Feb 18, 2016 - Temporal profiles of blood pressure, circulating nitric oxide, and adrenomedullin as predictors of clinical outcome in acute ischemic stroke ...
MOLECULAR MEDICINE REPORTS 13: 3724-3734 2016
3724
Temporal profiles of blood pressure, circulating nitric oxide, and adrenomedullin as predictors of clinical outcome in acute ischemic stroke patients MARTA SERRANO‑PONZ1, CARMEN RODRIGO‑GASQUÉ2, EVA SILES3, ESTHER MARTÍNEZ‑LARA3, LAURA OCHOA‑CALLEJERO4 and ALFREDO MARTÍNEZ4 1
Stroke Unit, Neurology Service; 2Radiology Unit, Hospital San Pedro, 26006 Logroño; 3Experimental Biology Department, University of Jaén, 23071 Jaén; 4Angiogenesis Group, Oncology Area, Center for Biomedical Research of La Rioja (CIBIR), 26006 Logroño, Spain Received December 3, 2015; Accepted February 18, 2016 DOI: 10.3892/mmr.2016.5001 Abstract. Stroke remains an important health and social challenge. The present study investigated whether blood pressure (BP) parameters and circulating levels of nitric oxide metabolites (NOx) and adrenomedullin (AM) may predict clinical outcomes of stroke. Patients (n=76) diagnosed with acute ischemic stroke were admitted to the stroke unit and clinical history data and monitored parameters were recorded. Blood plasma was collected at days 1, 2, and 7 to measure NOx and AM levels. Infarct volume, neurological severity [on the National Institutes of Health Stroke Scale (NIHSS)], and functional prognosis (on the Rankin scale) were measured as clinical outcomes. Patients with higher BP had more severe symptoms (NIHSS >3; P
