PERIODICUM BIOLOGORUM VOL. 116, No 4, 417–424, 2014
UDC 57:61 CODEN PDBIAD ISSN 0031-5362
Original scientific paper
Testing tumor type dependent relations between expression of ER and PgR with Ki-67 values in a single series of 1180 invasive ductal cancer patients Sven Kurbel1 Branko Dmitrović2 Ksenija Marjanović2 Branka Kristek3 1
ept. of Internal Medicine, School of Medicine, D Osijek, Croatia
2
ept. of Pathology and Forensic Medicine, D School of Medicine, Osijek, Croatia
3
ept. of Radiology, School of Medicine, D Osijek, Croatia
Correspondence: Branka Kristek MD, PhD School of Medicine J Huttlera 4, 31000 Osijek, Croatia E-mail:
[email protected]
Abstract Background: Model of cancer-associated epigenetic changes (Kurbel S. Tumour Biol. 2013;34:2011-7) proposes that dysfunctional estrogen receptors (ER), unable to adequately express progesterone receptors (PgR), beside in the ER+PgR – breast cancers might also be present in ER+PgR+ tumors showing weak PgR expression. Methods: In 1180 patients with invasive ductal cancers, ER and PgR positivity were semiquantitatively classified in four groups: “0” means no positive cells; “1+”
