Susceptibility to Vancomycin of Methicillin

966

Susceptibility

to Vancomycin

of Methicillin-Resistant

Staphylococcus aureus Isolated in a University Namiko

MORI1)2), Shigemi Chieko

1)Department

HITOMI1), SUGISHITA2)

of Infection Control and Prevention 2)Department

Katsuko

of Family

OKUZUMI3),

Akiko YONEYAMA3)

and Satoshi KIMURA1)

,3)Department

Nursing,

Hospital in Japan

Graduate

of Clinical Laboratory,

School of Medicine,

University

University

of Tokyo Hospital

of Tokyo

(Received: July 10,2000) (Accepted:

Key words:

vancomycin,

August

hetero-resistant,

15,2000)

Staphylococcus

aureus,

drug,

susceptibil-

been

widely

ity, MRSA

Summary Intravenous infections itial

vancomycin

caused

discovery

organism had

has

been

emerged

by

the

tory

dilution

1.0ƒÊg/ml,

a strain

set

of

nous use

an having

a 1/106

the

settings.

hospital

since

evaluated

on

and 69

or

strains

decrease

is so small

S. aureus

in Japan,

We the of

in 1988

all

of the to

were for

may that

14

have

more

not

be

the

were

12

(range:

lowered

use

examination. and

strains

among

the

the

significant

74

classified

median

vancomycin clinically.

1998

to

We

isolated conclude

addition,

no

and

group. has

been

vancomycin.

strains

inhibi-

0.75ƒÊg/ml

susceptible

susceptibility In

resistance

minimum was

inthis

determined

which

days).

of

concentrations

in the

MRSA

14 to 77

resistance

of the

vancomycin.

in

subpopulation

since

intravenous

The isolated

treatment

vancomycin

of

(hetero-VRSA),

other

for ever

vancomycin

inhibitory

vancomycin

days

slightly

it may

minimum

resistant

found or

the

whether of

used

. Consequently,

investigated

approval

resistance

resistant

has

(MRSA)

heterogeneously

hetero-VRSA

and

aureus

basis

isolated

however,

greater

vancomycin

the

a heterogeneous

MRSA

of vancomycin

intravenous

in our

no

in Japan

clinical

heterogeneously

investigations,

hospital,

in

(p