Testicular serous carcinoma of ovarian epithelial type

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Nov 1, 2016 - psammoma bodies nor hobnail cells in the pathology of our case. The diagnosis of low-grade serous carcinoma was confirmed based on ...
Accepted Manuscript Testicular serous carcinoma of ovarian epithelial type: A case report and review of the literature Chang-Hong Yeh, Pin-Pen Hsieh, Shyh-Jer Lin, Ying-Chung Hong, Tsung-Hsien Tsai, Lennex Hsueh-Lin Yu, Ming-Sun Yu PII:

S2311-3006(16)30128-8

DOI:

10.1016/j.jcrpr.2016.11.003

Reference:

JCRPR 44

To appear in:

Journal of Cancer Research and Practice

Received Date: 20 July 2016 Revised Date:

1 November 2016

Accepted Date: 14 November 2016

Please cite this article as: Yeh CH, Hsieh PP, Lin SJ, Hong YC, Tsai TH, Hsueh-Lin Yu L, Yu MS, Testicular serous carcinoma of ovarian epithelial type: A case report and review of the literature, Journal of Cancer Research and Practice (2016), doi: 10.1016/j.jcrpr.2016.11.003. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

ACCEPTED MANUSCRIPT

Testicular Serous Carcinoma of Ovarian Epithelial Type: A Case Report and Review of the Literature

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Chang-Hong Yeha, Pin-Pen Hsiehb, Shyh-Jer Lina, Ying-Chung Honga, Tsung-Hsien Tsaia, Lennex Hsueh-Lin Yuc, Ming-Sun Yua a

Hematology / Oncology Division, Department of Medicine, Kaohsiung Veteran General Hospital, Kaohsiung, Taiwan

b

SC

Department of Pathology & Laboratory Medicine, Kaohsiung Veteran General Hospital, Kaohsiung, Taiwan c Department of Anatomy and Medical Imaging, The University of Auckland, Auckland,

M AN U

New Zealand

Keywords: Serous; Papillary carcinoma; Testis. Abstract

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Epithelial tumor has been the most common group of ovarian neoplasia found in women. Ovarian epithelial tumors are extremely rare in the testicular

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and para-testicular tissue of men, though benign, borderline and malignant neoplasia have been reported.(1,

2)

However, no uniform consensus exists regarding the

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histogenesis, immunohistochemistry in pathological diagnosis, clinical behavior of the tumors, the role of chemotherapy, and prognosis due to the scarcity of the neoplasm. To date, no recommended guidelines have been circulated for treatment of ovarian epithelial tumors. Although infrequently reported in the Taiwanese medical literature, we report a case of low-grade serous papillary carcinoma of the ovarian epithelial-type in the testis, and review the English medical literature.

ACCEPTED MANUSCRIPT

Testicular Serous Carcinoma of Ovarian Epithelial-Type:

Keywords: Serous; Papillary carcinoma; Testis. Abstract

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A Case Report and Review of the Literature

SC

Epithelial tumor has been the most common group of ovarian neoplasia found in women. Ovarian epithelial tumors are extremely rare in the testicular

have been reported.(1,

2)

M AN U

and para-testicular tissue of men, though benign, borderline and malignant neoplasia However, no uniform consensus exists regarding the

histogenesis, immunohistochemistry in pathological diagnosis, clinical behavior of the tumors, the role of chemotherapy, and prognosis due to the scarcity of the

TE D

neoplasm. To date, no recommended guidelines have been circulated for treatment of ovarian epithelial tumors. Although infrequently reported in the Taiwanese medical literature, we report a case of low-grade serous papillary carcinoma of the

EP

ovarian epithelial-type in the testis, and review the English medical literature.

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Introduction

The most common scrotal pathology is primary testicular tumor, with an incidence of 5.4 cases per 100,000 men based on the US database.(3) Although solid testicular masses should first be considered as germ cell tumor until proven otherwise, other uncommon pathologies should not be neglected for purposes of differential diagnosis. These pathologies include ectopic tissue, metastasis, and other neoplastic growths. The spectrum of pathology of suchneoplasia includes serous, mucinous, endometrioid, and clear cell carcinoma.(1, 2) These ovarian-type epithelial

ACCEPTED MANUSCRIPT tumors usually occur in young and middle-aged adults. The mean age of patients with borderline serous neoplasm is 56 years (range 14-77 years), and 31 years for invasive tumor (range 16-42 years), respectively.(1, 4, 5) There has been considerably less data regarding the very rare ovarian-type surface epithelial tumor of the testis

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and para-testicular tissue. The most commonly reported are serous tumors, with the majority of the cases being the borderline-type.(2, 6, 7) However, serous tumors of the testis and para-testicular tissue remain rare, with only about 50 cases reported in the

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Case Presentation

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medical literature to date.(1, 6, 8)

A 63-year-old man presented with right scrotal swelling of 3 weeks duration. Physical examination showed a firm tender lump in the right scrotum. The left testis was normal and there was no palpable lymphadenopathy in the groin. The patient’s chest

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film was clear, and his abdominal CAT scan was unremarkable except that the pelvic part showed a multi-lobular cyst with an intramural component in the right scrotum suggestive of testicular tumor. Serum LDH level was high with 320 U/dL

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(normal range < 213 U/dL) whilst serum level of AFP 5.8 ng/ml (normal range < 10 ng/ml), and beta-HCG