quinoline. 23. 19.2. 8. 1 quinostatin, mepacrine, pyrvinium, primaquine, mefloquine, clioquinol, amodiaquine, ethaverine topoisomerase I/II inhibitor. 20. 16.7. 8.
Supplementary Table S7. Summary of top-ranking connectivities. Drug class
No of instances 23
% instances 19.2
No of drugs 8
p53 activation 1
topoisomerase I/II inhibitor
20
16.7
8
8
phenothiazine
12
10.0
6
-
glycoside antihistamine α-1 receptor antagonist PI3K inhibitor DNA intercalator dopamine agonist/serotonin antagonist phytosterol glucocorticoid NMDA antagonist Ca2+ blocker other
7 6 6 5 5 4
5.8 5.0 5.0 4.2 4.2 3.3
4 2 2 2 1 1
2 1 -
3 3 2 2 22
2.5 2.5 1.7 1.7 18.3
1 1 1 1 21
1 1 4
Total
120
100.0
59
18
quinoline
Drugs quinostatin, mepacrine, pyrvinium, primaquine, mefloquine, clioquinol, amodiaquine, ethaverine daunorubicin, irinotecan, ellipticine, mitoxantrone, etoposide, camptothecin, doxorubicin, harmine prochlorperazine, thioridazine, trifluoperazine, fluphenazine, promethazine, perphenazine digoxin, ouabain, quercetin, proscillaridin terfenadine, astemizole prazosin, phenoxybenzamine LY294002, wortmannin hycanthone metergoline resveratrol mometasone dizocilpine suloctidil
