Table S2. Differentially expressed genes in the liver of ...

Table S2. Differentially expressed genes in the liver of mice at 1, 2, 3 and 6 months after E. multilocularis infection compared with non-infected mice. Entrez Gene Symbol Gene Description Month 1 Month 2 Month 3 Month 6 Classification Gene ID 1110034B05Rik 68736 RIKEN cDNA 1110034B05 gene -2.53 unknown 1110067D22Rik 216551 RIKEN cDNA 1110067D22 gene 3.07 sugar binding 1190002H23Rik 66214 RIKEN cDNA 1190002H23 gene 3.15 cell cycle 1200006F02Rik 71706 RIKEN cDNA 1200006F02 gene -2.61 integral to membrane 1300013J15Rik 67473 RIKEN cDNA 1300013J15 gene -2.06 unknown 1810011O10Rik 69068 RIKEN cDNA 1810011O10 gene 2.51 apoptosis 1810015C04Rik 66270 RIKEN cDNA 1810015C04 gene 3.47 membrane 1810055G02Rik 72056 RIKEN cDNA 1810055G02 gene 4.78 extracellular space 2010003K11Rik 69861 RIKEN cDNA 2010003K11 gene -2.26 unknown 2010305C02Rik 380712 RIKEN cDNA 2010305C02 gene -3.15 extracellular space 2310007B03Rik 71874 RIKEN cDNA 2310007B03 gene -2.53 unknown 2310031A18RIK 69627 RIKEN CDNA 2310031A18 gene -4.28 unknown 2310076L09Rik 66968 RIKEN cDNA 2310076L09 gene 3.59 unknown 2610028AO1Rik 72400 RIKEN cDNA 2610028A01 gene -2.01 cell cycle 2610528J11Rik 66451 RIKEN cDNA 2610528J11 gene -2.53 membrane 3010026009Rik 68067 RIKEN cDNA 3010026O09 gene -2.70 unknown 3110001K24Rik 75698 RIKEN cDNA 3110001K24 gene 3.26 hydrolase activity 4930504E06Rik 75007 RIKEN cDNA 4930504E06 gene -2.12 unknown 4930515G01Rik 67642 RIKEN cDNA 4930515G01 gene 2.02 unknown 4930528F23Rik 75178 RIKEN cDNA 4930528F23 gene -2.20 unknown 5830443L24Rik 76074 RIKEN CDNA 5830443L24 gene 2.84 immune response 8430408G22Rik 213393 RIKEN cDNA 8430408G22 gene -2.14 -2.06 mitochondrion A330049M08Rik 230822 RIKEN cDNA A330049M08 gene -5.58 cytoskeleton AA986860 212439 expressed sequence AA986860 2.37 cytoplasm Abca8b 27404 ATP-binding cassette, sub-family A (ABC1), member 8b -2.26 transport

Table S2. Differentially expressed genes in the liver of mice at 1, 2, 3 and 6 months after E. multilocularis infection compared with non-infected mice.

Abcd3 Abp1 Acly Acsm2 Acss2 Acta2

Entrez Gene ID 19299 76507 104112 233799 60525 11475

ACTG1

11465

actin, gamma, cytoplasmic 1

Actr6 Acy3 Adck5 Adfp

67019 71670 268822 11520

ARP6 actin-related protein 6 homolog (yeast) Aspartoacylase (aminoacylase) 3 aarF domain containing kinase 5 adipose differentiation related protein

Adh4

26876

alcohol dehydrogenase 4 (class II), pi polypeptide

-2.38

Adra1b Afmid Agxt Ahcy Ahsg AI132487 AI842396 Akp2 Akr1c14 Akr1c19 Alas1 Alb Aldh1l1

11548 71562 11611 269378 11625 104910 103844 11647 105387 432720 11655 11657 107747

adrenergic receptor, alpha 1b arylformamidase alanine-glyoxylate aminotransferase S-adenosylhomocysteine hydrolase alpha-2-HS-glycoprotein expressed sequence AI132487 expressed sequence AI842396 alkaline phosphatase 2, liver aldo-keto reductase family 1, member C14 aldo-keto reductase family 1, member C19 aminolevulinic acid synthase 1 albumin 1 aldehyde dehydrogenase 1 family, member L1

-2.16 -2.18

Gene Symbol

Gene Description ATP-binding cassette, sub-family D (ALD), member 3 amiloride binding protein 1 ATP citrate lyase acyl-CoA synthetase medium-chain family member 2 acyl-CoA synthetase short-chain family member 2 actin, alpha 2, smooth muscle, aorta

Month 1

Month 2

Month 3

Month 6

2.61 6.63 3.37 -2.42 -2.51 2.31 2.17 2.63 -2.03 -2.00 2.63

-2.37 2.05 -4.08 3.59 -2.82

2.25 -3.12 2.35

2.01 -2.14 -2.63 3.12

Classification transport Response to stimulus biosynthetic process metabolism metabolism metabolism cell differentiation and development biosynthetic process metabolism metabolism metabolism alcohol dehydrogenase 4 (class II) metabolism metabolism metabolism metabolism Response to external stimulus transport oxidation reduction metabolism oxidoreductase activity oxidation reduction biosynthetic process response to external stimulus biosynthetic process

Table S2. Differentially expressed genes in the liver of mice at 1, 2, 3 and 6 months after E. multilocularis infection compared with non-infected mice. Entrez Gene Symbol Gene Description Month 1 Month 2 Month 3 Month 6 Classification Gene ID Aldoc 11676 Aldolase 3, C isoform 2.15 metabolism Alkbh2 231642 alkB, alkylation repair homolog 2 (E. coli) 2.24 response to stress Alkbh7 66400 alkB, alkylation repair homolog 7 (E. coli) -2.10 oxidoreductase activity alpha 1 microglobulin/bikunin (Ambp), mRNA Ambp 11699 -2.35 immune response [NM_007443] Amdhd1 71761 amidohydrolase domain containing 1 -2.14 metabolism Angptl4 57875 angiopoietin-like 4 2.90 response to stress intracellular acidic(leucine-rich) nuclear phosphoprotein 32 Anp32a 11737 -2.24 membrane-bound family,member a organelle Aox3 71724 aldehyde oxidase 3 -2.02 metabolism Ap3m1 55946 adaptor-related protein complex 3, mu 1 subunit 2.22 transport Apcs 20219 serum amyloid P-component 2.39 carbohydrate binding Apoa2 11807 apolipoprotein A-II -2.82 metabolism Apoa4 11808 Apolipoprotein A-IV -2.75 metabolism Apoc1 11812 apolipoprotein C-I -3.20 metabolism Apoe 11816 apolipoprotein E -4.14 metabolism Apol7a 75761 RIKEN CDNA 9130022K13 gene -2.50 unknown Apol7c 108956 RIKEN CDNA 2210421G13 gene -3.09 transport Arhgef19 213649 Rho guanine nucleotide exchange factor (GEF) 19 -2.30 signal transduction Arhgef3 71704 Rho guanine nucleotide exchange factor (GEF) 3 2.10 2.10 signal transduction Arl4a 11861 ADP-ribosylation factor-like 4A 2.64 GTPase activity Arl6ip2 56298 ADP-ribosylation factor-like 6 interacting protein 2 2.05 immune response Arntl 11865 aryl hydrocarbon receptor nuclear translocator-like 9.59 -2.57 transcription Arrdc2 70807 Arrestin domain containing 2 2.22 unknown Arrdc3 105171 arrestin domain containing 3 -2.67 unknown Atp1b1 11931 ATPase, Na+/K+ transporting, beta 1 polypeptide 2.29 transport Atp2c2 69047 ATPase, Ca++ transporting, type 2C, member 2 -2.18 transport

Table S2. Differentially expressed genes in the liver of mice at 1, 2, 3 and 6 months after E. multilocularis infection compared with non-infected mice. Gene Symbol AU018778 Baiap2l1 BC012278 BC014805 BC029214 BC048507 BC057170 Bcar3 Bcl2a1b Bcl2a1c

Entrez Gene ID 234564 66898 235956 236149 227622 408058 236573 29815 12045 12046

C1qb

12260

C1QC C1qg C3 C4b C730048C13Rik C8a Cabc1 Cacybp Capza2 Car14 Car3 Car5a Casp3 Casp6

12262 12279 12266 625018 319800 230558 16601 12301 12343 23831 12350 12352 12367 12368

Gene Description expressed sequence AU018778 BAI1-associated protein 2-like 1 cDNA sequence BC012278 cDNA sequence BC014805 cDNA sequence BC029214 cDNA sequence BC048507 cDNA sequence BC057170 breast cancer anti-estrogen resistance 3 B-cell leukemia/lymphoma 2 related protein A1b B-cell leukemia/lymphoma 2 related protein A1c complement component 1, q subcomponent, beta polypeptide complement component 1, q subcomponent, C chain Complement C1q subcomponent, C chain precursor. complement component 3 complement component 4B RIKEN CDNA C730048C13 gene complement component 8, alpha polypeptide chaperone, ABC1 activity of bc1 complex like (S. pombe) Calcyclin binding protein Capping protein (actin filament) muscle Z-line, alpha 2 Carbonic anhydrase 14 carbonic anhydrase 3 carbonic anhydrase 5a, mitochondrial Caspase 3 caspase 6

Month 1

Month 2

Month 3

Month 6 -2.25

2.62 2.31 2.63 -2.67 2.12 3.41 -2.37 3.01 3.14

immune response

3.58 2.18

inflammatory response inflammatory response response to wounding immuno-response transport inflammatory response metabolism metabolism metabolism metabolism metabolism metabolism apoptosis apoptosis

3.09 -2.68 3.98 -4.72

-3.40 2.42 -3.44

hydrolase activity biosynthetic process metabolism transport unknown cytoskeleton immune response signal transduction cell death cell death

2.12

-3.98

2.15 2.08 -2.21

Classification

-2.02 -3.84 -2.06


Cbr2 Cbx3 Cc15 Ccar1 Ccl12

Entrez Gene ID 12409 12417 20304 67500 20293

Ccl17

Gene Symbol

Gene Description

Month 1

carbonyl reductase 2 chromobox homolog 3 (Drosophila HP1 gamma) chemokine (C-C motif) ligand 5 cell division cycle and apoptosis regulator 1 chemokine (C-C motif) ligand 12

3.26

20295

chemokine (C-C motif) ligand 17

3.36

Ccl8 Cd14 Cd163 Cd3d Cd52 Cd5l Cd7

20307 12475 93671 12500 23833 11801 12516

29.58 2.23

Cd74

16149

Cd8a Cd8b1 Cdkn1a Cebpb Cfhr1 cfp Ch25h Chi313 Chit1 Chn1

12525 12526 12575 12608 12628 18636 12642 12655 71884 108699

Cidea

12683

chemokine (C-C motif) ligand 8 CD14 antigen CD163 antigen CD3 antigen, delta polypeptide CD52 antigen CD51 antigen-like CD7 antigen CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) CD8 antigen, alpha chain CD8 antigen, beta chain 1, cyclin-dependent kinase inhibitor 1A (P21) CCAAT/enhancer binding protein (C/EBP), beta Complement factor H-related 1 complement factor properdin cholesterol 25-hydroxylase chitinase 3-like 3 chitinase 1 (chitotriosidase) chimerin (chimaerin) 1 cell death-inducing DNA fragmentation factor, alpha subunit-like effector A

Month 2

Month 3

Month 6

2.11 2.35 2.20

2.16

5.64

2.56 2.14 2.48 2.69 2.19 3.13 4.41 3.13 2.54

5.60

4.42 3.67 2.66 2.19

31.29 137.15 2.30 2.12 4.09

Classification metabolism metabolism immune response apoptosis Immune response response to external stimulus Immune response response to wounding inflammatory response immune response immune system process cell death immune response antigen processing and presentation immune response immune response response to stress biosynthetic process immune response inflammatory response metabolism Defense response metabolism signal transduction metabolism


Cks2 Cldn14 CLEC1B Clec4d Clec4e

Entrez Gene ID 66197 56173 56760 17474 56619

CDC28 protein kinase regulatory subunit2 claudin 14 C-type lectin domain family 1, member b C-type lectin domain family 4, member d C-type lectin domain family 4, member e

3.97 5.08

Cnn1

12797

calponin 1

2.17

Cnn2 Coq10b COX2 Cpt1a Creld2 Crls1 Csrp3 Ctla2α Cx3crl Cxcl12 Cxcl9 Cyb5b Cyp2b13 Cyp2c39 Cyp2c40 Cyp2c67 Cyp2c68 Cyp2f2

12798 67876 17709 12894 76737 66586 13009 13024 13051 20315 17329 66427 13089 13098 13099 545288 433247 13107

calponin 2 Coenzyme Q10 homolog B (S. cerevisiae) cytochrome c oxidase II carnitine palmitoyltransferase 1a, liver cysteine-rich with EGF-like domains 2 cardiolipin synthase 1 cysteine and glycine-rich protein 3 cytotoxic t lymphocyte-associated protein 2 α chemokine (C-X3-C) receptor 1 chemokine (C-X-C motif) ligand 12 chemokine (C-X-C motif) ligand 9 cytochrome b5 type B cytochrome P450, family 2, subfamily b, polypeptide 13 cytochrome P450, family 2, subfamily c, polypeptide 39 cytochrome P450, family 2, subfamily c, polypeptide 40 RIKEN CDNA C730004C24 gene cytochrome P450, family 2, subfamily c, polypeptide 40 cytochrome P450, family 2, subfamily f, polypeptide 2

Cyp2g1

13108

cytochrome P450, family 2, subfamily g, polypeptide 1

Gene Symbol

Gene Description

Month 1

Month 2

Month 3

Month 6 -2.77 3.45 2.20

2.38

2.07 4.88

-3.85 3.55 2.72 2.07 -2.39 2.49 -2.00 -2.21 2.81 -2.63 -2.62 -2.08 -2.64 -2.08 -2.08 -2.95 -2.89

Classification cell cycle cell-cell adhesion signal transduction immune response immune response steroid delta-isomerase activity protein binding intracellular Transport metabolism cytoplasm biosynthetic process metabolism hydrolase activity protein binding cell differentiation inflammatory response electron transport electron transport electron transport electron transport electron transport electron transport electron transport electron transport/oxidation reduction


Cyp3a13 Cyp3a25 Cyp3a44 Cyp4a14 Cyp4f14 Cyp7b1

Entrez Gene ID 13113 56388 337924 13119 64385 13123

D14Ertd436e

218978

D14Ertd449e D3Ucla1 D4Bwg0951e D630002G06Rik Dbp

66039 28146 52829 236293 13170

Dcun1d1

114893

Ddc

13195

Ddx3x

13205

Dgat2 Dhcr24 Dhrs1 Dio1 Dnaja1 Dnajb10 Dnajb4 Dnajb9 Dnalc4 Dscr1

67800 74754 52585 13370 15502 56812 67035 27362 54152 54720

Gene Symbol

Gene Description cytochrome P450, family 3, subfamily a, polypeptide 13 cytochrome P450, family 3, subfamily a, polypeptide 25 cytochrome P450, family 3, subfamily a, polypeptide 44 cytochrome P450, family 4, subfamily a, polypeptide 14 cytochrome P450, family 4, subfamily f, polypeptide 14 cytochrome P450, family 7, subfamily b, polypeptide 1 DNA SEGMENT, CHR 14, ERATO DOI 436, EXPRESSED Uncharacterized protein C10orf57 homolog stress-associated endoplasmic reticulum protein 1 Uncharacterized protein C9orf150 homolog RIKEN cDNA D630002G06 gene D site albumin promoter binding protein DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) dopa decarboxylase DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked diacylglycerol O-acyltransferase 2 24-dehydrocholesterol reductase dehydrogenase/reductase (SDR family) member 1 deiodinase, iodothyronine, type I DnaJ (Hsp40) homolog, subfamily A, member 1 DnaJ (Hsp40) homolog, subfamily B, member 10 DnaJ (Hsp40) homolog, subfamily B, member 4 DnaJ (Hsp40) homolog, subfamily B, member 9 dynein, axonemal, light chain 4 Down syndrome critical region homolog 1 (human)

Month 1

Month 2

Month 3

Month 6

2.29

4.50

-2.27 -2.14 7.29 -2.25 -3.50

metabolism electron transport electron transport metabolism electron transport electron transport

2.70

unknown

-2.31

membrane transport unknown transport metabolism

2.03 2.35 -2.17 -3.57 2.05 2.17

unknown -4.42

2.92

-2.01 2.24 2.12

biosynthetic process hydrolase activity

2.15 2.95 -2.43

Classification

-3.28 3.01 3.55 3.78 -2.07 4.32

metabolism response to stress metabolism biosynthetic process response to stress metabolism metabolism protein folding microtubule-based process cell development


Dst Dusp1 Ear11 Ecgf1 Ecm1 Edem2 EG13909

Entrez Gene ID 13518 19252 93726 72962 13601 108687 13909

EG193330

100039226

EG236844 EG241041 EG434674 EG624219 Egfr Eif1a Eif4ebp3 Ell2 Elmo3

236844 634856 434674 624219 13649 13664 108112 192657 234683

Elov13

12686

Elovl6 Eno1 Enpp2 Eps8l2 Es1 Es31 Esrp2

170439 103324 18606 98845 13884 382053 77411

Gene Symbol

Gene Description dystonin dual specificity phosphatase 1 eosinophil-associated, ribonuclease A family, member 11 endothelial cell growth factor 1 (platelet-derived) extracellular matrix protein 1 ER degradation enhancer, mannosidase alpha-like 2 predicted gene, EG13909 similar to eukaryotic translation initiation factor 1a,X-chromosomal similar to ribosomal protein L22 like 1 predicted gene, EG241041 predicted gene, EG434674 predicted gene, EG624219 epidermal growth factor receptor (Egfr), transcript variant 2 eukaryotic translation initiation factor 1A eukaryotic translation initiation factor 4E binding protein 3 elongation factor RNA polymerase II 2 engulfment and cell motility 3, ced-12 homolog elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 ELOVL family member 6, elongation of long chain fatty acids (yeast) enolase 1, alpha non-neuron ectonucleotide pyrophosphatase/phosphodiesterase 2 EPS8-like 2 esterase 1 esterase 31 epithelial splicing regulatory protein 2

Month 1

Month 2

Month 3

Month 6 2.09

2.73 4.88 -2.18 -2.26 -4.83 -3.16 2.05

transport cell cycle hydrolase activity metabolism transport biosynthetic process catalytic activity unknown

2.13 -2.29 -2.68 2.19 -4.13

Classification

-2.15 5.75 2.41 2.26 3.17 -2.02

-2.67

unknown unknown unknown extracellular region cell proliferation biosynthetic process biosynthetic process metabolism apoptosis metabolism

4.64 2.11

3.36

-2.63 3.61

-2.94 -2.25 -2.96 -2.55

biosynthetic process metabolism response to stress signal transduction metabolism carboxylesterase activity nucleotide binding


Ethe1 Etnk2 Ets2 Expi F13a1 Fabp1 Fabp4 Fabp5 Fahd1 Fasn Fbp1 Fbxo31 Fcgr3 Fdft1

Entrez Gene ID 66071 214253 23872 14038 74145 14080 11770 16592 68636 14104 14121 76454 14131 14137

ethylmalonic encephalopathy 1 ethanolamine kinase 2 E26 avian leukemia oncogene2, 3' domain extracellular proteinase inhibitor coagulation factor XIII, A1 subunit fatty acid binding protein 1 fatty acid binding protein 4, adipocyte fatty acid binding protein 5, epidermal fumarylacetoacetate hydrolase domain containing 1 fatty acid synthase fructose bisphosphatase 1 F-box protein 31 Fc receptor, IgG, low affinity III farnesyl diphosphate farnesyl transferase 1

Ffar2

233079

free fatty acid receptor 2

2.15

Fgb Fgf1 Fgg Fgl1 Fkbp4 Fmo1 Fmo2

110135 14164 99571 234199 14228 14261 55990

fibrinogen, B beta polypeptide fibroblast growth factor 1 fibrinogen, gamma polypeptide fibrinogen-like protein 1 FK506 binding protein 4 flavin containing monooxygenase 1 flavin containing monooxygenase 2

-2.40

Fmo3

14262

flavin containing monooxygenase 3

Fshb

14308

Gabarapl1

57436

follicle stimulating hormone beta gamma-aminobutyric acid (GABA(A)) receptor-associated protein-like 1

Gene Symbol

Gene Description

Month 1

Month 2

Month 3

Month 6

Classification

-2.52 2.59 3.31

cytoplasmic part transport metabolism enzyme inhibitor activity response to wounding transport metabolism biosynthetic process metabolism biosynthetic process metabolism unknown inflammatory response metabolism G-protein coupled receptor protein signaling pathway response to wounding cell cycle response to wounding signal transduction metabolism electron transport metabolism metabolism/oxidation reduction cell proliferation

5.41 4.89 -2.61 2.06 2.40

2.17 -2.56 -2.09

6.22 -2.80

2.88 2.73 -2.52

2.04 -3.43 2.28

2.75

2.23 -2.96 2.20 2.07

-3.27 -6.66

-2.05

cytoplasm


Gadd45a Gadd45b Gadd45g Gal3st2 Gale Galm Gas6 Gbp3 Gck Gclc Ggh Ggt6 Gm1381 GNL3 GOs2 Gpbp1 Gpd1

Entrez Gene ID 13197 17873 23882 381334 74246 319625 14456 55932 103988 14629 14590 71522 384198 30877 14373 73274 14555

growth arrest and DNA-damage-inducible 45 alpha growth arrest and DNA-damage-inducible 45 beta growth arrest and DNA-damage-inducible 45 gamma galactose-3-O-sulfotransferase 2 galactose-4-epimerase, UDP galactose mutarotase growth arrest specific 6 guanylate nucleotide binding protein 3 glucokinase glutamate-cysteine ligase, catalytic subunit gamma-glutamyl hydrolase gamma-glutamyltransferase 6 gene model 1381, (NCBI) guanine nucleotide binding protein-like 3 (nucleolar) G0/G1 switch gene 2 GC-rich promoter binding protein 1 glycerol-3-phosphate dehydrogenase 1 (soluble)

Gpr171

229323

G protein-coupled receptor 171

2.38

Gpxl

14775

glutathione peroxidase 1

-2.29

Grrp1

72690

PREDICTED: glycine

2.51

Gsta3 Gstt3 H2-Aa H2-Ab1 H2-Ea

14859 103140 14960 14961 14968

glutathione S-transferase, alpha 3 glutathione S-transferase, theta 3 histocompatibility 2, class II antigen A alpha histocompatibility 2, class II antigen A beta1 histocompatibility 2, class II antigen E alpha

Gene Symbol

Gene Description

Month 1

Month 2

Month 3

Month 6

2.19 4.92

4.49 21.94 -2.63 -2.03 -2.32

-2.03 3.98 4.03 2.36 2.15 5.00 -2.47 2.49 2.11 2.03 -2.50 2.25

-2.72 2.02 -2.02

-2.07 -2.00 3.41 2.66 2.77

Classification cell cycle apoptosis signal transduction biosynthetic process metabolism metabolism cell cycle immune response biosynthetic process response to stress metabolism metabolism unknown cell proliferation cell cycle metabolism biosynthetic process G-protein coupled receptor protein signaling pathway response to stress complement activation, classical pathway metabolism metabolism antigen processing and presentation antigen processing and presentation antigen processing and presentation

Table S2. Differentially expressed genes in the liver of mice at 1, 2, 3 and 6 months after E. multilocularis infection compared with non-infected mice. Gene Symbol

Entrez Gene ID

Gene Description

Month 1

Month 2

Month 3

Month 6

Classification antigen processing and presentation metabolism hydrolase activity metabolism transport transport inflammatory response metabolism metabolism metabolism

H2-Eb1

14969

histocompatibility 2, class II antigen E beta

3.15

Hacl1 Hagh Hao3 Hba-a1 Hbb-b1 Hc Hck Hdhd3 Hectd2

56794 14651 56185 15122 15129 15139 15162 72748 226098

-2.52

-2.85 -2.05 -2.23 2.62 3.20 2.03 2.14 -3.41

Herpud1

64209

2.14

2.37

metabolism

Hes6 Hfe2 Hhex Hist1h1c Hmgcs1 Hmox1 Hnmt Hp Hpxn Hsd17b2

55927 69585 15242 50708 208715 15368 140483 15439 15458 15486

-2.05

2.75 2.28 -2.34

metabolism lipid binding metabolism metabolism biosynthetic process metabolism intracellular inflammatory response transport metabolism

Hsd3b1

15492

-2.31

metabolism

Hsd3b3

15494

-3.37

metabolism

Hsd3b4

15495

Hsd3b5

15496

2-hydroxyacyl-CoA lyase 1 hydroxyacyl glutathione hydrolase hydroxyacid oxidase (glycolate oxidase) 3 hemoglobin alpha, adult chain 1 hemoglobin, beta adult major chain hemolytic complement hemopoietic cell kinase haloacid dehalogenase-like hydrolase domain containing 3 HECT domain containing 2 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 hairy and enhancer of split 6 (Drosophila) hemochromatosis type 2 (juvenile) (human homolog) hematopoietically expressed homeobox histone cluster 1, H1c 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 heme oxygenase (decycling) 1 histamine N-methyltransferase haptoglobin hemopexin hydroxysteroid (17-beta) dehydrogenase 2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4 (Hsd3b4), mRNA [NM_008294] hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 (Hsd3b5), mRNA [NM_008295]

-2.02

2.37 -2.66

-3.00 -2.44

2.23 2.19

2.29 2.62

-8.75

metabolism

-8.60

metabolism


Entrez Gene ID

Gene Description

Hsd3b6

15497

Hsd3b7 Hsp25-ps1

101502 15508

Hsp90aa1

15519

Hsp90ab1 Hspa1a Hspa5 Hspa8 Hspb1 Hspb8 I11r1 I17r Idh1 Ifi202b Ifi203 Ifi204 Ifrd1 Igf1

15516 193740 14828 15481 15507 80888 17082 16197 15926 26388 15950 15951 15982 16000

Igfals

16005

Igfbp1

16006

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 heat shock protein25,pseudogene1 heat shock protein 90kDa alpha (cytosolic), class A member 1 heat shock protein 90kDa alpha (cytosolic), class B member 1 Heat shock protein 1A heat shock 70kD protein 5 (glucose-regulated protein) heat shock protein 8 heat shock protein 1 heat shock protein 8 interleukin 1 receptor-like 1 interleukin 7 receptor isocitrate dehydrogenase 1 (NADP+), soluble interferon activated gene 202 interferon activated gene 203 interferon activated gene 204 interferon-related developmental regulator 1 insulin-like growth factor 1 insulin-like growth factor binding protein, acid labile subunit insulin-like growth factor binding protein 1

Igfbp4 IGK-C Iigp1 Il13ra1 Il17r

16010 16071 60440 16164 16172

insulin-like growth factor binding protein 4 immunoglobulin kappa chain,constant region interferon inducible GTPase 1 interleukin 13 receptor, alpha 1 interleukin 17 receptor D

Month 1

Month 2

Month 3

Month 6 -2.21

-2.21 2.28 3.20

-2.80

-2.14

3.03

2.41

2.41 2.03 -2.00 -2.02

cell adhesion

14.22

cell cycle immuno-response/cell growth unknown GTPase activity signal transduction signal transduction

2.58 2.92 2.25

-3.33

2.72

6.94

biosynthetic process unknown

response to stress response to stress response to stress response to stress response to stress response to stress immune response immune response metabolism immune response immune response immune response cell differentiation biosynthetic process

2.43

2.17 2.88 2.13 2.47 2.20

metabolism

response to stress

2.38 2.03 2.83 3.55

Classification

2.13 6.91 2.11 2.39 2.90


Ing4 Insig1 Itih3 Junb Keg1 Klf13 Klf3 Krt23 Krtap16-10 L3mbt12 Lat Lbp Lcn2 Lect1 Lgals1 Lgals3 Lgmn Limd2 Lpin1 Lpl

Entrez Gene ID 28019 231070 16426 16477 64697 50794 16599 94179 71369 214669 16797 16803 16819 16840 16852 16854 19141 67803 14245 16956

Lrfn3 Lrg1 Lrrc24 Lrrc28 Ltf

233067 76905 378937 67867 17002

Gene Symbol

Gene Description inhibitor of growth family, member 4 insulin induced gene 1 inter-alpha trypsin inhibitor, heavy chain 3 Jun-B oncogene kidney expressed gene 1 Kruppel-like factor 13 Kruppel-like factor 3 (basic) keratin 23 keratin associated protein 16-10 l(3)mbt-like 2 linker for activation of T cells lipopolysaccharide binding protein lipocalin 2 leukocyte cell derived chemotaxin 1 lectin, galactose binding, soluble 1 lectin, galactose binding, soluble 3 legumain LIM domain containing 2 lipin 1 lipoprotein lipase leucine rich repeat and fibronectin type III domain containing 3 leucine-rich alpha-2-glycoprotein 1 leucine rich repeat containing 24 leucine rich repeat containing 28 lactotransferrin

Month 1

Month 2

Month 3

Month 6

-2.08 2.24

-3.45 2.98

2.58 -3.31 2.71 2.81 -5.03 -3.29 -2.02 2.12

3.85 3.24

3.73 29.78 -2.30 2.02 4.11 2.35

-2.05 6.85

7.66 2.79

2.58 8.64 2.81 2.57 3.17

Classification apoptosis response to stress metabolism cell cycle cell cycle metabolism metabolism cytoskeleton intracellular part biosynthetic process immune response defense response Response to stimulus signal transduction cell development carbohydrate binding metabolism zinc ion binding metabolism metabolism protein binding Cell differentiation signal transduction protein binding transport

Table S2. Differentially expressed genes in the liver of mice at 1, 2, 3 and 6 months after E. multilocularis infection compared with non-infected mice. Gene Symbol Lum Ly6a Ly6d Lyzs Lzp-s Mad2l2

Entrez Gene ID 17022 110454 17068 17105 17110 71890

Mafb

16658

Mal2 Marcks Mat1a Mbd1 Mcart1 Mefv Mfsd2

105853 17118 11720 17190 230125 54483 76574

Mg11

17312

Mg12

216864

Midn Mir16 Mmp3 Mmp7 Mmp9 Mocs2 Mon1a Morf4l2 Mpa2l

59090 56209 17392 17393 17395 17434 72825 56397 100702

Gene Description lumican lymphocyte antigen 6 complex, locus A lymphocyte antigen 6 complex, locus D lysozyme P lysozyme structural MAD2 mitotic arrest deficient-like 2 (yeast) v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) mal, T-cell differentiation protein 2 myristoylated alanine rich protein kinase C substrate methionine adenosyltransferase I, alpha methyl-CpG binding domain protein 1 mitochondrial carrier triple repeat 1 Mediterranean fever major facilitator superfamily domain containing 2 macrophage galactose N-acetyl-galactosamine specific lectin 1 macrophage galactose N-acetyl-galactosamine specific lectin 2 midnolin membrane interacting protein of RGS16 matrix metallopeptidase 3 matrix metallopeptidase 7 matrix metallopeptidase 9 molybdenum cofactor synthesis 2 MON1 homolog A (yeast) mortality factor 4 like 2 macrophage activation 2 like

Month 1

Month 2

Month 3

Month 6

2.06 2.46 4.42 2.14 -2.23

2.38 2.50

cell differentiation

2.12 3.80 2.08

protein binding calmodulin binding metabolism metabolism transport response to wounding transport

2.09

2.69 2.50

protein binding defense response extracellular space defense response defense response cell cycle

3.22 2.53

2.56

Classification

7.76

2.56

carbohydrate binding

4.64

carbohydrate binding 3.23 2.17

3.34 4.05 2.74 -2.01 -2.07 2.01 -2.33

3.99

metabolism metabolism metabolism metabolism immune response biosynthetic process transport cell cycle GTP binding


Mpeg1

Entrez Gene ID 17476

Mrps22

64655

mitochondrial ribosomal protein S22

Msr1 Msr2 Mt1 Mt2 MUP1 Mup2 Mup4 Mup5 Nat3 Nat8b Ncf1 Ndrg4 Nfil3 Nnmt Npc1 Npr2 Nr0b2 Nrg4 Nrn1 Nsbp1 Nsdhl

20288 80891 17748 17750 17840 17841 17843 17844 17962 434057 17969 234593 18030 18113 18145 230103 23957 83961 68404 50887 18194

macrophage scavenger receptor 1 macrophage scavenger receptor 2 metallothionein 1 metallothionein 2 major urinary protein 1 major urinary protein 2 major urinary protein 4 major urinary protein 5 N-acetyltransferase 3 similar to putative N-acetyltransferase camello1 neutrophil cytosolic factor 1 N-myc downstream regulated gene 4 nuclear factor, interleukin 3, regulated nicotinamide N-methyltransferase Niemann Pick type C1 natriuretic peptide receptor 2 nuclear receptor subfamily 0, group B, member 2 neuregulin 4 neuritin 1 nucleosome binding protein1 NAD(P) dependent steroid dehydrogenase-like

Nsg1

18196

neuron specific gene family member 1

Nsmce1

67711

non-SMC element 1 homolog (S. cerevisiae)

Gene Symbol

Gene Description

Month 1

Month 2

Month 3

Month 6

Classification

macrophage expressed gene1

2.38 -2.03

signal transduction structural molecule activity transport signal transduction Response to stimulus Response to stimulus transport transport transport transport metabolism unknown response to wounding development metabolism cytoplasm metabolism biosynthetic process metabolism cell growth cell differentiation metabolism biosynthetic process G-protein coupled receptor protein signaling pathway response to stress

2.11 2.25 58.26 25.51 -7.01 -6.73 -5.68 -5.04 -2.23 -2.25 2.26 2.04 2.76 2.73

3.40 2.13 -2.39 -2.18 3.88 -2.53 2.50

2.12 -3.41 -2.11


Entrez Gene ID

Gene Description

Month 1

Month 2

Month 3

Month 6

Classification

Nudt7

67528

odc1 OLFML1

18263 244198

nudix (nucleoside diphosphate linked moiety X)-type motif 7 ornithine decarboxylase, structural 1 olfactomedin-like1

Olfr1215

258451

olfactory receptor 1215

Olfr2 Oprs1 Orm1

18317 18391 18405

olfactory receptor 2 opioid receptor, sigma 1 orosomucoid 1

2.49

Orm2 Osbp13 Osgin1 OTTMUSG000000 16571 Pbx1 Pcdh1 Pck1 Pcsk9 Pde9a Pdlim3

18406 71720 71839

orosomucoid 2 oxysterol binding protein-like 3 oxidative stress induced growth inhibitor 1

2.67

433520

similar to zinc finger protein 97

2.66

nucleic acid binding

18514 75599 18534 100102 18585 53318

pre B-cell leukemia transcription factor 1 protocadherin 1 phosphoenolpyruvate carboxykinase 1, cytosolic proprotein convertase subtilisin/kexin type 9 phosphodiesterase 9A PDZ and LIM domain 3

2.19 -2.25

Pex11a

18631

peroxisomal biogenesis factor 11a

Pglyrp1

21946

peptidoglycan recognition protein 1

Picalm Pira3

233489 18726

2.33

Pla2g7

27226

2.57

inflammatory response

Pltp Pmvk Pnkd

18830 68603 56695

phosphatidylinositol binding clathrin assembly protein paired-Ig-like receptor A3 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) phospholipid transfer protein phosphomevalonate kinase paroxysmal nonkinesiogenic dyskinesia

immune response metabolism metabolism response to stress signal transduction protein binding peroxisome organization and biogenesis response to external stimulus immune response signal transducer activity

2.08 -2.50 -2.20

transport metabolism hydrolase activity

-2.78 2.20 -2.34 -2.53 3.24 -2.47 2.61 8.94

2.02 -2.13

3.57 -2.29

2.43 -2.05 -2.47

2.58 2.06 3.30 2.01

-3.22

metabolism biosynthetic process unknown G-protein coupled receptor protein signaling pathway signal transduction metabolism inflammatory response immuno-response/respons e to stress metabolism cell growth

Table S2. Differentially expressed genes in the liver of mice at 1, 2, 3 and 6 months after E. multilocularis infection compared with non-infected mice. Entrez Gene Symbol Gene Description Month 1 Month 2 Month 3 Month 6 Classification Gene ID Pnrc1 108767 proline-rich nuclear receptor coactivator 1 2.12 receptor activity Por 18984 P450 (cytochrome) oxidoreductase 3.23 electron transport Ppara 19013 peroxisome proliferator activated peceptor alpha 2.17 metabolism protein tyrosine phosphatase, receptor-type, F interacting -2.25 metabolism Ppfibp2 19024 protein, binding protein 2 Ppp1r14c 76142 protein phosphatase 1, regulatory (inhibitor) subunit 14c -3.16 enzyme inhibitor activity Ppp1r3c 53412 protein phosphatase 1, regulatory (inhibitor) subunit 3C -4.06 transport protein phosphatase 2, regulatory subunit B (B56), epsilon Ppp2r5e 26932 2.05 signal transduction isoform Pqlc2 212555 PQ loop repeat containing 2 -2.06 unknown Prepl 213760 prolyl endopeptidase-like 2.71 metabolism proteoglycan 4 (megakaryocyte stimulating factor, articular Prg4 96875 2.52 extracellular space superficial zone protein) Prkcq 18761 protein kinase C, theta -3.22 Signal transduction Prnd 26434 prion protein dublet 2.42 3.78 metabolism Pros1 19128 protein S (alpha) 2.29 response to stress Prss8 76560 protease, serine, 8 (prostasin) 2.14 metabolism Psen2 19165 presenilin 2 -2.59 cell death Pter 19212 phosphotriesterase related -2.13 metabolism Ptgds 19215 prostaglandin D2 synthase -3.11 metabolism G-protein coupled receptor Ptgir 19222 prostaglandin I receptor (IP) 5.13 protein signaling pathway Ptp4a1 19243 protein tyrosine phosphatase 4a1 2.07 cell migration Ptp4a1 627166 protein tyrosine phosphatase 4a1 2.08 cell cycle Ptpn1 19246 protein tyrosine phosphatase, non-receptor type 1 2.32 signal transduction Ptpn7 320139 protein tyrosine phosphatase, non-receptor type 7 2.65 cytoplasm Ptprz1 19283 protein tyrosine phosphatase, receptor type Z, polypeptide 1 -2.86 metabolism Qdpr 110391 quinoid dihydropteridine reductase -2.06 biosynthetic process Rab11fip1 75767 RAB11 family interacting protein 1 (class I) -2.29 transport

Table S2. Differentially expressed genes in the liver of mice at 1, 2, 3 and 6 months after E. multilocularis infection compared with non-infected mice. Gene Symbol Rac2 Ranbp2 Rap1b Rasgef1b

Entrez Gene ID 19354 19386 215449 320292

Gene Description

Month 1

Month 2

Month 3

RAS-related C3 botulinum substrate 2 RAN binding protein 2 RAS related protein 1b gpi-gamma4

2.16 2.05 3.40

Month 6

Classification

2.29

signal transduction metabolism signal transduction signal transduction response to temperature stimulus metabolism transport metabolism receptor binding signal transduction G-protein coupled receptor protein signaling pathway catalytic activity metabolism metabolism

3.48

Rbm3

19652

RNA binding motif protein 3

Rbp1 Rbp4 Rdh9 Retnla Rgs16

19659 19662 103142 57262 19734

retinol binding protein 1, cellular retinol binding protein 4, plasma retinol dehydrogenase 9 resistin like alpha regulator of G-protein signaling 16

Rgs18

64214

regulator of G-protein signaling 18

2.02

Rik3r5 Rnf125 Rnf13

320207 67664 24017

2.20

RP23-34B24.1 Rpl30 Rpl5 Rplp1 Rxrg S100a4 Saa1 Saa3 Saa4 Samhd1 Sat1

230161 19946 19983 56040 20183 20198 20208 20210 20211 56045 20229

phosphoinositide-3-kinase, regulatory subunit 5, p101 ring finger protein 125 ring finger protein 13 similar to bile acid coenzyme A:aminoacid N-acyltransferase ribosomal protein L30 ribosomal protein L5 ribosomal protein, large, P1 retinoid X receptor gamma S100 calcium binding protein A4 serum amyloid A 1 serum amyloid A 3 serum amyloid A 4 SAM domain and HD domain, 1 spermidine/spermine N1-acetyl transferase 1

2.37 -2.44 2.81 43.12 -2.13

2.25

3.23

-2.81 2.13 2.10 2.01 2.01 -2.08 -2.02 3.88 11.63 9.69 2.32 2.16 2.40

metabolism biosynthetic process biosynthetic process biosynthetic process transcription protein binding inflammatory response inflammatory response inflammatory response signal transduction metabolism

Table S2. Differentially expressed genes in the liver of mice at 1, 2, 3 and 6 months after E. multilocularis infection compared with non-infected mice. Entrez Gene Symbol Gene Description Month 1 Month 2 Month 3 Month 6 Classification Gene ID sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) Sc5d 235293 -3.33 metabolism homolog (S. cerevisae) Scd1 20249 stearoyl-Coenzyme A desaturase 1 3.54 2.35 biosynthetic process Sdc1 20969 syndecan 1 2.18 cytoskeleton Sdc3 20970 syndecan 3 2.67 cytoskeleton Sdpr 20324 serum deprivation response 2.65 protein binding Sdro 70061 orphan short chain dehydrogenase/reductase -2.39 metabolism Sds 231691 serine dehydratase 3.82 metabolism Selenbp1 20341 selenium binding protein 1 -2.37 transport cDNA fis, clone TRACH3033868, highly similar to Homo Sema3g 218877 2.74 cell differentiation sapiens semaphorin sem2 Senp1 223870 SUMO1/sentrin specific peptidase 1 -2.52 hydrolase activity Sepp1 20363 selenoprotein P, plasma, 1 -2.62 metabolism serine (or cysteine) peptidase inhibitor, clade A, member Serpina3h 546546 2.89 hydrolase activity 3H serine (or cysteine) peptidase inhibitor, clade A, member Serpina3k 20714 -3.38 immune response 3K serine (or cysteine) peptidase inhibitor, clade A, member Serpina3n 20716 3.12 inflammatory response 3N serine (or cysteine) peptidase inhibitor, clade A (alpha-1 Serpina7 331535 6.75 3.49 enzyme regulator activity antiproteinase, antitrypsin), member 7 Serpinald 20703 serine (or cysteine) peptidase inhibitor, clade A, member 1d -4.57 enzyme inhibitor activity serine (or cysteine) peptidase inhibitor, clade C Serpinc1 11905 -2.21 response to wounding (antithrombin), member 1 Setd4 224440 SET domain containing 4 -2.25 intracellular part Sfrs10 20462 splicing factor, arginine/serine-rich 10 2.72 metabolism Sfrs2 20382 splicing factor, arginine/serine-rich 2 (SC-35) 2.15 metabolism Sfrs5 20384 splicing factor, arginine/serine-rich 5 (SRp40, HRS) -2.82 metabolism Sh3bgrl 56726 sh3-binding domain glutamic acid-rich protein like 2.04 nucleus Shmt1 20425 serine hydroxymethyl transferase 1 (soluble) -2.97 metabolism solute carrier family 10 (sodium/bile acid cotransporter Slc10a1 20493 -2.12 transport family), member 1 Slc12a1 20495 solute carrier family 12, member 1 -3.84 transport

Table S2. Differentially expressed genes in the liver of mice at 1, 2, 3 and 6 months after E. multilocularis infection compared with non-infected mice. Entrez Gene Symbol Gene Description Month 1 Month 2 Month 3 Month 6 Classification Gene ID solute carrier family 22 (organic anion transporter), Slc22a7 108114 -2.64 transport member 7 solute carrier family 25 (mitochondrial carrier, glutamate), Slc25a22 68267 3.12 transport member 22 solute carrier family 25 (mitochondrial carrier, phosphate 2.05 Slc25a25 227731 carrier), member 25 2.06 transport solute carrier family 2 (facilitated glucose transporter), 2.00 transport Slc2a6 227659 member 6 Slc3a1 20532 solute carrier family 3, member 1 3.30 transport Slc45a3 212980 solute carrier family 45, member 3 4.08 transport Slpi 20568 secretory leukocyte peptidase inhibitor 3.12 hydrolase activity Socs3 12702 suppressor of cytokine signaling 3 3.97 metabolism Spbc24 67629 spindle pole body component 24 homolog (S. cerevisiae) -2.60 cell cycle Sponl 233744 spondin 1, (f-spondin) extracellular matrix protein 2.15 protein binding Spp1 20750 secreted phosphoprotein 1 3.54 immune response Sqle 20775 squalene epoxidase 2.29 metabolism Srebf1 20787 sterol regulatory element binding factor 1 -2.51 response to stress Srgn 19073 serglycin 3.40 2.63 2.34 apoptosis Srp54 24067 signal recognition particle 54 2.52 GTP binding Srp9 27058 signal recognition particle 9 2.06 biosynthetic process St3gal5 20454 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.62 metabolism Stab1 192187 stabilin 1 2.04 inflammatory response Steap4 117167 STEAP family member 4 2.75 2.66 6.08 oxidation reduction Stip1 20867 stress-induced phosphoprotein 1 2.72 response to stress Stra6 20897 stimulated by retinoic acid gene 6 -2.03 transport Strn3 94186 striatin, calmodulin binding protein 3 2.28 cell cycle Sucnr1 84112 succinate receptor 1 -11.40 signal transduction Sult1c2 69083 sulfotransferase family, cytosolic, 1C, member 2 -2.39 metabolism Sult1d1 53315 sulfotransferase family 1D, member 1 4.01 metabolism


Sult3a1 Sult5al Synj2bp Tardbp Tat Tfb2m Tff3 Tgfb1i4 Tgtp Thra Thrsp Tieg1 Tjp3 Tk1

Entrez Gene ID 57430 57429 24071 230908 234724 15278 21786 21807 21822 21833 21835 21847 27375 21877

Tmed5

73130

Tmem150 Tmem176b Tnfaip8l1 Tnmt Tppp3 Trf

232086 65963 66443 21743 67971 22041

Trp53inp1

60599

Tsc22d3 Tspan4 Ttc23

14605 64540 67009

Gene Symbol

Gene Description sulfotransferase family 3A, member 1 sulfotransferase family 5A, member 1 synaptojanin 2 binding protein TAR DNA binding protein tyrosine aminotransferase transcription factor B2, mitochondrial trefoil factor 3, intestinal TSC22 domain family,member1 T-cell specific GTPase thyroid hormone receptor alpha thyroid hormone responsive SPOT14 homolog (Rattus) kruppel-like factor 10 tight junction protein 3 thymidine kinase 1 transmembrane emp24 protein transport domain containing 5 transmembrane protein 150 transmembrane protein 176B tumor necrosis factor, alpha-induced protein 8-like 1 indolethylamine N-methyltransferase RIKEN cDNA 2700055K07 gene transferrin transformation related protein 53 inducible nuclear protein 1 TSC22 domain family 3 tetraspanin 4 tetratricopeptide repeat domain 23

Month 1

Month 2

Month 3

Month 6 -7.20

-4.09

3.06 -2.11 -2.14

catalytic activity catalytic activity transport metabolism biosynthetic process metabolism Secreted metabolism inflammatory response metabolism nucleus cell differentiation protein binding metabolism

2.08

2.32

transport

-2.44 2.13

protein binding cell differentiation unknown methyltransferase activity unknown transport

-5.74

2.38

2.28 2.03 4.16

2.05 -6.43

5.91 -3.20 2.79 -2.44 2.29

2.00 -2.14

-2.54 2.47 -2.27 5.41 2.18 2.59

Classification

3.38

apoptosis

2.07

apoptosis cytoplasm binding

2.20

Table S2. Differentially expressed genes in the liver of mice at 1, 2, 3 and 6 months after E. multilocularis infection compared with non-infected mice. Gene Symbol Tuba2 Tuba4a Tuba6 Tubb2a Tubb2c Tubb2c-ps1 Ubd Ube3a Ucp2 UGT1A10 Ugt1a5 Ugt2a3 Ugt2b1 Ugt2b37 Ulk1 Unc84b Upp2 Vbp1 Vcam1 Vill Vim Wasl Wdr33 Wdr81 Wfdc1

Entrez Gene ID 22143 22145 22146 22151 227613 100042651 24108 22215 22228 394430 394433 72094 71773 112417 22241 223697 76654 22327 22329 22349 22352 73178 74320 192652 67866

Gene Description tubulin, alpha 2 tubulin, alpha 4 tubulin, alpha 6 tubulin, beta 2a tubulin, beta 2c tubulin, beta 2c, pseudogene 1 ubiquitin D ubiquitin protein ligase E3A uncoupling protein 2 (mitochondrial, proton carrier) UDP glucuronosyltransferase 1 family, polypeptide A10 udp glucuronosyltransferase1 family,polypeptide a5 UDP glucuronosyltransferase 2 family, polypeptide A3 UDP glucuronosyltransferase 2 family, polypeptide B1 UDP glucuronosyltransferase 2 family, polypeptide B37 Unc-51 like kinase 1 (C. elegans) unc-84 homolog B (C. elegans) uridine phosphorylase 2 von Hippel-Lindau binding protein 1 vascular cell adhesion molecule 1 villin 1 vimentin Wiskott-Aldrich syndrome-like (human) WD repeat domain 33 WD repeat domain 81 WAP four-disulfide core domain 1

Month 1

Month 2

Month 3

2.06

Month 6 -2.40 -2.32 -2.56 -2.29

2.76 3.69 2.60

-2.64 2.26

3.07 2.10

2.52

2.81 2.12 2.67

2.98 -2.90 -2.59 -2.48 -2.30 -2.46 2.96 2.45 2.42 4.54

2.68 2.21 2.09 -2.02 -2.16 -2.01

Classification cytoskeleton transport cytoskeleton cytoskeleton cytoskeleton transport metabolism metabolism transport metabolism metabolism metabolism metabolism metabolism cell development membrane metabolism protein folding protein binding metabolism cytoplasm metabolism transport metabolism defense response


Wwp1 Ypel3

Entrez Gene ID 107568 66090

Ywhag Zbp1 Zc3h6 Zfp36l1 Zfp97

22628 58203 78751 12192 22759

Gene Symbol

Gene Description WW domain containing E3 ubiquitin protein ligase 1 yippee-like 3 (Drosophila) 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide Z-DNA binding protein 1 zinc finger CCCH type containing 6 zinc finger protein 36, C3H type-like 1 zinc finger protein 97

Month 1

Month 2

Month 3

Month 6

2.37

immune response unknown

-2.00 2.32 2.05 -2.48 2.09 2.32

Classification

2.23

developmental process hydrolase activity hemopoiesis biosynthetic process metabolism