Survival of a large cohort of HIV-infected ... - IngentaConnect

INT J TUBERC LUNG DIS 15(2):263–269 © 2011 The Union

Survival of a large cohort of HIV-infected tuberculosis patients in the era of highly active antiretroviral treatment L. Català,*† A. Orcau,*‡ P. García de Olalla,*‡ J-P. Millet,*‡§ A. Rodríguez-Mondragón,*† J. A. Caylà*‡§ and the TB-HIV Working Group¶ * Epidemiology Service, Public Health Agency of Barcelona, Barcelona, † Unidad Docente de Medicina Preventiva y Salud Pública H.Mar-UPF-ASPB, Barcelona, ‡ CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, § Departamento de Pediatría, Ginecología y Medicina Preventiva, Universidad Autónoma de Barcelona, Barcelona, Spain SUMMARY OBJECTIVES:

To determine the survival rate, predictive factors and causes of death in a cohort of human immunodeficiency virus (HIV) infected tuberculosis (TB) patients in the era of highly active antiretroviral treatment (HAART). D E S I G N : This retrospective cohort study included all HIV-infected TB patients reported in Barcelona between 1996 and 2006. A survival analysis was conducted based on the Kaplan-Meier estimator and Cox proportional hazards; hazard ratios (HRs) and their 95% confidence intervals (CIs) were calculated. Causes of death were classified using the International Classification of Diseases (ICD) 9 and ICD-10, and defined as acquired immunedeficiency syndrome (AIDS) related, non-AIDS-related or unknown. R E S U LT S : Of the 792 patients included, 341 (43.1%) died. Survival at 10 years was 47.4% (95%CI 45.2–

49.6). Poorer survival was observed in patients aged >30 years (HR 1.6, 95%CI 1.1–2.1), inner-city residents (HR 1.3, 95%CI 1.1–1.7), injecting drug users (HR 1.4, 95%CI 1.1–1.8), those with a non-cavitary radiological pattern (HR 1.5, 95%CI 1.0–2.2), those with