Abstract. Survivin is a unique inhibitor of apoptosis, which is frequently present within degenerated human nucleus pulposus. (NP) cells. Survivin has been ...
MOLECULAR MEDICINE REPORTS 13: 1026-1032, 2016
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Survivin is expressed in degenerated nucleus pulposus cells and is involved in proliferation and the prevention of apoptosis in vitro YAZHOU LIN, BIN YUE, HONGFEI XIANG, YONG LIU, XUEXIAO MA and BOHUA CHEN Department of Orthopedic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China Received December 13, 2014; Accepted November 5, 2015 DOI: 10.3892/mmr.2015.4605 Abstract. Survivin is a unique inhibitor of apoptosis, which is frequently present within degenerated human nucleus pulposus (NP) cells. Survivin has been extensively investigated using proliferation and apoptosis assays in tumor cells; however, studies conducted on survivin in degenerative NP cells remain limited to date. The aim of the present study was to investigate survivin expression and its effects on the proliferation and apoptosis of degenerated NP cells in vitro. The expression levels of survivin in the NP cells of patients (>45 years) with lumbar disc degenerative disease and the NP cells of patients (
