Supplementary Table 1: Odds ratios for elevated

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Supplementary Table 1. Odds ratios for elevated HbA1c≥6 at 45y (i) per SD of 5-year BMI change during different life periods adjusted for baseline BMI, and (ii) ...
SUPPLEMENTARY DATA  

Supplementary Table 1. Odds ratios for elevated HbA1c≥6 at 45y (i) per SD of 5-year BMI change during different life periods adjusted for baseline BMI, and (ii) per SD of BMI at each age adjusted for BMI at 45y (n=7855)*   HbA1c 6† BMI change between ages (y)

Odds ratio (95% CI) Adjusted for baseline BMI

Birth to 7

1.58 (1.34, 1.86)

7-11

1.50 (1.35, 1.67)

11-16

1.70 (1.46, 1.98)

16-23

2.63 (2.15, 3.21)

23-33

3.42 (2.49, 4.69)

33-45

4.17 (2.79, 6.23)

BMI (SD score) at (years)

Adjusted BMI at 45y

0

0.84 (0.73, 0.95)

7

0.94 (0.83, 1.08)

11

1.04 (0.91, 1.18)

16

1.13 (1.00, 1.28)

23

1.30 (1.12, 1.50)

33

1.43 (1.21, 1.69)

*Results estimated using multiple imputation † includes diagnosed type 2 diabetes. All models adjusted for gender, social class in childhood and at 42y, family history of diabetes, ethnicity 

©2011 American Diabetes Association. Published online at http://care.diabetesjournals.org/lookup/suppl/doi:10.2337/dc10-1482/-/DC1

SUPPLEMENTARY DATA  

Supplementary Table 2. Odds ratios for elevated HbA1c at 45y and difference in HbA1c (unit %) per SD increase in BMI at 45y, stratified by childhood BMI (n=7855)* HbA1c 7

HbA1c†

OR (95%CI)

Difference (95%CI)

Bottom 10%

1.86 (1.05, 3.29)

0.056 (0.006, 0.105)

10-50%

2.42 (1.83, 3.20)

0.103 (0.070, 0.136)

50-90%

2.62 (2.13, 3.23)

0.106 (0.078, 0.134)

Top 10%

2.11 (1.63, 2.73)

0.127 (0.074, 0.180)

Bottom 10%

2.30 (0.63, 8.49)

0.053 (0.009, 0.098)

10-50%

2.48 (1.78, 3.45)

0.081 (0.049, 0.113)

50-90%

2.32 (1.90, 2.84)

0.120 (0.093, 0.147)

Top 10%

1.93 (1.54, 2.42)

0.123 (0.064, 0.182)

Bottom 10%

2.93 (1.15, 7.46)

0.082 (0.031, 0.134)

10-50%

2.67 (1.77, 4.01)

0.079 (0.051, 0.108)

50-90%

2.12 (1.69, 2.66)

0.115 (0.088, 0.143)

Top 10%

1.87 (1.51, 2.31)

0.112 (0.053, 0.172)

Childhood BMI At 7 years

At 11 years

At 16 years

*Results estimated using multiple imputation † includes diagnosed type 2 diabetes. Models control for type 2 diabetes treatment All models adjusted for gender, social class in childhood and at 42y, family history of diabetes, ethnicity

©2011 American Diabetes Association. Published online at http://care.diabetesjournals.org/lookup/suppl/doi:10.2337/dc10-1482/-/DC1

SUPPLEMENTARY DATA  

Supplementary Table 3. Association between age of onset of overweight or obesity and adult HbA1c: odds ratios for elevated HbA1c≥6 Duration/age of onset (n=7855)†

HbA1c 6* OR (95%CI)

Unadjusted

Adjusted$

Obesity Never Childhood only

5.13 (1.93, 13.65)

4.01 (1.45, 11.05)

Onset in mid-adulthood

4.65 (3.43, 6.29)

1.42 (0.97, 2.09)

Onset in young adulthood

10.84 (7.96, 14.76)

2.01 (1.23, 3.30)

Onset in childhood

13.54 (8.42, 21.78)¶

1.68 (0.83, 3.37) ¶

Childhood only

0.92 (0.12, 7.36)

0.95 (0.12, 7.65)

Onset in mid-adulthood

2.04 (1.18, 3.53)

0.76 (0.43, 1.33)

Onset in young adulthood

5.58 (3.52, 8.85)

1.04 (0.62, 1.75)

Onset in childhood

10.86 (6.88, 17.15) ¶

1.32 (0.74, 2.36)

Overweight (including obesity) Never

*Type 2 diabetes or HbA1c≥6. § Models control for type 2 diabetes treatment. † Age at onset of obesity/overweight defined as: never (BMI < WHO cut-off at all ages); childhood only (BMI ≥ cut-off at 7, 11 or 16 years but not at 23, 33 & 45); onset in childhood or adolescence (BMI ≥ cut-off at 7, 11 or 16 plus 23, 33 or 45); onset in young adulthood (BMI ≥ cut-off at 23 or 33, but not in childhood); onset in mid-adulthood (BMI ≥ cut-off at 45 only). See table 1 footnotes for BMI cut-offs for overweight and obesity in childhood. $ gender, total cholesterol, HDL-cholesterol, family history of diabetes, menopausal status, smoking at 42y, alcohol consumption at 42y, social class in childhood, social class at 45y, qualifications by 42y. ¶ Linear trend from never to onset in mid-adulthood p