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[email protected] Anti-Cancer Agents in Medicinal Chemistry, 2016, 16(6),781-786
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Tannic Acid Inhibits Proliferation, Migration, Invasion of Prostate Cancer and Modulates Drug Metabolizing and Antioxidant Enzymes Serdar Karakurt1,* and Orhan Adali2 1 Department of Biochemistry, Faculty of Science, Selcuk University, Konya, Turkey; 2Department of Biological Sciences, Middle East Technical University, Ankara, Turkey
Abstract: The aim of this study was to investigate the effects of plant phenolic compound tannic acid (TA) on Please provide proliferative, metastatic, invasive properties of prostate cancer (PCa) cells; PC-3 and LNCaP, as well as drug corresponding author(s) metabolizing and antioxidant enzymes. Characterization of TA was done by using FT-IR and NMR. TA dose photograph dependently inhibited the proliferation of PC-3 and LNCaP cells with IC50 values 35.3 M and 29.1 M, size should be 4" x 4" inches respectively. Wound healing assay showed that TA significantly inhibited (92.7%) migration of PCa cells (p
