Supplementary Table 1. UniProt Accession numbers ...

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Mycolic Acid Biosynthesis: Transport. mmpL3. Trehalose monomycolate exporter. P9WJV5(MT), Q8NLS1(CG). cmaA1. Cyclopropane mycolic acid synthase 1.
Supplementary Table 1. UniProt Accession numbers for the reference sequences in the analysis Pathway Fatty Acid Synthesis-I

Fatty Acid Synthesis-II

Mycolic Acid Biosynthesis: Carboxylation

Mycolic Acid Biosynthesis: Condensation Mycolic Acid Biosynthesis: Activation Mycolic Acid Biosynthesis: Reduction Mycolic Acid Biosynthesis: Transport

Mycolic Acid Cyclization, Methylation

Mycolic Acid Desaturation

Abbreviation fas fabD fabH kasA kasB mabA

Description of Protein 3-oxoacyl-ACP synthase Malonyl CoA-acyl carrier protein transacylase 3-oxoacyl-[acyl-carrier-protein] synthase 3 3-oxoacyl-[acyl-carrier-protein] synthase 1 3-oxoacyl-[acyl-carrier-protein] synthase 2 3-oxoacyl-[acyl-carrier-protein] reductase

UniProt-ID P95029(MT), Q8NS46(CG)

hadA hadB hadC inhA accD6 accD4 accD5 accA3 accE pks13 fadD32 cmrA mmpL3 cmaA1 cmaA2 umaA1 pcaA mmaA1

(3R)-hydroxyacyl-ACP dehydratase subunit HadA (3R)-hydroxyacyl-ACP dehydratase subunit HadB (3R)-hydroxyacyl-ACP dehydratase subunit HadC Enoyl-[acyl-carrier-protein] reductase Acetyl-CoA carboxylase beta subunit Acyl-CoA carboxylase subunit beta 1 Acyl-CoA carboxylase subunit beta 2 Acyl/Acetyl-CoA carboxylase subunit alpha Acyl/Acetyl-CoA carboxylase subunit epsilon Polyketide synthase Long-chain-fatty-acid--AMP ligase Probable short-chain type dehydrogenase/reductase Trehalose monomycolate exporter Cyclopropane mycolic acid synthase 1 Cyclopropane mycolic acid synthase 2 Possible mycolic acid synthase Cyclopropane mycolic acid synthase 3 Mycolic acid methyltransferase

P9WFK1(MT) I6WYY7(MT)

mmaA2 mmaA3 mmaA4 desA1

Cyclopropane mycolic acid synthase Methoxy mycolic acid synthase Hydroxymycolate synthase Putative acyl-desaturase

Q79FX6(MT) P0CH91(MT) Q79FX8(MT) P9WNZ7(MT)

Putative acyl-desaturase NADPH-dependent stearoyl-CoA 9-desaturase 1,4-dihydroxy-2-naphthoate octaprenyltransferase 1,4-dihydroxy-2-naphthoyl-CoA synthase o-succinylbenzoate synthase 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase 2-succinylbenzoate--CoA ligase Isochorismate synthase Demethylmenaquinone methyltransferase Chorismate dehydratase Futalosine hydrolase Cyclic dehypoxanthine futalosine synthase 1,4-dihydroxy-6-naphtoate synthase

P9WNZ5(MT) P9WNZ3(MT) P9WIP3(MT)

Aminodeoxyfutalosine synthase Putative decarboxylase Putative octaprenyltransferase Flavin prenyltransferase Decaprenyl diphosphate synthase Geranylgeranyl pyrophosphate synthase Menaquinone reductase

Q8CJT5(SCO), Q5SK48(TT) Q9KYP3(SCO) Q9KYP2(SCO)

desA2 desA3 menA menB menC Menaquinone Biosynthesis Pathway: Classical menD menE menF menG mqnA mqnB mqnC mqnD Menaquinone Biosynthesis Pathway: Futalosine mqnE SCO4490 SCO4491 ubiX uppS Menaquinone Isoprenyl Chain Elongation hepST Menaquinone Isoprenyl Chain Saturation menJ

P9WNG5(MT) P9WNG3(MT) P9WQD9(MT) P9WQD7(MT) P9WGT3(MT)

P9WFJ9(MT) P9WGR1(MT) P9WQH5(MT) O53578(MT) P9WQH7(MT) P96890(MT) P96886(MT) I6X8D2(MT), Q8NLR7(CG) O53580(MT), Q8NLR6(CG) I6Y9I3(MT), Q8NMU2(CG) P9WJV5(MT), Q8NLS1(CG) P9WPB7(MT) P9WPB5(MT) Q6MX39(MT) P9WPB3(MT) P9WPB1(MT)

P9WNP5(MT) P9WJP3(MT) P9WK11(MT) P9WQ39(MT) P9WFW9(MT) P9WFR3(MT) Q9L0T8(SCO), A1W0R9(CJ), Q5SK49(TT) Q9KXN0(SCO), Q5SKT7(TT), A0LR22(ACE) Q9XAP2(SCO), Q9K864(BH) Q9KXN1(SCO), Q5SI12(TT)

Q9KYP1(SCO)

P9WFF7(MT) Q8NT37(CG) P9WNY9(MT)