Table S5. clusterig results - PLOS

Table S5. Results of the tests for clustering of the phenotype genes. See the main text for a description of the three tests Mod, Ini, and Rwr. whole network size [ Nodes / Edges ]

all

hprd

physical

[ 11,530 / 98,634 ]

[ 9,303 / 34,998 ]

[ 10,475 / 51,974 ]

[ 236 / 399 ]

[ 212 / 120 ]

[ 225 / 184 ]

Mod

< 1 10

< 1 10

-16 < 1 10

Ini Rwr degeneration

< 0.001 < 0.001

< 0.001 < 0.001

< 0.001 < 0.001

p-values

Mod p-values

Ini Rwr abnormal foliation

-16

[ 39 / 10 ]

-16

[ 34 / 2 ] -7

[ 38 / 4 ]

3 10

0.092

0.006

0.003 0.002

0.066 0.199

0.008 0.085

[ 55 / 47 ]

[ 49 / 15 ] -16

[ 52 / 21 ] -13

Mod

< 1 10

1 10

Ini Rwr abnormal vermis

< 0.001 < 0.001

< 0.001 < 0.001

p-values

Mod p-values

Ini Rwr absent cerebellum

[ 24 / 17 ]

[ 21 / 4 ] -16

3 10

< 0.001 < 0.001

< 0.001 0.184 [9 /0]

-16

< 0.001 < 0.001 [ 22 / 5 ]

-5

< 1 10

[ 10 / 13 ]

-16 < 1 10

3 10-6 < 0.001 0.27 [9 /1]

Mod

< 1 10

N/A

0.028

Ini Rwr small cerebellum

< 0.001 < 0.001

1 1

0.03 0.081

p-values

p-values

[ 60 / 20 ] -16

[ 64 / 27 ]

Mod

< 1 10

< 1 10

-16 < 1 10

Ini Rwr

< 0.001 < 0.001

< 0.001 < 0.001

< 0.001 < 0.001

ataxia p-values

[ 68 / 54 ]

[ 165 / 176 ] -16

-16

[ 149 / 49 ]

[ 157 / 84 ] -16

Mod

< 1 10

1 10

Ini Rwr

< 0.001 < 0.001

< 0.001 < 0.001

-16 < 1 10

< 0.001 < 0.001