Nov 1, 2016 - psammoma bodies nor hobnail cells in the pathology of our case. The diagnosis of low-grade serous carcinoma was confirmed based on ...
Accepted Manuscript Testicular serous carcinoma of ovarian epithelial type: A case report and review of the literature Chang-Hong Yeh, Pin-Pen Hsieh, Shyh-Jer Lin, Ying-Chung Hong, Tsung-Hsien Tsai, Lennex Hsueh-Lin Yu, Ming-Sun Yu PII:
S2311-3006(16)30128-8
DOI:
10.1016/j.jcrpr.2016.11.003
Reference:
JCRPR 44
To appear in:
Journal of Cancer Research and Practice
Received Date: 20 July 2016 Revised Date:
1 November 2016
Accepted Date: 14 November 2016
Please cite this article as: Yeh CH, Hsieh PP, Lin SJ, Hong YC, Tsai TH, Hsueh-Lin Yu L, Yu MS, Testicular serous carcinoma of ovarian epithelial type: A case report and review of the literature, Journal of Cancer Research and Practice (2016), doi: 10.1016/j.jcrpr.2016.11.003. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Testicular Serous Carcinoma of Ovarian Epithelial Type: A Case Report and Review of the Literature
RI PT
Chang-Hong Yeha, Pin-Pen Hsiehb, Shyh-Jer Lina, Ying-Chung Honga, Tsung-Hsien Tsaia, Lennex Hsueh-Lin Yuc, Ming-Sun Yua a
Hematology / Oncology Division, Department of Medicine, Kaohsiung Veteran General Hospital, Kaohsiung, Taiwan
b
SC
Department of Pathology & Laboratory Medicine, Kaohsiung Veteran General Hospital, Kaohsiung, Taiwan c Department of Anatomy and Medical Imaging, The University of Auckland, Auckland,
M AN U
New Zealand
Keywords: Serous; Papillary carcinoma; Testis. Abstract
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Epithelial tumor has been the most common group of ovarian neoplasia found in women. Ovarian epithelial tumors are extremely rare in the testicular
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and para-testicular tissue of men, though benign, borderline and malignant neoplasia have been reported.(1,
2)
However, no uniform consensus exists regarding the
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histogenesis, immunohistochemistry in pathological diagnosis, clinical behavior of the tumors, the role of chemotherapy, and prognosis due to the scarcity of the neoplasm. To date, no recommended guidelines have been circulated for treatment of ovarian epithelial tumors. Although infrequently reported in the Taiwanese medical literature, we report a case of low-grade serous papillary carcinoma of the ovarian epithelial-type in the testis, and review the English medical literature.
ACCEPTED MANUSCRIPT
Testicular Serous Carcinoma of Ovarian Epithelial-Type:
Keywords: Serous; Papillary carcinoma; Testis. Abstract
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A Case Report and Review of the Literature
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Epithelial tumor has been the most common group of ovarian neoplasia found in women. Ovarian epithelial tumors are extremely rare in the testicular
have been reported.(1,
2)
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and para-testicular tissue of men, though benign, borderline and malignant neoplasia However, no uniform consensus exists regarding the
histogenesis, immunohistochemistry in pathological diagnosis, clinical behavior of the tumors, the role of chemotherapy, and prognosis due to the scarcity of the
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neoplasm. To date, no recommended guidelines have been circulated for treatment of ovarian epithelial tumors. Although infrequently reported in the Taiwanese medical literature, we report a case of low-grade serous papillary carcinoma of the
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ovarian epithelial-type in the testis, and review the English medical literature.
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Introduction
The most common scrotal pathology is primary testicular tumor, with an incidence of 5.4 cases per 100,000 men based on the US database.(3) Although solid testicular masses should first be considered as germ cell tumor until proven otherwise, other uncommon pathologies should not be neglected for purposes of differential diagnosis. These pathologies include ectopic tissue, metastasis, and other neoplastic growths. The spectrum of pathology of suchneoplasia includes serous, mucinous, endometrioid, and clear cell carcinoma.(1, 2) These ovarian-type epithelial
ACCEPTED MANUSCRIPT tumors usually occur in young and middle-aged adults. The mean age of patients with borderline serous neoplasm is 56 years (range 14-77 years), and 31 years for invasive tumor (range 16-42 years), respectively.(1, 4, 5) There has been considerably less data regarding the very rare ovarian-type surface epithelial tumor of the testis
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and para-testicular tissue. The most commonly reported are serous tumors, with the majority of the cases being the borderline-type.(2, 6, 7) However, serous tumors of the testis and para-testicular tissue remain rare, with only about 50 cases reported in the
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Case Presentation
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medical literature to date.(1, 6, 8)
A 63-year-old man presented with right scrotal swelling of 3 weeks duration. Physical examination showed a firm tender lump in the right scrotum. The left testis was normal and there was no palpable lymphadenopathy in the groin. The patient’s chest
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film was clear, and his abdominal CAT scan was unremarkable except that the pelvic part showed a multi-lobular cyst with an intramural component in the right scrotum suggestive of testicular tumor. Serum LDH level was high with 320 U/dL
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(normal range < 213 U/dL) whilst serum level of AFP 5.8 ng/ml (normal range < 10 ng/ml), and beta-HCG
