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Table S4: Fold changes in transcript abundance of ...

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Prmt1. 0.19*. 1.14. Prmt6. 0.18*. 1.08. Dot1l. 0.14*. 0.67. HP. Aurkb. 0.47. 18.45*. Aurka. 0.53. 8.16*. HU. NONE. NONE. NONE. SET. Setd5. 0.29*. 1.15. Setd3.

Table S4: Fold changes in transcript abundance of chromatin-modifying enzymes at 3 days after anesthesia only or after anesthesia and needle injury Gene Group DHD DM HA

HD HM

HP HU SET

Genes Kdm5c Kdm6b NONE Csrp2bp Ncoa6 Esco2 NONE Suv39h1 Prmt1 Prmt6 Dot1l Aurkb Aurka NONE Setd5 Setd3

3dA 0.19* 0.14* NONE 0.25* 0.23* NS NONE 0.24* 0.19* 0.18* 0.14* 0.47 0.53 NONE 0.29* 0.28*

3dAN 0.95 0.92 NONE 1.16 0.61 10.12* NONE 1.61 1.14 1.08 0.67 18.45* 8.16* NONE 1.15 0.79

*Biological significance in single pools relative to un-injured. No statistical evaluation was possible. Groups: DHD (DNA/Histone Demethylases), DM (DNA Methyltransferases), HA (Histone Acetyltransferases), HD (Histone Deacetylases), HM (Histone Methyltransferases), HP (Histone Phosphorylation), HU (Histone Ubiquitination), SET (SET Domain Proteins; Histone Methyltransferase Activity)