Dec 20, 2013 ... Identification of sampling area for the US Survey. - PinC: Tamarozzi (UNIPV),
Akhan (HUSMDR), Cretu. (CCHUMFCD), Vutova (SHATIPD).
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TASKS ALLOCATION of
ULTRASOUND SCREENING and CE NATIONAL REGISTRIES - WP1 Task 1.1: Survey statistical assessment: - Delivery of the sampling methodology for the US Survey - PinC: Pezzotti, Vescio (ISS) - Due date: 01/02/2014 - Identification of sampling area for the US Survey - PinC: Tamarozzi (UNIPV), Akhan (HUSMDR), Cretu (CCHUMFCD), Vutova (SHATIPD) - Due date: 01/05/2014
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Task 1.2: Ultrasound Survey:
WP1
- Survey protocol agreement comprising: Ethics approvals, Informed consent, Questionnaire (in English) - PinC: Tamarozzi & Brunetti (UNIPV) - Due date: 01/02/2014 - Translation of the Survey protocol and Ethics approvals - PinC: Akhan (Turkish), Cretu (Romanian), Vutova (Bulgarian) - Due date: 01/03/2014 - Submission of protocol to local Ethic committee - PinC: PinC: Akhan (HUSMDR), Cretu (CCHUMFCD), Vutova (SHATIPD) - Due date: 01/04/2014
Task 1.2: Ultrasound Survey:
WP1
- Pre Survey Logistic agreement (flowchart of participants in the field) - PinC: Tamarozzi & Brunetti (UNIPV) - Due date: 01/02/2014 - Pre Survey arrangements (Turkey, Romania, Bulgaria) - PinC: Akhan (HUSMDR), Cretu (CCHUMFCD), Vutova (SHATIPD) - Due date: 01/05/2014 - Start the US survey - PinC: Tamarozzi (UNIPV), Akhan (Turkey), Cretu (Romania) Vutova (Bulgaria) - Start date: 01/06/2014 -
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WP1 Task 1.3: Human sample collection (WP2, Task 2.1): - Start collection after protocol agreement - PinC: Siles (CSIC) - Start date: 01/02/14 Task 1.4: CEE registries: Database development (WP2, Task 2.2)
- EE registry - PinC: Galati, Rossi, Di Benedetto (ISS), Tamarozzi (UNIPV) - Start date: 01/10/14 -
NEW MOLECULAR-BASED TOOLS – WP2
Task 2.1: Sample Repository: - Protocols for collection, storage and treatment of samples - PinC: Siles (CSIC) - Due date: 01/02/14
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Task 2.2: Database development:
WP2
- Databases structure (human and samples) based on RIEC (English) - PinC: Galati, Rossi (ISS) - Due date: 01/05/14 - Databases translation (Bulgarian, Romanian and Turkish) - PinC: Akhan (HUSMDR), Cretu (CCHUMFCD), Vutova (SHATIPD) - Due date: 01/07/14 From WP1, Task 1.4: - CEE registry - Start date: 01/10/14 -
WP2 Task 2.3: Production and testing recombinant antigens: - ELISA protocol - PinC: Siles (CSIC) - Due date: 01/02/2014 - Antigens testing in ELISA - PinC: Siles (CSIC), Cortes (VIRCELL) - Due date: 01/07/2014 - Production of selected antigens in automated fermentor - PinC: Siles (CSIC) - Due date: 01/12/2015
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WP2 Task 2.4: Development of POC-LOC devices: -Antigens testing in POC/LOC kits - PinC: Cortes (VIRCELL) - Start date: 01/02/2016 - POC-LOC devices, resulting in a pre-commercial product - PinC: Cortes (VIRCELL) - Due date: 01/07/2017
WP3 Task 3.2: HLA class I and II polymorphisms: - PinC: Martinetti (UNIPV); - Due date: 01/07/2016 Task 3.3: KIR gene polymorphisms: - PinC: Martinetti (UNIPV); - Due date: 01/12/2016
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HOST-PARASITE INTERPLAY – WP3 Task 3.4: HLA-G polymorphism: - PinC: Martinetti (UNIPV) - Due date: 01/07/2016 Task 3.5: Proteomic analysis: - PinC: Martinetti (UNIPV) - Due date: 01/12/2016
HOST-PARASITE INTERPLAY – WP3 Task 3.1: Genotypic characterization: - PinC: Casulli (ISS) - Due date: 01/07/2016 Task 3.6: Transcriptome analysis: -PinC: Ponzi (ISS) - Due date: 01/07/2017
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BIOAVAILABILITY of ABZ and ENANTIOMERIC DRUG SYNTHESIS – WP4 Task 4.1: Animal sample collection (WP2, Task 2.1): - PinC: Vural (Pendik) - Start date: 01/02/2014 -
WP4 Task 4.2: Parasite collection and drug formulations: - Parasite protocols: storage, viability evaluation, genotyping, protoscoleces inoculation - PinC: Vural (Pendik) - Due date: 01/02/2014 - Drug protocols: ABZ, HP-βCD, ABZ enantiomers - PinC: Vural (Pendik), Gomez (ISS) - Due date: 01/02/2014
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WP4
Task 4.3: Experimental design in the animal model: - Protocol for animal model - PinC: Vural (Pendik) - Due date: 01/03/2014 - Protoscoleces inoculation - PinC: Vural (Pendik) - Start date: 01/04/2014 -
WP4 Task 4.4: Necropsy and sample collection: - PinC: Vural (Penvik) - First Due date: 12 months after parasite inoculation Task 4.5: Pharmacokinetics and Toxicology: - Pharmacokinetics - PinC: Gallinella, Cirilli (ISS) - Due date: 01/03/2016 - Toxicology - PinC: Maranghi (ISS) - Due date: 01/03/2016
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EFFICENTLY!
TOGETHER!
ORGANIZATION!
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