Supplementary Table S7. Summary of top-ranking connectivities. - PLOS

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quinoline. 23. 19.2. 8. 1 quinostatin, mepacrine, pyrvinium, primaquine, mefloquine, clioquinol, amodiaquine, ethaverine topoisomerase I/II inhibitor. 20. 16.7. 8.
Supplementary Table S7. Summary of top-ranking connectivities. Drug class

No of instances 23

% instances 19.2

No of drugs 8

p53 activation 1

topoisomerase I/II inhibitor

20

16.7

8

8

phenothiazine

12

10.0

6

-

glycoside antihistamine α-1 receptor antagonist PI3K inhibitor DNA intercalator dopamine agonist/serotonin antagonist phytosterol glucocorticoid NMDA antagonist Ca2+ blocker other

7 6 6 5 5 4

5.8 5.0 5.0 4.2 4.2 3.3

4 2 2 2 1 1

2 1 -

3 3 2 2 22

2.5 2.5 1.7 1.7 18.3

1 1 1 1 21

1 1 4

Total

120

100.0

59

18

quinoline

Drugs quinostatin, mepacrine, pyrvinium, primaquine, mefloquine, clioquinol, amodiaquine, ethaverine daunorubicin, irinotecan, ellipticine, mitoxantrone, etoposide, camptothecin, doxorubicin, harmine prochlorperazine, thioridazine, trifluoperazine, fluphenazine, promethazine, perphenazine digoxin, ouabain, quercetin, proscillaridin terfenadine, astemizole prazosin, phenoxybenzamine LY294002, wortmannin hycanthone metergoline resveratrol mometasone dizocilpine suloctidil