PKH_020300 phosphatidylinositol-4-phosphate 5-kinase, putative (PIP5K). 15 ... 7.1. PKH_060310 eukaryotic translation initiation factor subunit eIF2A, putative ..... PKH_141200 eukaryotic translation initation factor 4 gamma, putative (EIF4G).
Table S2 List of annotated genes from six clinical isolates with >9 SNP's that co - associate with the Plasmodium knowlesi genome-wide dimorphism. Gene ID PKH_010260 PKH_010740 PKH_011630 PKH_011640 PKH_011650 PKH_011660 PKH_011670 PKH_011700 PKH_011714 PKH_020300 PKH_020580 PKH_020750 PKH_021090 PKH_030250 PKH_030610 PKH_030890 PKH_030920 PKH_031060 PKH_040430 PKH_040490 PKH_041100 PKH_041110 PKH_041220 PKH_041240 PKH_041310 PKH_041490 PKH_041520 PKH_041680 PKH_050090 PKH_050110 PKH_051180 PKH_052430 PKH_060230 PKH_060310 PKH_060730 PKH_060810 PKH_061750 PKH_061820 PKH_062240 PKH_062280 PKH_070180 PKH_070210 PKH_070230 PKH_070250 PKH_070260 PKH_070680 PKH_070750 PKH_070790 PKH_071250 PKH_071270 PKH_071330 PKH_071660 PKH_071710 PKH_072500 PKH_072660 PKH_072670 PKH_072830 PKH_072870 PKH_072930 PKH_073170 PKH_073220 PKH_073320 PKH_073340 PKH_073430 PKH_080250 PKH_083000 PKH_090100 PKH_090140 PKH_090460 PKH_090510 PKH_091340 PKH_091350 PKH_091410 PKH_092060 PKH_092110 PKH_092160 PKH_092360 PKH_092450 PKH_092690 PKH_092760 PKH_093150 PKH_093250 PKH_093290 PKH_093420 PKH_093620
Gene function phosphoinositide-binding protein, putative Cg2-like protein transcription factor with AP2 domain(s), putative (ApiAP2) gluatamate dehydrogenase, putative (GDH3) reductase, putative mannose-6-phosphate isomerase, putative sentrin-specific protease 2, putative (SENP2) protein kinase, putative unspecified product phosphatidylinositol-4-phosphate 5-kinase, putative (PIP5K) patched family protein, putative asparagine-rich antigen, putative ubiquitin carboxyl-terminal hydrolase, putative RNA binding protein, putative sporozoite invasion-associated protein 1, putative (SIAP1) lysine decarboxylase, putative pre-mRNA-processing-splicing factor 8, putative (PRPF8) transcription factor with AP2 domain(s), putative (ApiAP2) DNA-directed RNA polymerase II second largest subunit, putative ATP-dependent acyl-CoA synthetase, putative 6-cysteine protein (P230) 6-cysteine protein (P230p) cysteine protease, putative cysteine protease, putative merozoite surface protein 5 DEAD/DEAH box helicase, putative 5'-3' exonuclease, putative protein kinase, putative tryptophan/threonine-rich antigen, putative sporozoite invasion-associated protein 2, putative (SIAP-2) MAC/perforin, putative phosphatidylinositol 4-kinase, putative erythrocyte membrane-associated antigen, putative eukaryotic translation initiation factor subunit eIF2A, putative dynein heavy chain, putative chromodomain-helicase-DNA-binding protein 1 homolog, putative (CHD1) S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative aspartyl protease, putative GDP dissociation inhibitor, putative KIR-like protein ubiquitin specific protease, putative E1-E2_ATPase/hydrolase, putative nucleoporin NUP100/NSP100, putative (NUP100) dynein heavy chain, putative rhoptry protein, putative exoribonuclease, putative Ran-binding protein, putative DNA repair protein REV1, putative ribonuclease H2 subunit C, putative 6-phosphofructokinase, putative (PFK9) transporter, putative protein disulfide-isomerase, putative regulator of chromosome condensation, putative zinc finger protein, putative serine/threonine protein kinase, putative guanylate kinase, putative (GK) leucine-rich repeat protein (LRR8) diacylglycerol kinase, putative GTP binding protein, putative mitochondrial-processing peptidase subunit beta, putative (MAS1) DNA excision-repair helicase, putative vesicle transport protein, putative gametocyte development protein 1, putative (GDV1) lysophospholipase, putative U5 small nuclear ribonuclear protein, putative phd finger protein, putative CCR4-NOT transcription complex subunit 1, putative (NOT1) chromatin remodeling protein, putative (SNF2L) polyadenylate-binding protein-interacting protein 1, putative (PAIP1) transcription factor with AP2 domain(s), putative (ApiAP2) rhoptry neck protein 4, putative (RON4) serine esterase, putative cathepsin C precursor, putative asparagine-rich protein, putative RAP protein, putative beige/BEACH domain protein, putative threonine--tRNA ligase, putative (ThrRS) RNA binding protein, putative parasitophorous vacuolar protein 1, putative (PV1) transporter, putative RNA (uracil-5-)methyltransferase, putative zinc finger protein, putative protein phosphatase, putative tudor staphylococcal nuclease, putative (TSN) guanylyl cyclase, putative
No Co-assoc SNPs Total SNPs % co-assoc SNPs 11 68 16.2 12 259 4.6 34 230 14.8 13 60 21.7 76 339 22.4 12 77 15.6 28 180 15.6 15 76 19.7 10 80 12.5 15 141 10.6 13 79 16.5 14 213 6.6 10 224 4.5 13 96 13.5 15 56 26.8 17 165 10.3 10 199 5 27 403 6.7 11 74 14.9 16 42 38.1 27 175 15.4 18 134 13.4 14 89 15.7 11 79 13.9 10 35 28.6 10 33 30.3 25 83 30.1 30 205 14.6 14 23 60.9 12 34 35.3 10 48 20.8 23 351 6.6 14 198 7.1 10 207 4.8 15 342 4.4 16 201 8 22 84 26.2 10 64 15.6 24 94 25.5 14 24 58.3 29 139 20.9 40 186 21.5 18 103 17.5 35 311 11.3 14 41 34.1 11 109 10.1 21 75 28 11 121 9.1 10 43 23.3 17 77 22.1 21 123 17.1 10 35 28.6 27 284 9.5 22 108 20.4 13 41 31.7 10 17 58.8 20 48 41.7 10 84 11.9 12 65 18.5 12 20 60 16 97 16.5 31 123 25.2 21 50 42 19 90 21.1 33 81 40.7 11 448 2.5 12 256 4.7 11 82 13.4 32 246 13 21 145 14.5 15 97 15.5 33 131 25.2 12 32 37.5 11 152 7.2 11 83 13.3 13 119 10.9 16 63 25.4 17 103 16.5 10 33 30.3 10 25 40 17 71 23.9 25 197 12.7 17 104 16.3 11 63 17.5 31 241 12.9
PKH_094060 PKH_094280 PKH_094440 PKH_094520 PKH_100020 PKH_100820 PKH_100840 PKH_103010 PKH_103190 PKH_111420 PKH_112660 PKH_113250 PKH_113520 PKH_113530 PKH_113660 PKH_114550 PKH_114780 PKH_120090 PKH_120110 PKH_120190 PKH_120230 PKH_120290 PKH_120350 PKH_120460 PKH_121160 PKH_121190 PKH_121210 PKH_121330 PKH_121390 PKH_121420 PKH_121770 PKH_121970 PKH_122360 PKH_122410 PKH_123100 PKH_123980 PKH_124700 PKH_125210 PKH_125270 PKH_125430 PKH_125490 PKH_125590 PKH_125660 PKH_125680 PKH_125830 PKH_125840 PKH_125950 PKH_126090 PKH_126180 PKH_126240 PKH_126270 PKH_126280 PKH_126340 PKH_126380 PKH_126410 PKH_126490 PKH_126500 PKH_126680 PKH_126880 PKH_126950 PKH_126970 PKH_130070 PKH_130610 PKH_130710 PKH_130840 PKH_131400 PKH_131480 PKH_131540 PKH_131690 PKH_131750 PKH_131840 PKH_132040 PKH_132090 PKH_132240 PKH_132330 PKH_132370 PKH_132390 PKH_132990 PKH_133050 PKH_133100 PKH_133110 PKH_133220 PKH_133250 PKH_133270 PKH_133490 PKH_133600 PKH_133620 PKH_133730 PKH_133780
transcription factor with AP2 domain(s), putative (AP2-O) protein kinase, putative sporozoite asparagine-rich protein (SLARP) protein kinase, putative KIR-like protein karyopherin beta, putative transporter, putative merozoite surface protein 3b, putative rhoptry-associated protein 3, putative serine/threonine protein kinase, putative (ARK3) transcription factor with AP2 domain(s), putative (ApiAP2) TRAP-like protein, putative (TLP) transcription factor with AP2 domain(s), putative (ApiAP2) syntaxin binding protein, putative leucine-rich repeat protein (LRR6) transcription factor with AP2 domain(s), putative,SPE2-interacting protein, putative (SIP2) ATP-dependant RNA helicase, putative tryptophan-rich antigen vacuolar fusion protein MON1, putative ABC transporter, putative alveolin, putative (ALV6) phosphatidylinositol transfer protein, putative ubiquitin-activating enzyme e1, putative serine/threonine protein kinase, putative (TKL3) transcription factor with AP2 domain(s), putative (ApiAP2) myosin A, putative Casein kinase II regulatory subunit, putative sodium-dependent phosphate transporter, putative (PiT) nucleolar complex protein 2, putative ABC transporter, putative sporozoite surface protein 2, putative,thrombospondin-related anonymous protein (TRAP) ubiquitin activating enzyme, putative (UBA1) myosin, putative alpha/beta-hydrolase, putative SET domain protein, putative dynein beta chain, putative GTP-binding protein, putative aminopeptidase P, putative (APP) glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative rhoptry neck protein 2, putative (RON2) transcriptional regulatory protein sir2b, putative (Sir2b) zinc finger protein, putative exosome complex exonuclease RRP6, putative (RRP6) transcription factor with AP2 domain(s), putative (ApiAP2) TRAP-like protein (TREP) multidrug resistance protein 2, putative Glutamine cyclotransferase, putative serine/threonine kinase-1, putative Ser/Thr protein kinase, putative heat shock protein, putative spindle pole body protein, putative Poly(A)-specific ribonuclease PARN, putative (PARN) guanine-nucleotide-exchange-factor, putative protein prenyltransferase alpha subunit, putative probable GTP-binding protein, putative FACT complex subunit SSRP1, putative (FACT-S) serine/threonine protein kinase, putative Histone-like transcription factor, putative protein kinase, putative cysteine repeat modular protein 4, putative (CRMP4) bromodomain containing protein, putative ATP-dependent RNA helicase, putative small subunit rRNA processing factor, putative cysteine repeat modular protein 3, putative (CRMP3) 3',5'-cyclic-nucleotide phosphodiesterase, putative NAD(P)H-dependent glutamate synthase, putative P-loop containing nucleoside triphospahte hydrolase, putative protein kinase, putative leucine-rich repeat protein (LRR5) knob-associated histidine-rich protein, putative (KAHRP) syntaxin, putative ATP-dependent DNA helicase, putative rRNA methylase, putative WW domain-binding protein 11, putative lipase, putative phosphoenolpyruvate carboxylase, putative (PEPC) ATP-binding cassette sub-family G member 2, putative (ABCG2) ATP-dependent RNA helicase, putative cysteine protease ATG4, putative (ATG4) metacaspase-like protein (MCA3) GTP binding protein, putative uracil-DNA glycosylase, putative ubiquitin carboxyl-terminal hydrolase, putative atypical protein kinase, ABC-1 family, putative ATPase, putative GTP binding protein, putative POM1 homolog, putative (PREX) rhoptry-associated protein 1, putative (RAP1) cytidine diphosphate-diacylglycerol synthase (CDS)
19 11 31 11 15 16 12 12 15 10 22 36 118 23 16 10 10 14 12 21 32 43 13 41 45 10 10 10 18 15 18 10 16 27 25 18 11 11 11 60 13 13 12 11 25 48 11 12 15 13 37 22 25 22 31 10 63 23 11 82 11 15 10 48 13 29 42 26 15 19 21 14 28 15 20 17 11 12 29 37 12 11 11 44 31 15 19 17 21
147 157 272 49 123 48 34 73 34 435 273 132 462 64 140 213 78 32 38 64 134 103 80 134 381 25 38 40 55 67 38 132 144 75 262 333 60 38 43 156 91 129 121 95 86 133 25 45 102 64 117 72 192 56 78 28 254 150 66 340 48 49 74 252 71 189 661 219 171 52 59 66 218 48 99 62 43 53 102 204 52 27 112 152 95 41 128 52 32
12.9 7 11.4 22.4 12.2 33.3 35.3 16.4 44.1 2.3 8.1 27.3 25.5 35.9 11.4 4.7 12.8 43.8 31.6 32.8 23.9 41.7 16.2 30.6 11.8 40 26.3 25 32.7 22.4 47.4 7.6 11.1 36 9.5 5.4 18.3 28.9 25.6 38.5 14.3 10.1 9.9 11.6 29.1 36.1 44 26.7 14.7 20.3 31.6 30.6 13 39.3 39.7 35.7 24.8 15.3 16.7 24.1 22.9 30.6 13.5 19 18.3 15.3 6.4 11.9 8.8 36.5 35.6 21.2 12.8 31.2 20.2 27.4 25.6 22.6 28.4 18.1 23.1 40.7 9.8 28.9 32.6 36.6 14.8 32.7 65.6
PKH_133850 PKH_133910 PKH_134030 PKH_134120 PKH_134140 PKH_134230 PKH_134310 PKH_134580 PKH_140230 PKH_140780 PKH_141200 PKH_141520 PKH_141540 PKH_141620 PKH_142160 PKH_142730 PKH_142840 PKH_142870 PKH_143610 PKH_143910 PKH_144190 PKH_144230 PKH_144260 PKH_144590 PKH_144890 PKH_145070 PKH_145310 PKH_146780 PKH_146850 PKH_146940 PKH_146970 PKH_146990
oxidoreductase, aldo/keto reductase domain containing protein transcription factor with AP2 domain(s), putative (ApiAP2) ATP-dependent Clp protease, putative circumsporozoite protein, putative COBW domain-containing protein 1, putative (CBWD1) adenylyl cyclase 1, putative nuclear formin-like protein (MISFIT) erythrocyte binding protein (gamma) peptidase, putative mRNA-decapping enzyme 2, putative (DCP2) eukaryotic translation initation factor 4 gamma, putative (EIF4G) Exportin-1 domain containig protein inositol polyphosphate kinase, putative (IPK2) U4/U6.U5 tri-snRNP-associated protein 2, putative (USP39) zinc finger protein, putative CCR4-associated factor 1, putative (CAF1) ABC transporter, putative JmjC domain containing protein formin 2, putative transcription factor with AP2 domain(s), putative (ApiAP2) isoleucine--tRNA ligase, putative ribosome biogenesis protein, putative ubiquitin-activating enzyme e1, putative multidrug resistance-associated protein 1, putative (MRP1) asparagine-rich protein, putative asparagine/aspartate rich protein, putative transcription factor with AP2 domain(s), putative (ApiAP2) pfg377 homolog, putative DNA repair protein rhp16, putative tryptophan--tRNA ligase, putative reticulocyte binding protein, putative (fragment) tryptophan-rich antigen
11 44 14 13 10 17 44 17 59 12 21 10 16 13 13 19 15 24 15 18 10 10 21 89 18 16 14 27 12 11 91 27
83 123 88 60 32 55 167 86 741 90 77 69 145 48 77 164 62 51 245 232 161 38 58 198 193 442 322 162 101 49 326 70
13.3 35.8 15.9 21.7 31.2 30.9 26.3 19.8 8 13.3 27.3 14.5 11 27.1 16.9 11.6 24.2 47.1 6.1 7.8 6.2 26.3 36.2 44.9 9.3 3.6 4.3 16.7 11.9 22.4 27.9 38.6
