diabetes, ethnicity
©2011 American Diabetes Association. Published online at http://care.diabetesjournals.org/lookup/suppl/doi:10.2337/dc10-1482/-/DC1
SUPPLEMENTARY DATA
Supplementary Table 2. Odds ratios for elevated HbA1c at 45y and difference in HbA1c (unit %) per SD increase in BMI at 45y, stratified by childhood BMI (n=7855)* HbA1c 7
HbA1c†
OR (95%CI)
Difference (95%CI)
Bottom 10%
1.86 (1.05, 3.29)
0.056 (0.006, 0.105)
10-50%
2.42 (1.83, 3.20)
0.103 (0.070, 0.136)
50-90%
2.62 (2.13, 3.23)
0.106 (0.078, 0.134)
Top 10%
2.11 (1.63, 2.73)
0.127 (0.074, 0.180)
Bottom 10%
2.30 (0.63, 8.49)
0.053 (0.009, 0.098)
10-50%
2.48 (1.78, 3.45)
0.081 (0.049, 0.113)
50-90%
2.32 (1.90, 2.84)
0.120 (0.093, 0.147)
Top 10%
1.93 (1.54, 2.42)
0.123 (0.064, 0.182)
Bottom 10%
2.93 (1.15, 7.46)
0.082 (0.031, 0.134)
10-50%
2.67 (1.77, 4.01)
0.079 (0.051, 0.108)
50-90%
2.12 (1.69, 2.66)
0.115 (0.088, 0.143)
Top 10%
1.87 (1.51, 2.31)
0.112 (0.053, 0.172)
Childhood BMI At 7 years
At 11 years
At 16 years
*Results estimated using multiple imputation † includes diagnosed type 2 diabetes. Models control for type 2 diabetes treatment All models adjusted for gender, social class in childhood and at 42y, family history of diabetes, ethnicity
©2011 American Diabetes Association. Published online at http://care.diabetesjournals.org/lookup/suppl/doi:10.2337/dc10-1482/-/DC1
SUPPLEMENTARY DATA
Supplementary Table 3. Association between age of onset of overweight or obesity and adult HbA1c: odds ratios for elevated HbA1c≥6 Duration/age of onset (n=7855)†
HbA1c 6* OR (95%CI)
Unadjusted
Adjusted$
Obesity Never Childhood only
5.13 (1.93, 13.65)
4.01 (1.45, 11.05)
Onset in mid-adulthood
4.65 (3.43, 6.29)
1.42 (0.97, 2.09)
Onset in young adulthood
10.84 (7.96, 14.76)
2.01 (1.23, 3.30)
Onset in childhood
13.54 (8.42, 21.78)¶
1.68 (0.83, 3.37) ¶
Childhood only
0.92 (0.12, 7.36)
0.95 (0.12, 7.65)
Onset in mid-adulthood
2.04 (1.18, 3.53)
0.76 (0.43, 1.33)
Onset in young adulthood
5.58 (3.52, 8.85)
1.04 (0.62, 1.75)
Onset in childhood
10.86 (6.88, 17.15) ¶
1.32 (0.74, 2.36)
Overweight (including obesity) Never
*Type 2 diabetes or HbA1c≥6. § Models control for type 2 diabetes treatment. † Age at onset of obesity/overweight defined as: never (BMI < WHO cut-off at all ages); childhood only (BMI ≥ cut-off at 7, 11 or 16 years but not at 23, 33 & 45); onset in childhood or adolescence (BMI ≥ cut-off at 7, 11 or 16 plus 23, 33 or 45); onset in young adulthood (BMI ≥ cut-off at 23 or 33, but not in childhood); onset in mid-adulthood (BMI ≥ cut-off at 45 only). See table 1 footnotes for BMI cut-offs for overweight and obesity in childhood. $ gender, total cholesterol, HDL-cholesterol, family history of diabetes, menopausal status, smoking at 42y, alcohol consumption at 42y, social class in childhood, social class at 45y, qualifications by 42y. ¶ Linear trend from never to onset in mid-adulthood p
