Table S2. Incomplete truth tables (ITTs) in model M2. - PLOS

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Table S2. Incomplete truth tables (ITTs) in model M2. - PLOS

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jnk * erk * p90rsk â jnkerkp90rskd c-Fos jnkerkp90rskd Â· !pp2a â cfos p90rsk * erk12 â p90rskerk12d. Sos1 !p90rskerk12d Â· grb2 Â· sos1r â sos1. MKK4.

Table S2. Incomplete truth tables (ITTs) in model M2. All gates from model M1 (see Table S1.2) that point into nodes given in column 1 (nodes) are replaced by the interactions given in column 2. ITT gates are denoted with *, AND gates with ·. Nodes endocyt_degrad RN-tre Rac/Cdc42 Raf1 p70s6 kinase (autoinhibitory domain) CREB c-Fos Sos1 MKK4 p38 Gsk3 BAD PKC MEK1/2

interactions ccbl * rab5a → endocyt_degrad erbb11 * eps8r → rntre sos1_eps8_e3b1 * vav2 → rac_cdc42 pak1 * csrc → pak1crscd !aktd · pak1csrcd · ras → raf1 jnk * erk → p70s6_1 p90rsk * mk2 → creb jnk * erk * p90rsk → jnkerkp90rskd jnkerkp90rskd · !pp2a → cfos p90rsk * erk12 → p90rskerk12d !p90rskerk12d · grb2 · sos1r → sos1 mekk1 * mekk4 * mlk3 → mkk4 mkk4 * mkk3 * mkk6 → p38 !akt * !p90rsk → gsk3 !akt * !pak1 → bad dag * ca → dagcad dagcad · pdk1 → pkc raf1 * mekk1 → mek12