The Critical Role Of VP1 In Forming The ... - Semantic Scholar

The Critical Role Of VP1 In Forming The Necessary Cavities For Receptor-mediated Entry Of FMDV To The Host Cell Jahanshah Ashkani*, D.J.G Rees Agricultural

Research

Council,

Onderstepoort, 0110, South Africa ∗Corresponding

author

Email: [email protected] Tel: +27(0)216503982

Supplementary Figures Figures 1S – 3S Supplementary Tables Table 1S

Biotechnology

Platform,

Private

Bag

X5,

Supplementary Figures Figure 1S: Multiple sequence alignment (MSA) illustrations of the evolutionary conservation profile of VP1 calculated by ConSurf-DB1. Amino acid sequences similar to VP1 sequence in the 2WZR PDB (2WZR1) are retrieved and aligned using CSI-BLAST2,3 and MAFFT4, respectively. The MSA is coloured by evolutionarily conservation scores calculated for each residue using an empirical Bayesian inference in Rate4Site5. Figure 2S: Multiple sequence alignment (MSA) illustrations of the evolutionary conservation profile of VP2 calculated by ConSurf-DB1. Amino acid sequences similar to VP2 sequence in the 2WZR PDB (2WZR2) are retrieved and aligned using CSI-BLAST2,3 and MAFFT4, respectively. The MSA is coloured by evolutionarily conservation scores calculated for each residue using an empirical Bayesian inference in Rate4Site5. Figure 3S: Multiple sequence alignment (MSA) illustrations of the evolutionary conservation profile of VP3 calculated by ConSurf-DB1. Amino acid sequences similar to VP3 sequence in the 2WZR PDB (2WZR3) are retrieved and aligned using CSI-BLAST2,3 and MAFFT4, respectively. The MSA is coloured by evolutionarily conservation scores calculated for each residue using an empirical Bayesian inference in Rate4Site5.

ConSurf-DB Color-Coded MSA

http://bental.tau.ac.il/new_ConSurfDB/DB/2WZR/1/color_msa.html

Figure 1S

ConSurf-DB Color-Coded MSA 2WZR1 UniRef90_Q6PMU0_725_943 UniRef90_F1AW55_725_943 UniRef90_A0PG93_1_219 UniRef90_A0PG86_1_219 UniRef90_A0PG77_1_219 UniRef90_Q6PMU2_725_943 UniRef90_Q8V0G8_526_744 UniRef90_A0PG80_1_219 UniRef90_Q8BDT2_1_218 UniRef90_A0PG94_1_219 UniRef90_C8YS70_1_219 UniRef90_Q6PMT8_726_934 UniRef90_Q6PMT3_724_939 UniRef90_B8Y0J7_726_934 UniRef90_E2IU95_1_209 UniRef90_Q80JY0_1_209 UniRef90_A0PFY2_1_209 UniRef90_Q80K03_1_209 UniRef90_Q1L757_525_734 UniRef90_Q80K16_1_209 UniRef90_Q1L752_527_735 UniRef90_A0PG17_1_209 UniRef90_Q80JY2_1_209 UniRef90_Q80JY8_1_209 UniRef90_Q8JVD0_525_739 UniRef90_Q80JU2_1_209 UniRef90_A0PFY7_1_209 UniRef90_A0PFY4_1_209 UniRef90_Q80JZ5_1_205 UniRef90_A0PFZ0_1_209 UniRef90_Q1L748_525_740 UniRef90_Q80JY7_1_209 UniRef90_A0PG12_1_209 UniRef90_A0PFY8_1_209 UniRef90_Q80JZ1_1_209 UniRef90_Q80JU1_1_209 UniRef90_B2MZR9_1_211 UniRef90_P49303_726_936 UniRef90_Q2I5Z0_71_281 UniRef90_Q9DJ49_1_212 UniRef90_A1EBZ1_1_211 UniRef90_A1EBZ4_1_211 UniRef90_I0AZ32_1_211 UniRef90_A8D5K4_1_211 UniRef90_Q2I5X3_80_290 UniRef90_I0AYZ5_1_211 UniRef90_I0AZ39_1_210 UniRef90_H9T7U2_127_337 UniRef90_Q9DJF9_1_211 UniRef90_I0AYY0_1_211 UniRef90_Q2I5X1_23_232 UniRef90_B2ZHQ6_1_211 UniRef90_A4ZPM0_1_211 UniRef90_E7D638_1_210 UniRef90_Q8JUM5_1_211 UniRef90_Q8BED5_1_209 UniRef90_A0ZXF2_1_211 UniRef90_F1BVI2_1_211 UniRef90_I0AYX9_1_210 UniRef90_I0AZ13_1_211 UniRef90_A4ZPL8_1_211 UniRef90_Q6PMY9_724_932 UniRef90_Q8JUP6_1_211 UniRef90_B1A0W6_1_210 UniRef90_C0LRW1_1_211 UniRef90_Q8JUN6_1_211 UniRef90_A1EC01_1_211 UniRef90_A2I8Z5_725_935

1 of 16

TTSAGEGA--DPV-TTDASAHGGDT-RTTRRAHTDVTFLLDRFTLVGKTN TTSAGEGA--EPV-TTDASQHGGDR-RTARRYHTDVSFLLDRFTLVGRTQ TTSAGEGA--EPV-TTDATQHGGHS-RRTRRHHTDVSFLLDRFTLIGKTT TTSAGEGA--EPV-TTDASQHGGTS-RRVRRQHTDVSFLLDRFTLIGKTH TTSAGEGA--DVV-TVDAAAHGGNQ-RRTRRVHTDVAFLLDRFTLVGKTQ TTSAGEGA--DPV-TTDATQHGGGR-RTARRHHTDVSFLLDRFTLVGKTQ TTSAGEGA--DVV-TVDATVHGGNQ-RRTRRVHTDVAFLLDRFTLVGKTQ TTSAGEGA--EPV-TTDASQHGGNA-RPTRRYHTNVEFLLDRFTLIGKTH TTSAGEGA--EPV-TTDASQHGGGR-RAARRQHTDVSFLLDRFTLVGKTV TTSAGEGA--DVV-TXDASAHGGNT-RPTRRVHTDVAFLLDRFTLVGKTV TTSAGEGA--DVV-TVDATAHGGTQ-RATRRVHTDVAFLLDRFTLVGKTV TTSAGEGA--EVV-STDATAHGGNR-RRARRVHTDVAFLLDRFTLIGKTV TTSAGEGA--EVV-TTDPSTHGGQV-KEKRRMHTDVAFVLDRFTHV-HTN TTSAGEGA--DVV-TTDVTTHGGEV-SVPRRQHTNVEFLLDRFTHVGKVN TTSAGEGA--DVV-TTDPSTHGGAV-REGSRKHTEVAFLLDRSTHV-HTN TTSAGEGA--DVV-TTDPSTHGGSV-VEKRRMHTDVAFVLDRFTHV-HTN TTSSGEGA--DVI-TTDPSTHGGSV-VEKRRMHTDVAFVLDRFTHV-HTN TTSAGEGA--DVV-TTDPSTHGGNV-QEGRRKHTEVAFLLDRSTHV-HTN TTTAGEGA--DVV-TSDPSTHGGQV-SEKRRMHTDVTXVLDRFTHV-HTN TTSAGEGA--DVV-TTDPSTHGGVVDTKKRRWHTDVSFVMDRATHV-HTN TTSAGEGA--DVV-TTDPTTHGGSV-QTPRRVHTDVAFLLDRSTHV-FTD TTSAGESA--DVV-TTDPTTHGGAV-TNPRRKHTDVAFLLDRSTHV-HTG TTSAGEGA--DVV-TTDPTTHGGSV-RNPRRIHTDVTFLLDRSTHV-HTN TTSAGEGA--DVV-TTDPTTHGGHP-NAARRKHTDIAFLLDRSTHV-HTN TTSSGEGA--DVV-TTDPSTHGGAV-TEKRRMHTDVAFVMDRFTHV-LTD TTSAGEGG--DVV-TTDVTTHGGAV-DTPRRQHTNVEFLLDRFTHIGTIT TTSAGEGA--DVV-TTDPTTHGGAV-ANPRRKHTDVSFLLDRSTHV-HTG TTSAGEGA--DVV-TIDPTTHGGSV-TPARRIHTDVAFLLDRSTHV-HTN TTSAGEGA--DVV-TTDPSTHGGNV-LEKRRMHTDVAFVLDRFTHV-HTS TTSAGEGA--DVV-TTVPSTHGGRV-VEKRRMHTDVAFVLDRFTHV-HTS TTSAGEGA--DVV-TTDPTTHGGTV-TAARRVHTDVAFLLDRSTHV-HTN TTSSGEGA--DVV-STTVETHGGTE-QVARRQHTDVAFLLDRFTHIGSMA TTSAGEGA--DVV-TTDPSTHGGVV-VEKRRMHTDVAFVMDRFTHV-LTD TTSAGEGA--EVV-TTDPTTHGGSV-GAPRRVHTDVAFLLDRSTHV-HTQ TTSASEGA--DVI-TTGPATHGGTE-GTARRIHTDVAFLLDRSTHV-HTN TTSAGEGA--DVV-TTDPSTHGGSV-IEKRXMHTDVALXLDRFTHV-HTN TTSAGEGA--DVV-TTDPSTHGGAV-TSVKRKHTEVAFVMDRFTHV-HTN TTSTGESA--DPV-TTAVEYYGGET-QIQRRQHTDVSFIMDRFVNIDSLTTSTGESA--DPV-TTTVENYGGET-QVQRRQHTDVTFIMDRFVKIQNLTTSTGESA--DPV-TATVENYGGET-QVQRRQHTDVSFILDRFAKVTP-V TTSAGESA--DPV-TATVENYGGET-QVQRRQHTDVSFILDRFVKVTPTN TTTAGESA--DPV-STTVENYGGET-QAQRRQHTDVSFIMDRFVRINAVTTSAGESA--DPV-TTTVENYGGET-QVQRRHHTDVGFIMDRFVKIGNTTTATGESA--DPV-TTTVENYGGET-QVQRRHHTDIGFIMDRFVKITRTTTSTGESA--DPV-TATVENYGGET-QVQRRQHTDVSFILDRFVKVTP-K TTSAGESA--DPV-TTTVENYGGET-QVQRRHHTDVGFIMDRFVKINNTTTATGESA--DPV-TTTVENYGGET-QTQRRQHTDVGFIMDRFVKIDQQTTATGESA--DPV-TTTVENYGGET-QVQRRHHTDVSFILDRFVKISTQTTSVGESA--DPV-TATVENYGGET-QVQRRQHTDVAFILDRFVKVTP-K TTSAGESA--DPV-TTTVENYGGET-QVQRRQHTDVXIILDRFVKVTP-K TTATGESA--DPV-TTTVENYGGET-QVQRRQHTDIGFIMDRFVKIKDPTTTAGESA--DPV-TTTVENYGGET-QVQRRHHTDVHFIMDRFVKISPTTTSTGESA--DPV-TATVENYGGET-QVQRRHHTDVSFILDRFVKVTP-Q TTATGESA--DPV-TTTVENYGGET-QVRRRQHTDVSFIMDRFVKINSPTTTTGESA--DPV-TTTVENYGGET-QVQRRRHTDVSFIMDRFVQIKPATTTAGESA--DPV-TTTVENYGGET-QDQRRQHTDVSFIMDRFVKVNTVTTTTGESA--DPV-TTTVENYGGET-QTARRLHTDVAFVLDRFVKLTAPTTSTGESA--DPV-TSTVENYGGET-QVQRRHHTDVAFILDRFVKVTP-K TTTVGESA--DPV-TTTVENYGGET-QIQRRHHTDVGLIMDRFVKIGTTTTAVGESA--DPV-TTTVENYGGET-QTQRRQHTDTGFIMDRFVKISPQTTATGESA--DPV-TTTVENYGGET-QVQRRHHTDIGFIMDRFVKIKDLTTATGESA--DPV-TTTVENYGGET-QVQRRHHTDVGFIMDRFVKVNSSTTTAGESA--DPV-TTTVENYGGET-QAARRLHTDVAFVLDRFVKLTQPTTTTGESA--DPV-TTTVENYGGET-QVQRRKHTDVGFVLDRFVKINSITTATRESA--DPV-TTTVENYGGET-QTRRRQHTDVDFIMDRFVKISPVTTTTGESA--DPV-TTTVENYGGET-QAQRRHHTDISFIMDRFVKVNAVTTTAGESA--DPV-TTTVENYGGET-QVQRRHHTDVSFIMDRFVKISTVTTLTGESA--DPV-TTTVENYGGET-QVQRRHHTDVSFILDRFVKINNPTTSAGESA--DPV-TATVENYGSET-QVQRRQHTDVTFILDRFVKVKP-K

2016/02/23, 3:09 PM


UniRef90_B1A0W7_1_211 UniRef90_Q9DJ38_1_212 UniRef90_A1EC10_1_211 UniRef90_E2FZV2_1_211 UniRef90_I0AYY6_1_211 UniRef90_A7XPU3_1_209 UniRef90_Q999Y2_1_211 UniRef90_B2MZR8_1_211 UniRef90_A1EC03_1_211 UniRef90_Q8BEA7_1_208 UniRef90_C0LYR0_1_209 UniRef90_C0LS35_1_211 UniRef90_I0AZ16_1_210 UniRef90_A4ZPP1_1_210 UniRef90_A0ZXC4_1_211 UniRef90_Q8JUS6_1_211 UniRef90_A1EC12_1_211 UniRef90_F6KYM9_1_211 UniRef90_B1A0X1_1_211 UniRef90_I0AZ19_1_211 UniRef90_Q912K6_1_211 UniRef90_A4ZPL9_1_211 UniRef90_Q9YPW9_1_211 UniRef90_A1EC13_1_211 UniRef90_B2MZQ3_1_211 UniRef90_E2J011_1_211 UniRef90_I0AZ31_1_211 UniRef90_D7RFC4_1_211 UniRef90_E2IZY3_1_211 UniRef90_Q9DJ33_1_211 UniRef90_Q9DJ21_1_192 UniRef90_Q0PV54_36_239 UniRef90_C8YS67_1_209 UniRef90_F6KYY3_1_211 UniRef90_B1A0W4_1_211 UniRef90_B3FHW7_1_211 UniRef90_A0ZXB5_1_211 UniRef90_A1EBZ3_1_211 UniRef90_Q9DJA4_1_210 UniRef90_Q0QED4_407_613 UniRef90_Q8JUU0_1_211 UniRef90_Q9DJF0_19_211 UniRef90_I0AZ37_1_211 UniRef90_Q67462_1_211 UniRef90_I0AZ36_1_211 UniRef90_Q91EM4_1_211 UniRef90_Q0PV56_33_229 UniRef90_C0LYW2_1_209 UniRef90_B2MZX2_1_207 UniRef90_Q01124_1_209 UniRef90_E2J004_1_192 UniRef90_Q8JUL9_1_209 UniRef90_Q6X5M0_1_179 UniRef90_Q2I5Y3_113_321 UniRef90_Q01121_1_189 UniRef90_Q6X5M1_1_179 UniRef90_A3RGT7_2_181 UniRef90_P03310_11_218 UniRef90_B3FHW2_1_211 UniRef90_Q8JUM1_1_211 UniRef90_Q65051_1_200 UniRef90_Q8JUL2_2_187 UniRef90_B2BF63_11_200 UniRef90_Q0PV58_32_197 UniRef90_Q65102_9_211 UniRef90_Q8BED3_1_210 UniRef90_A0PG53_1_160 UniRef90_B3FHW0_1_211 UniRef90_B3FHV9_1_211 UniRef90_B3FHV8_1_211 UniRef90_A0PG60_5_160 UniRef90_Q91NQ7_2_163 UniRef90_B3FHV6_1_211

2 of 16


TTTAGESA--DPV-TTTVENYGGET-QAQRRQHTDVGFIMDRFVKINPVTTSAGESA--DPV-TATVENYGGET-QVRRRQHTDVSFILDRFVKVTPKA TTSAGESA--EPV-TTTVEDYGGET-QVQRRHHTDVSFIMDRFVKIGTTTTSPGESA--DPV-TATVENYGGET-QIQRRQHTDVSFILDRFVKVTP-Q TTATGESA--DPV-TTTVENYGGET-QIQRRHHTDIGFIMDRFVKIAPLTTTTGESA--DPV-TTTVENYGGET-QAARRLHTDVAFVLDRFVKLTQPTSASGESV--DPV-TTTVENYGGET-QVQRRHHTDVGFIMDRFVKINSPTTDTGESA--DPV-TTTVENYGGET-QVQRRHHTDIGFIMDRFVKIKXVTTSAGESA--DPV-TTTVENYGGET-QAQRRHHTDVSFIMDRFVKIDAATTTAGESA--DPV-TTTVENYGGET-QSARRIHTDVAFVLDRFVKLT-PTTTTGESA--DPV-TTTVEDYGGET-QTARRLHTDVSFVLDRFVKLTRPTTTTGGSA--DPV-TTTVGNYGGET-QVQRRHHTDVGFIMDRFVKIYYTTTATGESA--DPV-TTAVENYGGET-QTQRRHHTDVSFIMDRFVKIQNPTTATGESA--DPV-TTTVENYGGET-QAQRRHNTDVSFIMDRFVRIKPVTTATGXXX--DPV-TTTVENYGGET-QVQRRHHTDVGFIMDRFVKINSPTTTAGESA--DPV-TTTVENYGGET-QAQRRHHTDVSFIMDRFVKVNTVTTSAGESA--EPV-TTTVEDYGGET-QVQRRHHTDVSFIMDRFVKNWTTTTSAGESA--DPV-TSTVENYGGET-QVQRRHHTDVSFIMDRFVKVTP-T TTATGESA--DPV-TTTVENFGGET-QARRRQHTDVGFIMDRFVKINPVTTATGESA--DPV-TTTVENYGGET-QVQKRHHTDIGFIMDRFVKVSALTTATGESA--DPV-TTTVENYGGET-QVQRRHHTXVGFIMDRFVKINXVTTAAGESA--DPV-TTTVENYGGET-QVQRRHHTSVGFILDRFVKVNNPTTSAGESA--DPV-TATVENYGGET-QVQRRQHTDISFILDRFVKVTP-K TTSGGESP--DPV-TTTVENYGGET-QAQRRHHTDVSFIMDRFVKIGTITTSAGESA--YPV-TTTVENYGGET-QIQRRQHTDVSFIMDRFVKVTP-Q TTSPGESA--DPV-TATVENYGGET-QVQRRQHTDVSFILDRFVKVTP-Q TTATGESA--DPV-TTTVENYGGET-QVQRRHHTDVGFIMDRFVKIKDTTTSRSSQA--DPV-SATVENYGGET-QVQRRHHTDVSFILDRFVKVTP-Q TTCPGESA--GPV-NATVEKTGGAT-QVQRRQHTDVSFILDRFVKVTP-Q TTSPGESA--DPV-TATVENYGGET-QXXRRQHTDXXXXLDRFVKVTP-X TTSAGESA--DPV-TTTVENYGAET-QVQRRQHTDVXFILDRFVKVTPXE TTATGESA--DPI-TTTVENYGGET-QPRRRQHTDVGFIMDRFVKINPVTTTTGESA--DPV-TTTVENYGGET-QVQRRHHTDVAFILDRFVRAQVATTSAGESA--DPV-TATVENYGGET-QIQRRQHTDVSFIMDRFVKVTP-K TTATGESA--DPV-TTTVENYGGET-QAQGGQHTDVGFIMDRFVKISPKTTTAGESA--DPV-TTTVENYGGET-QVQRRHHTDVGFIMDRFVKIGNTTTATGXSA--DPV-TTTVENYGGET-QVQRRHHTDVGFIMDRFVKVTTTTTSAGEIL--DHR-VPTVENYGGET-QAQRRQHTDVSFIMDRFVRINAVTTSLGESA--XPV-TATVENYGGAT-XVQRRQHTDVSFILDRFVKITP-Q TTTTGESA--DPV-ITTVENYGGET-QVQRRHHTDVAFVLDRFVEVTVSTTATGESA--DPV-TTTVENYGGET-QVQRRQHTDVGFIMDRFVKINSL---------------------GGXT-QGXRRQHTDVXFILDRFVKVTP-K TTATGESA--DPV-TTTVGNYGGET-QTQRRHHTDIGFIMDRFVKINSLTTSMGESA--DPV-TATVENYGGDT-QVQRRQHTDVSFIMDRFVKVTP-Q TTATGESA--DPV-TTTVENYGGET-QTQRRHHTDIGFIMDRFVKITSLTPXTGESA--DPV-TATVENYGGXT-QVXRRQHTDVAXIXDRFVXVTP-X TTATGESA--DPV-TTTVENYGGET-QVRRRQHTDVSFIMDRFVKIKPVTTTAGESA--DPV-TTTVENYGGET-QTARRLHTDVAFVLDRFVKLTQPTTTAGESA--DPG-TTTVENYGGET-QVQRRHHTDVAFVLDRFVKVQVSTTTTXXSA--DPV-TTTVENYGGET-QVQRRHHTDVAFVLDRFVKVPVSG TTSPGQSV--DPV-TATVENYGGAT-QVQRAQPTDVSFILDTFVKVTP-Q TTATGESA--DPV-TTTVENYGGET-QVQRRHHTDVGFIMDRFVKINSLTTATGESA--DPV-TTTVENYGGET-QVQRRHHTDVSFIMDRFVKINSPTTSAGESA--DPV-TTTVENYGGET-QVQRRHHTDVGFIMDRFVKINNTTTATGESA--DPV-TTTVENYGGET-QVQRRHHTDVAXVLDRFVKVKASTTATGESA--DPV-TTTVENYGGET-QVQRRHHTDIAFIMDRFVKIESL----------------------------------DVSFIMDRFVKINPVTTTTGESA--DPV-TTTVENYGGET-QIQRRHHTDVAFVLDRFVKVHVSTTSTFESA--DPL-TTTVDNYGGKT-QTRRRQHTDVSFMLDRFVKLTP-N TTTAGESA--DPV-TTTVENYGGET-QAQRRHHTDVSFIMDRFVKVNTV------------V-TTTXENYGGET-QTQRRHHTDVGFTMDRFVKINSL-----------------------------RRQHTDVTFIMDRFVKVNHV----RRSR--DAS-TRMSRSY------------------WDRFVKVTP-K TTATGESA--DPV-TTTVENYGGET-QVRRRQHTDVSFIMDRFVKINPV----------DPV-TATVENYGGDT-QVQRRQHTDVSFIMDRFVKVTP-Q TTTTGESA--DPV-TTTVENYGGET-QTARRLHTDVAFVLDRFVKLTAP-------------------------------------------------TTSTGESA--DPV-ATTVKNYGGKT-QVHRRQHVYVPFILDRFVKVTP-N TTSTGESA--DPV-ATTVKNYGGKT-QIRRGQHAYASFIRDRFVKLTP-R TTSTGESA--EPA-ATTVENYGGKT-NIRRRQHTYAFFIMDRLVKLTP-H --------------------------------------------------------------------------------------------------TTSTGESA--DPL-ATTVDNYGGKT-QNRRRQHTYASFIMDRFVTLTP-N

2016/02/23, 3:09 PM


3 of 16


UniRef90_B3FHV7_1_211 UniRef90_A0PG54_1_160 UniRef90_B3FHW1_1_211 UniRef90_Q65068_1_206 UniRef90_Q9YPF0_1_208 UniRef90_Q8BEF3_1_209 UniRef90_B3FHV4_1_211 UniRef90_Q8JUN9_1_211 UniRef90_Q9YPG1_1_165 UniRef90_A0PG23_5_162 UniRef90_Q9DJ61_1_156 UniRef90_Q65097_1_206 UniRef90_Q01126_1_208 UniRef90_Q67461_13_173 UniRef90_Q00280_54_209 UniRef90_H9AY35_719_926

TTSTGESA--DPV-ATTVENYGGKA-HIRRGQHAYAFFIRDRFVKLTP-R -------------------------------------------------TTSTGESA--DPV-ATTVKNYGGKT-QIRRRQHAYASFMRDRFVKLTP-N TTATGXSA--DPV-XTTVENYGXET-QVQRRHHTDVAXVLDRFVKVTVSTTTTGXSA--DPX-XTTVENYGGET-QVQRRHXXDVAFVLDRFVKVHVSD TTTTGESA--DPVTTTTVENYGGET-QXXXXXXXXVAFVLDRFVKLTTPTTSTGESA--EPA-ATTVENYGGKA-HIGMGQHADVSFIMDRFVKLTP-R TTTAGESA--DPV-TTTVENYGGET-QAQRRHHTDVSFIMDRFVKVNTV-TAXGESA--DPV-XTTVENYGGDT-QTQRRHHTDVXFIMDRFVKXNSL--------------------------------------------------------------------------------------------------TTTTGXSA--XPV-TTTVENYGGET-QVQRRHHTDVAXVLDRFVKVTVSTTTTGESA--DPX-TTTVEXYGGET-QVQXRYHTXXXXXXXXXXKIPVSD --------------------------------------------------------------------------------------------------TTDVGESGVGH---DATPEQLGGTT-GPAFRSHTEVSWVLDRYALAAKVN

2WZR1 UniRef90_Q6PMU0_725_943 UniRef90_F1AW55_725_943 UniRef90_A0PG93_1_219 UniRef90_A0PG86_1_219 UniRef90_A0PG77_1_219 UniRef90_Q6PMU2_725_943 UniRef90_Q8V0G8_526_744 UniRef90_A0PG80_1_219 UniRef90_Q8BDT2_1_218 UniRef90_A0PG94_1_219 UniRef90_C8YS70_1_219 UniRef90_Q6PMT8_726_934 UniRef90_Q6PMT3_724_939 UniRef90_B8Y0J7_726_934 UniRef90_E2IU95_1_209 UniRef90_Q80JY0_1_209 UniRef90_A0PFY2_1_209 UniRef90_Q80K03_1_209 UniRef90_Q1L757_525_734 UniRef90_Q80K16_1_209 UniRef90_Q1L752_527_735 UniRef90_A0PG17_1_209 UniRef90_Q80JY2_1_209 UniRef90_Q80JY8_1_209 UniRef90_Q8JVD0_525_739 UniRef90_Q80JU2_1_209 UniRef90_A0PFY7_1_209 UniRef90_A0PFY4_1_209 UniRef90_Q80JZ5_1_205 UniRef90_A0PFZ0_1_209 UniRef90_Q1L748_525_740 UniRef90_Q80JY7_1_209 UniRef90_A0PG12_1_209 UniRef90_A0PFY8_1_209 UniRef90_Q80JZ1_1_209 UniRef90_Q80JU1_1_209 UniRef90_B2MZR9_1_211 UniRef90_P49303_726_936 UniRef90_Q2I5Z0_71_281 UniRef90_Q9DJ49_1_212 UniRef90_A1EBZ1_1_211 UniRef90_A1EBZ4_1_211 UniRef90_I0AZ32_1_211 UniRef90_A8D5K4_1_211 UniRef90_Q2I5X3_80_290 UniRef90_I0AYZ5_1_211 UniRef90_I0AZ39_1_210 UniRef90_H9T7U2_127_337 UniRef90_Q9DJF9_1_211 UniRef90_I0AYY0_1_211 UniRef90_Q2I5X1_23_232 UniRef90_B2ZHQ6_1_211

D--------------NKLVLDLLSTKEKSLVGALLRAA-TYYFSDLEVAC N--------------CRLTLDLLQTKEKALVGAILRAA-TYYFSDLEVAC D--------------NKIVLDLLQTREKALVGAILRSA-TYYFSDLEVAC D--------------NKLVLDLLQTKEKALVGAILRSA-TYYFSDLEVAC D--------------NKMVLDMLKTKEKALVGAILRAA-TYYFSDLEVAC N--------------NRLTLDLLQTKEKALVGAILRAA-TYYFSDLEVAC D--------------NRMVLDMLKTKEKALVGAILRSA-TYYFADLEVAC N--------------NKMVLDMLRTEKKALVGAILRSA-TYYFSDLEVAC N--------------NKLTLDLLKTKEKALVGAILRSA-TYYFADLEVAC D--------------NKMVLDLLKTKEKALVGAVLRSA-TYYFSDLEVAC D--------------NKMVLDMLQTKKKALVGAILRSA-TYYFADLEVAC N--------------NKMVLDLLKTKEKALVGAILRSA-TYYFSDLEVAC K--------------TTFNVDLMDTKEKTLVGALLRAS-TYYFCDLEIAC E--------------SR-TISLMDTKEHTLVGAILRSA-TYYFCDLEVAI K--------------TSFAVDLMDTKEGALVGAILRAS-TYYFCDLEIAC K--------------TTFNVDLMNTKQQTLVGALLRAS-TYYFCDLEIAC K--------------TSFVVDLMDTNERTLVGALLRAS-TYYFCDLEIAC K--------------TSFVVDLMDTKKKALVGAILRAS-TYYFCDLEIAC K--------------TSFNVDLMDTKDKALVGALLRAS-TYYFCDLEIAC K--------------TTFAVDLLDTKDKTLVGALLRAT-TYYFADLEIAC K--------------TSFAVDLMDTKEKALVGAILRSA-TYYFCDLEIAC K--------------TTFEVNLMDTKEKALVGAVLRAA-TYYFCDLEIAC K--------------TSFAVDLMDTKEKALVGAILRSA-THYFCDLEIAC K--------------TSFAVDLMDTKEKALVGAVLRSA-TYYFCDLEVAC K--------------TAFAVDLMDTNEKTLIGALLRAA-TYYFCDLEIAC G--------------SK-TIDLMDTKEHTLVGAILRSV-TYYFCDLEVAV K--------------TTFEVNLMDTKEKALVGAVLRAA-TYYFCDLEITC K--------------TTFNIDLMDTKEKALVGAILRSA-TYYFCDLEIAC K--------------TTFNVDLMDTKQHALVGALLRAS-TYYFCDLEITC K--------------TTFNVDLMDTKEKTLVGALLRAS-TYYFCDLEIAC K--------------TTFAVDLMDTKEKALVGAILRSA-TYYFCDLEIAC G--------------TK-TLDLLTTKEHTLVGAILRSA-TYYFCDLEVAV K--------------SAFAVDLMDTNEKTLVGALLRAS-TYYFCDLEIAC K--------------TSFAVDLLDTKEKALVGAILRSA-TYYFCDMDITC K--------------TAFAVDLMDTKRKALVGAILRSA-TYYFCDLEVAC K--------------TTFNVDLMDTKDKTLVGALLRAS-TYYFCDLEIAC K--------------TTFEINLMDTNDKTLIGALLRSA-TYYFCDLEIAC S--------------PTHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIVV N--------------PIHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIVV D--------------QINVLDLMQTPAHTLVGALLRAA-TYYFADLEVAV N--------------QINVLDLMQIPAHTLVGALLRAA-TYYFSDLELAV S--------------PTHVIDLMQTHQRGLVGALLRAA-TYYFSDLEIVA S--------------PTHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIVV S--------------PTHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIVV D--------------QINVLDLMQTPAHTLVGALLRTA-TYYFADLEVAV S--------------PTHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIVV S--------------PTHVIDLMQTHQNGLVGAMLRAA-TYYFSDLEIVV T--------------PTHVIDLMQTHQHSLVGALLRAA-TYYFSDLEIVV D--------------QINVLDLMQTPAHTLVGALLRTA-TYYFADIEVAV D--------------QINVLDLMQTPSYTLVGALLRTA-TYYFADLEVAV T--------------PTHVIDLMQTHQHGLVGAMLRAA-TYYFSDLEIVV T--------------PTHVIDLMQTHQHSLVGALLRAA-TYYFSDLEVVV P--------------QINVLDLMQTPSHTLVGALLRTA-TYYFADLEVAV

2016/02/23, 3:09 PM


UniRef90_A4ZPM0_1_211 UniRef90_E7D638_1_210 UniRef90_Q8JUM5_1_211 UniRef90_Q8BED5_1_209 UniRef90_A0ZXF2_1_211 UniRef90_F1BVI2_1_211 UniRef90_I0AYX9_1_210 UniRef90_I0AZ13_1_211 UniRef90_A4ZPL8_1_211 UniRef90_Q6PMY9_724_932 UniRef90_Q8JUP6_1_211 UniRef90_B1A0W6_1_210 UniRef90_C0LRW1_1_211 UniRef90_Q8JUN6_1_211 UniRef90_A1EC01_1_211 UniRef90_A2I8Z5_725_935 UniRef90_B1A0W7_1_211 UniRef90_Q9DJ38_1_212 UniRef90_A1EC10_1_211 UniRef90_E2FZV2_1_211 UniRef90_I0AYY6_1_211 UniRef90_A7XPU3_1_209 UniRef90_Q999Y2_1_211 UniRef90_B2MZR8_1_211 UniRef90_A1EC03_1_211 UniRef90_Q8BEA7_1_208 UniRef90_C0LYR0_1_209 UniRef90_C0LS35_1_211 UniRef90_I0AZ16_1_210 UniRef90_A4ZPP1_1_210 UniRef90_A0ZXC4_1_211 UniRef90_Q8JUS6_1_211 UniRef90_A1EC12_1_211 UniRef90_F6KYM9_1_211 UniRef90_B1A0X1_1_211 UniRef90_I0AZ19_1_211 UniRef90_Q912K6_1_211 UniRef90_A4ZPL9_1_211 UniRef90_Q9YPW9_1_211 UniRef90_A1EC13_1_211 UniRef90_B2MZQ3_1_211 UniRef90_E2J011_1_211 UniRef90_I0AZ31_1_211 UniRef90_D7RFC4_1_211 UniRef90_E2IZY3_1_211 UniRef90_Q9DJ33_1_211 UniRef90_Q9DJ21_1_192 UniRef90_Q0PV54_36_239 UniRef90_C8YS67_1_209 UniRef90_F6KYY3_1_211 UniRef90_B1A0W4_1_211 UniRef90_B3FHW7_1_211 UniRef90_A0ZXB5_1_211 UniRef90_A1EBZ3_1_211 UniRef90_Q9DJA4_1_210 UniRef90_Q0QED4_407_613 UniRef90_Q8JUU0_1_211 UniRef90_Q9DJF0_19_211 UniRef90_I0AZ37_1_211 UniRef90_Q67462_1_211 UniRef90_I0AZ36_1_211 UniRef90_Q91EM4_1_211 UniRef90_Q0PV56_33_229 UniRef90_C0LYW2_1_209 UniRef90_B2MZX2_1_207 UniRef90_Q01124_1_209 UniRef90_E2J004_1_192 UniRef90_Q8JUL9_1_209 UniRef90_Q6X5M0_1_179 UniRef90_Q2I5Y3_113_321 UniRef90_Q01121_1_189 UniRef90_Q6X5M1_1_179 UniRef90_A3RGT7_2_181

4 of 16


G--------------PTHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIVV S--------------PIHVIDLMQTHQHGLVGAMLRAA-TYYFSDLEIVV S--------------PTHVIDLMQTHQHALVGALLRAA-TYYFSDLEIVV K--------------NTQTLDLMQIPSHTLVGALLRSA-TYYFSDLEVAL D--------------QINILDLMQIPSHTLVGALLRAS-TYYFSDMEIVV N--------------PTHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIMV T--------------PTHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIVV S--------------PTHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIVV T--------------PTHVIDLMQTHQHGLVGALLRSA-TYYFSDLEVVV K--------------NTQTLDLMQIPSHTLVGALLRSA-TYYFSDLEVAL S--------------PTHVIDLMQTHQHGLVGALFRAA-TYYFSDLEIVV S--------------PTHVIDLMQTHQHALVGALLRAA-TYYFSDLEVVV S--------------PIHVIDLMQTPQNTLVGALLRAA-TYYFSDLEIVV S--------------PTHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIVV S--------------PTHVIDLMQTHQHGLVGAMLRAA-TYYFSDLEIVV E--------------QVNVLDLMQIPAHTLVGALLRTA-TYYFSDLELAV S--------------PTHVIDLMQTHPHALVGALLRAA-TYYFSDLEIVV D--------------QINVLDLMQIPAHTLVGGLVRAA-TYYFSDLELAV N--------------PTHVIDLMQTHHHGLVGALLRAA-TYYFSDLEIVV E--------------QINVLDLMQTPAHTLVGALLRTA-TYYFADLEVAV T--------------PTHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIVV K--------------STQVLDLMQIPSHTLVGALLRSA-TYYFSDLEIAL S--------------PTHVIDLMQTHQHGLVGGLLRAA-TYYFSDLEIVV Q--------------PTHVIDLMQTHQHGLVGAMLRAA-TYYFSDLEIVV S--------------PIHVIDLMQTPHNTLVGALFRAA-TYYFSDLEIVV K--------------NTQILDLMQIPSHTLVGALLRSA-TYYFSDLEVAL K--------------DTQTLDLMQIPSHTLVGALLRSA-TYYFSDLEVAL R--------------PTHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIVV S--------------PIHAIDLMQTHQHGLVGALLRAA-TYYFSDLEIVV S--------------PTHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIVV K--------------STHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIVA S--------------STHVIDLTQTPQHTLVGALLRAA-TYYFSDLEIVV T--------------HAHFMDLMQTHQHGLVGALLRAA-TYYFSDLEIVV S--------------GINVLDLMQIXAHTLVGALLXAX-TYYFSDMEIAV T--------------PTHVIDLMQTHQHALVGALLRAA-TYYFSDLEIVV S--------------PIHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIVV K--------------PTHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIVV N--------------PTHVIDLMQTHQHGLVGAMLRAA-TYYFSDLEIVV D--------------QINVLDLMQIPAHTLVGALLRTA-AYYFSDSELAV T--------------PTHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIVV N--------------QINTLDLMQIPSHTLVGALXRAS-TYYFSDLEIAV D--------------QINVLDLMQTPAHTLVGALLRTA-TYYFADIEVAV D--------------STHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIVV D--------------QINVLNQMQAAPNTLVGSLLRTA-TYYFADLEVAV D--------------QVNVLDLMQIPAHTLMGALLHAS-TYYFGDLEVAV D--------------QINVLDLMQTPAHTLVGALLRTA-TYYFADIXVAV N--------------QINVLDLMQTPAHTLVGALXRVA-TYYFADLEVAV T--------------PTHVIDLMQTHQHALVGALLRAA-TYYFSDLEVVV G--------------NQHTLDMMQTHKDGIVGALLRAA-TYYFSDLEIAV N--------------QVNVLDLMQIXSHTLVGALLRAF-TYYFSDLXIXX T--------------PTHVIDLMQTHQYALVGALLRAA-TYYFSDLEIVV S--------------PTHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIVV A--------------PTHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIVV S--------------PTHVIDLMQTHQRGLVGALLRAA-TYYFSDLEIVA D--------------QINVXDLMQIPAHTLVGALLRAS-TYYFADLEVAV G--------------NQHTLDVMQAHKDNIVGALLRAA-TYYFSDLEIAV S--------------PTHVIDLMHTHKHGIVGALPRAA-TYYFSDLEIVV D--------------QINVLDLMQTPAHTLVGALLRTA-TYYFADLEVAV S--------------PTHVIDLMQTHQNGLVGALLRAA-TYYFSDLEIVV S--------------SINTLDLMQIPSHTLVGALLRAS-TYYFSDLEIVV S--------------PIHVIDLMQTHQNGLVGALLRAA-TYYFSDLEIVV A--------------QINVXDLMXTPXHTLVGALLRTA-TYYFADLEVAV T--------------PTHVIDLMQTHQHALVGALLRAA-TYYFSDLEIVV K--------------NTQTLDLMQIPSHTLVGALLRSA-TYYFSDLEVAL D--------------NQHTLDMMQVHKDSIVGALLRAA-TYYFSDLEIAV G--------------QQHTLDVMQVHKDSIVGALLRAA-TYXFSXLEIAV D--------------QINVLDLMQIPAHTLVGALLRAS-TYNFADLEVAV S--------------PTHVIDLMHTQKHGTVGAXXXAA-TYYFSDLEIVV S--------------STHVIDLMQTHKHGLVGALLRAA-TYYFSDLEIVV S--------------PTHVIDLMQTHQHGLVGAL-------------CVL G--------------NQHTLDVMQVHKDSIXXALLRAA-TYYFSDLEIAV S--------------PTHVIDLMQTHQHGLVGALLRAA-TYYFSDLEIVV T--------------PTHVIDLMQTHQHALVGALLRAA-TYYFSDLEIVV

2016/02/23, 3:09 PM


5 of 16


UniRef90_P03310_11_218 UniRef90_B3FHW2_1_211 UniRef90_Q8JUM1_1_211 UniRef90_Q65051_1_200 UniRef90_Q8JUL2_2_187 UniRef90_B2BF63_11_200 UniRef90_Q0PV58_32_197 UniRef90_Q65102_9_211 UniRef90_Q8BED3_1_210 UniRef90_A0PG53_1_160 UniRef90_B3FHW0_1_211 UniRef90_B3FHV9_1_211 UniRef90_B3FHV8_1_211 UniRef90_A0PG60_5_160 UniRef90_Q91NQ7_2_163 UniRef90_B3FHV6_1_211 UniRef90_B3FHV7_1_211 UniRef90_A0PG54_1_160 UniRef90_B3FHW1_1_211 UniRef90_Q65068_1_206 UniRef90_Q9YPF0_1_208 UniRef90_Q8BEF3_1_209 UniRef90_B3FHV4_1_211 UniRef90_Q8JUN9_1_211 UniRef90_Q9YPG1_1_165 UniRef90_A0PG23_5_162 UniRef90_Q9DJ61_1_156 UniRef90_Q65097_1_206 UniRef90_Q01126_1_208 UniRef90_Q67461_13_173 UniRef90_Q00280_54_209 UniRef90_H9AY35_719_926

G--------------NQHTLDVMQVHKDSIVGALLRAA-TYYFSDLEIAV Y--------------LIPVLNLMQTPPHTLVGTLVRSA-PYYFADLYSTV G--------------STHVIDLTXXXXXXXXXXXXRAA-TYYFSDLEIVV S--------------PTHVIDLMQXHQHGLXXALLRAA-TYYFSDSEXVV S--------------PTHVIDLMQTHQHALVGALLRAA-TYYFSDLEIVV D--------------QINVLDLMQTPAHTLVGALLRTA-TYYFADLEVAV A--------------PTHVIDLMQTHQHALVGALLRAA-TYYFSDLEIVV S--------------SINTLDLMQIQSHTLVXXXXXAS-TYYFSDLEIVV K--------------NTQTLDLMQIPSHTLVGALFRSAXXXXXXXXXXXX -----------------YVLDLMQDPAHTLVGALLRTA-TYYFADLEVAV Y--------------LITVLNLMRTPSHTLGGTLLRSA-IYYFSDWKGTG L--------------QITILNLVRIPSHTLGGTLVRTA-TYYFSDLYITG L--------------HIPVLNLVGSPSDTLGGTLFRTA-TYYFSDMESKA ---------------------LMQTPAHTLVGALLRTA-TYYFADLEVAV ------------------VLDLMQAPAHTLVGALLRTA-TYYFADLEVAV Y--------------LIPILNQMRAPPHTLVGTLVRTA-PYYFSDLYSTV L--------------QIPFLNLVRIPPHTLVGTLVRTS-TYYFSDLYRTC -----------------LCLGLDATPAHTLVGALLRTA-TYYFADLEVAV Y--------------LINVLNLVRTPSHTLGGTLFRTA-TYYFADLDMTG D--------------NQHXLDVMQAXRDXXVXALLRAA-TYYFSDLEIAV X--------------XXXXLDVMQVHKDSIVGALLRAA-TYYFSDLEXAV K--------------NTQTLDLMQIPSHTLVGALLRSA-TYYFSDL-XXX L--------------QIPILNLVRVPSHTLGGTLVRTS-TYYFSDLYRAV G--------------STHVIDLTQTPQHTLVGALLRAA-TYYFSDLEIVV S--------------PTHVIDLMXTXQHGLVXALLRAA-TYYFSDLEIVV ---------------------LFQTPAHSLVVRLLRTA-TYYFADLEVAV ------------------------TPAHTLVGALLRTA-TYYFADLEVAV D--------------NQHTLDVMQAHKDNIVGALLRAA-TYXXSXLEIAV G--------------QQHTLDLMQVHKDSIVGALLRAA-TYYFSXLEIAV -------------------LDLMQIPSHTLVGALLRAS-TYYFSDLEIVV ---------------------VMQVHKDSIVGALLRAA-TYYFSALEIAV G--------YKEALGAGLVLDPVALPETSMMGQLLRAA-TYYFADMELAV

2WZR1 UniRef90_Q6PMU0_725_943 UniRef90_F1AW55_725_943 UniRef90_A0PG93_1_219 UniRef90_A0PG86_1_219 UniRef90_A0PG77_1_219 UniRef90_Q6PMU2_725_943 UniRef90_Q8V0G8_526_744 UniRef90_A0PG80_1_219 UniRef90_Q8BDT2_1_218 UniRef90_A0PG94_1_219 UniRef90_C8YS70_1_219 UniRef90_Q6PMT8_726_934 UniRef90_Q6PMT3_724_939 UniRef90_B8Y0J7_726_934 UniRef90_E2IU95_1_209 UniRef90_Q80JY0_1_209 UniRef90_A0PFY2_1_209 UniRef90_Q80K03_1_209 UniRef90_Q1L757_525_734 UniRef90_Q80K16_1_209 UniRef90_Q1L752_527_735 UniRef90_A0PG17_1_209 UniRef90_Q80JY2_1_209 UniRef90_Q80JY8_1_209 UniRef90_Q8JVD0_525_739 UniRef90_Q80JU2_1_209 UniRef90_A0PFY7_1_209 UniRef90_A0PFY4_1_209 UniRef90_Q80JZ5_1_205 UniRef90_A0PFZ0_1_209 UniRef90_Q1L748_525_740 UniRef90_Q80JY7_1_209 UniRef90_A0PG12_1_209 UniRef90_A0PFY8_1_209 UniRef90_Q80JZ1_1_209 UniRef90_Q80JU1_1_209

----------VGTNA-----WVGW--------TPNGSPVLT----EVGD----------VGTNE-----WVGW--------TPNGAPELS----EVGD----------VGNNK-----WVGW--------TPNGAPLLH----EVGD----------VGTNK-----WVGW--------TPNGAPQLT----EVGD----------VGTNK-----WVGW--------TPNGAPELN----EVGD----------VGENK-----WVGW--------TPNGAPELS----EVGD----------VGTNK-----WVGW--------LPNGAPVPK----EVGD----------VGTNE-----WVGW--------VPNGTPDVS----EVGD----------VGTNR-----WVGW--------LPNGAPVPQ----EVGD----------VGTNK-----WVGW--------VPNGAPVPK----EVGD----------VGTNK-----WVGW--------LPNGAPVPS----EVGD----------LGTNK-----WVGW--------LPNGAPMPT----EVGD----------VGTHK-----RVYW--------QPNGAPRTT----QLGD----------LGTAP-----WAAW--------VPNGCPHTG----RVED----------VGDHK-----RVFW--------QPNGAPRTT----QLGD----------VGTHQ-----RVYW--------QPNGAPRTT----KLGD----------LGKHA-----RVWW--------QPNGAPRTT----QLRD----------VGDHT-----RVFW--------QPNGAPRTT----QLGD----------VGKHT-----RVFW--------QPNGAPRTS----ELGD----------VGDHK-----RVYW--------QPNGAPRTT----QLGD----------VGDHT-----RVFW--------QPNGAPRTT----KLGD----------VGDHK-----RVFW--------QPNGAPRAT----QLGD----------VGDHK-----RVFW--------QPNGAPRTV----QLGD----------VGDHA-----RVFW--------QPNGAPRTT----QLGD----------LGEHT-----RVWW--------QPNGSPRTT----XLRD----------LGTG------WVGW--------VPNGCPHTT----RVED----------VGEHA-----RVFW--------QPNGAPRTT----QLGD----------VGEHK-----RVFW--------QPNGAPRTT----TLGD----------VGEHS-----RVYW--------QPNGAPRTT----QLGD----------VGEHA-----RVYW--------QPNGAPRTT----QLGD----------VGEHK-----RVFW--------QPNGAPRTT----QLGD----------KGDSP-----YAAW--------VPNGCPEVS----RVED----------IGEHA-----RVWW--------QPNGAPRTT----QLRD----------VGEHA-----RVFW--------QPNGAPRTN----ELGE----------VGEHK-----RVFW--------QPNGAPRTT----VLGD----------VGDHT-----RVFW--------QPNGAPRTT----VLGD----------VGDHQ-----RVFW--------QPNGAPRTT----QLRD-

2016/02/23, 3:09 PM


UniRef90_B2MZR9_1_211 UniRef90_P49303_726_936 UniRef90_Q2I5Z0_71_281 UniRef90_Q9DJ49_1_212 UniRef90_A1EBZ1_1_211 UniRef90_A1EBZ4_1_211 UniRef90_I0AZ32_1_211 UniRef90_A8D5K4_1_211 UniRef90_Q2I5X3_80_290 UniRef90_I0AYZ5_1_211 UniRef90_I0AZ39_1_210 UniRef90_H9T7U2_127_337 UniRef90_Q9DJF9_1_211 UniRef90_I0AYY0_1_211 UniRef90_Q2I5X1_23_232 UniRef90_B2ZHQ6_1_211 UniRef90_A4ZPM0_1_211 UniRef90_E7D638_1_210 UniRef90_Q8JUM5_1_211 UniRef90_Q8BED5_1_209 UniRef90_A0ZXF2_1_211 UniRef90_F1BVI2_1_211 UniRef90_I0AYX9_1_210 UniRef90_I0AZ13_1_211 UniRef90_A4ZPL8_1_211 UniRef90_Q6PMY9_724_932 UniRef90_Q8JUP6_1_211 UniRef90_B1A0W6_1_210 UniRef90_C0LRW1_1_211 UniRef90_Q8JUN6_1_211 UniRef90_A1EC01_1_211 UniRef90_A2I8Z5_725_935 UniRef90_B1A0W7_1_211 UniRef90_Q9DJ38_1_212 UniRef90_A1EC10_1_211 UniRef90_E2FZV2_1_211 UniRef90_I0AYY6_1_211 UniRef90_A7XPU3_1_209 UniRef90_Q999Y2_1_211 UniRef90_B2MZR8_1_211 UniRef90_A1EC03_1_211 UniRef90_Q8BEA7_1_208 UniRef90_C0LYR0_1_209 UniRef90_C0LS35_1_211 UniRef90_I0AZ16_1_210 UniRef90_A4ZPP1_1_210 UniRef90_A0ZXC4_1_211 UniRef90_Q8JUS6_1_211 UniRef90_A1EC12_1_211 UniRef90_F6KYM9_1_211 UniRef90_B1A0X1_1_211 UniRef90_I0AZ19_1_211 UniRef90_Q912K6_1_211 UniRef90_A4ZPL9_1_211 UniRef90_Q9YPW9_1_211 UniRef90_A1EC13_1_211 UniRef90_B2MZQ3_1_211 UniRef90_E2J011_1_211 UniRef90_I0AZ31_1_211 UniRef90_D7RFC4_1_211 UniRef90_E2IZY3_1_211 UniRef90_Q9DJ33_1_211 UniRef90_Q9DJ21_1_192 UniRef90_Q0PV54_36_239 UniRef90_C8YS67_1_209 UniRef90_F6KYY3_1_211 UniRef90_B1A0W4_1_211 UniRef90_B3FHW7_1_211 UniRef90_A0ZXB5_1_211 UniRef90_A1EBZ3_1_211 UniRef90_Q9DJA4_1_210 UniRef90_Q0QED4_407_613 UniRef90_Q8JUU0_1_211

6 of 16


----------RHDGN------LTW--------VPNGTPEAA---LSNAS----------RHDGN------LTW--------VPNGAPEAA---LSNMG----------KHEGN------LTW--------VPNGAPETA---LDNTT----------VHEGN------LTW--------VPNGAPEAA---LNNST----------RHEGN------LTW--------VPNGAPEAA---LSNAS----------RHDGN------LTW--------VPNGAPEAA---LSNTG----------RHDGS------LTW--------VPNGAPETA---LSNAS----------KHEGN------LTW--------VPNGAPEAA---LDNTT----------RHEGN------LTW--------VPNGAPEAA---LSNAG----------RHDGN------LTW--------VPNGAPESA---LSNAS----------RHDGN------LTW--------VPNGAPEAA---LLNTS----------KHEGN------LTW--------VPNGAPETA---LDNAT----------KHEGN------LTW--------XPNGAPETA---LDNTT----------RHDGN------LTW--------VPNGAPETA---LDNTS----------RHDGN------LTW--------VPNGAPEAA---LSNTS----------KHEGD------LTW--------VPNGAPEAA---LENTT----------KHEGN------LTW--------VPNGTPESA---LQNAS----------NHTGN------LTW--------VPNGAPEAA---LNNTS----------RHDGN------LTW--------VPNGAPEAA---LSNTS----------VHTGP------ATW--------VPNGSPKHA---LDNQT----------KHEGN------LTW--------XPNGAPEVA---LDNTT----------RHSGN------LTW--------VPNGAPEAA---LSNTG----------RHEGN------LTW--------VPNGAPEGA---LANTS----------RHDGN------LTW--------VPNGAPVSA---LLNTS----------KHQGN------LTW--------VPNGAPEAA---LANTS----------VHTGS------VTW--------VPNGAPKDA---LDNHT----------RHDGN------LTW--------VPNGAPEAA---LRNTG----------RHEGN------LTW--------VPNGAPEAA---LSNTS----------RHTDN------LTW--------VPNGAPEAA---LSNTS----------HHEGN------LTW--------VPNGAPEAA---LGNVS----------RHDDN------LTW--------VPNGAPVDA---LSNTS----------KHEGD------LTW--------VPNGAPETA---LDNTT----------RHDGN------LTW--------VPNGAPVEA---LANTG----------KHEGN------LTW--------VPNGAPEAA---LDNTT----------RHAGN------LTW--------APNGAPEAA---LSNTG----------KHEGD------LTW--------VPNGAPETA---LDNTT----------RNEGN------LTW--------VPNGPPNRA---LLKAS----------VHTGP------VTW--------VPNGAPKVA---LDNQT----------QHDGN------LTW--------VPNGAPESA---LSYSS----------RHDGN------LTW--------VPNGAPESA---LDNTG----------RHTDN------LTW--------VPNGAPEAA---LSNTG----------IHTGS------VTW--------VPNGAPRTR---LDNYT----------VHTGP------VTW--------VPNGAPKTA---LDCQT----------RHEGN------LTW--------VPNGAPEVA---LNNAG----------RHDGN------LTW--------VPNGAPVAA---LSNTS----------HHTGN------LTW--------VPNGAPEAA---LDNTS----------RHDGN------LTW--------VPNGAPVSA---LSNTS----------RHTGN------LTW--------VPNGAPEAA---LSNTS----------RHDGN------LTW--------VPNGAPEAA---LSNTG----------RHEGN------LTW--------VPNGAPEQA---LDNTT----------RHEGN------LTW--------VPNGTPEVA---LSNMS----------RHDGN------LTW--------VPNGAPESD---LSNTS----------HHDGN------LTW--------VPNGAPESA---LSNIS----------RHEGN------LTW--------VPNGAPESA---LLNTS----------KHKGG------LTW--------VPNGAPETA---LDNTT----------RHDGT------LTW--------VPNGAPEAA---LSNTG----------KHEGD------LTW--------VPNGAPEKA---LDNTT----------KHERN------LTW--------VPNGAPEST---LDNTT----------RHDGN------LTW--------VLNGALESA---LLNTS----------KHEGD------LTW--------VPNGAPEAA---LGNTT----------KHDGN------LTW--------VPNGAPESA---LDNTT----------KHEGN------LXG--------APNGAPESA---XDNTT----------KHEGN------LTW--------VPNGAPETA---LENTT----------RHEGN------LTW--------VPNGTPEAA---LSNMS----------THTGK------LTW--------VPNGAPVSA---LDNTS----------EXEXD------LTW--------VPTEAPEKA---LDNTT----------RHEGN------LTW--------VPNGAPEAA---LSNTS----------RHDGN------LTW--------VPNGAPEAA---LSNTG----------RHEGN------LTW--------VPNGAPESA---LSNTS----------RHEGN------LTW--------VPNGAPEAA---LSNAS----------KHEGN------LTW--------VPNGAPETA---XDNTT----------THTGK------LTW--------VPNGAPVSA---LNNTT----------RHDGN------LTW--------VPNGAPEAA---LSNTS-

2016/02/23, 3:09 PM


7 of 16


UniRef90_Q9DJF0_19_211 UniRef90_I0AZ37_1_211 UniRef90_Q67462_1_211 UniRef90_I0AZ36_1_211 UniRef90_Q91EM4_1_211 UniRef90_Q0PV56_33_229 UniRef90_C0LYW2_1_209 UniRef90_B2MZX2_1_207 UniRef90_Q01124_1_209 UniRef90_E2J004_1_192 UniRef90_Q8JUL9_1_209 UniRef90_Q6X5M0_1_179 UniRef90_Q2I5Y3_113_321 UniRef90_Q01121_1_189 UniRef90_Q6X5M1_1_179 UniRef90_A3RGT7_2_181 UniRef90_P03310_11_218 UniRef90_B3FHW2_1_211 UniRef90_Q8JUM1_1_211 UniRef90_Q65051_1_200 UniRef90_Q8JUL2_2_187 UniRef90_B2BF63_11_200 UniRef90_Q0PV58_32_197 UniRef90_Q65102_9_211 UniRef90_Q8BED3_1_210 UniRef90_A0PG53_1_160 UniRef90_B3FHW0_1_211 UniRef90_B3FHV9_1_211 UniRef90_B3FHV8_1_211 UniRef90_A0PG60_5_160 UniRef90_Q91NQ7_2_163 UniRef90_B3FHV6_1_211 UniRef90_B3FHV7_1_211 UniRef90_A0PG54_1_160 UniRef90_B3FHW1_1_211 UniRef90_Q65068_1_206 UniRef90_Q9YPF0_1_208 UniRef90_Q8BEF3_1_209 UniRef90_B3FHV4_1_211 UniRef90_Q8JUN9_1_211 UniRef90_Q9YPG1_1_165 UniRef90_A0PG23_5_162 UniRef90_Q9DJ61_1_156 UniRef90_Q65097_1_206 UniRef90_Q01126_1_208 UniRef90_Q67461_13_173 UniRef90_Q00280_54_209 UniRef90_H9AY35_719_926

----------KHEGD------LTW--------VPNGAPETA---LDNTT----------RHDGN------LTW--------VPNGPPKSA---LQKTS----------KHEGD------LTW--------VPNGAPVKA---LGNTT----------RHDGN------LTW--------VPNGAPKSA---LSNTS----------KHXGN------LTX--------XPNGAPETA---LDNTT----------RHEGN------LTW--------VPNGAPEAA---LSNTS----------VHTGP------VTW--------VPNGPPKDA---LNNHT----------THTGK------LTW--------VPNGAPVSA---LENTS----------THTGK------LXW--------VPNGAPVSA---LDNTT----------KHEGN------LTW--------VSNGAPESA---LDNTT----------RHDGN------LTW--------VPNGAPEAA---LSXXX----------KHDGN------LTW--------VPNGAPEAA---LQNMS----------PRTTS------QTWRLWCTMKATDVGAQRGTRGGLSNAG----------THTGK------LTW--------VPNGAPVSA---LDNTS----------RHEGN------LTW--------VPNGAPEAA---LQNTS----------RHEGN------LTW--------VPNGAPEAA---LSNTS----------THTGK------LTW--------VPNGAPVSA---LDNTA----------KLPVY------LTW--------IPNGAPDTA---LDNTS----------RXXXX------XXX--------XXXXXXXXX---XXXXX----------RHDGN------XTR--------VPNGAPEAA---LSNTS----------RHDGN------LTW--------VPNGAPEAA---LSNTG----------KHEGN------LTW--------VPNGAPETA---LDNTT----------RHEGN------LTW--------VPNGAPEAA---LSNTS----------KHEGD------LTW--------VRNGAXXQA---LDNTT----------XXXXX------XXX--------XXXXXPKIA---LDNQT----------KHEGN------LTW--------VPNGAPESA---LDNTT----------KHEGN------LTW--------IPNGAPDKA---LDNTT----------KHQGN------LTW--------IPNGAPEKA---LDNTT----------KHEGN------LTW--------VPNGAPDKA---MHNTT----------KHEGN------LTW--------XPNGAPESA---LDNTT----------KHEGD------LTW--------VPNGAPESA---LDNTT----------KLQGN------LTW--------IPNVAPDKA---LDNTT----------KHQGN------LTW--------IPNGAPGKA---LDNTT----------KHEGN------LTW--------VPNGAPESA---LDNTT----------KHEGN------LTW--------IPNGAPDKA---LDNTT----------THXGK------LTW--------VPXGAPVSA---LNNXT----------THTGK------LTW--------VPXGAPVSA---LDXXT----------XXXXX------XXX--------XXXXXXXXX---XXXXT----------KHQGN------LTW--------VPNGAPEKA---LDNTT----------RHTGN------LTW--------VPNGAPXXX---XXXXX----------RHXGN------LTW--------VPNGAPEAA---LSNTS----------KHEGN------FTW--------VPNGAPESV---WDNTT----------KHEGN------LTW--------VPNGAPETA---LDNTT----------THTGK------LTW--------VPXGAPVSX---LNNTT----------AHXXX------XXX--------XXXXXXXXX---XNNTT----------KHEGD------LTW--------VPNGASEKA---LDNTT----------THTGK------LTW--------VPXGAPVSA---LDNTT----------VPRGQPGEYAMVKW--------LPVGTPFDL-RDSSL---

2WZR1 UniRef90_Q6PMU0_725_943 UniRef90_F1AW55_725_943 UniRef90_A0PG93_1_219 UniRef90_A0PG86_1_219 UniRef90_A0PG77_1_219 UniRef90_Q6PMU2_725_943 UniRef90_Q8V0G8_526_744 UniRef90_A0PG80_1_219 UniRef90_Q8BDT2_1_218 UniRef90_A0PG94_1_219 UniRef90_C8YS70_1_219 UniRef90_Q6PMT8_726_934 UniRef90_Q6PMT3_724_939 UniRef90_B8Y0J7_726_934 UniRef90_E2IU95_1_209 UniRef90_Q80JY0_1_209 UniRef90_A0PFY2_1_209 UniRef90_Q80K03_1_209 UniRef90_Q1L757_525_734 UniRef90_Q80K16_1_209

--------------NPVVF---------------SRRGTTRFALPYTAPH --------------NPVVF---------------STNNTTRFALPYTAPH --------------NPVVF---------------SHNGTTRFALPYTAPH --------------NPSHF---------------SHNGTTRFALPYTAPH --------------NPVVF---------------SHNETTRFALPYTAPH --------------NPVVF---------------SHNGTTRFALPYTAPH --------------NPVVF---------------SHNGTTRFALPFTAPH --------------NPVVF---------------SRDGATRFALPFTAPH --------------NPVVF---------------SHNGTTRFALPFTAPH --------------NPVIF---------------SHNGTTRFALPYTAPH --------------NPVVF---------------SHNGVTRFALPYTAPH --------------NPVVF---------------STNGATRFALPFTAPH --------------NPMVF---------------SNNGVTRFAVPYTAPH --------------NPVVH---------------SKGSVVRFALPYTAPH --------------NPMVF---------------ATNGVTRFAVPFTAPH --------------NPMVF---------------SHNGVTRFAIPYTAPH --------------NPMVF---------------SHNNVTRFALPYTAPH --------------NPMVY---------------AKGGVTRFAIPFTAPH --------------NPMVF---------------SHNAVTRFAVPYTAPH --------------NPMVF---------------SHNRVTRFAIPYTAPH --------------NPMVY---------------AHNHVTRFAIPFTAPH

2016/02/23, 3:09 PM


UniRef90_Q1L752_527_735 UniRef90_A0PG17_1_209 UniRef90_Q80JY2_1_209 UniRef90_Q80JY8_1_209 UniRef90_Q8JVD0_525_739 UniRef90_Q80JU2_1_209 UniRef90_A0PFY7_1_209 UniRef90_A0PFY4_1_209 UniRef90_Q80JZ5_1_205 UniRef90_A0PFZ0_1_209 UniRef90_Q1L748_525_740 UniRef90_Q80JY7_1_209 UniRef90_A0PG12_1_209 UniRef90_A0PFY8_1_209 UniRef90_Q80JZ1_1_209 UniRef90_Q80JU1_1_209 UniRef90_B2MZR9_1_211 UniRef90_P49303_726_936 UniRef90_Q2I5Z0_71_281 UniRef90_Q9DJ49_1_212 UniRef90_A1EBZ1_1_211 UniRef90_A1EBZ4_1_211 UniRef90_I0AZ32_1_211 UniRef90_A8D5K4_1_211 UniRef90_Q2I5X3_80_290 UniRef90_I0AYZ5_1_211 UniRef90_I0AZ39_1_210 UniRef90_H9T7U2_127_337 UniRef90_Q9DJF9_1_211 UniRef90_I0AYY0_1_211 UniRef90_Q2I5X1_23_232 UniRef90_B2ZHQ6_1_211 UniRef90_A4ZPM0_1_211 UniRef90_E7D638_1_210 UniRef90_Q8JUM5_1_211 UniRef90_Q8BED5_1_209 UniRef90_A0ZXF2_1_211 UniRef90_F1BVI2_1_211 UniRef90_I0AYX9_1_210 UniRef90_I0AZ13_1_211 UniRef90_A4ZPL8_1_211 UniRef90_Q6PMY9_724_932 UniRef90_Q8JUP6_1_211 UniRef90_B1A0W6_1_210 UniRef90_C0LRW1_1_211 UniRef90_Q8JUN6_1_211 UniRef90_A1EC01_1_211 UniRef90_A2I8Z5_725_935 UniRef90_B1A0W7_1_211 UniRef90_Q9DJ38_1_212 UniRef90_A1EC10_1_211 UniRef90_E2FZV2_1_211 UniRef90_I0AYY6_1_211 UniRef90_A7XPU3_1_209 UniRef90_Q999Y2_1_211 UniRef90_B2MZR8_1_211 UniRef90_A1EC03_1_211 UniRef90_Q8BEA7_1_208 UniRef90_C0LYR0_1_209 UniRef90_C0LS35_1_211 UniRef90_I0AZ16_1_210 UniRef90_A4ZPP1_1_210 UniRef90_A0ZXC4_1_211 UniRef90_Q8JUS6_1_211 UniRef90_A1EC12_1_211 UniRef90_F6KYM9_1_211 UniRef90_B1A0X1_1_211 UniRef90_I0AZ19_1_211 UniRef90_Q912K6_1_211 UniRef90_A4ZPL9_1_211 UniRef90_Q9YPW9_1_211 UniRef90_A1EC13_1_211 UniRef90_B2MZQ3_1_211

8 of 16


--------------NPMVF---------------SHNKVARFAIPFTAPH --------------NPMVF---------------SHNGVPRFAIPFTAPH --------------NPMVF---------------AHNKVTRFAIPYTAPH --------------NPMVF---------------SHNKVTRFAVPYTAPH --------------NPVVH---------------AKGGVTRFALPYTAPH --------------NPMVF---------------SHNNVTRFAIPYTAPH --------------NPMVY---------------SHNGVTRFAIPYTAPH --------------NPMVF---------------AHNGVTRFAVPYTAPH --------------NPMVF---------------SHNKVTRFAIPYTAPH --------------NPMVF---------------SHKKVTRFAIPFTAPH --------------NPVVF---------------AKGGLARFALPYTAPH --------------NPMVF---------------SHNNVTRFAVPYTAPH --------------NPMVF---------------SHNKVTRFAIPYTAPH --------------NPMVF---------------AHNGVTRFAIPYTAPH --------------NPMVF---------------PHNKVTRFAVPYTAPH --------------NPMVF---------------AHNNVTRFALPYTRPH --------------NPTAY---------------NKAPFTRLALPYTAPH --------------NPTAY---------------PKAPFTRLALPYTAPH --------------NPTAY---------------HKAPLTRLALPYTAPH --------------NPTAY---------------HKAPLTRLALPYTAPH --------------NPTAY---------------HKEPFTRLALPYTAPH --------------NPTAY---------------NKAPFTRLALPYTAPH --------------NPTVY---------------KKEPFTRLALPYTAPH --------------NPTAY---------------HKAPLTRLALPYTAPH --------------NPTAY---------------NKAPFTRLALPYTAPH --------------NPTAY---------------NKAPFTRLALPYTAPH --------------NPTAY---------------NKAPFTRLALPYTAPH --------------NPTAY---------------HKAPLTRLALPYTAPH --------------NPTAY---------------HKAXLTRLALPYTAPH --------------NPTAY---------------VKSPFTRLALPYTAPH --------------NPTAY---------------RKEPFTRLALPYTAPH --------------NPTAY---------------HKAPLTRLALPYTAPH --------------NPTAY---------------HKAPFTRLALPYTAPH --------------NPTAY---------------HKAPFTRLALPYTAPH --------------NPTAY---------------HRAPFTRLALPYTAPH --------------NPTAY---------------QKQPITRLALPYTAPH --------------NPTAY---------------YKAPITRLALPYTAPH --------------NPTAY---------------NKEPFTRLALPYTAPH --------------NPTAY---------------AKAPFTRLALPYTAPH --------------NPTAY---------------NKKPFTRLALPYTAPH --------------NPTAY---------------HKAPFTRLALPYTAPH --------------NPTAY---------------QKQPITRLALPYTAPH --------------NPTAY---------------HKAPFTRLALPYTAPH --------------NPTVY---------------PKQPFTRLALPYTAPH --------------NPTAY---------------HKAPFTRLALPYTAPH --------------NPTAY---------------HKAPFTRLALPYTAPH --------------NPTAY---------------NKAPYTRLALPYTAPH --------------NPTAY---------------HKEPLTRLALPYTAPH --------------NPTAY---------------HKQPFTRLALPYTAPH --------------NPTAY---------------HKEPLTRLALPYTAPH --------------NPTAY---------------NKAPFTRLVLPYTAPN --------------NPTAY---------------HKAPLTRLALPYTAPH --------------NPTGY---------------VKAPFTRLALPYIAPH --------------NPTAY---------------QKQPITRLALPYTAPH --------------NPTAY---------------KKAPFTRLALPYTAPH --------------NPTAY---------------NKAPFTRLALPYTAPH --------------NPTAY---------------HKAPFTRLALPYTAPH --------------NPTAY---------------QKKPITRLALPYTAPH --------------NPTAY---------------QKQPITRLALPYTAPH --------------NPTAY---------------NKAPFTRLALPYTAPH --------------NPTAY---------------NKAPFTRLALPYTAPH --------------NPTAY---------------HKAPFTRLALPYTAPH --------------NPTAY---------------NKAPFTRLALPYTAPH --------------NPTAY---------------XXXXXXXLALPYTAPH --------------NPTAY---------------TKAPFTRLALPYTAPH --------------NPTAY---------------HKAPITRLALPYTAPH --------------NPTVY---------------PKQPFTRLALPYTAPH --------------YPTVY---------------RKEPLTRLALPYTAPH --------------NPTAY---------------NKAPFTRLALPYTAPH --------------NPTAY---------------HKAPFTRLALPYTAPH --------------NPTAH---------------HKAPLTRLALPYTAPH --------------NPTAY---------------NKAPFTRLALPYTAPH --------------NPTAY---------------HKAPLTRLALPYTAPH

2016/02/23, 3:09 PM


9 of 16


UniRef90_E2J011_1_211 UniRef90_I0AZ31_1_211 UniRef90_D7RFC4_1_211 UniRef90_E2IZY3_1_211 UniRef90_Q9DJ33_1_211 UniRef90_Q9DJ21_1_192 UniRef90_Q0PV54_36_239 UniRef90_C8YS67_1_209 UniRef90_F6KYY3_1_211 UniRef90_B1A0W4_1_211 UniRef90_B3FHW7_1_211 UniRef90_A0ZXB5_1_211 UniRef90_A1EBZ3_1_211 UniRef90_Q9DJA4_1_210 UniRef90_Q0QED4_407_613 UniRef90_Q8JUU0_1_211 UniRef90_Q9DJF0_19_211 UniRef90_I0AZ37_1_211 UniRef90_Q67462_1_211 UniRef90_I0AZ36_1_211 UniRef90_Q91EM4_1_211 UniRef90_Q0PV56_33_229 UniRef90_C0LYW2_1_209 UniRef90_B2MZX2_1_207 UniRef90_Q01124_1_209 UniRef90_E2J004_1_192 UniRef90_Q8JUL9_1_209 UniRef90_Q6X5M0_1_179 UniRef90_Q2I5Y3_113_321 UniRef90_Q01121_1_189 UniRef90_Q6X5M1_1_179 UniRef90_A3RGT7_2_181 UniRef90_P03310_11_218 UniRef90_B3FHW2_1_211 UniRef90_Q8JUM1_1_211 UniRef90_Q65051_1_200 UniRef90_Q8JUL2_2_187 UniRef90_B2BF63_11_200 UniRef90_Q0PV58_32_197 UniRef90_Q65102_9_211 UniRef90_Q8BED3_1_210 UniRef90_A0PG53_1_160 UniRef90_B3FHW0_1_211 UniRef90_B3FHV9_1_211 UniRef90_B3FHV8_1_211 UniRef90_A0PG60_5_160 UniRef90_Q91NQ7_2_163 UniRef90_B3FHV6_1_211 UniRef90_B3FHV7_1_211 UniRef90_A0PG54_1_160 UniRef90_B3FHW1_1_211 UniRef90_Q65068_1_206 UniRef90_Q9YPF0_1_208 UniRef90_Q8BEF3_1_209 UniRef90_B3FHV4_1_211 UniRef90_Q8JUN9_1_211 UniRef90_Q9YPG1_1_165 UniRef90_A0PG23_5_162 UniRef90_Q9DJ61_1_156 UniRef90_Q65097_1_206 UniRef90_Q01126_1_208 UniRef90_Q67461_13_173 UniRef90_Q00280_54_209 UniRef90_H9AY35_719_926

--------------NPTAY---------------HKAPLTRLALPYTAPH --------------LPTAY---------------NXAPFTRLALPYAAPH --------------NPTAY---------------HKAPLTRLALPYTAPH --------------NPTAY---------------HKAPLTRLALPYTAPH --------------TXTAY---------------HKAPLTRLALPYTAPH --------------NPTAY---------------HKALLTRLALPYTAPH --------------NPTAY---------------PKQPFTRLALPYTAPH --------------NPTAY---------------HKGPLTRLALPYTAPH --------------NPTAY---------------HKAPLTRLAVPYTAPH --------------NPTAY---------------HKAPFTRLALPYTAPH --------------NPTAY---------------NGTTFTRQALPYSAPH --------------NPTAY---------------KKAPFTRLALPYTAPH --------------NPTAY---------------HKEPFTRLALPYTAPH --------------NPTAY---------------YKAPLTRLALPYTAPH --------------NPTAY---------------HKGPVTRLALPYTAPH --------------NPTAY---------------NKAPFTRLALPYTAPH --------------NPTAY---------------HKAXLTRLALPYTAPH --------------HPXAY---------------NKAPFTRLFFPYTGPQ --------------NPTAY---------------YKKPLTRLALPYTAPY --------------NPSDY---------------NKAPFTRLVXPYXAPH --------------NPXAY---------------HKAXLTXLELPYXAPH --------------NPTAY---------------HKEPFTRLALPYTAPH --------------NPTAY---------------QKQPITRLALPYTAPH --------------NPTAY---------------HKGPLTRLALPYTAPH --------------NPTAY---------------HKGPLTRLALPYTAPH --------------PPTAY---------------HKAPLTRLALPYTAPH --------------XXXXX---------------XXXXXXXXXXPYTAPH --------------NPTAY---------------HKAPFTRLALPYTAPH --------------NPTAY---------------NKAPFTRLALPYTAPH --------------NPTAY---------------HKGPLTRLALPYTAPH --------------NPTVY---------------HKAPFTRLALPYTAPH --------------NPTAY---------------HKEPFTRLALPYTAPH --------------NPTAY---------------HKGPLTRLALPYTAPH --------------NPACY---------------HNVPFMLFALPYSAPQ --------------XXXXX---------------XXXPFTRLALPYTAPH --------------NPTAY---------------NKAPFTRLALPYTAPH --------------NPTAY---------------HRAPFTRLALPYTAPH --------------NPTAY---------------HKAPLTRLALPYTAPH --------------NPTAY---------------HKEPFTRLALPYTAPH --------------NPNAY---------------YKKRLTRLALPYTAPH --------------NPTAY---------------QKQPITRLALPYTAPH --------------NPTAY---------------HKEPLTRLALPYTAPH --------------NAAVY---------------HKVPFTRFALPYSAPH --------------NAAVY---------------HKVAFTRFAMPFSAPH --------------NAAVY---------------YKVPFTGFALPYTALH --------------NPTAY---------------HKAPLTRLALPYTAPH --------------NPTAY---------------HKAPLTRLALPYTAPH --------------NAAFY---------------HKVPLTLLALPYSAPH --------------NAAVY---------------QKVPFTRFALPYSAPH --------------NPTAY---------------HKKPLTRLALPYTAPH --------------NAAVY---------------HKVPFTRFALPFSAPH --------------XPTAY---------------XXGPVTRLALPYXAPX --------------XPTAX---------------HXGPLTRLALPXXAPX --------------NPTAY---------------QKQPTTRLALPYTAPH --------------NAAVY---------------QKVPLTLFALPYTAPH --------------XXXXX---------------XXXXXXXXXXXXXXXX --------------NPTAY---------------NKAPFTRLALPYTAPH --------------NPTAY---------------HKAPLTRLALPYTAPH --------------NPTAY---------------HKAXLTRLELPYTAXH --------------NPTAY---------------HKGXVTXLAXPYTAPH --------------NPTAY---------------HKGPLTXLAXPYTAPH --------------NPTAY---------------YKKPLTRLALPYTAPH --------------NPTAY---------------XXXXXXXXXXXYTAPH --------------DGLALQGLDSTCSVGFAGSAGNGSAAVMAIPYNSPM

2WZR1 UniRef90_Q6PMU0_725_943 UniRef90_F1AW55_725_943 UniRef90_A0PG93_1_219 UniRef90_A0PG86_1_219

RVLATVYNGDCKYKPTGTAPRENIRGDLATLAARI-ASETH-IP-TTFNY RCLATSYNGDCKYKPAGTTPRENIRGDLATLAGRI-ASETH-IP-TTFNY RLLATTYNGDCKYKPAGQEPRTAIRGDLAVIAERI-ASETH-IP-TSFNY RLLATVYNGDCKYKPTEQPPRTNIRGDLAVLAQRI-ASKTH-IP-TSFNY RCLATAYNGDCKYKPNSEAPRTHIRGDFTTLAERI-ASETH-IP-TTFNY

2016/02/23, 3:09 PM


UniRef90_A0PG77_1_219 UniRef90_Q6PMU2_725_943 UniRef90_Q8V0G8_526_744 UniRef90_A0PG80_1_219 UniRef90_Q8BDT2_1_218 UniRef90_A0PG94_1_219 UniRef90_C8YS70_1_219 UniRef90_Q6PMT8_726_934 UniRef90_Q6PMT3_724_939 UniRef90_B8Y0J7_726_934 UniRef90_E2IU95_1_209 UniRef90_Q80JY0_1_209 UniRef90_A0PFY2_1_209 UniRef90_Q80K03_1_209 UniRef90_Q1L757_525_734 UniRef90_Q80K16_1_209 UniRef90_Q1L752_527_735 UniRef90_A0PG17_1_209 UniRef90_Q80JY2_1_209 UniRef90_Q80JY8_1_209 UniRef90_Q8JVD0_525_739 UniRef90_Q80JU2_1_209 UniRef90_A0PFY7_1_209 UniRef90_A0PFY4_1_209 UniRef90_Q80JZ5_1_205 UniRef90_A0PFZ0_1_209 UniRef90_Q1L748_525_740 UniRef90_Q80JY7_1_209 UniRef90_A0PG12_1_209 UniRef90_A0PFY8_1_209 UniRef90_Q80JZ1_1_209 UniRef90_Q80JU1_1_209 UniRef90_B2MZR9_1_211 UniRef90_P49303_726_936 UniRef90_Q2I5Z0_71_281 UniRef90_Q9DJ49_1_212 UniRef90_A1EBZ1_1_211 UniRef90_A1EBZ4_1_211 UniRef90_I0AZ32_1_211 UniRef90_A8D5K4_1_211 UniRef90_Q2I5X3_80_290 UniRef90_I0AYZ5_1_211 UniRef90_I0AZ39_1_210 UniRef90_H9T7U2_127_337 UniRef90_Q9DJF9_1_211 UniRef90_I0AYY0_1_211 UniRef90_Q2I5X1_23_232 UniRef90_B2ZHQ6_1_211 UniRef90_A4ZPM0_1_211 UniRef90_E7D638_1_210 UniRef90_Q8JUM5_1_211 UniRef90_Q8BED5_1_209 UniRef90_A0ZXF2_1_211 UniRef90_F1BVI2_1_211 UniRef90_I0AYX9_1_210 UniRef90_I0AZ13_1_211 UniRef90_A4ZPL8_1_211 UniRef90_Q6PMY9_724_932 UniRef90_Q8JUP6_1_211 UniRef90_B1A0W6_1_210 UniRef90_C0LRW1_1_211 UniRef90_Q8JUN6_1_211 UniRef90_A1EC01_1_211 UniRef90_A2I8Z5_725_935 UniRef90_B1A0W7_1_211 UniRef90_Q9DJ38_1_212 UniRef90_A1EC10_1_211 UniRef90_E2FZV2_1_211 UniRef90_I0AYY6_1_211 UniRef90_A7XPU3_1_209 UniRef90_Q999Y2_1_211 UniRef90_B2MZR8_1_211 UniRef90_A1EC03_1_211

10 of 16


RCLATAYNGDCKYKPNAEAPRTHIRGDLAVLAERI-ASETH-IP-TTFNY RVLATVYNGGCKYKPTNEDARTNIRGDLATLAERI-REQSH-IP-TTFNY RVVATSYNGNCKYQDQSTTPLTHVRGDLATLAERI-AQNAH-IP-TSFNY RVLATVYNGDCKYKPINEDTRTNIRGDLATLAARV-REQSH-IP-TTFNY RVLATTYNGDCKYKAQPVENRE-IRGDLAVLAVRV-AEETH-IP-TTFNY RVLATVYNGNCRYKPNTEAPRPTIRGDLATLAARI-AEQAH-IP-TTFNY RLLATQYAGDCKYKQQPETPRENIRGDLATLAARI-SSESH-IP-TTFNY RLLSTVYNGECEYGTTVTA----IRGDRAVLAAKY-ANTRHTLP-STFNF GVLATVYNGNCKYSETQRV--TSRRGDLAVLAQRVENETTRCLP-TTFNF RLLSTVYNGECEYKTTVSA----IRGDRXVLANKY-AGVKHALP-STFNF RLLATRYNGECKYTDRSPA----IRGDRAVLAAKY-ANSRHTLP-STFNF RLLSTRYNGECKYTQTSGA----IRGDRAVLAAKY-ANTKHELP-STFNF RLLSTVYNGECTYTKTATA----IRGDRAALAAKY-ADNVHTLP-QTFNF RLLSTVYNGECRYTERVTA----IRGDRAVLAAKY-ANTRHALP-STFNF RLLSTVYNGECVYADTVAP----IRGDRQVLAAKY-SNRKHQLP-STFNY RLLSTVYNGECEYRTNVTA----IRGDRQVLAQKY-ASTKHALP-STFNF RLLSTVYNGECNYSTSVTP----IRGDRAVLAAKY-ASTKHTLP-STFNF RLLSTVYNGECDYNSKVTA----IRGDRQVLQQKY-ASTRHALP-STFNF RLLSTVYNGECEYTKTVSA----IRGDRAVLAAKY-ASGKHTLP-STFNF RLLSTRYNGECKYTQRSTR----IRGDPAVLAAKY-ANTKHELP-STFNF GVLATVYNGNCKYSKTQHV--VPRRGDLAVLAQRVENETTRCRP-TTFNF RLLSTVYNGECKYDTTVQP----IRGDRAVLANKY-ANRKHTLP-STFNF RLLSTVYNGECDYKKASTA----IRGDRAVLAAKY-ANTKHTLP-STFNF RVLATRYNGECKYTDRVSP----IRGDRAVLAAKY-ADSRHSLP-STFNF RLLATRYNGECKYTQEARA----IRGDRAVLAAKY-AGAKHALP-STFNF RLLSTVYNGECKYTEKTIA----IRGDRAVLAQKY-ASTKHALP-STFNF QVLATVYNGTCVYRKNAPV--TPRRGDLQALQARVDAERERCIP-TSFNF RLLSTRYNGECKYTQQSTA----IRGDRAVLASKY-SNIKHELP-STFNF RLLSTVYNGECAYSKPVSA----IRGDRQALAAKY-ASGRHTLP-STFNF RLLSTVYNGECEYNKTSNP----IRGDRAVLAAKH-KDVAHSLP-STFNF RLLSTVYNGECTYVHKTQA----IRGDRAVLAQKY-ANTKHSLP-STFNF RLLATHYNGECTYTKKVVP----IRGDRAALRAKY-ADTKHSLP-STFNF RVLATVYNGTCKYSTGT-T---GRQGDLESLAARV----ATQLP-TSFNY RVLATVYNGTGKYSAGG-M---GRRGDLEPLAARV----AAQLP-TSFNF RVLATVYNGNCKYGVSPMT---NVRGDLQVLAQKA----ARTLP-TSFNY RVLATAYNGECRYGTHTTT---NVRGDLQVLAQKA----ARTLP-TSFNY RVLATVYNGTSKYSATG-A---STRGDLGSLAARV----AEQLP-ASFNF RVLATVYNRTCKYSATG-G---RMRGDLGTFAARV----AAQLP-ASFNF RVLATVYNGTSRYASSG-S---SGRGDMGSLAARV----ARQLP-SSFNY RVLATVYNGDCKYGKSPVT---NLRGDLQVLTQKA----ARTLP-TSFNY RVLATVYNGTSKYSTTG-G---RTRGDLGALAARV----ATQLP-ASFNF RVLATVYNGVNKYAESG-S---NRRGDLGSLAARV----AKRLP-ASFNF RVLATVYNGTSKYSVST-S---GRRGDLGSLAARV----AKHLP-ASFNF RVLATVYNGNCKYGDSPVT---NVRGDLQVLAQKA----ARTLP-TSFNY RVLATVYNGNCKYAQGPLA---NVRGDLQVLAQKA----ARPLP-TSFNY RVLATVYNGVNKYTVSS-S---GRRGDLGALAARV----ARQLP-TSFNY RVLATVYNGTNKY-STT-G---SRRGDLGALAARV----AAQLP-ASFNF RVLATVYNGSCKYAEGSLT---KVRGDLQVLAQKA----AKPLP-TSFNY RVLATVYNGTSKYSVTT-S---PRRGDLGSLAARV----AAQLP-ASFNY RVLATVYNGASKYSVPA-A----RRGDLGSLAARL----AAQLP-ASFNY RVLATVYNGTSKYSATV-T---DGRGDLGALAAKV----AAQLP-ASFNF RVLATVYNGKTTYGETT-P----RRGDMAALAQRL----MGQLP-TSFNY RVLATVYNGECKYTNDNAP---NVRGDLQVLARKA----ARSLP-TSFNY RVLATVYNGTSKYSTGS-G---RTRGDLGQLAART----AAQLP-ASFNF RVLATVYNGTNKYS-TA-T---TRRGDLGALAARI----ASQLP-ASFNY RVLATVYNGTSEYAVSG-P---DSRGDTGPLAARA----ANQLP-ASFNY RVLATVYNGTSKYSTGA-S---PRRGDLGVLAARV----ATQLP-SSFNY RVLATVYNGKTTYGEQS-T----RHGDLATLAQGV----SNRLP-TSFNY RVLATVYNGTSKYSATG-E---HRRGDLGQLAARV----AAQLP-ASFNF RVLATVYNGVSKYSTTG-G---GRRGDLGSLAARV----AAQLP-ASFNF RVLATVYNGTSKYSTAG-I---GRRGDLGALAARV----AAQLP-ASFNF RVLATVYNGTNKYTAPN-T---GRRGDLGPLAARV----AAQLP-ASFNF RVLATVYNGTNKYSAAS-G---RTRGDLGQLAARV----AAQLP-ASFNF RVLATVYNGSSKYGDTSTN---NVRGDLQVLAQKA----ERTLP-TSFNY RVLATVYNGVSRYSTTG-N---GRRGDLGPLAARV----AAQLP-SSFNF RVLATVYNGNCKYTSVAMA---NGRGDLQVLTQKA----ARPLP-TSFNY RLLVTVYNGTNKYSAAS-G---RTRGDLGAVAARI----AAQLP-ASFNF RVLATVYNGSCRYSGAVTP---NVRGDLQVLARRA----APMLP-TSFNF RVLATVYNGTNKYSASA-P---NRRGDLGALAARL----AKQLP-ASFNY RVLATVYNGKTAYGETT-T----RRGDLAALAQRV----SRQLP-PSFNY RVLATVYNGTSEYTVSG-S---NGRGDMAPLAARV----AKTLP-ASFNY RVLATVYNGTSKYTVGG-S---GRRGDMGSLAARV----AEQLP-ASFNY RVLATVYNGTNKYSAAS-G---RTRGDLGTVAERT----ATQLP-ASFNF

2016/02/23, 3:09 PM


UniRef90_Q8BEA7_1_208 UniRef90_C0LYR0_1_209 UniRef90_C0LS35_1_211 UniRef90_I0AZ16_1_210 UniRef90_A4ZPP1_1_210 UniRef90_A0ZXC4_1_211 UniRef90_Q8JUS6_1_211 UniRef90_A1EC12_1_211 UniRef90_F6KYM9_1_211 UniRef90_B1A0X1_1_211 UniRef90_I0AZ19_1_211 UniRef90_Q912K6_1_211 UniRef90_A4ZPL9_1_211 UniRef90_Q9YPW9_1_211 UniRef90_A1EC13_1_211 UniRef90_B2MZQ3_1_211 UniRef90_E2J011_1_211 UniRef90_I0AZ31_1_211 UniRef90_D7RFC4_1_211 UniRef90_E2IZY3_1_211 UniRef90_Q9DJ33_1_211 UniRef90_Q9DJ21_1_192 UniRef90_Q0PV54_36_239 UniRef90_C8YS67_1_209 UniRef90_F6KYY3_1_211 UniRef90_B1A0W4_1_211 UniRef90_B3FHW7_1_211 UniRef90_A0ZXB5_1_211 UniRef90_A1EBZ3_1_211 UniRef90_Q9DJA4_1_210 UniRef90_Q0QED4_407_613 UniRef90_Q8JUU0_1_211 UniRef90_Q9DJF0_19_211 UniRef90_I0AZ37_1_211 UniRef90_Q67462_1_211 UniRef90_I0AZ36_1_211 UniRef90_Q91EM4_1_211 UniRef90_Q0PV56_33_229 UniRef90_C0LYW2_1_209 UniRef90_B2MZX2_1_207 UniRef90_Q01124_1_209 UniRef90_E2J004_1_192 UniRef90_Q8JUL9_1_209 UniRef90_Q6X5M0_1_179 UniRef90_Q2I5Y3_113_321 UniRef90_Q01121_1_189 UniRef90_Q6X5M1_1_179 UniRef90_A3RGT7_2_181 UniRef90_P03310_11_218 UniRef90_B3FHW2_1_211 UniRef90_Q8JUM1_1_211 UniRef90_Q65051_1_200 UniRef90_Q8JUL2_2_187 UniRef90_B2BF63_11_200 UniRef90_Q0PV58_32_197 UniRef90_Q65102_9_211 UniRef90_Q8BED3_1_210 UniRef90_A0PG53_1_160 UniRef90_B3FHW0_1_211 UniRef90_B3FHV9_1_211 UniRef90_B3FHV8_1_211 UniRef90_A0PG60_5_160 UniRef90_Q91NQ7_2_163 UniRef90_B3FHV6_1_211 UniRef90_B3FHV7_1_211 UniRef90_A0PG54_1_160 UniRef90_B3FHW1_1_211 UniRef90_Q65068_1_206 UniRef90_Q9YPF0_1_208 UniRef90_Q8BEF3_1_209 UniRef90_B3FHV4_1_211 UniRef90_Q8JUN9_1_211 UniRef90_Q9YPG1_1_165

11 of 16


RVLATVYNGETTYGETN-P----RRGDLAVLAQRE----SKRLP-TSFNY RVLATVYNGKTAYGAET-P----RRGDLAAIAQRV----NSSLP-TSFNY RVLATVYNGTSRYSTTG-G---RTRGDLGALAARV----SAQLP-ASFNF RVLATVYNGTSKYSTSS-P---G-RGDVGPLAARV----VKQLP-ASFNY RVLATVYHGTSKYSTPG-T----RRGDLGSFAARV----AAQLP-TSFNF RVLATVYNGTSKYTVSG-S---SRRGNLGSLAARV----AKALP-ASFNY RVLATVYNGTNKYSTAG-T---GRRGDLGALAARV----AAQLP-ASFNF RVLATVYNGTNKYSAAS-G---RTRGDLGQLAARV----AAQLP-ASFNF RVLATVYNGSCKYSSGAVP---NVRGDLRVLAQKA----TRSLP-TSFNY RVLATVYNGVNKYYTAH-S---GRRDDLGSLEARV----AAQLP-ASFNF RVLATVYNGTSKYTTSD-S---SRRGDMGALAARV----AKQLP-ASFNY RVLATEYNGTNRYTVSG-S---NRRGDLGSLAARV----AKALP-ASFNY RVLATVYNGTTKYATES-S---GRRGDLGPLAARV----AAQLP-ASFNY RVLATVYNGSCKYSDARVS---NVRGDLQVLAQKA----ERALP-TSFNY RVLATVYNGTSKYSAPG-L---CTRGDLGYPGARV----AAELP-ASFNF RVLATVYNGECRYSRNAVP---NLRGDLQVLAQKV----ARTLP-TSFNY HVLATVYNVTCRYCRAPVT---NVRGDLQVLSQKA----ARTLP-TSFNY RVLATVYNGTSRYAVSG-S---GRRGDLGPLAARV----AKALP-ASFNY RVLATVYNGNCKYAGGPLT---NVRGDLQVLAQKA----ARPLP-TSFNY RVLATVYNGNCKYGGTPVT---NVRGDLQVLAQKA----ARTLP-TSFNY RVLATVYNGNCRYGRAPVT---NVRGDLQVLAQKA----ARTLP-TSFNY RVLATVYNGNCKYXDAAVT---NVRGDLQVLAQKA----ARSLP-TSFNY RVLATVYNGVNKYSAAS-G---GRRGDLGSLAARV----AAQLP-ASFNF RVLATVYTGTATYATAN-P----RRGDPGQLAATR----SRHLP-ASFNF RVLATVYNGRCEYSKNPAS---NVRGDLQVLAQKA----ARALP-TSFNY RVLATVYNGVNKYSSTS-G---GRRGDLGPLATRV----AAQLP-SSFNF RGLATVCNGTNKYSAGS-G---RRRGDLGPLAARI----AAELP-ASFNF RVLATVYNGVSKYTANG-S---NRRGDMAALAARV----AKALP-ASFNY RVLATVYNGTSKYSVSG-S---NRRGDLGSPRSAV----RKQLP-ASFNY RVLATVYNGNYKYDDTPVT---NVRGDLQVLAQKA----ARTLP-TSFNY RVLATAYTGTTTY-TAS-A-----RGDLAHLTTTH----ARHLP-TSFNF RVLATVYNGTSKYSAXX-X---XXXXXXXXXXXXX----AAQLP-ASFNY RVLATVYNGNCKYAEGPLA---NVRGDLQVLAQKA----ARALP-TSFNY RVXGTVYXGVXKYAVGG-S---GRRGDLGSLAARV----ARQLP-ASFXY RVLATVYNGECTYSSNAVP---NVRGDPNLLEQKA----ARMLP-AYFNY GVXATVYNGVNKYAVGG-S---SRRGDSGPLAARV----ARQLP-ASFKY RVLATVYNGNCKYGESPVT---NVRGDLQVLAQKA----ARTLP-TSFNY RVLATVYNGTNKYAVTG----------------------AKQLP-SSFNF RVLVNSVQRKTTYGGET-S----ERGDFAALTQRL----SNWLP-TSFNY RVLATAYTGTTTY-T-S-T----RGGDLTHLAAAH----ARRLP-TSFNF RVLATRYTGTTTY-TTS-A----RRGDLAQLAAAH----ARHLP-TSFNF RVLATVYNGNCKYGGPPVT---NVRGDLQVLAQKA----ARTLP-ISFNY RVLATVYNGTSKYSARR-S-----RGDLGSLATRV----XTQLP-ASFNY RVLATVYNGTNKYSTGG-S---TRRGDLGALAARV----AAQLP-ASFNY RVLATVYNGTSKYSAG--E---RTRGDLGALAARV----ATQLP-ASFNF RVLATAYTGTTTY-TTS-A----RRGDLAHLAATH----ARRLP-TSFNF RVLATVYNGTSKYSTGG-S---SRRGDLGSLAARV----AAQLP-TSFNY RVLATVYNGTNKY-AAT-G---ARRGDLGSLAARV----AAQLP-SSFNF RVLATTYTGTTAY-TAS-A----RRGDLAHLAAAH----ARHLP-TSFNF FVMATGYHRDCLYSPNPII---NVRGDLQVLPQKG----ARTLP-TCFNY RVLATVYNGTNKYSTAG-T---GRRGDLGALAARV----AAQLP-ASFNF RVLATVYNGTNKYSTDG-P----RRDDMGSPAARA----AKQLP-ASFNY RVLATVYNGTSKXXXXX-X---XXXXXXXXXAAKV----AAQLP-ASFNF RVLATVYNGNCKYGESHTT---NVRGDLQVLAQKA----ARTLP-TSFNY RVLATVYNGTNKY-AAT-G---ARRGDLGSLAARV----AAQLP-SSFNF RVLATVYNGECKYSSXAVP---NVRGDLNVLEQKA----ARTLP-TSFNY RVLATVYNGKTTYGETT-P----RRGDMAALAQRL----MGQLP-TSFNY RVLATVYNGNCKYGGAPPT---NRRGDLQVLAQKA----ARPLP-TSFNY CVMATGYNGVCLYCQSPIT---NLRGDLQVLPQKG----ARTLP-TSFNY FVMTTGYNGVCLYSPNPRT---NLRGDLRALPQKV----ARTLP-SSFKY FVMATVYNGVCLYSPNPIS---NVRGDLQVLPQKV----AGTLP-TSFNY RVLATVYNGNCRYGNAPVN---NVRGDLQVLAQKA----ARTLP-TSFNY RVLATVYNGSCKYSRVEVP---KVRGDLQVLAQRA----ARTLP-TSFNF LVMGTVYPGNCLYSPNPII---NVRGDLQVLPQKG----ARTLP-SCFNY LVMRTGYHGVCLYSPNPIS---NVRGDLQVLPQKV----SRTLP-TSFNY RVLATVYNGNCKYDTAPLT---NVRGDLQVLAQKA----ARTLP-TSFNY CVMGTGYNGVCLYSQNPRT---NLRGDLQVLPQKV----ARALP-TSFNY RVLATAYTGTTTY-TAS-A-----RGDLAHLTTTH----AXHLP-TSFNF RVLATTYTGTTTX-TTS-A----RRGDLAHLATAH----ARHLP-TSFXF RVLATVYNGKTTYGETT-S----RRGDMAVLAQRL----MGRLP-TSFNY RVMRTGYHGVCLYSPNPIT---NVRGDLRVLPPKV----VRTLP-TSFNY XXXXXXXXXXXKYSTAG-T---GRRGDLGALAARV----AAQLP-ASFNF RVLATVCNGTNKYSTDG-P----RRGDMGXXXXXA----AKQLP-ASFNY

2016/02/23, 3:09 PM


12 of 16


UniRef90_A0PG23_5_162 UniRef90_Q9DJ61_1_156 UniRef90_Q65097_1_206 UniRef90_Q01126_1_208 UniRef90_Q67461_13_173 UniRef90_Q00280_54_209 UniRef90_H9AY35_719_926

RVLATVYNGNCRYGEVSVT---NVRGDLQVLAQKA----ARTLP-TSFNY RVLATVYNGNCKYGESSVT---NVRGDLQVLAQKA----ARTLP-TSFNY XVLATAYTGTTTY-IAS-A-----RGDLAHLKTTH----ARHLP-TSFNF RVLATEXAGTTTY--TT-T----RRGDLAQLATSR----AXRLP-TSFNF RVLATVYNGECKYSSNAVP---NVRGDPNVLEQKA----ARTLP-XXXXX RVLATTYTGTTAY-TTS-V----RRGDLAXLAATH----ARHLP-TSFNF RAIPTKYAGTTQYTHVTPA-----------------------RP-GTANF

2WZR1 UniRef90_Q6PMU0_725_943 UniRef90_F1AW55_725_943 UniRef90_A0PG93_1_219 UniRef90_A0PG86_1_219 UniRef90_A0PG77_1_219 UniRef90_Q6PMU2_725_943 UniRef90_Q8V0G8_526_744 UniRef90_A0PG80_1_219 UniRef90_Q8BDT2_1_218 UniRef90_A0PG94_1_219 UniRef90_C8YS70_1_219 UniRef90_Q6PMT8_726_934 UniRef90_Q6PMT3_724_939 UniRef90_B8Y0J7_726_934 UniRef90_E2IU95_1_209 UniRef90_Q80JY0_1_209 UniRef90_A0PFY2_1_209 UniRef90_Q80K03_1_209 UniRef90_Q1L757_525_734 UniRef90_Q80K16_1_209 UniRef90_Q1L752_527_735 UniRef90_A0PG17_1_209 UniRef90_Q80JY2_1_209 UniRef90_Q80JY8_1_209 UniRef90_Q8JVD0_525_739 UniRef90_Q80JU2_1_209 UniRef90_A0PFY7_1_209 UniRef90_A0PFY4_1_209 UniRef90_Q80JZ5_1_205 UniRef90_A0PFZ0_1_209 UniRef90_Q1L748_525_740 UniRef90_Q80JY7_1_209 UniRef90_A0PG12_1_209 UniRef90_A0PFY8_1_209 UniRef90_Q80JZ1_1_209 UniRef90_Q80JU1_1_209 UniRef90_B2MZR9_1_211 UniRef90_P49303_726_936 UniRef90_Q2I5Z0_71_281 UniRef90_Q9DJ49_1_212 UniRef90_A1EBZ1_1_211 UniRef90_A1EBZ4_1_211 UniRef90_I0AZ32_1_211 UniRef90_A8D5K4_1_211 UniRef90_Q2I5X3_80_290 UniRef90_I0AYZ5_1_211 UniRef90_I0AZ39_1_210 UniRef90_H9T7U2_127_337 UniRef90_Q9DJF9_1_211 UniRef90_I0AYY0_1_211 UniRef90_Q2I5X1_23_232 UniRef90_B2ZHQ6_1_211 UniRef90_A4ZPM0_1_211 UniRef90_E7D638_1_210 UniRef90_Q8JUM5_1_211 UniRef90_Q8BED5_1_209 UniRef90_A0ZXF2_1_211 UniRef90_F1BVI2_1_211 UniRef90_I0AYX9_1_210 UniRef90_I0AZ13_1_211 UniRef90_A4ZPL8_1_211

GMI----YTQAEVD-----VYLRMKRAELYCPRPVLTHYDHNGRDRYKTT GRI----YTQADVD-----VYVRMKRAELYCPRPLLTHYDHAGKDRYKTA GQL----YTESEVD-----VYVRMKRAELYCPRPLLTHYDHDGKDRYKVA GQI----YTESEVD-----VYVRMKRAELYCPRPVLTHYDHGDKDRYKIE GRI----YTEAEVD-----VYVRMKRAELYCPRPVLTHYDHQGRDRYKVA GRI----YTEADVD-----VYVRMKRAELYCPRPVLTHYDHKGRDRYKVA GIV----LTEAQVD-----VYVRMKRAELYCPRPLLTTYDHASTDRYKVS GQI----YTEAEVD-----VYVRMKRAETYCPRPLLTHYDHAGKNRYKTK GII----LTEAEVD-----VYVRMKRAELYCPRPVLTTYDHASADRYKVP GMI----LTESEVD-----VYVRMKRAELYCPRFLLTTYDHDGADRYKTT GII----LTEGEVD-----VYVRMKRAELYCPRFVLTMYDHAGQDRRKIR GII----ITEAEVD-----VYVRMKRAELYCPRFLLTTYDHQTAERYKTK GHV----TADQPVD-----VYYRMKRAELYCPRPLLPAYNHADRDRFDAP GRL----LCEEG-D-----AYYRMKRAELYCPRPLRVRYTHTT-DRYKTP GFV----TVDKPVD-----VYYRMKRAELYCPRPLLVTYDHANRDRFDAP GHV----TADQPVD-----VYYRMKRAELYCPRPLLPAYQHGTRDRFDAP GFV----TADEPVD-----AYYRMKRAELYCPRPLLPAYDHGSRDRFDAP GFV----TVDKPVD-----VYYRMKRAELYCPRPLLPAYDHASRDRFDAP GHV----TADKPVD-----VYYRMKRAELYCPRPLLPAYDHANRDRFDSP GYV----TADEPVD-----VYYRMKRAEFYCPRALLPAYDHHSRDRFDSP GFV----TTDKPVD-----VYYRMKRAELYCPRPLLPAYDHQNRDRFDAP GYV----TADAPVD-----VYYRMKRSELYCPRPLLPAYDHQSHDRFDAP GFV----TADKPVD-----VYYRMKRAELYCPRPLLPAYDHKNRDRFDAP GFV----TADKPVN-----VYYRMKRAELYCPRPFLPAYDHASRDRFDAP GYV----TADKPVD-----VYYRMKRAELYCPRPLLPGYDHADRDRFDSP GRL----LCDTG-D-----VYYRMKRAELYCPXALRVRYAHTT-DRYKTK GYV----TADKPVD-----VYYRMKRAELYCPRPLLPAYDHQSRDRFDAP GHV----TADAPVD-----VYYRMKRAELYCPRALLPAYDHVGRDRFDAP GHV----TADRPVD-----VYYRMKRAELYCPRPLLPAYQHNNRDRFDAP GHV----TADAAVD-----VYYRMKRAELYCPRPLLPAYEHLSRDRF--GFV----TADKPVD-----VYYRMKRAELYCPRALLPAYTHQDRDRFDAP GRL----YAESG-E-----LYLRMKRAELYCPRWIFVRYTHTT-DRYKVP GYV----TADKPVS-----VYYRMKRTELYCPRPLLPAYDHADRGRFDAP GFV----TADKPVD-----VYYRMKRAELYCPRALLPAYDHANRDRFDAP GFV----TADKPVD-----VYYRMKRAELYCPRPLLPAYSHNGRDRFDAP GHV----TADEAVD-----VYYRMKRAELYCPRPLLPAYEHNDRDRYDGP GFV----TADKPVD-----VYFRMKRTELYCPRALLPAYDHAHNDRFDAP GAV----KATKIHE-----LLVRMKRAELYCPRPLL-AVEVSAQDRHKQK GAI----QATTIHE-----LLVRMKRAELYCPRPLL-AVEVSSQDRHKQK GAI----KATRVIE-----LLYRMKRAETYCPRPLL-AVH-PSEARHKQK GAI----KATRVIE-----LLYRIKRAETYCPRPLL-AIH-PSEARHKQK GAI----RATTIHE-----LLVRMKRAELYCPRPLL-AVEVSSQDRYKQK GAI----RATNIHE-----LLVRMKRAELYCPRPLL-AVEVTVQDRHKQK GAI----KADTIHE-----LLVRMKRAELYCPRPLL-AVEVFGQDRHKQK GAI----KATRVTE-----LLYRMKRAETYCPRPLL-AIH-PSETRHKQK GAI----RATDISE-----LLVRMKRAELYCPRPLL-AVEVTAQDRHKQK GAI----KADTIHE-----LLVRMKRAELYCPRPLL-ALEVSSQDRHKQK GAI----RATNIHE-----LLVRMKRAELYCPRPLL-AVE-ASQDRYKQK GAI----KATRVTE-----LLYRMKRAETYCPRPLL-AIH-PSGARHKQK GAI----KATRVTE-----LLYRMKRAETYCPRPLL-AIQ-PNEARHKQK GAI----RAQTIHE-----LLVRMKRAELYCPRPLL-AVAVSSQDRHKQK GAI----RATNIHE-----LLVRMKRAELYCPRPLL-STEVTTQDRHKQR GAI----KATQVTE-----LLYRMKRAETYCPRPLL-AVH-PNEARHKQK GAI----RATTIHE-----LLVRMKRAELYCPRPLL-AVAVSSTDRHKQK GAV----RATEIQE-----LLVRMKRAELYCPRPLL-AVEVSSQDRHKQK GAI----RATTIHE-----LLVRMKRAELYCPRPLL-AVKVSSQDRHKQK GAV----KADTITE-----LLIRMKRAETYCPRPLL-ALD-TTQDRRKQK GAI----KATRVTE-----LLYRMKRAETYCPRPLL-AIH-PTEARHKQK GAI----KADGIHE-----LLVRMKRAELYCPRPLL-AVEVSSHDRHKQK GAI----RAQTIHE-----LLVRMKRAELYCPRPLL-AVEVSSQDRHKQK GAI----KAKVIHE-----LLVRMKRAELYCPRPLL-AVEVSSQDRYKQK GAL----RAETIQE-----LLVRMKRAELYCPRPLL-PAEVGSADRHKQK

2016/02/23, 3:09 PM


UniRef90_Q6PMY9_724_932 UniRef90_Q8JUP6_1_211 UniRef90_B1A0W6_1_210 UniRef90_C0LRW1_1_211 UniRef90_Q8JUN6_1_211 UniRef90_A1EC01_1_211 UniRef90_A2I8Z5_725_935 UniRef90_B1A0W7_1_211 UniRef90_Q9DJ38_1_212 UniRef90_A1EC10_1_211 UniRef90_E2FZV2_1_211 UniRef90_I0AYY6_1_211 UniRef90_A7XPU3_1_209 UniRef90_Q999Y2_1_211 UniRef90_B2MZR8_1_211 UniRef90_A1EC03_1_211 UniRef90_Q8BEA7_1_208 UniRef90_C0LYR0_1_209 UniRef90_C0LS35_1_211 UniRef90_I0AZ16_1_210 UniRef90_A4ZPP1_1_210 UniRef90_A0ZXC4_1_211 UniRef90_Q8JUS6_1_211 UniRef90_A1EC12_1_211 UniRef90_F6KYM9_1_211 UniRef90_B1A0X1_1_211 UniRef90_I0AZ19_1_211 UniRef90_Q912K6_1_211 UniRef90_A4ZPL9_1_211 UniRef90_Q9YPW9_1_211 UniRef90_A1EC13_1_211 UniRef90_B2MZQ3_1_211 UniRef90_E2J011_1_211 UniRef90_I0AZ31_1_211 UniRef90_D7RFC4_1_211 UniRef90_E2IZY3_1_211 UniRef90_Q9DJ33_1_211 UniRef90_Q9DJ21_1_192 UniRef90_Q0PV54_36_239 UniRef90_C8YS67_1_209 UniRef90_F6KYY3_1_211 UniRef90_B1A0W4_1_211 UniRef90_B3FHW7_1_211 UniRef90_A0ZXB5_1_211 UniRef90_A1EBZ3_1_211 UniRef90_Q9DJA4_1_210 UniRef90_Q0QED4_407_613 UniRef90_Q8JUU0_1_211 UniRef90_Q9DJF0_19_211 UniRef90_I0AZ37_1_211 UniRef90_Q67462_1_211 UniRef90_I0AZ36_1_211 UniRef90_Q91EM4_1_211 UniRef90_Q0PV56_33_229 UniRef90_C0LYW2_1_209 UniRef90_B2MZX2_1_207 UniRef90_Q01124_1_209 UniRef90_E2J004_1_192 UniRef90_Q8JUL9_1_209 UniRef90_Q6X5M0_1_179 UniRef90_Q2I5Y3_113_321 UniRef90_Q01121_1_189 UniRef90_Q6X5M1_1_179 UniRef90_A3RGT7_2_181 UniRef90_P03310_11_218 UniRef90_B3FHW2_1_211 UniRef90_Q8JUM1_1_211 UniRef90_Q65051_1_200 UniRef90_Q8JUL2_2_187 UniRef90_B2BF63_11_200 UniRef90_Q0PV58_32_197 UniRef90_Q65102_9_211 UniRef90_Q8BED3_1_210

13 of 16


GAV----KADTITE-----LLIRMKRAETYCPRPLL-ALD-TTQDRRKQE GAI----QATTIHE-----LLVRMKRAELYCPRPLL-AVEVSFQDRHKQK GAI----RATNIQE-----LLVRMKRAELYCPRPLL-PVEVLSQDRYKQK GAI----RATTIHE-----LLVRMKRAELYCPRPLL-AVEVSTQDRHKQK GAI----RATTISE-----LLVRMKRAELYCPRPLL-AVEVSANDRHKQK GAI----RATAIHE-----LLVRMKRAELYCPRPLL-AVEVSSQDRHKQK GAI----KATRVTE-----LLYRMKRAETYCPRPLL-AIQ-PSTARHKQK GAI----RATTIHE-----LLVRMKRAELYCPRPLL-AVEVLSQDRHKQK GAI----KATRLVE-----LLYRMKRAEAYCPRPLL-AIQ-PSEARHKQK GAI----KADAIHE-----LLVRMKRAELYCPRPLL-AVEVSSQDRHKQK GAI----KATRVTE-----LLYRMKRAETYCPRPLL-AFH-PSEARHKQK GAI----KADTIHE-----LLVRMKRAELYCPRPLL-AVEVSSQDRHKQK GAV----NAESITE-----LLIRIKRAETYCPRPLL-ALD-TVQERRKQE GAI----KADNIHE-----LLVRMKRAELYCPRPLL-ATEVPSQGRYKQK GAI----KATDIHE-----LLVRMKRAELYCPRPLL-AVEVSSQDRHKQK GAI----KATTIHE-----LLVRMKRAELYCPRPLL-AVEVSSQDRHKQK GAV----KAENITE-----LLIRMKRAETYCPRPLL-ALD-TTHDRRKQE GAV----KAESITE-----LLIRMKRAETYCPRPLL-ALE-TTQDRRKQE GAI----RATAISE-----LLVRMKRAELYCPRPLL-AVEVTEQDRHKQK GAI----KATKIHE-----LLVRMKRAELYCPRPLL-AIEVVSQDRHKQK GAI----RATGIQE-----LLVRMKRAELYCPRPLL-AVEVSSQDRHKQR GXI----KADXVHE-----LXVRMKRAELYCPRPLL-ALEVSSQDRHKQK GAI----RATTIEE-----LLVRMKRAELYCPRPLL-AVEVTAQDRHKXX GAV----QATTIHE-----LLVRMKRAELYCPRPLL-AVEVSSQDRHKQK GAI----KATQVTE-----LLYRMKRAETYCPRPLL-AIH-PSEARHKQK GAI----RATNIQE-----LLVRMKRAELYCPRPLL-AVEVSSQSRHKQK GAI----KADTIHE-----LLVRMKRAELYCPRPLL-AVEVSSQDRHKQK GAI----KADNIHE-----LLVRMKRAELYCPRPLL-AIXLSSQNRHKQR GAL----KATTIHE-----LLVRMKRAELYCPRPLL-AVEVSSQDRHKQK GAI----KATRVTE-----LLYRMKRAETYCPRPLL-AIQ-PSDARHKQE GAI----KNKSMHE-----LLVSMKRAELYCPRRLQ-TVEVSSQDRHKQK GAI----KATRVTE-----LLYRMKRAETYCPRPLL-AIH-PTEARHRQK GAI----KTTLPTE-----LLYRRKRAETYCPRPLL-ATH-PSEARHKQR GAI----KADNIHE-----LLVRMKRAELYCPRPLL-AIEVSSQDRHKQK GAI----KATRVTE-----LLYRMKRAETYCPRPLL-AVH-PDQARHKQK GAI----KATRVTE-----LLYRMKRAETYCPRPLL-AIH-PCEARHKQK GAI----KATRVIE-----LLYRMKRAETYCPRPLL-ATH-PSEARHKQR GAI----KATRVTE-----LLYRMKRAE-YCXRPLL-------------GAI----RATSIQE-----LLVRMKRAELYCPRPLL-AVKVSSQDRHKTK GAV----KAETITE-----LLVRMKRAELYCPRPIL-PVQ-PTGDRHKQP GAI----KATQVTE-----LLYRMKRAETYCPRPLL-AIH-PTEARHKQK GAI----RATTIHE-----LLVRMKRAELYCPRPLL-AVEVSSQDRHKQK GAI----KNKSMHE-----LLVSMKRAELYCPRTLQ-TVEVSSQDRHKQK GAI----KATNIHE-----LLVRMKRAELYCPRPLL-AIEVSSQDRHKQK GAI----KADHVHE-----LLVRMKRAELYCPRPLL-AIEVSSQDRHKQK GAI----KATRVTE-----LLYRMKRAETYCPRPLL-AIH-PSEARHKQK GAV----KAETITE-----LLVRMKRAELYCPRPIL-PIQ-PTGDRRKQP GAI----KATAIHE-----LLVRMKRAELYCPRPLL-AIEVSSQDRYKQK GAI----KATRVTE-----LLYRMKRAETYCPRPLL-AVH-PSEARHKQK GAI----KADTIHE-----ILVRMKRAELYCPRPLL-AIEVSSQDRHKQK GAI----KATRVTE-----LLYRMKRAETYCPRPLL-AIH-PTDARHKRK GAI----KATTIHE-----ILVRMKRAELYCPRPLL-AIEVSSQDRHKQK GAI----KATRVTE-----LLYRMKRAETYCPRPLL-AIH-PSEXRHKQK GAI----RATTIHE-----LLVRMRRAELYCPRPLL-AMEVSAEGRHKQK GAV----QAETITE-----LLIRMKRAETYCPRPLL-ALD-TTQDRRKQE GAV----KAETITE-----LLVRMKRAELYCPRPIL-PVQ-STGDRHKQP GAV----KAETVXE-----LLVRMKRAELYCPRPIL-PIQ-PTGDRHKQP GAI----KGTRVTE-----LLYRMKRAETYCPRPLL-------------GAI----KAQAIHE-----LLVRMKRAELYCPRPLL-AIEVSSQDRHKQK GAL----KAQDIHE-----LLVRM-------------------------GAI----QATNISE-----LLVRMKRAELYCPRPLL-AVEVTTQDRHKQK GAV----KAETITE-----LLVRMKRAELYCPRPIL-------------GAL----RADTIHE-----ILVRM-------------------------GAI----RATTIHE-----LLVRMRRAELYCPRPLL-AMEVSAEGRHKQK GAV----KAETITE-----LLVRMKRAELYCPRPVL-PVQ-PTGDRHKQP GVI----QATRLTE-----LVYRMKRSENYCPRPLL-AIH-PNEARHKQK GAI----RATTIEE-----LLVRMKRAELYCPRPLL-AVEVTAQDRHKQR GAI----RADTIHE-----LLVRMKRAELYCPRPLL-AIEVSSQDRHKQR GAI----RATTIHE-----LLVRMKRAELYCPRPLL-AVEVSSQDRHKQK GAI----KATRVTE-----LLYRMKRAETYCPRPLL-AIH-PNEARHKQK GAI----------------------------------------------GAI----KASRVTE-----LLYRMKRAETYCPRPLL-AIH-PTDARHKQK GAV----KADTITE-----LLIRMKRAETYCPRPLL-ALD-TTQDRRKQE

2016/02/23, 3:09 PM


UniRef90_A0PG53_1_160 UniRef90_B3FHW0_1_211 UniRef90_B3FHV9_1_211 UniRef90_B3FHV8_1_211 UniRef90_A0PG60_5_160 UniRef90_Q91NQ7_2_163 UniRef90_B3FHV6_1_211 UniRef90_B3FHV7_1_211 UniRef90_A0PG54_1_160 UniRef90_B3FHW1_1_211 UniRef90_Q65068_1_206 UniRef90_Q9YPF0_1_208 UniRef90_Q8BEF3_1_209 UniRef90_B3FHV4_1_211 UniRef90_Q8JUN9_1_211 UniRef90_Q9YPG1_1_165 UniRef90_A0PG23_5_162 UniRef90_Q9DJ61_1_156 UniRef90_Q65097_1_206 UniRef90_Q01126_1_208 UniRef90_Q67461_13_173 UniRef90_Q00280_54_209 UniRef90_H9AY35_719_926

2WZR1 UniRef90_Q6PMU0_725_943 UniRef90_F1AW55_725_943 UniRef90_A0PG93_1_219 UniRef90_A0PG86_1_219 UniRef90_A0PG77_1_219 UniRef90_Q6PMU2_725_943 UniRef90_Q8V0G8_526_744 UniRef90_A0PG80_1_219 UniRef90_Q8BDT2_1_218 UniRef90_A0PG94_1_219 UniRef90_C8YS70_1_219 UniRef90_Q6PMT8_726_934 UniRef90_Q6PMT3_724_939 UniRef90_B8Y0J7_726_934 UniRef90_E2IU95_1_209 UniRef90_Q80JY0_1_209 UniRef90_A0PFY2_1_209 UniRef90_Q80K03_1_209 UniRef90_Q1L757_525_734 UniRef90_Q80K16_1_209 UniRef90_Q1L752_527_735 UniRef90_A0PG17_1_209 UniRef90_Q80JY2_1_209 UniRef90_Q80JY8_1_209 UniRef90_Q8JVD0_525_739 UniRef90_Q80JU2_1_209 UniRef90_A0PFY7_1_209 UniRef90_A0PFY4_1_209 UniRef90_Q80JZ5_1_205 UniRef90_A0PFZ0_1_209 UniRef90_Q1L748_525_740 UniRef90_Q80JY7_1_209 UniRef90_A0PG12_1_209 UniRef90_A0PFY8_1_209 UniRef90_Q80JZ1_1_209 UniRef90_Q80JU1_1_209 UniRef90_B2MZR9_1_211 UniRef90_P49303_726_936 UniRef90_Q2I5Z0_71_281 UniRef90_Q9DJ49_1_212 UniRef90_A1EBZ1_1_211 UniRef90_A1EBZ4_1_211 UniRef90_I0AZ32_1_211 UniRef90_A8D5K4_1_211 UniRef90_Q2I5X3_80_290

14 of 16


GAI----KAAQVTE-----LLYRMKRAETYCPRPLL-AIH-PSEARHKQK GAI----QATRVTE-----LLYRMKRAETYCPRPLL-VIH-PNEARHRPQ GAI----QATRVTE-----MVYRMKRSETYCPRPLL-AIH-PNEARHKQK GVI----QATRLSQ-----MVYRMKRSESYCPRRLL-AIH-PNEARHKQK GAI----KATRVTE-----LLYRMKRAETYCPRPLL-AIH-PSEARHKQK GAI----KATRVTE-----LLYRMKRAETYCPRPLL-AVH-PSETRHKQK GVI----QATRLTE-----LVYRMKRSENYCPRPLL-AIH-PNEARHKQK GVI----QATRVTE-----LVYRMKRSENYCPRPLL-AIH-PNEARHKQK GAI----KATRVTE-----LLYRMKRAETYCPRPLL-AVH-PTEARHKQK GAI----QATRVTE-----LLYRMKRVETYCARHLL-AIH-PNEARHKQK GAV----KAETIXE-----LLVRMKRAELYCPRPIL-PIQ-PTGXRHKQX GAV----XAETVTE-----LLVRMKRAELYCPRPIL-PIQ-PTGDRHKQP GAV----KAETITE-----LLIRMKRAETYCPRPLL-ALD-TTQDRRXQK GVI----QATRLTE-----LVYRMKRSENYCPRPLL-AIH-PNEARHKQK GAI----RATTIEE-----LLVRMKRAELYCPRPLL-AVEVTAQDRHKQR GAI----------------------------------------------GAI----KATRVSE-----LLYRMKRAETYCPRPLL-AIH-PSETRHKQK GAI----KATRVTE-----LLYRMKRAXTYCPRPLL-AIH-PSEARXKQK XAV----KAETIXE-----LLVRXKRAXLYCPRPIL-PIX-PTDXRHXQP GAV----KADTVTE-----LLVRMKRAELYCPRPIL-PIQ-PXGDRHKQL XXX----XXTRVTE-----LLYRMKRAETYCPRPLL-AIH-PTDARHKQK GAV----KAETITE-----LLVRMKRAELYCPRPVL-PVQ-PAGDRHKQP GLVFVVGESGVSFR-----ILYRLKRTELYC

L I L L L L L L L L L L I L I I I I I I I I I I I L I I I I L I I I I I I I I I I I I I I

V T V V T T V V V V V V V V T I I V V I I I V I

K K A K K K A A A A A A K A K A A A A A A A A A

P P P P P P P P P P P P P P P P P P P P P P P P

A V A A A A E A E E A E D D E A A V T A A A V A

K K K K K K K K K K K K K K K K K K K K K K K K

Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q

2016/02/23, 3:09 PM


UniRef90_I0AYZ5_1_211 UniRef90_I0AZ39_1_210 UniRef90_H9T7U2_127_337 UniRef90_Q9DJF9_1_211 UniRef90_I0AYY0_1_211 UniRef90_Q2I5X1_23_232 UniRef90_B2ZHQ6_1_211 UniRef90_A4ZPM0_1_211 UniRef90_E7D638_1_210 UniRef90_Q8JUM5_1_211 UniRef90_Q8BED5_1_209 UniRef90_A0ZXF2_1_211 UniRef90_F1BVI2_1_211 UniRef90_I0AYX9_1_210 UniRef90_I0AZ13_1_211 UniRef90_A4ZPL8_1_211 UniRef90_Q6PMY9_724_932 UniRef90_Q8JUP6_1_211 UniRef90_B1A0W6_1_210 UniRef90_C0LRW1_1_211 UniRef90_Q8JUN6_1_211 UniRef90_A1EC01_1_211 UniRef90_A2I8Z5_725_935 UniRef90_B1A0W7_1_211 UniRef90_Q9DJ38_1_212 UniRef90_A1EC10_1_211 UniRef90_E2FZV2_1_211 UniRef90_I0AYY6_1_211 UniRef90_A7XPU3_1_209 UniRef90_Q999Y2_1_211 UniRef90_B2MZR8_1_211 UniRef90_A1EC03_1_211 UniRef90_Q8BEA7_1_208 UniRef90_C0LYR0_1_209 UniRef90_C0LS35_1_211 UniRef90_I0AZ16_1_210 UniRef90_A4ZPP1_1_210 UniRef90_A0ZXC4_1_211 UniRef90_Q8JUS6_1_211 UniRef90_A1EC12_1_211 UniRef90_F6KYM9_1_211 UniRef90_B1A0X1_1_211 UniRef90_I0AZ19_1_211 UniRef90_Q912K6_1_211 UniRef90_A4ZPL9_1_211 UniRef90_Q9YPW9_1_211 UniRef90_A1EC13_1_211 UniRef90_B2MZQ3_1_211 UniRef90_E2J011_1_211 UniRef90_I0AZ31_1_211 UniRef90_D7RFC4_1_211 UniRef90_E2IZY3_1_211 UniRef90_Q9DJ33_1_211 UniRef90_Q9DJ21_1_192 UniRef90_Q0PV54_36_239 UniRef90_C8YS67_1_209 UniRef90_F6KYY3_1_211 UniRef90_B1A0W4_1_211 UniRef90_B3FHW7_1_211 UniRef90_A0ZXB5_1_211 UniRef90_A1EBZ3_1_211 UniRef90_Q9DJA4_1_210 UniRef90_Q0QED4_407_613 UniRef90_Q8JUU0_1_211 UniRef90_Q9DJF0_19_211 UniRef90_I0AZ37_1_211 UniRef90_Q67462_1_211 UniRef90_I0AZ36_1_211 UniRef90_Q91EM4_1_211 UniRef90_Q0PV56_33_229 UniRef90_C0LYW2_1_209 UniRef90_B2MZX2_1_207 UniRef90_Q01124_1_209

15 of 16


I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I X I I I I I I I I I I I I I I I I I I I I I I L I I I I I I L I I I I I V I I L L

I I V V I I V I I I I V I I I I I I I I I I V I V I V I I I I I I I I I I I I M V I I I I V N V V I V V I I V I N I I V V I V I V I V I I I I

A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A X A A A A A A A A A A A

P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P S P P S P P P P P P P P P P P P P P P P P P P P P P

A A V E A A V A A A E V A A A A E A A A A A A A V A V A E A A A E E A A A E A E V A T A A A A V A A V V A A L A A A A X A A V A V A V A E A A

K K K K K K K K K K K K K K K K K K K K K K K K K K K K K K K K K K K K K K K K K K K K R K K K K K K K K K K K K K K K K K K K K K K K R K K

Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q R Q Q Q Q Q Q

2016/02/23, 3:09 PM



UniRef90_E2J004_1_192 UniRef90_Q8JUL9_1_209 UniRef90_Q6X5M0_1_179 UniRef90_Q2I5Y3_113_321 UniRef90_Q01121_1_189 UniRef90_Q6X5M1_1_179 UniRef90_A3RGT7_2_181 UniRef90_P03310_11_218 UniRef90_B3FHW2_1_211 UniRef90_Q8JUM1_1_211 UniRef90_Q65051_1_200 UniRef90_Q8JUL2_2_187 UniRef90_B2BF63_11_200 UniRef90_Q0PV58_32_197 UniRef90_Q65102_9_211 UniRef90_Q8BED3_1_210 UniRef90_A0PG53_1_160 UniRef90_B3FHW0_1_211 UniRef90_B3FHV9_1_211 UniRef90_B3FHV8_1_211 UniRef90_A0PG60_5_160 UniRef90_Q91NQ7_2_163 UniRef90_B3FHV6_1_211 UniRef90_B3FHV7_1_211 UniRef90_A0PG54_1_160 UniRef90_B3FHW1_1_211 UniRef90_Q65068_1_206 UniRef90_Q9YPF0_1_208 UniRef90_Q8BEF3_1_209 UniRef90_B3FHV4_1_211 UniRef90_Q8JUN9_1_211 UniRef90_Q9YPG1_1_165 UniRef90_A0PG23_5_162 UniRef90_Q9DJ61_1_156 UniRef90_Q65097_1_206 UniRef90_Q01126_1_208 UniRef90_Q67461_13_173 UniRef90_Q00280_54_209 UniRef90_H9AY35_719_926

1

2 3 Variable

4

5 6 Average

I I I L I I I I I I I I I I I I I I I I V L L I I I I I L X I X

I I I I V I I I V V I V V V V V V V V V V V I X V I E V V V V I

A A A A A A A A A A A A P A A A A A A A V A A T A A A A A A A A

P P P P P P P P P A P P T P P P P P P P T P P P P P P P P P P P

A A A A A A A A V V E V A A M A E V A A E A A V V A E V A

K K K K K K K K K K K K K K K K K K K K X K K K K K X K K

Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q

7 8 9 Conserved

X - Insufficient data - the calculation for this site was performed on less than 10% of the sequences.

16 of 16

2016/02/23, 3:09 PM



Figure 2S

ConSurf-DB Color-Coded MSA 2WZR2 UniRef90_F1AW55_285_503 UniRef90_Q6PMU0_285_503 UniRef90_Q8V0G8_86_304 UniRef90_Q6PMU2_285_503 UniRef90_Q6PMT8_285_503 UniRef90_A2I8Z5_287_504 UniRef90_Q1L754_86_304 UniRef90_B8Y0J7_285_503 UniRef90_Q1L757_86_304 UniRef90_P49303_287_504 UniRef90_A6XP89_287_504 UniRef90_Q6PMT3_285_502 UniRef90_Q1L752_86_304 UniRef90_Q1L748_86_303 UniRef90_P15072_287_504 UniRef90_Q8JVD0_86_303 UniRef90_H9AY35_273_496 UniRef90_B0Z3W9_300_527 UniRef90_Q91LX8_289_537 UniRef90_Q66776_291_513 UniRef90_Q100Y4_72_320 UniRef90_Q2XP17_290_516 UniRef90_P12296_138_384 UniRef90_Q02472_148_405 UniRef90_A4ZKN2_144_403 UniRef90_C3U5A3_174_435 UniRef90_P08544_148_405 UniRef90_E3TMG9_144_405 UniRef90_G9FTJ7_144_402 UniRef90_B3VTU7_149_406 UniRef90_Q155Z9_151_421 UniRef90_G1C9J1_14_204 UniRef90_I1YLT5_69_326 UniRef90_G0Y2E2_141_365 UniRef90_G0Y2E0_150_361 UniRef90_Q8B552_195_378 UniRef90_B5A1N0_195_378 UniRef90_Q2LKZ0_129_301 UniRef90_Q65481_129_301 UniRef90_G1DFA4_229_430 UniRef90_H9LG14_129_301 UniRef90_H6VLP2_125_335 UniRef90_B9VIN1_70_329 UniRef90_G1JYY8_171_367 UniRef90_Q8QUZ6_80_281 UniRef90_I1YLT7_70_335 UniRef90_F5B9S5_80_301 UniRef90_G0Y2E4_163_340 UniRef90_B8XTQ1_73_321 UniRef90_H9C6N6_131_322 UniRef90_I1YLT4_70_334 UniRef90_B8XTQ0_73_332 UniRef90_B9V442_80_329 UniRef90_D2IW00_80_316 UniRef90_Q2LL04_129_301 UniRef90_I1YLT6_69_335 UniRef90_G5DC73_80_330 UniRef90_A5GZE4_80_318 UniRef90_D9D8F3_70_328 UniRef90_G0ZNT5_127_322 UniRef90_B9V459_80_317 UniRef90_A8S322_129_323 UniRef90_C7DUC7_127_322 UniRef90_G8IJE2_80_317 UniRef90_Q2LKZ8_129_301 UniRef90_B8XTP8_70_327 UniRef90_H2E685_80_301 UniRef90_Q5YJ95_199_371

1 of 20

DKKTEETTLLEDRIVTTSHGTTTSTTQSSVGVTYGYALTDKFLPGPN-TDKKTEETTLLEDRILTTSHGTTTSTTQSSVGITYGYASSDKFVPGPN-TDKKTEETTLLEDRILTTSHGTTTSTTQSSVGVTRGYADSDKFLPGPN-TDKKTEETTLLEDRILTTSHGTTTSTTQSSVGVTYGYAASDQFLPGPN-TDKKTEETTLLEDRILTTSHGTTTSTTQSSVGVTYGYAASDKFLPGPN-TDKKTEETTLLEDRIVTTRHGTTTSTTQSSVGITYGYADADSFRPGPN-TDKKTEETTLLEDRILTTRNGHTTSTTQSSVGVTYGYATAEDLVSGPN-TDKKTEETTLLEDRIVTTRHGTTTSTTQSSVGVTYGYADSDSFHPGPN-TDKKTEETTLLEDRILTTRHGTTTSTTQSSVGVTLGYADADAFRPGPN-TDKKTEETTLLEDRILTTRHGTTTTTTQSSVGVTYGYADSDRFVPGPN-TDKKTEETTLLEDRILTTRNGHTTSTTQSSVGVTYGYSTQEDHVSGPN-TDKKTEETTLLEDRILTTRNGHTTSTTQSSVGVTYGYAVAEDAVSGPN-TDKKTEETTHLEDRILTTRHNTTTSTTQSSVGVTYGYASADRFLPGPN-TDKKTEETTLLEDRILTTRHGTTTSTTQSSVGVTFGYADADSFTAGPN-TDKKTEETTLLEDRILTTRHGTTTSTTQSSVGVTYGYASADKFLPGPN-TDKKTEETTLLEDRILTTRNGQTTSTTQSSVGVTFGYATAEDSTSGPN-TDKRTEETTLLEDRILTTRHNTTTFTTQSSVGVTHGYASADRFLPGPN-TDHKTEETTKLEDRILVTRSGPTTKTTQSSVGVVQGYGG-----PSPQSTK DKKTEETTKLEDRIMTTRHHTDITTTQSTVGITHGYAHSE--LDQVNAADQDTEETTRQPDRIVTTLDGNTSRTTQSSVGILRGYNYTPGKHVNP-SSDQDTEDVTRQPDRIVTVLDGNTSRTTQSSVGILRGYNYAPGKHTQP-SSDQETEDVTRQPDRIVTVLDGNTSRTTQSSVGILRGYNYKPGKHVPP-SSDKKTEETTNIEDRIETTVVGVTIINSQGSVGTTYCYSRPDSKAP---STDQNTEEMENLSDRVSQDTAGNTVTNTQSTVGRLVGYGTV-HDGEHP-ASDENTEEMENLSDRVDSDKAGNSATNTQSSVGRLHGYGAT-HRGDHP-ASDQNTEEMTNLSDRVSSDTAGNTATNTQSTVGRLFAFGSR-HKGKHP-ASDQDTEEMTNLSDRVASDTAGNTATNTQSTVGRLFGYASR-HRGKHP-ASDQNTEEMENLSDRVASDKAGNSATNTQSTVGRLCGYGKS-HHGEHP-ASDQNTEEMTNLSDRVSSDTAGNTATNTQSTVGRLFGFGQR-HKGKHP-ASDQDTEEMTNLSDRVSSDTAGNTATNTQSTVGRLFAFGSR-HKGKHP-ASDQNTEEMENLSDRVDSDKAGNSAVNTQSSVGRLCGYGMH-HKGKHP-ASDHNTEEMENSADRVTTQTAGNTAINTQSSLGVLCAYVEDPTKSDPP-SS-----------DRIMQLTMGNSTITTQEAANAVVAYGVWPDFAPGL-GEDPKTENTTNMEDRILTRRHGNTAISSQAAEGVLYGYGMESDKSDPTSCG---TVEEAGFSDRIMQITSGNSTITTQEAANAIVGYGVWPEIDQGV-GQ-----------DRIMQLTAGNSTITTQEAASAVVAYGVWPTHDVGV-GE-----------------------------------------TYNIDAGE-----------------------------------------SYNIDAGE--------------------------------------------------------------------------------------------------DPDTEESTELPDRITEDTAGNTNITTQSSVGTLVAYHQL--RSKHPVTS------------------------------------------------------------DRIMQITSGNSTITTQEAVQAIVAYGEWPEYEVGI-GE-PSAENSTNMGDRILTLREGNTAISSQATEGILHGYNKETDTSQPTSCG-----------DRILSITTGNSTITTQEAASAIVGYATWPEYYAGA-GE-----------DRVAQLTMGNSTITTQEAANITVAYGEWPSYLSDLDAT-PQREKQNIQEDRIFTRNAGNTSVNSQASEGVLQAYGKESDNTDPTSCG-----------DRVAQLTLGNSTITTQEAANITVAYGEWPGYLSDFDAT-------------------------------------------VGV-GH----EGATYLEDRLLTRRAGNTAVNSQAAEGVLLAYGKESDKTCPTSCG--------------------------------------------------PRVETTTNQEDRILTRNAGNTSINSQASEGVLHAYGRESDDTDPTSCG----ESSRDAEDRVITRQAGNTTVNSQASEGVLCAYGVDSLGTWPTSCG-----------DRIIQITRGDSTITSQDVANAVVGYGVWPHYLTPQDAT-----------DRIIQITRGNSTITSQDVANAVVGYGVWPQYLPDDDAS-------------------------------------------------NPRTENSTYLEDRVLTRTAGNTSINSQAAEGVLNAYAKESDQTCPTSCG-----------DRIIQITRGDSTITSQDVANAVVAYGVWPHYLSSGDAT-----------DRIIQITRGDSTITSQDVANAVVGYGVWPHYLTSRDAT-PRVENSTYQEDRILSRVAGNTSINSQASEGVLCAYAHETDGSDPTSCG------------------------------------------------------------DRIIQITRGDSTMTSQDVANAVVGYGVWPHYLTAQDAT-------------------------------------------------------------------------------------------------------------DRIIQITRGDSTITSQDVANAVVAYGVWPHYLSSKDAT--------------------------------------------------PRTETGMMMEDRVLSRTAGNTSVNSQAAEGVLQAYGTETDSNSPTSCG-----------DRVAQLTLGNSTITTQEAANITVAYGEWPSYLSDKDAT--------------------------------------------------

2016/02/23, 3:10 PM


UniRef90_Q9IM09_80_305 UniRef90_A5GZE9_80_317 UniRef90_Q66790_80_316 UniRef90_A5GZD8_131_315 UniRef90_P12915_129_301 UniRef90_Q5XLP5_80_317 UniRef90_G0Z2U8_195_360 UniRef90_A1E4A3_131_303 UniRef90_G0Y2E3_141_369 UniRef90_B9V482_80_298 UniRef90_B8XTP9_157_328 UniRef90_F8V2V4_80_316 UniRef90_A1E4A2_131_303 UniRef90_Q8V5Z9_80_307 UniRef90_G8IJE1_80_316 UniRef90_P12916_80_317 UniRef90_P03303_80_315 UniRef90_B8XTQ4_69_329 UniRef90_Q9YLJ1_78_316 UniRef90_B9V466_80_318 UniRef90_Q05ED6_131_323 UniRef90_B5BSU7_131_316 UniRef90_A5GZF1_80_316 UniRef90_B9V453_80_313 UniRef90_Q05EE3_80_323 UniRef90_A5GZE7_80_317 UniRef90_B9V485_80_315 UniRef90_G8IJH5_80_318 UniRef90_B9V435_80_318 UniRef90_Q8V398_80_292 UniRef90_Q82081_159_315 UniRef90_Q6W9F6_159_316 UniRef90_Q03053_159_316 UniRef90_A5GZD6_131_315 UniRef90_Q2YEN8_80_316 UniRef90_G8HH17_117_311 UniRef90_A7KC08_80_331 UniRef90_Q6W9G1_131_314 UniRef90_G8IQ64_80_315 UniRef90_I0IY47_80_323 UniRef90_G5DC75_80_317 UniRef90_Q05ED2_80_316 UniRef90_Q5VAK8_80_316 UniRef90_A7KC11_80_330 UniRef90_B5BSU6_131_316 UniRef90_Q05ED0_80_316 UniRef90_Q5VAL5_159_315 UniRef90_A4UHT9_129_315 UniRef90_H8Y6P9_127_322 UniRef90_P29813_80_316 UniRef90_P32537_131_305 UniRef90_G5D5E2_159_315 UniRef90_Q9YLG5_80_319 UniRef90_B8XTQ3_70_330 UniRef90_A7KC13_88_321 UniRef90_O41174_80_282 UniRef90_A5GZF9_80_318 UniRef90_G8IJE5_80_295 UniRef90_Q9QCF0_72_316 UniRef90_G5DC71_157_324 UniRef90_A8S330_157_325 UniRef90_Q9WN78_80_316 UniRef90_A0MHB7_86_316 UniRef90_O89280_159_323 UniRef90_G8IJG2_80_318 UniRef90_F6M9Y3_80_316 UniRef90_A5GZE0_80_317 UniRef90_Q7T7N9_80_323 UniRef90_A7YF31_159_315 UniRef90_H9X8D4_80_317 UniRef90_G9K146_80_316 UniRef90_G9K138_159_330 UniRef90_G0YPI0_80_292

2 of 20


-----------DRVAQLTIGNSTITTQEAANVVVAYGQWPEYLDSKDAT-----------DRIIQITRGDSTITSQDVANAVVGYGVWPHYLTPQDAT-----------DRVRSITLGNSTITTQESANVVVAYGRWPKYLEDDQAT-------------------------------------------------------------------------------------------------------------DRIIQITRGDSTITSQDVANAVVGYGVWPHYLTADDAS-----------------------------------------------------------------------------------------------------TVEELGYSDRIMQITSGNSTITTQEAVNAVVAYGVWPSIDEGV-GQ-----------DRVQQITLGNSTITTQEAANAVVCYAEWPEYLPDKDAS------------------------------------------------------------DRVRSITLGNSTITTQECANVVVGYGVWPDYLSDEEAT------------------------------------------------------------DRVAQLKLGNTSITTQEAANITVGYGEWPTFLSNVDAN-----------DRIIQITRGDSTITSQDVANAVVGYGVWPHYLSPEDAT-----------DRIIQITRGDSTITSQDVANAVVGYGVWPHYLTPQDAT-----------DRVQQITLGNSTITTQEAANAVVCYAEWPEYLPDVDASKPKVENDTNMEDRVITLKAGNTIVNSQASEGVLHGYGIGTNTQRPSSCG---------FSDRVRSLTLGNSTITTQESANVVVGYGRWPDYLADDQAT-----------DRIIQITRGDSTITSQDVANAVIGYGIWPHYLSAEDAT-------------------------------------------------------------------------------------------------------------DRIIQITRGDSTITSQDVANAVVGYGVWPHYLTSQDAT-----------DRIIQITRGDTTITSQDIANAVVGYGVWPTYLDSKDAS-----------DRVRSITLGNSTITTQESANVVVSYGEWPRYLKDDEAT-----------DRIIQITRGDSTITSQDVANAVVGYGVWPHYLSATDAT-----------DRVQQITLGNSTITTQEAANAVVCYAEWPEYLPDKDAS-----------DRIIQITRGDSTITSQDVANAVVGYGVWPHYLTAQDAT-----------DRIIQITRGDSTITSQDVANAVVGYGVWPHYLTPQDAT-----------DRVLQLTLGNSTITTQEAANIVVGYGKWPEHLKPIDAN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DRVRSLTLGNSTITTQESANVVVGYGRWPEYLKDEEAT---TVEECGFSDRIMQITSGNSTITTQEAVNAVVAYGCWPSFDSGA-GE-----------DRIMQITRGDSTITSQDVANAVVAYGVWPHYLTPQDAT------------------------------------------------------------DRVQQITLGNSTITTQEAANAVVCYAEWPEYLPDNDAS-----------DRVLQLTLGNSTITTQEAANAVVGYGEWPTLLNSNEAN-----------DRIIQITRGDSTITSQDVANAVVGYGVWPHYLSGTDAT-----------DRVRSITLGNSTITTQESANVVVAYGKWPDYLKDEEAT-----------DRVRSITLGNSTITTQECANVVVGYGVWPSYLKDNEAV-----------DRIIQITRGDSTITSQDVANAVVGYGVWPHYLTPQDAT------------------------------------------------------------DRVRSLTLGNSTITTQESANVVIGYGVWPNYLSDDQAT--------------------------------------------------------------------------------------------------------------------------------------------------------------DRVRSITLGNSTITTQESANVVVGYGRWPEYLKDNEAT-------------------------------------------------------------------------------------------------------------DRVRSITLGNSTITTQECANVVVGYGTWPRYLSDKEAT-PKVENSLYTEDRLLTRKAGNTSVNSQAAEGVLQGYGHESDFSNPTSCG-------------------GNSTITTQEAANAIVAYAEWPSFLKDDDAS-----------DRVAQLTLGNSTITTQEAANITVAYGEWPSYLSDLDAT-----------DRIIQITRGDSTITSQDVANAVVAYGVWPHYLTPQDAT-----------DRIIQITRGDSTITSQDVANAVVGYGVWPHYLTPQDAT---TAEECGYSDRVRSITLGNSTITTQECANVVVGYGTWPDYLHDDEAT-------------------------------------------------------------------------------------------------------------DRVRSITLGNSTITTQECANVVVGYGVWPTYLSDHEAT-------------------GSSTITTQDSVNTIVAYGEWPSYLSDLDAS------------------------------------------------------------DRIIQITRGNSTITSQDIANAVVAYGVWPEYLPSQDAS-----------DRIIQITRGNSTITSQDIANAVVGYGVWPQYLSDADAN-----------DRIIQITRGDSTITSQDVANAVVGYGVWPHYLTSQDAT-----------DRVLQLTLGNSTITTQEAANAVVAYGEWPRFINDQEAN------------------------------------------------------------DRIIQITRGDSTITSQDVANAVVGYGVWPHYLTPQDAT-----------DRIIQITRGDSTITSQDVANAVVGYGVWPHYLTPQDAT------------------------------------------------------------DRVAQLTVGNSTITTQEAANIVVGYGEWPNYCPDTDAT-

2016/02/23, 3:10 PM


3 of 20


UniRef90_O91734_159_316 UniRef90_B9V473_80_315 UniRef90_Q9WHH4_131_316 UniRef90_Q2L970_80_316 UniRef90_Q80GI2_159_316 UniRef90_Q05ED1_131_316 UniRef90_B9V440_80_317 UniRef90_G1CSA8_80_313 UniRef90_B1PZZ4_80_316 UniRef90_B9V457_80_316 UniRef90_D8VCT6_80_323 UniRef90_G8IRN4_129_324 UniRef90_Q80GI1_159_316 UniRef90_I1XV41_80_323 UniRef90_P21404_159_316 UniRef90_P23008_135_293 UniRef90_A5GZE2_80_315 UniRef90_Q6W9F4_159_316 UniRef90_B3SRP0_80_317 UniRef90_Q6JKS0_159_312 UniRef90_G8IJG6_157_325 UniRef90_D4AH62_131_316 UniRef90_A5GZD9_129_321 UniRef90_Q66331_80_318 UniRef90_Q6W9E8_159_323 UniRef90_P04936_159_330 UniRef90_A7KC07_80_326 UniRef90_Q66806_80_316 UniRef90_A5GZF5_80_318 UniRef90_Q05ED4_159_315 UniRef90_G8IRN3_129_329 UniRef90_Q82122_80_315 UniRef90_Q8V601_80_317 UniRef90_B9V433_129_314 UniRef90_G5EN04_80_318 UniRef90_Q8V613_159_316 UniRef90_Q6W9F9_80_316 UniRef90_H9C6N7_159_315 UniRef90_B9V434_80_314 UniRef90_A5GZF6_80_318 UniRef90_A5GZF2_80_318 UniRef90_C7DUC8_80_317 UniRef90_G5CZJ4_127_322 UniRef90_B9V477_80_318 UniRef90_G8IJH3_88_314 UniRef90_Q8UY33_159_317 UniRef90_P07210_80_318 UniRef90_Q66577_131_323 UniRef90_G8IJF0_127_318 UniRef90_E7CRL8_159_323 UniRef90_Q995Z1_80_314 UniRef90_C6ZEZ9_129_315 UniRef90_Q5G9Z5_159_312

------------------------------------------------------------DRIIQITRGNSTITSQDIANAVVAYGVWPQYLSDADAN------------------------------------------------------------DRVRSITLGNSTITTQESANVVVGYGVWPDYLSDEEAT-------------------------------------------------------------------------------------------------------------DRIIQITRGDSTITSQXVANAVVGYGVWPHYLTPEDAT-----------DRVAQLTVGNSTITTQEAANITVGYGEWPEYCPDTDAT-----------DRVRSITLGNSTITTQESANVVVAYGRWPEYLKDDEAT-----------DRIIQITRGNSTITSQDIANAVVAYGVWPHYLSDTDAN-----------DRVLQLTLGNSTITTQEAANAVIGYGEWPQFLNSADAN-------------------------------------------------------------------------------------------------------------DRVMQLTLGNSTITTQEAANAVVAYGEWPSFLNPQEAN-------------------------------------------------------------------------------------------------------------DRIIQITRGDSTITSQDVANAVVGYGVWPHYLTPEDAT------------------------------------------------------------DRVAQLTVGNSTITTQEAANITVGYGVWPEYSKDTEAT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DRVRSITLGNSTITTQECANVVVGYGVWPDYLKDSEAT-------------------------------------------------------------------------------------------------------------DRIIQITRGDSTITSQDIANAVVAYGVWPHYLSAEDAN-----------DRVRSITLGNSTITTQESANVVVGYGVWPEYLRDEEAT-----------DRIIQITRGNSTITSQDIANAVVGYGVWPEYLTDDDAS-------------------------------------------------------------------------------------------------------------DRIIQITRGDSTITSQDVANAVVGYGVWPHYLTPQDAT-----------DRVAQLTVGNSTITTQEAANITVGYGVWPEYSKDTEAT------------------------------------------------------------DRVAQLTVGNSTITTQEAANIVLSYGEWPEYCPSTDAT------------------------------------------------------------DRVRSMTLGNSTITTQESANVVVAYGEWPHYLSDDEAT------------------------------------------------------------DRIIQITRGDTTITSQDIANAVVAYGVWPTYLNSKDAT-----------DRIIQITRGNSTITSQDVANAVVAYGVWPEYLSAQDAS-----------DRLMQITRGDSTITSQDIANAVVGYGVWPSYLTPDDAT-----------DRIMQITRGDSTITSQDVANAVVGYGVWPHYLSAKDAT------------------------------------------------------------DRIIQITRGNSTITSQDIANAVVAYGVWPEYLSSDDAS-------------------GNSTITTQEAANAIVGYGEWPSFLDDKDAS------------------------------------------------------------DRLIQITRGDSTITSQDTANAVVAYGVWPSYLTPDDAT--------------------------------------------------------------------------------------------------------------------------------------------------------------DRVRSITLGNSTITTQECANVVVGYGVWPTYLSDTEAT---------------------------------------------------------------------------------------------------

2WZR2 UniRef90_F1AW55_285_503 UniRef90_Q6PMU0_285_503 UniRef90_Q8V0G8_86_304 UniRef90_Q6PMU2_285_503 UniRef90_Q6PMT8_285_503 UniRef90_A2I8Z5_287_504 UniRef90_Q1L754_86_304 UniRef90_B8Y0J7_285_503 UniRef90_Q1L757_86_304 UniRef90_P49303_287_504 UniRef90_A6XP89_287_504 UniRef90_Q6PMT3_285_502 UniRef90_Q1L752_86_304 UniRef90_Q1L748_86_303 UniRef90_P15072_287_504

---NGLETRVEQAERFFKHKLFDW--------------TLDQQFGT--TY ---NGLETRVEQAERFFKHKLFDW--------------TLEQKFGT--TH ---NGLETRVEQAERFFKHKLFDW--------------TTDQQFGV--AH ---NGLETRVEQAERFFKQKMFDW--------------TTEQSFGT--TH ---NGLETRVEQAERYFKQKLFDW--------------DTTQKFGV--TH ---SGLETRVQQAERFFKEKLFDW--------------TSEKPFGT--LH ---SGLETRVVQAERFFKTHLFDW--------------VTSDSFGR--CH ---SGLETRVEQAERFFKEKLFDW--------------TSDKPFGT--LH ---SGLETRVQQAERFFKEKLFDW--------------TSDKPFGT--LY ---SGLETRVRQAERIFKEKLFDW--------------TSDKPFGT--LH ---SGLETRVVQAERFFKKYLFDW--------------TPDKAFGH--LE ---SGLETRVQQAERFFKKHLFDW--------------TPNLAFGH--CH ---SGLESRVEQAERFFKEKLFTW--------------TASQEFAH--VH ---SGLETHVPQAERFFKEKLFDW--------------TSDKPFGT--TC ---SGLDTRVEHAERFFKEKLFTW--------------TANQEYAH--VH ---SGLETRVHQAERFFKMALFDW--------------VPSQNFGH--MH

2016/02/23, 3:10 PM


UniRef90_Q8JVD0_86_303 UniRef90_H9AY35_273_496 UniRef90_B0Z3W9_300_527 UniRef90_Q91LX8_289_537 UniRef90_Q66776_291_513 UniRef90_Q100Y4_72_320 UniRef90_Q2XP17_290_516 UniRef90_P12296_138_384 UniRef90_Q02472_148_405 UniRef90_A4ZKN2_144_403 UniRef90_C3U5A3_174_435 UniRef90_P08544_148_405 UniRef90_E3TMG9_144_405 UniRef90_G9FTJ7_144_402 UniRef90_B3VTU7_149_406 UniRef90_Q155Z9_151_421 UniRef90_G1C9J1_14_204 UniRef90_I1YLT5_69_326 UniRef90_G0Y2E2_141_365 UniRef90_G0Y2E0_150_361 UniRef90_Q8B552_195_378 UniRef90_B5A1N0_195_378 UniRef90_Q2LKZ0_129_301 UniRef90_Q65481_129_301 UniRef90_G1DFA4_229_430 UniRef90_H9LG14_129_301 UniRef90_H6VLP2_125_335 UniRef90_B9VIN1_70_329 UniRef90_G1JYY8_171_367 UniRef90_Q8QUZ6_80_281 UniRef90_I1YLT7_70_335 UniRef90_F5B9S5_80_301 UniRef90_G0Y2E4_163_340 UniRef90_B8XTQ1_73_321 UniRef90_H9C6N6_131_322 UniRef90_I1YLT4_70_334 UniRef90_B8XTQ0_73_332 UniRef90_B9V442_80_329 UniRef90_D2IW00_80_316 UniRef90_Q2LL04_129_301 UniRef90_I1YLT6_69_335 UniRef90_G5DC73_80_330 UniRef90_A5GZE4_80_318 UniRef90_D9D8F3_70_328 UniRef90_G0ZNT5_127_322 UniRef90_B9V459_80_317 UniRef90_A8S322_129_323 UniRef90_C7DUC7_127_322 UniRef90_G8IJE2_80_317 UniRef90_Q2LKZ8_129_301 UniRef90_B8XTP8_70_327 UniRef90_H2E685_80_301 UniRef90_Q5YJ95_199_371 UniRef90_Q9IM09_80_305 UniRef90_A5GZE9_80_317 UniRef90_Q66790_80_316 UniRef90_A5GZD8_131_315 UniRef90_P12915_129_301 UniRef90_Q5XLP5_80_317 UniRef90_G0Z2U8_195_360 UniRef90_A1E4A3_131_303 UniRef90_G0Y2E3_141_369 UniRef90_B9V482_80_298 UniRef90_B8XTP9_157_328 UniRef90_F8V2V4_80_316 UniRef90_A1E4A2_131_303 UniRef90_Q8V5Z9_80_307 UniRef90_G8IJE1_80_316 UniRef90_P12916_80_317 UniRef90_P03303_80_315 UniRef90_B8XTQ4_69_329 UniRef90_Q9YLJ1_78_316 UniRef90_B9V466_80_318

4 of 20


---SGLETRVEQAERFFKEKLLTW--------------TAAQEYAH--VH TLAAGLAVDVPSAEKFYDLGTWDW--------------NSTHPAGR--TM ---SGTHEHVDHVSRIYMKKLFTW--------------SMSDATGY--YH -AQDTPSKHEQSVECGFTFKLTKW--------------TAVASTWD--HL -AQDTPSKAEQSVERGFTFQLAQW--------------ETSRNIWD--HL -AQDKPSRAEQSVERGFTFKLTKW--------------ENSRHVWD--HL -VSDPVTRLGPTLSRHYTFKVGEW--------------PHSQSHGH--AW -CADTASEKILAVERYYTFKVNDW--------------TSTQKPFE--YI -CADTATDKVLAAERYYTIDLATW--------------TTAQTTFS--HI -CADTATDKVLAAERYYTLKLVTW--------------TTTQKPFD--HV -CADRATDKVLAAERYYTIKLATW--------------DTTLKAFD--HI -CADTATDKVLAAERYYTIDLASW--------------TTSQEAFS--HI -CADTATDKVLAAERYYTIKLASW--------------TKTQESFD--HI -CADTATDKVLAAERYYTFKIATW---------------STQKAFD--HV -CADTATDKVLSAERYYTIDLATW--------------TTTLSTFS--HI -STDQPTTTFTAIDRWYTGRLNSW--------------TKAVKTFS--FQ -AVDQSTTPGTAVDRFYTLDSFAW--------------T---ANNF-SGI ---DAPSRATPATSRSFVIPLQDW--------------LSSIDPYQ--YQ -AIDMQTIPGPSCERFYTLDSLKW--------------T---RTGL--GY -AVDMQTTPGPAVERFYTLDSWYW--------------T---KGSAQEGR -ALDLDTRPGPSCDRFYTFDSLNW--------------Q----NTQYGEW -ALDLDTKPGPSCDRFYTFDALSW--------------G----STEYGEW ------------AERFYTLPSVQW--------------T---NSFK--GH ------------AERFYTLPSVQW--------------T---TTFK--GR -CADKPTIGGPAMERNFVQYIGTW--------------ETAQVEYQ--CR ------------AERFYTLPSVQW--------------T---PTFK--GR -ALDKQSEPGPACDRFYTLDSWQW--------------T---NSSR--GY ---DRASKATPATQRSFIIPLKDW--------------TSSQNSYS--AL -SVDQFSRPGPASDRFYTLRSVNW--------------T---KNMD--PI -AVDKTTKPGVACDRFYTLPSKKW--------------E---QNSI--GW ---DKPSRGTAATDRSFVIQLKGW--------------TREQAAYD--AQ -AVDKTTKPGVACDRFYTLPGKKW--------------E---ASSL--GW -AIDKETKPGPAVERFYTLDSIYW--------------N---QDWK--GR ---DEPSEGTAATDRSFVIQLQPW--------------VKTNQAYT--AQ --------------RFYTLESKTW--------------T---NSSK--GW ---DEPSRGTAATDRSFVIQLKEW--------------TKTQASYD--AQ ---DKPSEGTDATDRNFVFQLLPW--------------AQGQKSYD--AQ -AIDKPSRPDTSSNRFYTLESKMW--------------T---SDSK--GW -AIDKPTHPDTSSNRFYTLESKEW--------------K---SDSK--GW ------------AERFYTLRSKAW--------------E---ANSP--GW ---DKPSEGTPATDRGFVVQLKPW--------------AKTNAAYD--AQ -AIDKPSRPDTSSNRFYTLKSITW--------------S---RSSK--GW -AIDKPSQPDTSSNRFYTLESKTW--------------T---SDSK--GW ---DTPSKGTAATDRSFIVQLQQW--------------STTQAAYD--AQ ------------ADRFYTLESVRW--------------T---QNSL--GW -AIDKPTQPDTSSNRFYTLESKLW--------------D---ETSK--GW --------------RFYTLTSVDW--------------T---TTSK--GW ------------ADRFYTLDSVQW--------------T---SDSK--GW -AIDKPSRPDTSSNRFYTLKSITW--------------S---SASK--GW ------------AERFYTLRSKPW--------------Q---SDSP--GW ---DDPSKGTHATDRAFVIQLLPW--------------KQTTNSYF--AQ -AVDKPTQPGVSCDRFYTLPGKKW--------------A---TEDR--GW -----------AVDRFYTFDSLQW--------------T----NTQVGEW -AVDKPTQPDVASNRFYTLKTVSW--------------E---KSST--GW -AIDKPTQPDTSSNRFYTLESKTW--------------V---ETSK--GW -AEDQPTQPDVATCRFYTLESVQW--------------E---ANSA--GW --------------RFYTLESKTW--------------T---NSSK--GW ------------ADAFYTLRSKPW--------------Q---ADSK--GW -AIDKPTQPDTSSNRFYTLESKVW--------------K---RDSK--GW -----------AVDRFYTFDSLQW--------------T----NTQVGEW --------------RFYTLKSVKW--------------E---AGST--GW -AIDMQTVPGPSCERFYTFSSQSW--------------T---TTTV--GY -DVNKTSKPDTSVCRFYTLDSKDW--------------S---ANSK--GW --------------------------------------------------AEDQPTQPDVATCRFYTLNSVKW--------------E---MQSA--GW --------------RFYTLKSVKW--------------E---GTSK--GW -AVDAPTHPDVSVNRFYTLKAVXW--------------E---KTST--GW -AIDKPTRPDTSSNRFYTLESKIW--------------M---NDSK--GW -AIDKPTQPDTSSNRFYTLESKHW--------------N---GDSK--GW -DVNKTSKPDTSVCRFYTLDSKTW--------------T---TGSK--GW ---DDPSIATHCIERGFTINLADW--------------DKSKESWQ--AL -AEDQPTQPDVATCRFYTLESVSW--------------Q---SGSA--GW -AIDKPTQPDTSSNRFYTLESKIW--------------H---TNSK--GW

2016/02/23, 3:10 PM


UniRef90_Q05ED6_131_323 UniRef90_B5BSU7_131_316 UniRef90_A5GZF1_80_316 UniRef90_B9V453_80_313 UniRef90_Q05EE3_80_323 UniRef90_A5GZE7_80_317 UniRef90_B9V485_80_315 UniRef90_G8IJH5_80_318 UniRef90_B9V435_80_318 UniRef90_Q8V398_80_292 UniRef90_Q82081_159_315 UniRef90_Q6W9F6_159_316 UniRef90_Q03053_159_316 UniRef90_A5GZD6_131_315 UniRef90_Q2YEN8_80_316 UniRef90_G8HH17_117_311 UniRef90_A7KC08_80_331 UniRef90_Q6W9G1_131_314 UniRef90_G8IQ64_80_315 UniRef90_I0IY47_80_323 UniRef90_G5DC75_80_317 UniRef90_Q05ED2_80_316 UniRef90_Q5VAK8_80_316 UniRef90_A7KC11_80_330 UniRef90_B5BSU6_131_316 UniRef90_Q05ED0_80_316 UniRef90_Q5VAL5_159_315 UniRef90_A4UHT9_129_315 UniRef90_H8Y6P9_127_322 UniRef90_P29813_80_316 UniRef90_P32537_131_305 UniRef90_G5D5E2_159_315 UniRef90_Q9YLG5_80_319 UniRef90_B8XTQ3_70_330 UniRef90_A7KC13_88_321 UniRef90_O41174_80_282 UniRef90_A5GZF9_80_318 UniRef90_G8IJE5_80_295 UniRef90_Q9QCF0_72_316 UniRef90_G5DC71_157_324 UniRef90_A8S330_157_325 UniRef90_Q9WN78_80_316 UniRef90_A0MHB7_86_316 UniRef90_O89280_159_323 UniRef90_G8IJG2_80_318 UniRef90_F6M9Y3_80_316 UniRef90_A5GZE0_80_317 UniRef90_Q7T7N9_80_323 UniRef90_A7YF31_159_315 UniRef90_H9X8D4_80_317 UniRef90_G9K146_80_316 UniRef90_G9K138_159_330 UniRef90_G0YPI0_80_292 UniRef90_O91734_159_316 UniRef90_B9V473_80_315 UniRef90_Q9WHH4_131_316 UniRef90_Q2L970_80_316 UniRef90_Q80GI2_159_316 UniRef90_Q05ED1_131_316 UniRef90_B9V440_80_317 UniRef90_G1CSA8_80_313 UniRef90_B1PZZ4_80_316 UniRef90_B9V457_80_316 UniRef90_D8VCT6_80_323 UniRef90_G8IRN4_129_324 UniRef90_Q80GI1_159_316 UniRef90_I1XV41_80_323 UniRef90_P21404_159_316 UniRef90_P23008_135_293 UniRef90_A5GZE2_80_315 UniRef90_Q6W9F4_159_316 UniRef90_B3SRP0_80_317 UniRef90_Q6JKS0_159_312

5 of 20


--------------RFYTLDSVDW--------------Q---NNSA--GW --------------RFYTMESVNW--------------E---SNSY--GW -AIDKPSRPDTSSNRFYTLESKEW--------------S---ANSK--GW -AIDKPTQPDTSANRFYTLESKEW--------------T---PDSK--GW -AEDKPTQPDVATCRFYTLESINW--------------E---KGSA--GW -AIDKPTQPDTSSNRFYTLESKVW--------------T---STSQ--GW -DVNKTSKPDTSVCRFYTLDSKTW--------------N---NTSK--GW -AIDKPSQPDTSSNRFYTLESKLW--------------T---NESK--GW -AIDKPSHPDTSSNRFYTLESKTW--------------S---NESK--GW -SIDAPTKPDVAVNRFYTLKAKKW--------------E---KNSS--GW -----------------------------------------------------------------------------------------------------------------------------------------------------------------RFYTLDSKTW--------------Q---QDSK--GW -AEDQPTQPDVATCRFYTLESVQW--------------E---KNSA--GW -AIDKLTDPGPSVDRFYTLDSIEW--------------S---TTTQ--GY -AIDKPSRPDTSSNRFYTLESKTW--------------T---GTSK--GW --------------RFYTLESVDW--------------S---ANSN--GW -DVNKTSKPDTSVCRFYTLESKTW--------------Q---NNSK--GW -SVDAPTVPDTSSDRFYTLDSVDW--------------E---KASR--GW -AIDKPSRPDTSSNRFYTLESKVW--------------T---PTSQ--GW -AEDQPTQPDVATCRFYTLDSVEW--------------S---KNSQ--GW -AEDQPTQPDVATCRFYTLDSVQW--------------Q---KTSN--GW -AIDKPTQPDTSSNRFYTLESKIW--------------T---TDSK--GW --------------RFYTLDSIQW--------------Q---KTSP--GW -AEDQPTQPDVATCRFYTLESVKW--------------D---KASA--GW ---------------------------------------------------------------RFYTLKSVTW--------------E---VGSS--GW ------------ADRFYTLKSVEW--------------G---ATSI--GW -AEDQPTQPDVATCRFYTLESVTW--------------E---RDSP--GW --------------RFYTLKSKKW--------------E---SNST--GW --------------------------------------------------AEDQPTQPDVATCRFYTLSSVQW--------------Q---RESA--GW ---DAPSKAVPATSRGYTVHLKDW--------------TSTIYAYY--AQ -DVNKPTRPDTSACRFYTLASKTW--------------S---RESK--GW -AVDKTTKPGVSCDRFYTLPGKKW--------------E---ATTK--GW -AIDKPSQPETSSNRFYTLESKTW--------------D---SSSK--GW -AIDKPSKPDTSSNRFYTLESQTW--------------T---NESK--GW -AEDQPTQPDVATCRFYTLESIQW--------------Q---KTSD--GW ---------------------------------------------------------------------------------------------------AVDQPTQPDVATCRFYTLESVKW--------------E---SSSA--GW -SVDKPTHPETSADRFYTLDSVQW--------------G---GSSK--GW --------------------------------------------------AIDKPTHPDTSSNRFYTLESKNW--------------T---ATSK--GW -AIDKPTHPDTSSNRFYTLDSKLW--------------T---NTSK--GW -AIDKPTRPDTSSNRFYTLESQLW--------------T---NTSK--GW -PVDAPTEPDASANRFYTLDSVDW--------------G---ADSK--GW --------------------------------------------------AIDKPTQPDTSSNRFYTLESKHW--------------T---NTSK--GW -AIDKPSRPDTSSNRFYTLASKEW--------------D---YNSK--GW --------------------------------------------------AVDKPTRPDVSVNRFYTLSTKSW--------------T---QNSR--GW --------------------------------------------------AIDKPSHPDTSSNRFYTLDSKLW--------------E---NGSK--GW --------------RFYTLDSVEW--------------Q---KNSP--GW -AEDQPTQPDVATCRFYTLDSVSW--------------M---KESQ--GW ---------------------------------------------------------------RFYTLDSVSW--------------E---ETSQ--GW -AIDKPSQPDTSTNRFYTLESKVW--------------D---SESK--GW -AVDKPTRPDVSVNRFYTLPAKLW--------------TKEGTGSK--GW -AEDQPTQPDVATCRFYTLESVTW--------------E---KDSP--GW -AIDKPSHPDTSSDRFYTLDSKLW--------------S---NESK--GW -PVDAPTLPDSSSNRFYTLESVEW--------------Q---SSSR--GW --------------RFYTLESVTW--------------N---GSSQ--GW --------------------------------------------------PVDAPTMPDASSNRFYTLDSVDW--------------E---KTSR--GW ---------------------------------------------------------------------------------------------------AIDKPSHPDTSSNRFYTLDSKLW--------------S---GDSK--GW --------------------------------------------------AVDKPTRPDVSVNRFYTLSAKLW--------------Q---TDSK--GW --------------------------------------------------

2016/02/23, 3:10 PM


6 of 20


UniRef90_G8IJG6_157_325 UniRef90_D4AH62_131_316 UniRef90_A5GZD9_129_321 UniRef90_Q66331_80_318 UniRef90_Q6W9E8_159_323 UniRef90_P04936_159_330 UniRef90_A7KC07_80_326 UniRef90_Q66806_80_316 UniRef90_A5GZF5_80_318 UniRef90_Q05ED4_159_315 UniRef90_G8IRN3_129_329 UniRef90_Q82122_80_315 UniRef90_Q8V601_80_317 UniRef90_B9V433_129_314 UniRef90_G5EN04_80_318 UniRef90_Q8V613_159_316 UniRef90_Q6W9F9_80_316 UniRef90_H9C6N7_159_315 UniRef90_B9V434_80_314 UniRef90_A5GZF6_80_318 UniRef90_A5GZF2_80_318 UniRef90_C7DUC8_80_317 UniRef90_G5CZJ4_127_322 UniRef90_B9V477_80_318 UniRef90_G8IJH3_88_314 UniRef90_Q8UY33_159_317 UniRef90_P07210_80_318 UniRef90_Q66577_131_323 UniRef90_G8IJF0_127_318 UniRef90_E7CRL8_159_323 UniRef90_Q995Z1_80_314 UniRef90_C6ZEZ9_129_315 UniRef90_Q5G9Z5_159_312

---------------------------------------------------------------RFYTLESVEW--------------Q---GSSA--GW ------------ACRFYTLDSKTW--------------T---NLSK--GW -AEDQPTQPDVATCRFYTLDSVQW--------------Q---KTSP--GW ---------------------------------------------------------------------------------------------------AIDKPTRPDTSSNRFYTLESKQW--------------M---ENSK--GW -AQDQPTQPDVATCRFYTLESVMW--------------E---KSSA--GW -AIDKPTHPDTSSNRFYTLESKHW--------------E---NNSK--GW ---------------------------------------------------------------RFYTLASVDW--------------T---QSSK--GW -AIDKPTQPDTSSNRFYTLDSKMW--------------N---STSK--GW -AVDKPTKPDVSVNRFYTLSAKLW--------------Q---SNSK--GW ------------ACRFYTLDSKMW--------------T---QGSK--GW -AVDKPTRPDVSVNRFYTLSTKSW--------------K---TEST--GW --------------------------------------------------AEDQPTQPDVATCRFYTLDSVTW--------------Q---KNSN--GW --------------------------------------------------AIDKPTQPDTSTNRFYTLESREW--------------R---SDSK--GW -AIDKPSHPDTSSNRFYTLESKNW--------------T---NTSK--GW -AIDKPTQPDTSSNRFYTLDSRTW--------------T---SASL--GW -AIDKPTQPDTSSNRFYTLDSKIW--------------K---PGSK--GW ------------ADRFYTLDSVNW--------------T---STSL--GW -AIDKPTHPDTSSNRFYTLESKQW--------------D---TNSK--GW -DVNKPTRPDTSACRFYTLASKTW--------------S---QSSK--GW --------------------------------------------------AIDKPTQPDTSSNRFYTLDSRSW--------------T---SASS--GW --------------RFYTLESVQW--------------Q---ENSA--GW ------------ADRFYTLRSVNW--------------G---ATSK--GW --------------------------------------------------AEDQPTQPDVATCRFYTLESVNW--------------Q---KESA--GW --------------RFYTLESVDW--------------K---SGSK--GW --------------------------------------------------

2WZR2 UniRef90_F1AW55_285_503 UniRef90_Q6PMU0_285_503 UniRef90_Q8V0G8_86_304 UniRef90_Q6PMU2_285_503 UniRef90_Q6PMT8_285_503 UniRef90_A2I8Z5_287_504 UniRef90_Q1L754_86_304 UniRef90_B8Y0J7_285_503 UniRef90_Q1L757_86_304 UniRef90_P49303_287_504 UniRef90_A6XP89_287_504 UniRef90_Q6PMT3_285_502 UniRef90_Q1L752_86_304 UniRef90_Q1L748_86_303 UniRef90_P15072_287_504 UniRef90_Q8JVD0_86_303 UniRef90_H9AY35_273_496 UniRef90_B0Z3W9_300_527 UniRef90_Q91LX8_289_537 UniRef90_Q66776_291_513 UniRef90_Q100Y4_72_320 UniRef90_Q2XP17_290_516 UniRef90_P12296_138_384 UniRef90_Q02472_148_405 UniRef90_A4ZKN2_144_403 UniRef90_C3U5A3_174_435 UniRef90_P08544_148_405 UniRef90_E3TMG9_144_405 UniRef90_G9FTJ7_144_402 UniRef90_B3VTU7_149_406 UniRef90_Q155Z9_151_421 UniRef90_G1C9J1_14_204 UniRef90_I1YLT5_69_326 UniRef90_G0Y2E2_141_365 UniRef90_G0Y2E0_150_361

VLELP----T------DHKGIYGQLVDSHAYIRNGWDVQVSATATQFNGG VLELP----T------DHKGIYGQLVDSHSYIRNGWDVQVSATATQFNGG ILELP----T------DHKGIYGQLVDSHSYIRNGWDVEVSATATQFNGG VLELP----T------DHKGIYGQLVDSHAYIRNGWDVEVSATATLFNGG VLELP----T------DHKGVYGQLVDSYTYMRNGWDVQVSATATQFNGG VLELP----K------DHKGIYGSLTDAYTYMRNGWDVQVTATSTQFNGG LLELP----T------DHKGVYGSLTDSYAYMRNGWDVEVTAVGNQFNGG ILELP----K------DHKGIYGSLTESYAYMRNGWDVQVSATSTQFNGG VLELP----K------DHKGIYGKLTDSYTYMXNGWDVQVSATSTQFNGG VLELP----K------DHKGIYGQLTEAYTYMRNGWDVQVTATSTQFNGG KLELP----T------DHKGVYGHLVDSFAYMRNGWDVEVSAVGNQFNGG YLELP----T------EHKGVYGSLMDSYAYMRNGWDIEVTAVGNQFNGG LLELP----T------DHKGIYGAMVESHAYVRNGWDVQVSATSTQFNGG VLELP----K------DHKGIYGKLNDSYAYMRNGWDVQVSATSTQFNGG CLELP----T------DHKGVYGQLVDSHTYIRNGWDVQVTATSTQSNGG KVVLP----H------EPKGVYGGLVKSYAYMRNGWDVEVTAVGNQFNGG LLELP----V------DHKGIYGAMLDSHAYVRNGWDVQVSATSTQFNGG RYPLPS---S------LRKGAFANLSKTYVLMQNGWEVVVTAQGTLSHGG AYPLPDLILT------EARE-YHNLLKSYALYRNGWEVHVSVVSTMYHSG AIPLPMS-----PGLFKNSGMYKNFVETHYLIKNGWKVQVQSNSSQFHSG TIPLPMC-----PGLIKVSGMYKAFIETHAYIKNGWKIQVQCNASQFHSG TIPLPMC-----PGLMKISGMYKSFVETHYLIKNGWKVQVQCNASQFHSG ICPLP-------GDKLKKMGSFHEVVKSHHLVKNGWDVVVQVNASFAHSG RIPLPHVL----SG--EDGGVFGATLRRHYLVKTGWRVQVQCNASQFHAG RVPLPHAL----AG--EHGGVFGATLRRHYLAKCGWRVQVQCNASQFHAG RIPLPHVL----AG--KQGGVFGSTLRRHYLCKCGWRIQVQCNASQFHAG RVPFPHIL----SG--KEGGVFGATLRRHYLCKCGWRIQVQCNASQFHAG RIPLPHVL----AG--EDGGVFGATLRRHYLCKTGWRVQVQCNASQFHAG RVPLPHAL----AG--ENGGVFSSTLRRHYLCKCGWRIQVQCNASQFHAG RVPFPHVL----SG--SKGGVFGSTLRRHYLCKCGWRIQVQCNASQFHAG RIPLPHVL----AG--EDGGVFGSTLRRHYLCKCGWRIQVQCNASQFHAG AVPLPGAFLSRQGG--LNGGAFTATLHRHFLMKCGWQVQVQCNLTQFHQG CYRLPGVL--------SDMGMFGQNLRYHYLMRCGFLCHVQINATKFHQG IYRTSQLRKE------SVGNLYSKSLNSHSYTKTGFEVTLQVNTSPFHAG GIKLPAAL--------TDLGVFGQNCQFHFLCHTGYCVHVQVNASKFHQG AYKLPAAL--------TDLGVFGQNCQFHFLCRSGFCVHVQVNATKFHQG

2016/02/23, 3:10 PM


UniRef90_Q8B552_195_378 UniRef90_B5A1N0_195_378 UniRef90_Q2LKZ0_129_301 UniRef90_Q65481_129_301 UniRef90_G1DFA4_229_430 UniRef90_H9LG14_129_301 UniRef90_H6VLP2_125_335 UniRef90_B9VIN1_70_329 UniRef90_G1JYY8_171_367 UniRef90_Q8QUZ6_80_281 UniRef90_I1YLT7_70_335 UniRef90_F5B9S5_80_301 UniRef90_G0Y2E4_163_340 UniRef90_B8XTQ1_73_321 UniRef90_H9C6N6_131_322 UniRef90_I1YLT4_70_334 UniRef90_B8XTQ0_73_332 UniRef90_B9V442_80_329 UniRef90_D2IW00_80_316 UniRef90_Q2LL04_129_301 UniRef90_I1YLT6_69_335 UniRef90_G5DC73_80_330 UniRef90_A5GZE4_80_318 UniRef90_D9D8F3_70_328 UniRef90_G0ZNT5_127_322 UniRef90_B9V459_80_317 UniRef90_A8S322_129_323 UniRef90_C7DUC7_127_322 UniRef90_G8IJE2_80_317 UniRef90_Q2LKZ8_129_301 UniRef90_B8XTP8_70_327 UniRef90_H2E685_80_301 UniRef90_Q5YJ95_199_371 UniRef90_Q9IM09_80_305 UniRef90_A5GZE9_80_317 UniRef90_Q66790_80_316 UniRef90_A5GZD8_131_315 UniRef90_P12915_129_301 UniRef90_Q5XLP5_80_317 UniRef90_G0Z2U8_195_360 UniRef90_A1E4A3_131_303 UniRef90_G0Y2E3_141_369 UniRef90_B9V482_80_298 UniRef90_B8XTP9_157_328 UniRef90_F8V2V4_80_316 UniRef90_A1E4A2_131_303 UniRef90_Q8V5Z9_80_307 UniRef90_G8IJE1_80_316 UniRef90_P12916_80_317 UniRef90_P03303_80_315 UniRef90_B8XTQ4_69_329 UniRef90_Q9YLJ1_78_316 UniRef90_B9V466_80_318 UniRef90_Q05ED6_131_323 UniRef90_B5BSU7_131_316 UniRef90_A5GZF1_80_316 UniRef90_B9V453_80_313 UniRef90_Q05EE3_80_323 UniRef90_A5GZE7_80_317 UniRef90_B9V485_80_315 UniRef90_G8IJH5_80_318 UniRef90_B9V435_80_318 UniRef90_Q8V398_80_292 UniRef90_Q82081_159_315 UniRef90_Q6W9F6_159_316 UniRef90_Q03053_159_316 UniRef90_A5GZD6_131_315 UniRef90_Q2YEN8_80_316 UniRef90_G8HH17_117_311 UniRef90_A7KC08_80_331 UniRef90_Q6W9G1_131_314 UniRef90_G8IQ64_80_315 UniRef90_I0IY47_80_323

7 of 20


TCPLPGAL--------MDTGVFGQNLRFHYLYRSGFCVHVQVNASSFHQG ALPLPGGL--------SDMGVFGQNLKFHYLYRSGFCVNVQCNASKFHQG YWKLPDAL--------SELGLFGQNLQFHYLYRGGWVIHVQCNATKFHQG FWKLPDAL--------SQLGLFGQNLQFHYLYRGGWAIHVQCNATKFHQG YLPLPHGL--------EEMGVFETTAIRHYTMKCGWKIQVQLNTSHFHAG YWKLPDAL--------SDLGLFGQNLQYHYLYRGGWAIHVQCNATKFHQG GYDLPGCL--------TDIGIFGQNCTYHFLMRSGFCIHVQLNASKFHQG VYRTSHMSKD------AVGNLFSKNMNTHAYTKTGWTATLQINTSPFHSG IVPFPGAL--------QDIGVFGQNLKFHFLYNGGACFHVQCNASQFHQG EWKLPDAL--------TELGVFGQNSQYHFLSRCGWAIHVQANATRFHQG WVKLTQELRKE-----HKGNVFAKNLKTHTFVKAGYEVTLQINTSPFHTG EWKLPDAL--------TQLGVFGQNCQFHYLSRCGWTIHVQCNATKFHQG VIRLPGAL--------TDLGMFGQNCQFHFLMRSGFCVHVQVNASKFHQG WVRLTQELRQD-----HKGNVFAKNLKSHAFAKLGFEVTVQVNTSPFHCG CWKLPDAL--------KEMGVFGQNMFFHALGRTGYTIHVQCNATKFHSG WVRLTQELRKE-----IKGNVFAKNLKTHTFVKAGYEVTLQVNTSPFHCG WIRITKDLRQD-----NKGNVFAKNMKSHAYMKAGYEVTLQVNTSPFHCG WWKLPDAL--------KNMGIFGENMFYHFLGRSGYTVHVQCNASKFHQG WWKLPDAL--------KNMGIFGENLFYHFLGRAGYTVHVQCNASKFHQG YWKLPDAL--------NNTGMFGQNAQFHYIYRGGWAVHVQCNATKFHQG WYRITDQLKID-----ERGNIFTKNMKSHAYLKAGYEVTLQVNTSPFHCG WWKLPDAL--------RDMGIFGENMFYHYLGRSGYTVHVQCNATKFHQG WWKLPDAL--------KEMGVFGQNMYYHFLGRSGYTVHVQCNSSKFHQG WVRLTQELRAD-----NKGNVFAKNLKTHSYAKMGFEVTLQVNTSPFHCG WWKLPDCL--------KDMGLFGQNMYHHSMGRTGYIIHVQCNATKFHSG WWKLPDAL--------KDMGIFGENMFYHFLGRSGYTVHVQCNASKFHQG WWKLPDCL--------KDMGIFGQNLYHHALGRSGYIIHTQCNATKFNSG WWKLPDAL--------KDMGLFGQNMYYHSMGRSGYIVHVQCNATKFHSG WWKLPDAL--------RDMGIFGENMFYHYLGRSGYTVHVQCNATKFHQG YWKLPDAL--------NNTGMFGQNAQFHYIYRGGWAVHVQCNATKFHQG WVRLTQKLSNN-----LHGNVMAKNIKSHAFAKMGFEVMLQANTSPFHNG EWKLPDAL--------TELGVFGQNCQYHYLARCGWIIHVQCNATKFHQG SLPLPGGL--------MDTGVFGQNLRFHYLSRMGFCVHVQCNASKFHQG YWKFSDCL--------ASVGLFGQNVQYHYLGRYGLAVHVQCNASKFHQG WWKLPDAL--------KDMGIFGENMFYHFLGRSGYTVHVQCNASKFHQG WWKFPEAL--------KDMGLFGQNMYYHYLGRAGYTIHVQCNASKFHQG CWKLPDAL--------KDMGVFGQNMFFHALGRTGYTIHVQCNATKFHSG YWKLPDAL--------NNTGMFGQNAQFHYIYRGGWAVHVQCNATKFHQG WWKLPDAL--------KDMGIFGENMYYHFLGRSGYTVHVQCNASKFHQG SLPLPGGL--------MDVGVFGQNLRFHYLSRMGFCVHVQCNASKFHQG WWKLPDAL--------NNIGMFGQNVQHHYLYRSGFLIHVQCNATKFHQG GLKLPLAL--------TDMGVFGQNCQYHFLCHSGFCVHVQVNASKFHQG CWKLPDAL--------KDMGVFGQNMFFHSLGRTGYTIHVQCNATKFHSG --------LQN-----NKANVFAKNLKAHSYLRAGYEVTLQVNTSPFHIG WWKFPDAL--------SEMGLFGQNMQYHYLGRSGYTIHVQCNASKFHQG WWKLPDAL--------NQTGMFGQNVQYHYLYRSGFLCHVQCNATKFHQG YWKLPDCL--------NQLGVFGQNAQYHYLYRSGFAVHVQCNASKFHQG WWKLPDAL--------KDMGVFGQNMYYHFLGRSGYTIHVQCNASKFHQG WWKLPDAL--------KEMGIFGENMYYHFLGRSGYTVHVQCNASKFHQG CWKLPDAL--------KDMGVFGQNMFFHSLGRSGYTVHVQCNATKFHSG VYRLSDHLKDD-----TVGNMFSKTLGTHAYTKCGYRVSLQINTSPFHSG WWKFPEAL--------KDMGLFGQNMYYHYLGRAGYTIHVQCNASKFHQG WWKLPDAL--------KDMGIFGENMYYHYLGRSGYTVHVQCNASKFHQG WWKFPNAL--------KDMGLFGQNMHYHYLGRTGYTVHVQCNASKFHQG WWKFPEAL--------KNMGLFGQNMYYHYLGRAGYTIHVQCNASKFHQG WWKLPDAL--------KDMGIFGENMFYHFLGRSGYTVHVQCNASKFHQG WWKLPDAL--------KDMGVFGENMFYHALGRSGYLIHVQCNASKFHSG WWKFPIAL--------KDMGLFGQNMLYHYLGRAGYTIHVQCNASKFHQG WWKLPDAL--------KDMGIFGENMFYHYLGRSGYTVHVQCNASKFHQG CWKLPDAL--------KDMGVFGQNMFFHSLGRSGYTIHVQCNATKFHSG WWKLPDAL--------KDMGVFGQNMYYHFLGRSGYTVHVQCNSSKFHQG WWKLPDAL--------KDMGIFGQNMYYHFLGRSGYTVHVQCNSSKFHQG MWKLPDCL--------NDTGVFGQNCWYHFLYRGGWAVHVQCNASKFHQG -------------------GVFGQNMFYHSLGRTGYTIHVQCNATKFHSG -------------------GLFGQNMLYHYLGRTGYTIHVQCNASKFHQG -------------------GLFGQNMQYHYLGRAGYTVHVQCNASKFHQG CWKLPDAL--------KDMGVFGQNMFYHTLGRTGYTIHVQCNATKFHSG WWKFPEAL--------KDMGLFGQNMLYHYLGRAGYTIHVQCNASKFHQG YYNLPGCL--------TNLGMFGQNCAYHYLMRSGFCVHIQVNASKFHQG WWKLPDAL--------KEMGIFGENMFYHFLGRSGYTVHVQCNASKFHQG WWKFPEAL--------KDMGLFGQNMLYHYLGRAGYTIHVQCNASRFHQG CWKLPDAL--------KDMGVFGQNMFFHSLGRSGYTIHVQCNATKFHSG WWKLPDAL--------KDMGMFGQNMYHHYLGRAGYTIHVQCNASKFHQG

2016/02/23, 3:10 PM


UniRef90_G5DC75_80_317 UniRef90_Q05ED2_80_316 UniRef90_Q5VAK8_80_316 UniRef90_A7KC11_80_330 UniRef90_B5BSU6_131_316 UniRef90_Q05ED0_80_316 UniRef90_Q5VAL5_159_315 UniRef90_A4UHT9_129_315 UniRef90_H8Y6P9_127_322 UniRef90_P29813_80_316 UniRef90_P32537_131_305 UniRef90_G5D5E2_159_315 UniRef90_Q9YLG5_80_319 UniRef90_B8XTQ3_70_330 UniRef90_A7KC13_88_321 UniRef90_O41174_80_282 UniRef90_A5GZF9_80_318 UniRef90_G8IJE5_80_295 UniRef90_Q9QCF0_72_316 UniRef90_G5DC71_157_324 UniRef90_A8S330_157_325 UniRef90_Q9WN78_80_316 UniRef90_A0MHB7_86_316 UniRef90_O89280_159_323 UniRef90_G8IJG2_80_318 UniRef90_F6M9Y3_80_316 UniRef90_A5GZE0_80_317 UniRef90_Q7T7N9_80_323 UniRef90_A7YF31_159_315 UniRef90_H9X8D4_80_317 UniRef90_G9K146_80_316 UniRef90_G9K138_159_330 UniRef90_G0YPI0_80_292 UniRef90_O91734_159_316 UniRef90_B9V473_80_315 UniRef90_Q9WHH4_131_316 UniRef90_Q2L970_80_316 UniRef90_Q80GI2_159_316 UniRef90_Q05ED1_131_316 UniRef90_B9V440_80_317 UniRef90_G1CSA8_80_313 UniRef90_B1PZZ4_80_316 UniRef90_B9V457_80_316 UniRef90_D8VCT6_80_323 UniRef90_G8IRN4_129_324 UniRef90_Q80GI1_159_316 UniRef90_I1XV41_80_323 UniRef90_P21404_159_316 UniRef90_P23008_135_293 UniRef90_A5GZE2_80_315 UniRef90_Q6W9F4_159_316 UniRef90_B3SRP0_80_317 UniRef90_Q6JKS0_159_312 UniRef90_G8IJG6_157_325 UniRef90_D4AH62_131_316 UniRef90_A5GZD9_129_321 UniRef90_Q66331_80_318 UniRef90_Q6W9E8_159_323 UniRef90_P04936_159_330 UniRef90_A7KC07_80_326 UniRef90_Q66806_80_316 UniRef90_A5GZF5_80_318 UniRef90_Q05ED4_159_315 UniRef90_G8IRN3_129_329 UniRef90_Q82122_80_315 UniRef90_Q8V601_80_317 UniRef90_B9V433_129_314 UniRef90_G5EN04_80_318 UniRef90_Q8V613_159_316 UniRef90_Q6W9F9_80_316 UniRef90_H9C6N7_159_315 UniRef90_B9V434_80_314 UniRef90_A5GZF6_80_318

8 of 20


WWKLPDAL--------KDMGIFGENMFYHYLGRSGYTVHVQCNASKFHQG WWKFPEAL--------KDMGLFGQNMLYHYLGRTGYTIHVQCNASKFHQG WWKFPDAL--------KDMGLFGQNMLYHYLGRAGYTIHVQCNASRFHQG WWKLPDAL--------KDMGIFGQNMYYHFLGRSGYTIHVQCNASKFHQG WWKFPDAL--------KDMGLFGQNMYYHYLGRAGYTVHVQCNASKFHQG WWKFPEAL--------KDMGLFGQNMYYHYLGRSGYTIHVQCNASRFHQG -------------------GLFGQNMHYHYLGRAGYTIHVQCNASKFHQG WWKLPDCL--------RDMGVFGQNMYHHAMGRSGYIIHTQCNATKFHSG WWKLPDCL--------KDMGIFGQNMYYHSFGRSGFLIHVQCNATKFHTG WWKFPDAL--------KDMGLFGQNMYYHYLGRAGYTLHVQCNASKFHQG WWKLPDAL--------NQIGMFGQNVQYHYLYRSGFLCHVQCNATKFHQG -------------------GVFGQNMFFHSLGRSGYTIHVQCNATKFHSG WWKFPDAL--------SDMGLFAQNMMYHYLGRTGYTIHVQCNASKFHQG LYRISDRIKDP-----AIGNLFSRNMDAHSFTKTGYEVMLQVNTSPFHSG CWKLPDAL--------KDMGIFGQNMFYHSQGRTGYTIHVQCNATKFHSG EWKLPDAL--------TELGVFGQNCQFHFLYRCGWSIHVQCNATKFHQG WWKLPDAL--------KDMGIFGQNMYYHFLGRSGYTVHVQCNASKFHQG WWKLPDAL--------KDMGIFGENMFYHFLGRSGYTVHVQCNASKFHQG WWKFPEAL--------KDMGLFGQNMHYHYLGRSGYTIHVQCNASKFHQG -------------------GIFGQNMYHHAMGRSGYIIHTQCNATKFHSG -------------------GMFGQNMYYHALGRSGYIFHVQCNATKFHSG WWKFPEAL--------SDMGLFGQNMQYHYLGRAGYTIHVQCNASKFHQG WWKLPDCL--------KNMGIFGQNMYYHAMGRSGYIIHTQCNATKFHSG -------------------GLFGQNMQYHYLGRSGYTIHVQCNASKFHQG WWKLPDAL--------KNMGIFGENLFYHFLGRAGYTVHVQCNASKFHQG WWKLPDAL--------KNMGIFGENMFYHFLGRAGYTVHVQCNASKFHQG WWKLPDAL--------KDMGIFGENMFYHFLGRSGYTVHVQCNASKFHQG WWKLPDAL--------KDMGMFGQNMYYHYLGRAGYTVHVQCNASKFHQG -------------------GLFGQNMHYHYLGRSGYTIHVQCNASKFHQG WWKLPDAL--------KDMGIFGENMYYHFLGRSGYTVHVQCNASKFHQG WWKLPDAL--------KDMGIFGENMFYHFLGRSGYTVHVQCNASKFHQG -------------------GIFGENMFYHFLGRSGYTVHVQCNASKFHQG YWKFPDVL--------NDVGVFGQNAQYHYLYRSGFCVHVQCNASKFHQG -------------------GLFGQNMYYHYLGRAGYTIHVQCNASKFHQG WWKLPDAL--------KNMGIFGENMFYHFLGRAGYTVHVQCNASKFHQG WWKFPDAL--------NDMGLFGQNMLYHYLGRAGYTIHVQCNASKFHQG WWKFPDAL--------RDMGLFGQNMQYHYLGRSGYTIHVQCNASKFHQG -------------------GLFGQNMYYHYLGRAGYTIHVQCNASRFHQG WWRFPDAL--------QDMGLFGQNMLYHYLGRTGYTIHVQCNASKFHQG WWKLPDAL--------KDMGVFGQNMYYHFLGRSGYTIHVQCNASKFHQG YWKFPDVL--------TEKGVFGQNAQFHFLYRSGFCIHVQCNASKFHQG WWKFPDAL--------KDMGLFGQNMYYHYLGRAGYTIHVQCNASKFHQG WWKLPDAL--------KDMGIFGENMFYHFLGRTGYTIHVQCNASKFHQG WWKLPDAL--------KDMGMFGQNMYYHYLGRAGYTVHVQCNASKFHQG WWKLPDCL--------KDMGIFGQNMYHHAMGRSGYIIHTQCNATKFHSG -------------------GMFGQNMFYHYLGRAGYTIHVQCNASRFHQG WWKLPDAL--------KDMGMFGQNMYHHYLGRAGYTVHVQCNASKFHQG -------------------GLFGQNMQYHYLGRAGYTIHLQCNASKFHQG -------------------GIFGENMYYHFLGRSGYTVHVQCNASKFHQG WWKLPDAL--------RDMGVFGQNMYYHFLGRSGYTVHVQCNSSKFHQG -------------------GLFGQNMYYHYLGRAGYTIHVQCNASRFHQG YWKFPDVL--------TETGVFGQNAQYHYLYRSGFCIHVQCNASKFHQG -------------------GVFGQNAQYHYLYRSGFCIHVQCNASKFHQG -------------------GIFGQNMYYHSMGRSGYIIHTQCNATKFNSG WWKFPEAL--------KDMGLFGQNMHYHYLGRAGYTIHVQCNASKFHQG CWKLPDAL--------KDMGIFGQNMFFHSQGRTGYTIHVQCNATKFHSG WWKLPDAL--------SNLGLFGQNMQYHYLGRTGYTDHVQCNASKFHQG -------------------GLFGQNMYYHYLGRSGYTLHVQCNASRFHQG -------------------GIFGENMFYHYLGRSGYTIHVQCNASKFHQG WWKLPDAL--------KDMGIFGENMFYHFLGRAGYTIHVQCNASKFHQG WWKFPDAL--------ADMGLFGQNMLYHYLGRSGYTIHVQCNASKFHQG WWKLPDAL--------KSMGIFGENMFYHHLGRAGYTIHVQCNASKFHQG -------------------GLFGQNMYYHYLGRAGYTIHVQCNASKFHQG WWKIPDCL--------KDMGMFGQNMFHHALGRSGYIIHTQCNATKFHSG WWKLPDAL--------KDMGIFGENMFYHFLGRSGYTVHVQCNASKFHQG YWKFPDVL--------TETGVFGQNAQFHYLYRSGFCIHVQCNASKFHQG CWKLPDAL--------KDMGIFGQNMFFHSQGRTGYTIHVQCNATKFHSG YWKFPDVL--------NDTGVFGQNAQFHYLYRSGFCMHVQCNASKFHQG -------------------GLFGQNMLYHYLGRAGYTFHVQCNASRFHQG WWKFPDAL--------KDMGLFGQNMYYHYLGRAGYTIHVQCNASKFHQG -------------------GIFGENMFYHFLGRAGYTVHVQCNASKFHQG WWKLPDAL--------KDMGVFGENMFYHSLGRAGYMIHVQCNASKFHSG WWKLPDAL--------KNMGIFGENLFYHFLGRAGYTVHVQCNASKFHQG

2016/02/23, 3:10 PM


9 of 20


UniRef90_A5GZF2_80_318 UniRef90_C7DUC8_80_317 UniRef90_G5CZJ4_127_322 UniRef90_B9V477_80_318 UniRef90_G8IJH3_88_314 UniRef90_Q8UY33_159_317 UniRef90_P07210_80_318 UniRef90_Q66577_131_323 UniRef90_G8IJF0_127_318 UniRef90_E7CRL8_159_323 UniRef90_Q995Z1_80_314 UniRef90_C6ZEZ9_129_315 UniRef90_Q5G9Z5_159_312

WWKLPDAL--------KNMGIFGENMFYHFLGRSGYTIHVQCNSSKFHQG WWKLPDAL--------KEMGIFGENMHYHYLGRSGYTVHVQCNASKFHQG WWKLPDCL--------REMGLFGQNMYYHSMGRTGYIIHVQCNATKFHSG WWKLPDAL--------KSMGIFGENMFYHHLGRAGYTIHVQCNASKFHQG CWKLPDAL--------KDMGIFGQNMFYHSQGRTGYTIHVQCNATKFHSG -------------------GVFGQNAQFHYLYRSGFCIHVQCNASKFHQG WWKLPDAL--------KNMGIFGENMFYHFLGRSGYTIHVQCNSSKFHQG WWKFPDAL--------SNMGLFGQNMLYHYLGRSGYTIHVQCNASKFHQG WWKFPDAL--------SEMGVFGQNMYYHAMGRSGYIIHTQCNATKFHSG -------------------GLFGQNMYYHYLGRSGYTVHVQCNASKFHQG WWKFPDAL--------RDMGLFGQNMLYHYLGRSGYTIHVQCNASKFHQG WWKFPDAL--------KDMGMFGQNMYHHSMGRFGALIHVQCNATKFHSG -------------------GVFGQNAQFHYLYRSGFCVHVQCNASKFHQG

2WZR2 UniRef90_F1AW55_285_503 UniRef90_Q6PMU0_285_503 UniRef90_Q8V0G8_86_304 UniRef90_Q6PMU2_285_503 UniRef90_Q6PMT8_285_503 UniRef90_A2I8Z5_287_504 UniRef90_Q1L754_86_304 UniRef90_B8Y0J7_285_503 UniRef90_Q1L757_86_304 UniRef90_P49303_287_504 UniRef90_A6XP89_287_504 UniRef90_Q6PMT3_285_502 UniRef90_Q1L752_86_304 UniRef90_Q1L748_86_303 UniRef90_P15072_287_504 UniRef90_Q8JVD0_86_303 UniRef90_H9AY35_273_496 UniRef90_B0Z3W9_300_527 UniRef90_Q91LX8_289_537 UniRef90_Q66776_291_513 UniRef90_Q100Y4_72_320 UniRef90_Q2XP17_290_516 UniRef90_P12296_138_384 UniRef90_Q02472_148_405 UniRef90_A4ZKN2_144_403 UniRef90_C3U5A3_174_435 UniRef90_P08544_148_405 UniRef90_E3TMG9_144_405 UniRef90_G9FTJ7_144_402 UniRef90_B3VTU7_149_406 UniRef90_Q155Z9_151_421 UniRef90_G1C9J1_14_204 UniRef90_I1YLT5_69_326 UniRef90_G0Y2E2_141_365 UniRef90_G0Y2E0_150_361 UniRef90_Q8B552_195_378 UniRef90_B5A1N0_195_378 UniRef90_Q2LKZ0_129_301 UniRef90_Q65481_129_301 UniRef90_G1DFA4_229_430 UniRef90_H9LG14_129_301 UniRef90_H6VLP2_125_335 UniRef90_B9VIN1_70_329 UniRef90_G1JYY8_171_367 UniRef90_Q8QUZ6_80_281 UniRef90_I1YLT7_70_335 UniRef90_F5B9S5_80_301 UniRef90_G0Y2E4_163_340 UniRef90_B8XTQ1_73_321 UniRef90_H9C6N6_131_322 UniRef90_I1YLT4_70_334 UniRef90_B8XTQ0_73_332 UniRef90_B9V442_80_329 UniRef90_D2IW00_80_316 UniRef90_Q2LL04_129_301

CLLVAMVPEL---------------------------------------CLLVAMVPEL---------------------------------------CLLVAMVPEL---------------------------------------CLLVAMVPEL---------------------------------------CLLVAMVPEL---------------------------------------SLLVAMVPEL---------------------------------------CLLVAMVPEL---------------------------------------SLLVAMVPEL---------------------------------------SLLVAMVPEL---------------------------------------SLLVAMVPEL---------------------------------------CLLVAMVPEW---------------------------------------CLLVALVPEL---------------------------------------TLLVAMVPEL---------------------------------------SLLVAMVPEL---------------------------------------ALLVALVPEL---------------------------------------CLQAALVPEM---------------------------------------TLLVAMVPEL---------------------------------------MLLVAMVPEL---------------------------------------CLIVAMVPEF---------------------------------------CLLVVMVPEYVAE------------QQRDFRGS---------WQDKDSDG CLLVAMIPEYLST------------AQQDFLGS---------WRDKTTDS CLLVVMVPEYVAT------------SQTDFRGS---------WQDKENDN ALCVAAVPEY------------------KHTHE---------KALKWSEL SLLVFMAPEY---------------PT--------------------LDV SLLVFLAPEF---------------YTGTGVAT---------SGQEPNKV SLLVFMAPEF---------------DTSSYSAV---------DDPIGEEP SLLIFMAPEF---------------DTSPYESE---------TEPDKNKV SLLVFMAPEF---------------YTGKGTKT---------GTMEPSDP SLLVFMAPEF---------------DTSNHSTE---------VEPRADTA SLLVFMAPEF---------------DTSPYNAT---------TEPTKAVP SLLVFMAPEF---------------YTGHTPAT---------GVTEPATP ALLVAMVPETTLDV----------KPDGKAKSL---------QELNEEQW CVMVVAIPECEYID----T-NVTGLDDTYTPGA---------QWRA---LVGLFMVPEFVRYTSP-SLTWENMLTK-FN--L-FKN-----TNIYTQDA MLLVCAIPDCKVDG----R---DNAT-VYNLEA---------KDLE---MLLVAAIPDCQVTE----H----GMNSAYPLSA---------VDFV---CLLVAMVPEHQ--------------------------------TPKQQNN MLLVAMVPEHQ--------------------------------TPTQLAN TLLVVATPEHKIQ-----------SAESPAFAR---------TNPGEQGA TLLVVAIPEHKIQ-----------SQQTPEFAK---------TNPGEDGY CLGVFAVPEA-----------------------------------QWVGK TLLVVAIPEHKIQ-----------AQQTPDFTR---------TNPGENGA MMLVCAIPECQSSS----G---ERSNSIFQLQE---------RDFA---LIGLFMVPEFVRKISD-DLEWIDLVAAGFNTTL-FKD-----SNTYNQDS ALLVAAVPEAVKLADD-FDPDQTHRPEVYPYQS---------KLGA---CLLVVAVPEHQLG-----------SKLNPEFGT---------TMPGKEGR MIGLFLVPKFTRMDLM-TWAWQNFHRK---LFFSLKV-----PNSMTPRV CLLVVAVPEHQLG-----------YTENIEFTQ---------AMPGKNGR MLLVAMVPEAQHPT----IGTNDNAA----LSD---------ETLA---MLGLFLVPEFTRPGPV-NLEWKDLTEK---SVI-INN-----TDIYKPQT CLLVVVIPEHQLASHT-E------GNVSVKYKY---------THPGETGI LVGLFLVPEFTRYGPE-NLGWQNLTTR---LSL-VKN-----SNLYETQN LIGLFLVPEFTRPGPV-NLEWKNLADR---RPI-MSD-----TSIWTPQN TLIVVMIPEHQLASAS-T------GNVTAGYNL---------THPGEQGR ALVVAAIPEHQLAYIG-S------ENVSVGYKH---------THPGESGR TLLVVAIPEHQIA-----------TQEQPDFGR---------TMPGDDGG

2016/02/23, 3:10 PM


UniRef90_I1YLT6_69_335 UniRef90_G5DC73_80_330 UniRef90_A5GZE4_80_318 UniRef90_D9D8F3_70_328 UniRef90_G0ZNT5_127_322 UniRef90_B9V459_80_317 UniRef90_A8S322_129_323 UniRef90_C7DUC7_127_322 UniRef90_G8IJE2_80_317 UniRef90_Q2LKZ8_129_301 UniRef90_B8XTP8_70_327 UniRef90_H2E685_80_301 UniRef90_Q5YJ95_199_371 UniRef90_Q9IM09_80_305 UniRef90_A5GZE9_80_317 UniRef90_Q66790_80_316 UniRef90_A5GZD8_131_315 UniRef90_P12915_129_301 UniRef90_Q5XLP5_80_317 UniRef90_G0Z2U8_195_360 UniRef90_A1E4A3_131_303 UniRef90_G0Y2E3_141_369 UniRef90_B9V482_80_298 UniRef90_B8XTP9_157_328 UniRef90_F8V2V4_80_316 UniRef90_A1E4A2_131_303 UniRef90_Q8V5Z9_80_307 UniRef90_G8IJE1_80_316 UniRef90_P12916_80_317 UniRef90_P03303_80_315 UniRef90_B8XTQ4_69_329 UniRef90_Q9YLJ1_78_316 UniRef90_B9V466_80_318 UniRef90_Q05ED6_131_323 UniRef90_B5BSU7_131_316 UniRef90_A5GZF1_80_316 UniRef90_B9V453_80_313 UniRef90_Q05EE3_80_323 UniRef90_A5GZE7_80_317 UniRef90_B9V485_80_315 UniRef90_G8IJH5_80_318 UniRef90_B9V435_80_318 UniRef90_Q8V398_80_292 UniRef90_Q82081_159_315 UniRef90_Q6W9F6_159_316 UniRef90_Q03053_159_316 UniRef90_A5GZD6_131_315 UniRef90_Q2YEN8_80_316 UniRef90_G8HH17_117_311 UniRef90_A7KC08_80_331 UniRef90_Q6W9G1_131_314 UniRef90_G8IQ64_80_315 UniRef90_I0IY47_80_323 UniRef90_G5DC75_80_317 UniRef90_Q05ED2_80_316 UniRef90_Q5VAK8_80_316 UniRef90_A7KC11_80_330 UniRef90_B5BSU6_131_316 UniRef90_Q05ED0_80_316 UniRef90_Q5VAL5_159_315 UniRef90_A4UHT9_129_315 UniRef90_H8Y6P9_127_322 UniRef90_P29813_80_316 UniRef90_P32537_131_305 UniRef90_G5D5E2_159_315 UniRef90_Q9YLG5_80_319 UniRef90_B8XTQ3_70_330 UniRef90_A7KC13_88_321 UniRef90_O41174_80_282 UniRef90_A5GZF9_80_318 UniRef90_G8IJE5_80_295 UniRef90_Q9QCF0_72_316 UniRef90_G5DC71_157_324

10 of 20


LVGLFMVPEWTRYGPTGEISWTNLLTR---LTL-VKN-----NDLYEPQT TLVVAMIPEHQIASLQ-H------GDVNVGYNF---------THPGEEGR TLIVAMIPEHQLAAAE-K------GNVTAGYNL---------THPGETGR LVGLFLVPEFTRFGPD-NLTWQDITTR---LSL-VNN-----PSLYDPQN CLMVAVVPEHQLAFIG-A------DGTKVKYSQ---------THPGERGH TLLVAMVPEHQLASAS-R------GNVTAGYNY---------THPGELGR CLIVAVVPEHQLAYIG-E------ANVNVGYDH---------THPGEGGH CLMVAVIPEHQLSYIG-G------DGTNVKYKH---------THPGEAGH TLIVAMIPEHQIASLQ-H------GNVNVGYKF---------THPGEEGR TLLVVAIPEHQIA-----------TQEQPDFGR---------TMPGETGG ILGLFLVPEFVRKGEI-TDEWIDLTPT---SSL-VSN-----TELYNPQT CLLVLAVPDHQLG-----------TTYNPDFNN---------TMPGKAGR ALIVAMIPEHQ--------------------------------TPTQVSN TLLVLAIPEWEIGVS---------NADRASFNL---------TNPDKNGH TLLVAMVPEHQLASAN-I------GNVTVGYNY---------THPGESGR CLLVVCVPEAEMGCAK--------PDENVDATN---------LTNGENTC CLLVVVVPEHQLASHT-Q------GNVSVKYKY---------THPGEQGI TLLVLAIPEHQIA-----------TQEQPAFDR---------TMPGSEGG TLLIAMVPEHQLASAN-Y------GNVTAGYNY---------THPGEAGR ALLVAMVPEHQ--------------------------------TPQQVSN ALLVVAIPEHQRGAYN--------TNTSPEFND---------IMKGEEGG LLLVCAIPDCQVQG----RLEGDSVTGLYTLES---------KDFE---CLLVVVIPEHQLASHD-G------GTVSVKYKF---------THPGEQGI LIGLFLVPEFTRPGPE-NLEWRDLTEM---KRI-LND-----TNIYNSQT CLLVVCVPEAEMGCTN--------VENAPAYGD---------LCGGETAK ALLVVAIPEHQLGKYN--------TGTSASFDD---------VMKGKSGG ALLVVAIPEWTQGRGL-TSS----TNTYMEYSQ---------TNPGKNGG TLIVAAIPEHQLASAE-K------GNVNTGYNY---------THPGETGR TLLVAMIPEHQLASAK-N------GSVTAGYNL---------THPGEAGR CLLVVVIPEHQLASHE-G------GNVSVKYTF---------THPGERGI LIGLFLVPECCIPASL-NMDWIDLKTQ---LPL-LTS-----SSHYQGLG CLLVVCVPEAEMGCAD--------VTSVVTALN---------LINGEDAH TLLVVMIPEHQLANAN-S------AKAGAGYNY---------THPGERGR CLLVVCVPEAEMGCAD--------VERTVVEES---------LSKSESPC CLLVACVPEAEMGCAD--------TTTVVTQDS---------LSNGDVPM TLIVAMIPEHQLASAT-T------GNATAGYNL---------THPGEGGR TLLVVAIPEHQLAYIG-T------GNVTVGYKH---------THPGETGR CLLVVCVPEAEMGCAK--------TDYTVTEDA---------LSKGEEPC TLLVVMIPEHQLASAH-T------GNVTAGYNF---------THPGEKGR CLLVVVIPEHQLASHQ-G------GNVSVKYTL---------THPGEAGI TLIVAMIPEHQLAAAE-K------GNVTAGYNL---------THPGERGR TLIVAMIPEHQLAAAE-R------GNVTAGYNF---------THPGEPGR ALLVFLAPDFTRGAPT-TTTTG--TIPNVSYSD---------TMPGEDGT CLLVVVIPEHQLASHE-G------GTVSVKYKY---------THPGDRGI CLLVVCVPEAEMGCAT--------VTNTLNATA---------LCNGDTAM CLLVVCVPEAEMGCAT--------LANKPDQKS---------LSNGETAN CLLIVVIPEHQLASHD-G------GTVSVKYKF---------THPGDQGI CLLVVCVPEAEMGCSQ--------TDKEVAAMN---------LTKGETAH TLMIVAVPECQFPG----EPTAEFGTIPDTLRT---------EFWK---TLIVAMIPEHQLASAT-T------GNVRAGYNL---------THPGESGR CLLVVCVPEAEMGSAV--------PGKALLASD---------LTGAEEPM CLLVVVIPEHQLASHK-G------GNVSVKYKY---------THPGEGGI TLFVAAIPEFMMASNA-AD-----GTGGITYER---------ANPGEAGG TLLVVMIPEHQLAAAN-T------GNVAAGYNF---------THPGEKGR CLLVVCVPEAEMGCAM--------KDGKVSAES---------LTKGESAC ALLVVCVPEAEMGCAT--------IDRTVNATA---------LCEGDKAK TLIVAAIPEHQLASAH-K------GNVNTGYNY---------THPGETGR CLLVVCVPEAEMGGRP--------TGQAFLNEE---------LTKGEVAC CLLVVCVPEAEMGNFN--------IQGALTAAD---------LTNGETAH CLLVVCVPEAEMGSAT--------VGQAFEHTA---------LTNQDTPH CLLVAVVPEHQLAYIG-G------DNTRVKYKH---------THPGELGH CLIVAVIPEHQLSYVG-A------ADVKVRYDH---------THPGEDGH CLLVVCVPEAEMGCSQ--------VDGTVNEHG---------LSEGETAK TLLIVAIPEHQIGKKG--------TGTSASFAE---------VMKGAEGG CLLVVVIPEHQLASHE-G------GNVSVKYKL---------THPGEGGI CLLVVCVPEAEMGCTN--------KENTPLFEK---------LCGQDNAK LIGLFLVPELVRSTGS-DLEWMVMTQK---LSL-YQPPAEEIAHSHYSTQ TLLVVIIPEHQLASAE-G------GNVSVFYDQ---------THPGERGI TLLVVAVPDHQLG-----------TTYQPEFDN---------VMPGKAGR TLIVAMIPEHQLASAR-H------GNLTAGYNF---------THPGENGR TLLVAMIPEHQLATAV-G------GSVSAGYNY---------THPGEKGR CLLVVCVPEAEMGCAT--------VENEVSAAA---------LSSGETAK CLLVAVVPEHQLAYIG-G------DNTQVNYEH---------THPGERGH

2016/02/23, 3:10 PM


11 of 20


UniRef90_A8S330_157_325 UniRef90_Q9WN78_80_316 UniRef90_A0MHB7_86_316 UniRef90_O89280_159_323 UniRef90_G8IJG2_80_318 UniRef90_F6M9Y3_80_316 UniRef90_A5GZE0_80_317 UniRef90_Q7T7N9_80_323 UniRef90_A7YF31_159_315 UniRef90_H9X8D4_80_317 UniRef90_G9K146_80_316 UniRef90_G9K138_159_330 UniRef90_G0YPI0_80_292 UniRef90_O91734_159_316 UniRef90_B9V473_80_315 UniRef90_Q9WHH4_131_316 UniRef90_Q2L970_80_316 UniRef90_Q80GI2_159_316 UniRef90_Q05ED1_131_316 UniRef90_B9V440_80_317 UniRef90_G1CSA8_80_313 UniRef90_B1PZZ4_80_316 UniRef90_B9V457_80_316 UniRef90_D8VCT6_80_323 UniRef90_G8IRN4_129_324 UniRef90_Q80GI1_159_316 UniRef90_I1XV41_80_323 UniRef90_P21404_159_316 UniRef90_P23008_135_293 UniRef90_A5GZE2_80_315 UniRef90_Q6W9F4_159_316 UniRef90_B3SRP0_80_317 UniRef90_Q6JKS0_159_312 UniRef90_G8IJG6_157_325 UniRef90_D4AH62_131_316 UniRef90_A5GZD9_129_321 UniRef90_Q66331_80_318 UniRef90_Q6W9E8_159_323 UniRef90_P04936_159_330 UniRef90_A7KC07_80_326 UniRef90_Q66806_80_316 UniRef90_A5GZF5_80_318 UniRef90_Q05ED4_159_315 UniRef90_G8IRN3_129_329 UniRef90_Q82122_80_315 UniRef90_Q8V601_80_317 UniRef90_B9V433_129_314 UniRef90_G5EN04_80_318 UniRef90_Q8V613_159_316 UniRef90_Q6W9F9_80_316 UniRef90_H9C6N7_159_315 UniRef90_B9V434_80_314 UniRef90_A5GZF6_80_318 UniRef90_A5GZF2_80_318 UniRef90_C7DUC8_80_317 UniRef90_G5CZJ4_127_322 UniRef90_B9V477_80_318 UniRef90_G8IJH3_88_314 UniRef90_Q8UY33_159_317 UniRef90_P07210_80_318 UniRef90_Q66577_131_323 UniRef90_G8IJF0_127_318 UniRef90_E7CRL8_159_323 UniRef90_Q995Z1_80_314 UniRef90_C6ZEZ9_129_315 UniRef90_Q5G9Z5_159_312

LLLVAIVPEHQLAYIG-G------TNANVGYNH---------THPGEGGH CLLVVCVPEAEMGAAT--------TDHAMNHTK---------LSNIGQAM CLLVAVVPEHQLAYIG-V------D-AQVSYKH---------THPGERGH CLLVVCVPEAEMGCSN--------LNNAPLAAD---------LSAGEVAR TLIVAAIPEHQLAFIS-K------GNVTVGYNY---------THPGEQGR TLVIAAIPEHQLAYIG-S------GNVSVGYKQ---------THPGENGR TLLIATIPEHQLATAV-G------GSVSAGYNY---------THPGEKGR TLFVAAIPEYMMASNS-GT-----NTGGIIYEF---------ANPGEAGG CVLVVCVPEAEMGCAD--------IDSTFEHTA---------LTKQELPY TLLVAMIPEHQLASAK-H------GSVTVGYKL---------THPGEAGR TLIVAMIPEHQLASAT-T------GNATAGYNL---------THPGETGR TLIVAMIPEHQLASAT-Y------GNVAAGYKL---------THPGETGR ALLVAMVPEFVIASKS-ERSKPNDPAQYPAFSV---------TNPGKNGR CILVVCVPEAEMGSAQ--------TSGVVNYEH---------ISKGEIAS TLVVAAIPEHQLAYIG-S------GNVSVGYRH---------THPGEQGR CLLVVCVPEAEMGCTQ--------HDKTVNQEH---------LSQGERAM CLLVVCVPEAEMGAAK--------INEKINREH---------LSKGEVAN CLLVVCVPEAEMGSST--------PGQAFTVEE---------LTKGEEAM CILVVCVPEAEMGCSK--------VDDTVSASE---------LSKGERAC TLIVAAIPEHQLASAT-K------GNVTAGYNY---------THPGEMGR TLLVACLPEYVNARAS-TNDTNA-TAPHPPYAV---------TQPGPNGK CLMVVCVPEAEMGCSQ--------IDGTVNEHS---------LSEGETAK TLVVAAIPEHQLAFIG-K------GNVSVGYRH---------THPGENGR ALFVAAIPEFMMASNS-AD-----QTGGITYEK---------ANPGEAGG CLLVAVVPEHQLAYIG-G------SNAQVSYEH---------THPGERGH CLLVVCVPEAEMGSSQ--------VGQNFPASA---------LTKGERAS TLFVAAIPEFMMASNS-AD-----STGGITYEK---------ANPGEAGG CLLVVCVPEAEMGGAV--------VGQAFSATA---------MANGDKAY TLLVAMIPEHQLASAK-H------GSVTAGYKL---------THPGEAGR TLIVAMIPEHQLASAE-K------GNVTAGYKL---------THPGEAGR CLLVVCVPEAEMGSHT--------PGTAFASDA---------VSKGEVAL TLLVAAIPEYVVARAS-NEQDPN-TAPHPNYNV---------TQPGPGGK ALLVAAVPEMVLGANS-SDPKPN-TAKHPEFAT---------TMPGANGG CLLVVVVPEHQLAYIG-G------TKASVSYNH---------THPGESGH CLLVVCVPEAEMGCSN--------VDRVVTASA---------LTSGERAS CLLVVVIPEHQLASIQ-G------GSVSVYYEK---------THPGEKGI CLLVVCVPEAEMGCAT--------LDNTPSSAE---------LLGGDTAK CLMVVCVPEAEMGCAD--------ITRVVNAAA---------LSGGELAK TLIVALIPEHQIASAL-H------GNVNVGYNY---------THPGETGR TLMVVAIPEHQLAYIG-T------GNVTVGYKH---------THPGESGR CLLVVCVPEAEMGSAQ--------LDKTLNHTK---------LSNTEHAS TLIVVAIPEHQLAYIG-G------GNVTVGYNH---------THPGESGR CLLVVCVPEAEMGCAD--------VQGVVTAEE---------LTKGEVAS LLLVAVVPEHQLAYVG-G------TNANVGYRH---------THPGETGH TLLVVMIPEHQLATVN-K------GNVNAGYKY---------THPGEAGR TLLVAAIPEYVVARAS-DDAKPN-TAPHPNYAV---------TQPGPGGE CLLVVVIPEHQLASAE-G------GNVSVLYDK---------THPGEKGI ALLVAAIPEFVVAASS-PATKPNGQGLYPDFAH---------TNPGKNGQ CLLVVCVPEAEMGCSN--------VNNQPSFEQ---------LANGDTAH CLLVVCVPEAEMGCAK--------TDGALVATS---------LTNGEMAH TLVVAAIPEHQLAYIG-S------GNVSVGYKH---------THPGETGR TLLVVAIPEHQLSYLG-T------GNVTVGYRH---------THPGENGR TLIVAAIPEHQLAFIK-S------GNVTVGYKY---------THPGEQGR LLIVAAIPEHQLASAV-K------GNVSVGYKH---------THPGEQGR TLLILMIPEHQLANAN-A------TNADAGYNY---------THPGERGR CLMVAVIPEHQMAYIG-A------GGTNVRYDQ---------THPGEAGH TLIVVAIPEHQLAYVG-G------GNVTVGYNH---------THPGETGR TLLVVVIPEHQLASAK-G------GNVSVYYDK---------THPGENGI TLLVVAIPEFTVARSD-TSTNPA-TAKHPSYAA---------AQPGKNGK LLIVAAIPEHQLASAT-S------GNVSVGYNH---------THPGEQGR RPIVVCVPEAEMGCSK--------VDGVVNAQG---------LSKGETPI AIIVAVVPEHQLAYIG-G------TKANVSYGH---------THPGENGH ALGVFAIPEYCLAGDS-D------KQRYTSYAN---------ANPGERGG ALLVVCVPEAQMGSAK--------VKEAFTHEA---------LSKGEIAK CLLIMVVPEHQLAYIG-A------EGVKVRYEH---------THPGEKGH ALLVVAIPEYVQGRSS-NSTTPA-SAPHPTYQA---------VQPGKNGK

2WZR2 UniRef90_F1AW55_285_503 UniRef90_Q6PMU0_285_503

--------------------------------CKLDDREKY------QLT --------------------------------CKLTDREKY------QLT --------------------------------CKLEDREKY------QLT

2016/02/23, 3:10 PM


UniRef90_Q8V0G8_86_304 UniRef90_Q6PMU2_285_503 UniRef90_Q6PMT8_285_503 UniRef90_A2I8Z5_287_504 UniRef90_Q1L754_86_304 UniRef90_B8Y0J7_285_503 UniRef90_Q1L757_86_304 UniRef90_P49303_287_504 UniRef90_A6XP89_287_504 UniRef90_Q6PMT3_285_502 UniRef90_Q1L752_86_304 UniRef90_Q1L748_86_303 UniRef90_P15072_287_504 UniRef90_Q8JVD0_86_303 UniRef90_H9AY35_273_496 UniRef90_B0Z3W9_300_527 UniRef90_Q91LX8_289_537 UniRef90_Q66776_291_513 UniRef90_Q100Y4_72_320 UniRef90_Q2XP17_290_516 UniRef90_P12296_138_384 UniRef90_Q02472_148_405 UniRef90_A4ZKN2_144_403 UniRef90_C3U5A3_174_435 UniRef90_P08544_148_405 UniRef90_E3TMG9_144_405 UniRef90_G9FTJ7_144_402 UniRef90_B3VTU7_149_406 UniRef90_Q155Z9_151_421 UniRef90_G1C9J1_14_204 UniRef90_I1YLT5_69_326 UniRef90_G0Y2E2_141_365 UniRef90_G0Y2E0_150_361 UniRef90_Q8B552_195_378 UniRef90_B5A1N0_195_378 UniRef90_Q2LKZ0_129_301 UniRef90_Q65481_129_301 UniRef90_G1DFA4_229_430 UniRef90_H9LG14_129_301 UniRef90_H6VLP2_125_335 UniRef90_B9VIN1_70_329 UniRef90_G1JYY8_171_367 UniRef90_Q8QUZ6_80_281 UniRef90_I1YLT7_70_335 UniRef90_F5B9S5_80_301 UniRef90_G0Y2E4_163_340 UniRef90_B8XTQ1_73_321 UniRef90_H9C6N6_131_322 UniRef90_I1YLT4_70_334 UniRef90_B8XTQ0_73_332 UniRef90_B9V442_80_329 UniRef90_D2IW00_80_316 UniRef90_Q2LL04_129_301 UniRef90_I1YLT6_69_335 UniRef90_G5DC73_80_330 UniRef90_A5GZE4_80_318 UniRef90_D9D8F3_70_328 UniRef90_G0ZNT5_127_322 UniRef90_B9V459_80_317 UniRef90_A8S322_129_323 UniRef90_C7DUC7_127_322 UniRef90_G8IJE2_80_317 UniRef90_Q2LKZ8_129_301 UniRef90_B8XTP8_70_327 UniRef90_H2E685_80_301 UniRef90_Q5YJ95_199_371 UniRef90_Q9IM09_80_305 UniRef90_A5GZE9_80_317 UniRef90_Q66790_80_316 UniRef90_A5GZD8_131_315 UniRef90_P12915_129_301 UniRef90_Q5XLP5_80_317 UniRef90_G0Z2U8_195_360

12 of 20


--------------------------------CKLEQREKY------QLT --------------------------------CKLDEREKY------QLT --------------------------------CSLRDREEF------QLS --------------------------------CSITKREQY------QLT --------------------------------CSPREREEF------QLT --------------------------------CSLKSXEEF------QLT --------------------------------CSLREREEF------QLG --------------------------------KELTPREKY------QLT --------------------------------KTLDTRQKY------QLT --------------------------------HSLDKRDVS------QLT --------------------------------SSIRDREEF------QPT --------------------------------KSLDKRCVS------QLT --------------------------------GDISDREKY------QLT --------------------------------HTLDKRDVS------QLT --------------------------------NFKDTSDSQ-PPDYRQYT --------------------------------VKENTNGSTYNPTFAQLT LPGEWKWQSYDALP---------------------RHLPPQ------QLT TPGTWVWNTYEAFP---------------------PGFPPQ------QIT LPGAWMWQTYDARP---------------------STLPPQ------QLT EEPAYTYQ---------------------------------------QLS FAMDNRWSKDN-LP---NGTRTQTNRKG---PFAMDHQNFW------QWT FLMDTTWQEPQAAP---TGFRYDGKNGF----FTLNHQNYW------QWT FKVDTTWQTGS--L---RGHSYEDKSTQTLRPLALNHQNYW------QWT FTMDTTWQSGTKCL---RGHSFESKTNQSLRPLSLNHQNTW------QWT FTMDTEWRSPQGAP---TGYRYDSRTGF----FATNHQNQW------QWT FKVDANWQKHTQIL---TGHAYVNTTTKVNVPLALNHQNFW------QWT FQMDTQWQSGK--L---LGHSYESTTLQGLRPLALNHQNYW------QWT FTMDSSWQTPQQNP---VGFRYDGRTGY----FALNHQNYW------QWM VEMSDDYRTGKNMPFQSLGTYYRPPNWT----WGPNFINPY------QVT ------------------------------------------QYPIHQLT D----ITDNLDEKN-SFDLA----------------------DITPEQMF ------------------------------------------DYPRFQLT ------------------------------------------NYPKHQLT DFQYYETKEFCGTEYPTE-----------------------------QLT GWAYREGEKYCGKQYPTE-----------------------------QLT AY--Q-------------FP----------------FTFED-GTALGNAL EF--Q-------------FP----------------FTLED-GSALGNAL FTMSTEWE---GLP---------------------TDMRPE------SFF EF--N-------------FN----------------FTLED-GSALGNAL ------------------------------------------DYPLAQLT A----LVGKIDDKN-TFDLA----------------------STTPEQFF ------------------------------------------GLPLAQLT NL--E-------------YA----------------YNFED-GTSIANSL M----VLPDLDTKVVLLIMA----------------------DFTPEQFL DI--T-------------DA----------------FNLED-GTSLANSL ------------------------------------------EIPVPQLT Y----AGDRAFDTEGSFDMG----------------------DFTPEQFM NLSDA-VA----TGGASHDP----------------VYSMN-GTLVGNLL Y----GAGTPWNEAGSFDLA----------------------DFTPEQFL YGPGTNSTRKFDDENSFDMG----------------------DMTPEQFF DVG-I-TRVEDLLKQPSDDS----------------WLNFD-GTLLGNIT TL-ND-RENNN-SQQPTDES----------------WLNCD-GTLLGNIT TF--Q-------------EP----------------FWLED-GTCLGNAL Y----TSPSTLIEDYSFDLA----------------------DFTPEQMM EVKNT-TR-EHLQQQPTEEH----------------WLNFD-GTLLGNIT DVGIT-VR-EHPNKQPSDDN----------------WLNFD-GTLLGNIT Y----AGDRALDTDGSFDMA----------------------DFSPEQFM TIEET-T--IRNRFNPDENP----------------FYLCN-GTLFGNIQ VVGQA-RV-QTNDNQPSDDN----------------WLNFD-GTFLGNLL VIGSN-V--RRDNKQPDEDP----------------FFNCN-GTLLGNIT RIGAR-T--DRGDHNPDENP----------------FYLCN-GTLFGNIQ EVRTN-RT-EYLGQQPTEEY----------------WLNFD-GTLLGNIT TF--Q-------------EP----------------FWLED-GTSLGNAL Y-----ANFPFDAKHSFDYS----------------------DITPEQFM TI--T-------------EP----------------FDMDD-GTSLANAL GFAYRDGVNYQGNNYPTE-----------------------------QLT TMTGQ-------------EA----------------YCLHN-GTNIHSSL DVGQD-R--RSNDKQPSDDN----------------WLNFD-GTLLGNLL ELTAGAAP---AEKGKVQTA----------------VCNATMGVAVGNLT DLDSV-AE----TGGASHDP----------------VYSMN-GTLIGNLL TF--Q-------------EP----------------FWLED-GTSLGNSL DVGQQ-R--TNNEKQPSDDN----------------WLNFD-GTLLGNLL EFVYRNNANYQGNNYPTE-----------------------------QLT

2016/02/23, 3:10 PM


UniRef90_A1E4A3_131_303 UniRef90_G0Y2E3_141_369 UniRef90_B9V482_80_298 UniRef90_B8XTP9_157_328 UniRef90_F8V2V4_80_316 UniRef90_A1E4A2_131_303 UniRef90_Q8V5Z9_80_307 UniRef90_G8IJE1_80_316 UniRef90_P12916_80_317 UniRef90_P03303_80_315 UniRef90_B8XTQ4_69_329 UniRef90_Q9YLJ1_78_316 UniRef90_B9V466_80_318 UniRef90_Q05ED6_131_323 UniRef90_B5BSU7_131_316 UniRef90_A5GZF1_80_316 UniRef90_B9V453_80_313 UniRef90_Q05EE3_80_323 UniRef90_A5GZE7_80_317 UniRef90_B9V485_80_315 UniRef90_G8IJH5_80_318 UniRef90_B9V435_80_318 UniRef90_Q8V398_80_292 UniRef90_Q82081_159_315 UniRef90_Q6W9F6_159_316 UniRef90_Q03053_159_316 UniRef90_A5GZD6_131_315 UniRef90_Q2YEN8_80_316 UniRef90_G8HH17_117_311 UniRef90_A7KC08_80_331 UniRef90_Q6W9G1_131_314 UniRef90_G8IQ64_80_315 UniRef90_I0IY47_80_323 UniRef90_G5DC75_80_317 UniRef90_Q05ED2_80_316 UniRef90_Q5VAK8_80_316 UniRef90_A7KC11_80_330 UniRef90_B5BSU6_131_316 UniRef90_Q05ED0_80_316 UniRef90_Q5VAL5_159_315 UniRef90_A4UHT9_129_315 UniRef90_H8Y6P9_127_322 UniRef90_P29813_80_316 UniRef90_P32537_131_305 UniRef90_G5D5E2_159_315 UniRef90_Q9YLG5_80_319 UniRef90_B8XTQ3_70_330 UniRef90_A7KC13_88_321 UniRef90_O41174_80_282 UniRef90_A5GZF9_80_318 UniRef90_G8IJE5_80_295 UniRef90_Q9QCF0_72_316 UniRef90_G5DC71_157_324 UniRef90_A8S330_157_325 UniRef90_Q9WN78_80_316 UniRef90_A0MHB7_86_316 UniRef90_O89280_159_323 UniRef90_G8IJG2_80_318 UniRef90_F6M9Y3_80_316 UniRef90_A5GZE0_80_317 UniRef90_Q7T7N9_80_323 UniRef90_A7YF31_159_315 UniRef90_H9X8D4_80_317 UniRef90_G9K146_80_316 UniRef90_G9K138_159_330 UniRef90_G0YPI0_80_292 UniRef90_O91734_159_316 UniRef90_B9V473_80_315 UniRef90_Q9WHH4_131_316 UniRef90_Q2L970_80_316 UniRef90_Q80GI2_159_316 UniRef90_Q05ED1_131_316 UniRef90_B9V440_80_317

13 of 20


TF--N-------------HP----------------YVLDD-GTSLACAT ------------------------------------------DYPAPQLT DLGTS-GE----RTGPAKDA----------------VYNMD-GTLIGNLT L-PGSFS---FDSDHSFDLG----------------------DFTPEQFL SFEQNAAT---GET-AVQTA----------------VCNAGMGVGVGNLT VF--N-------------HP----------------YVLDD-GTSLACSL TF--N-------------HP----------------YLLDN-GTAVSMAL DVGKD--R-ESTRYQPSDDN----------------WLNFD-GTLLGNIT VVGQQ-R--DANLRQPSDDS----------------WLNFD-GTLLGNLL DLSSA-NE----VGGPVKDV----------------IYNMN-GTLLGNLL L---STGQGTISEKGSIDAA----------------------GTIPQQLF TFSPSEAT---AEAGKVQTA----------------VCNAGMGVAVGNLT QVGDP-RE-NITAAHPSDDN----------------WLNFD-GTMLGNVL EFTPSSVT---GEN-AVQTA----------------VCNAAMGVAVGNLT KFSNQKET---SAN-KVQNA----------------VWNAGMGVGVGNLT DVSLS-NR-ADLSKQPSDDA----------------WLNFD-GTLLGNIT VIATT-TDKQ--TRQPSFDS----------------WLNCN-GTLLGNAL LFTESESS---ETH-GVQTA----------------VHNAAMGIAAGNLT TVGDR-R--DHHDKQPSDDN----------------WLNFD-GTSLGNAL DLSKA-EV----DKGPSNNP----------------VYSMN-GTLLGNLL TIGIP-DR-LHPNKQPSDDN----------------WLNFD-GTLLGNIT EVGKP-NR-QYTSKQPSDDN----------------WLNFD-GTLLGNIT TF--R-------------NP----------------LFLDN-GTMLQQAT DLDTV-EV----AGGPTSDA----------------IYNMD-GTLLGNLL NFTKTRAN---TTN-GVQTA----------------IHNAGMGVATGNLT TFDSQNTT---GQT-AVQAN----------------VINAGMGVGVGNLT DLSTA-EE----TNGPVKNP----------------VYNMD-GTLLGNLL KFEPTTTT---GEH-TVQSI----------------VCNAGMGVGVGNLT ------------------------------------------QYPRSQLT NVDPI-TR-DNPTKQPSDDS----------------WLNFD-GTLLGNIT EFKNTDTT------TGVQAN----------------VINAGMGVGVGNLT DLSTP-QD----EEGPVKDP----------------VYSMN-GTLLGNLL KFQKN-------------FTPS-STAPAKNSFAPVDWLLGC-GVMAGNIT EVGSP-R--ETHPNHPSDDS----------------WLNFD-GTLLGNAL TFSEAEAT---SENGKVQNA----------------VCNAAMGVGVGNLT EFTAGAVS---SQN-GVQTA----------------VYNAAMGVAVGNLT DVGTE-VR-DTANYQPSDDA----------------WLNFD-GTLLGNIT VFTANKEE---GTSKSVQAA----------------VCNAGMGVGVGNLT KFTTDPAQ---GTGNGVQTA----------------VCNAAMGVGVGNLT TFTEGAST---GR--AVQTA----------------VCNAGMGVGVGNLT KIGSN-S--ERGDNQPDENP----------------FFNCN-GTLLGNLT TFKAP-T--ERGQQNPDENP----------------FYLCN-GTLLGNIT KFSSTSTN---GTN-TVQTI----------------VTNAGMGVGVGNLT VF--E-------------QP----------------YLLDD-GTSLACAL DLSTN-VE----ADGPVKDP----------------VYNMN-GTLLGNLL EFTREGPTISKGAT-DVQTA----------------VCNAGMGVGVGNLT T----ITPN---KNVSFDLA----------------------DMTAEQMM DLGTV-IE----K-GPMTDP----------------IYNMD-GTLLGNVL EV--K-------------YP----------------YNFED-GTSLANSL NVGQL-RT-EYLDKQPSDDN----------------WLNFD-GTLLGNIT DVGKL-NR-ESNQRQPSDDN----------------WLNFD-GTLLGNLT YFAKTGAT---GTH-TVQSI----------------VTNAGMGVGVGNLT TIGSN-S--DRGNNQPDENP----------------FFNCN-GTLLGNLT EIGKN-T--ERNDKQPDEDP----------------LFNCN-GTLLGNLT EFSAGKST---DQT-GPQTA----------------VHNAGMGVAVGNLT EIGRN-T--NRDDNQPDENP----------------FFNCN-GTLLGNLT QFTVEPAN---GQN-QVQTA----------------VHNAAMGVAVGNLT EIGTF-GPSSTLDRQPSDEN----------------WLNCD-GTLLGNIT TIDDT-RVNTM-SNQPTDES----------------WLNCD-GTLLGNIT DVGKM-DR-ERNDRQPSDDS----------------WLNFD-GTLLGNLT RFSST-------------FTPD-TQAPGKNKFAPLDWLLGC-GVMAGNIT EFTANPVT---GK--VVQTA----------------VCNAGMGVGVGNLT DVSQE-R--DTSLKQPSDDS----------------WLNFD-GTLLGNLL DVSPK-VR-ENPDKQPSDDA----------------WLNFD-GTLLGNIT DVSLS-RT-ENRDKQPSDDN----------------WLNFD-GTLLGNIT EF--T-------------DP----------------YVLDA-GIPLSQAL RFTTTTT----AEDHGVQAA----------------VWNAGMGVGVGNLT VI-GT-RENRN-TNQPTDES----------------WLNCD-GTLLGNIT SFKT-ETT---GEEHSVQAA----------------VWNAGLGVGAGNLT TFTGTKSS---NTN-DVQQA----------------VFNAGMGVAVGNLT EFTAGNHQ---GTTASVQKA----------------VCNAGMGVGVGNLT AFTSGKAT---AAAGTIQTA----------------VFNAGMGVGVGNLT DVGKI-GR-ENNGKQPSDDN----------------WLNFD-GTLLGNIT

2016/02/23, 3:10 PM


14 of 20


UniRef90_G1CSA8_80_313 UniRef90_B1PZZ4_80_316 UniRef90_B9V457_80_316 UniRef90_D8VCT6_80_323 UniRef90_G8IRN4_129_324 UniRef90_Q80GI1_159_316 UniRef90_I1XV41_80_323 UniRef90_P21404_159_316 UniRef90_P23008_135_293 UniRef90_A5GZE2_80_315 UniRef90_Q6W9F4_159_316 UniRef90_B3SRP0_80_317 UniRef90_Q6JKS0_159_312 UniRef90_G8IJG6_157_325 UniRef90_D4AH62_131_316 UniRef90_A5GZD9_129_321 UniRef90_Q66331_80_318 UniRef90_Q6W9E8_159_323 UniRef90_P04936_159_330 UniRef90_A7KC07_80_326 UniRef90_Q66806_80_316 UniRef90_A5GZF5_80_318 UniRef90_Q05ED4_159_315 UniRef90_G8IRN3_129_329 UniRef90_Q82122_80_315 UniRef90_Q8V601_80_317 UniRef90_B9V433_129_314 UniRef90_G5EN04_80_318 UniRef90_Q8V613_159_316 UniRef90_Q6W9F9_80_316 UniRef90_H9C6N7_159_315 UniRef90_B9V434_80_314 UniRef90_A5GZF6_80_318 UniRef90_A5GZF2_80_318 UniRef90_C7DUC8_80_317 UniRef90_G5CZJ4_127_322 UniRef90_B9V477_80_318 UniRef90_G8IJH3_88_314 UniRef90_Q8UY33_159_317 UniRef90_P07210_80_318 UniRef90_Q66577_131_323 UniRef90_G8IJF0_127_318 UniRef90_E7CRL8_159_323 UniRef90_Q995Z1_80_314 UniRef90_C6ZEZ9_129_315 UniRef90_Q5G9Z5_159_312

EL--T-------------FP----------------YVLDA-GIPINQLL KFAATSTN---GTN-TVQSI----------------VTNAGMGVGVGNLT TLNGS-RVDGN-SKQPTEES----------------WLNCD-GTLLGNIT KFQAS-------------FTPS-AEDGKKNTFAPVDWLLGC-GVMAGNIT EIGSN-T--NRDRNQPDEDP----------------FFNCN-GTLLGNLT VFTSGEHQ---STEKGVQTA----------------VCNAGMGVGVGNLT KFQPT-------------FTPS-SEDGKKNTFAPVDWLLGC-GVMAGNVT EFTSATQS---DQT-KVQTA----------------IHNAGMGVGVGNLT DVSQE-R--DASLRQPSDDS----------------WLNFD-GTLLGNLL DVSIT-NR-DHVSRQPSDEN----------------WLNFD-GTLLGNIT QFTETGSG---GTTAGVQTA----------------VCNAGMGVAVGNLT EI--A-------------FP----------------YLLDN-GTALSQAL TF--E-------------NP----------------YIMDM-GVPLSQAL EIGKNTT--NRGNHEPDENP----------------FFSCN-GTLLGNLT TFQATINS---NQN-DVQNV----------------VHNAAMGVGVGNLT DLNES-DG----D-GPMLDP----------------LYMMD-GTLIGNSL EFADKPVA--SGSNKLVQRV----------------VYNAGMGVGVGNLT EFKEAPTT---GQN-EVQAA----------------AHNAGMGVAVGNLT EVKAE-TR-LNPDLQPTEEY----------------WLNFD-GTLLGNIT IIANN-ADNN--TRQPSDDN----------------WLNCD-GTLMGNLP TFGSMNSN---EAG-AVQNV----------------VHNAGMGVGVGNLT RIGGF-DGTER-NRQPSDEN----------------WLNCN-GTLLGNLT VFSNTNTT---GQG-KVQNQ----------------VCNAGMGVGVGNLT TITGNTA--NRSSGEPDDDP----------------FFNCN-GTLLGNLT EVGTQ----VENEKQPSDDN----------------WLNFD-GTLLGNLL EL--A-------------FP----------------YLLDN-GTALSQAP DLSEA-DS----T-GPMKDP----------------LYMMD-GTLIGNSL EF--R-------------DP----------------YVLDA-GIPLSQAL VFTEDAAT---GEQ-GVQTA----------------VCNAAMGVGVGNLT EFTESAAP---STQGNVQTA----------------VCNAAMGVGVGNLT II-GS-RDNNM-TGQPTDES----------------WLNCD-GTLLGNIT EIAEV-ANRN--ERQPSYDS----------------WLNCN-GTLLGNAL EIGTF-GENSVLDRQPSDEN----------------WLNCD-GTLLGNIT EISSE-RR-TDDDRRPSDDS----------------WLNFD-GTLLGNLP EVGSD-R--VAHANLPSDDN----------------WLNFD-GTLLGNAL TIMAS-K--QWGEHNPDENP----------------FYNLN-GTLFGNIQ RIGGY-ENVPR-NRQPSDEN----------------WLNCN-GTLLGNLT DLSVV-DE----L-GPKTDP----------------VYNMD-GTLLGNAL EF--S-------------IP----------------YVLDS-GVPLSQAL EVVPS-RT-SSDNKRPSDDS----------------WLNFD-GTLLGNLP EFERTSTT---AEVGVVQKA----------------VYNAGMGVGVGNLT EIRGPDSGHDRGNNNPDEDP----------------LFNCN-GTLLGNIT KFYSQ-------------FNKDNAVTSPKREFCPVDYLLGC-GVLLGNAF EF--TPSD---ATD-GVQTA----------------VHNAAMGVAVGNLT TLKGS-Q--DRSTNNPDDNP----------------FYMCN-GTLLGNGM EL--A-------------FP----------------YVLDA-GIPLSEAL

2WZR2 UniRef90_F1AW55_285_503 UniRef90_Q6PMU0_285_503 UniRef90_Q8V0G8_86_304 UniRef90_Q6PMU2_285_503 UniRef90_Q6PMT8_285_503 UniRef90_A2I8Z5_287_504 UniRef90_Q1L754_86_304 UniRef90_B8Y0J7_285_503 UniRef90_Q1L757_86_304 UniRef90_P49303_287_504 UniRef90_A6XP89_287_504 UniRef90_Q6PMT3_285_502 UniRef90_Q1L752_86_304 UniRef90_Q1L748_86_303 UniRef90_P15072_287_504 UniRef90_Q8JVD0_86_303 UniRef90_H9AY35_273_496 UniRef90_B0Z3W9_300_527 UniRef90_Q91LX8_289_537 UniRef90_Q66776_291_513 UniRef90_Q100Y4_72_320 UniRef90_Q2XP17_290_516

LFPHQFLNPRTNTTAHIQVPYLGVDRHD-----------------QGTRH LFPHQFLNPRTNTTAHIQVPYLGVDRHD-----------------QGVRH LFPHQFLNPRTNTTAHIQVPYLGVDRHD-----------------QGMRH LFPHQFLNPRTNTTAHIQVPYLGVDRHD-----------------QGHKH LFPHQYINPRTNTTAHIQVPYLGVDRHD-----------------QGKRH LYPHQFINPRTNTTAHIQVPYLGVNRHD-----------------QGKRH LFPHQFINPRTNMTAHITVPYLGVNRYD-----------------QYKVH LYPHQFINPRTNTTAHIQVPYLGVNRHD-----------------QGKRH LYPHQFINPRTNTTAHIQVPYLGVNRHD-----------------QGKRH LYPHQFINPRTNTTAHIQVPHLGVNRHD-----------------QGKRH LFPHQFISPRTNMTAHIVVPYLGVNRYD-----------------QYKKH LFPHQFINPRTNMTAHINVPFVGVNRYD-----------------QYVLH LFPHQYINPRTNTTAHIVVPYVGVNRHD-----------------QVQMH LYPHQFINPRTNTTAHIQVPYLGVNRHD-----------------QGKRH LFPHQFINPRTNTTAHLVVPYIGVNRHD-----------------QVNQH LYPHQFINPRTNMTAHITVPYVGVNRYD-----------------QYKQH LFPHQHINPRTNTTAHIVVPYVGVNRHD-----------------QVKMH VYPHQMINPRTNTTAHIRVPYVGAFSME-----------------DVNKH LYPHQLINLRTNTTASIRVPYVGATDMD-----------------DHRLH LYPHQFLNLRTNTTVDIEVPYMNFVPAS-----------------APVMH LFPHQFLNLRTNTTVDLEVPYTNFAPSS-----------------SPTLH LFPHQFLNLRTNTTVDLEVPYMNCVPSS-----------------SPKMH VFPHQLLNLRTNSSVHLVMPYIGPGPTT-----------------NLTLH

2016/02/23, 3:10 PM


UniRef90_P12296_138_384 UniRef90_Q02472_148_405 UniRef90_A4ZKN2_144_403 UniRef90_C3U5A3_174_435 UniRef90_P08544_148_405 UniRef90_E3TMG9_144_405 UniRef90_G9FTJ7_144_402 UniRef90_B3VTU7_149_406 UniRef90_Q155Z9_151_421 UniRef90_G1C9J1_14_204 UniRef90_I1YLT5_69_326 UniRef90_G0Y2E2_141_365 UniRef90_G0Y2E0_150_361 UniRef90_Q8B552_195_378 UniRef90_B5A1N0_195_378 UniRef90_Q2LKZ0_129_301 UniRef90_Q65481_129_301 UniRef90_G1DFA4_229_430 UniRef90_H9LG14_129_301 UniRef90_H6VLP2_125_335 UniRef90_B9VIN1_70_329 UniRef90_G1JYY8_171_367 UniRef90_Q8QUZ6_80_281 UniRef90_I1YLT7_70_335 UniRef90_F5B9S5_80_301 UniRef90_G0Y2E4_163_340 UniRef90_B8XTQ1_73_321 UniRef90_H9C6N6_131_322 UniRef90_I1YLT4_70_334 UniRef90_B8XTQ0_73_332 UniRef90_B9V442_80_329 UniRef90_D2IW00_80_316 UniRef90_Q2LL04_129_301 UniRef90_I1YLT6_69_335 UniRef90_G5DC73_80_330 UniRef90_A5GZE4_80_318 UniRef90_D9D8F3_70_328 UniRef90_G0ZNT5_127_322 UniRef90_B9V459_80_317 UniRef90_A8S322_129_323 UniRef90_C7DUC7_127_322 UniRef90_G8IJE2_80_317 UniRef90_Q2LKZ8_129_301 UniRef90_B8XTP8_70_327 UniRef90_H2E685_80_301 UniRef90_Q5YJ95_199_371 UniRef90_Q9IM09_80_305 UniRef90_A5GZE9_80_317 UniRef90_Q66790_80_316 UniRef90_A5GZD8_131_315 UniRef90_P12915_129_301 UniRef90_Q5XLP5_80_317 UniRef90_G0Z2U8_195_360 UniRef90_A1E4A3_131_303 UniRef90_G0Y2E3_141_369 UniRef90_B9V482_80_298 UniRef90_B8XTP9_157_328 UniRef90_F8V2V4_80_316 UniRef90_A1E4A2_131_303 UniRef90_Q8V5Z9_80_307 UniRef90_G8IJE1_80_316 UniRef90_P12916_80_317 UniRef90_P03303_80_315 UniRef90_B8XTQ4_69_329 UniRef90_Q9YLJ1_78_316 UniRef90_B9V466_80_318 UniRef90_Q05ED6_131_323 UniRef90_B5BSU7_131_316 UniRef90_A5GZF1_80_316 UniRef90_B9V453_80_313 UniRef90_Q05EE3_80_323 UniRef90_A5GZE7_80_317 UniRef90_B9V485_80_315

15 of 20


LYPHQFLNLRTNTTVDLEVPYVNIAPTS-----------------SWTQH VYPHQILNLRTNTSVDLEVPYVNVAPTS-----------------SWTQH VYPHQILNLRTNTTCDLEVPYVNICPTS-----------------SWTQH IYPHQILNLRTNTTCDIEVPYVNICPTS-----------------SWTQH VYPHQILNLRTNTTVDLEVPYVNVAPSS-----------------SWTQH TYPHQILNLRTNTTCDLEVPYVNVCPTS-----------------SWTQH VYPHQILNLRTNTTCDLEVPYVNICPTS-----------------SWTQH VYPHQILNLRTNTSVDLEVPFTNIAPTS-----------------SWTQH VFPHQILNARTSTSVDINVPYIGETPTQ-----------------SSETQ LFPHQFINLRTNNSATLVLPYVNPCPME-----------------NAASH LYPHQLINPKETTIATVRVPYINAAPQN-----------------DPNVH LYPHQFINLRTNNSATLILPYVAASPAE-----------------SPLTH LYPHQLINLRTNNSATLILPYVSASPAE-----------------SPLTH LFPHQFLNLRTNNSVTIVYPYTNCTPSG-----------------FGLSH LFPHQFINLRTNNSATIIYPYTNVTPAS-----------------FGLAH IYPHQWVNLRTNNSATLVLPYVNALPMD-----------------SGIRH IYPHQWINLRTNNSATLILPYVNALPMD-----------------SGIRH LYPHQLINCRTNTSVDLILPYLNFVPTS-----------------AYGYH IYPHQWINLRTNNSATLILPYVNAIPMD-----------------SGIRH LFPHQLINLRTNNSATLILPYVNASPSE-----------------NPLSH LYPHQLINPKETTMATVSVPYVNVAPSS-----------------DPSVH VFPHQIINLRTNNSATILMPYVGPTPAT-----------------FGLTH IYPHQWINLRTNNSATLVLPYMNAVPMD-----------------SAIRH LYPHHFINPKDTNIATVRVPYISVAPTN-----------------DSTVH IYPHQWINLRTNNSATIVLPYINCIPMA-----------------SAIRH LFPHQLINLRTNNSATIIYPYTNCTPAE-----------------NALTH LFPHQLINPKDNNIATVRVPYINIAPTN-----------------DPTVH IFPHQFINLRTNNTATLIVPYINSVPMD-----------------SMTRH LYPHQFINPKDTNIATVRVPYISVAPTN-----------------DSTVH LFPHQLINPKDTNVAIVRVPYVNIAPSN-----------------DTTVH IFPHQFINLRSNNSATIIVPYVNAVPMD-----------------SMPRH IFPHQFINLRSNNSATLILPYVNAVPMD-----------------SMVRH IYPHQWINLRTNNSATLILPYVNAIPMD-----------------SAIRH LFPHQFINPKDTNIATVRVPYVNAAPTN-----------------DPTVH IFPHQFINLRSNNSATIIVPYVNAVPMD-----------------SMRSH IFPHQFINLRSNNSATIIVPYVNAVPMD-----------------SMLRH LFPHQFINPKDTNIATVRVPYVNIAPTS-----------------DTTVH IFPHQMINLRTNNSATIIVPYINCLPMD-----------------SMLRH IFPHQFINLRTNNSATIIVPYVNAVPMD-----------------SMLRH IFPHQLINLRTNNSSTIVVPYINCVPMD-----------------NMLRH IYPHQMINLRTNNSATIVVPYINCLPMD-----------------NMLRH IFPHQFINLRSNNSATIIVPYVNAVPMD-----------------SMRSH IYPHQWINLRTNNSATLILPYVNAIPMD-----------------SAIRH IFPHQLINPKDTNVATVRVPYINIAPTN-----------------DTTVH IYPHQWINVRTNNSATLVLPYINSIPMD-----------------SPIRH IFPHQIINLRTNNSATIVYPYTNCTPAG-----------------FGLAH VFPHQFINLRTNNCATLVLPYVGATPLD-----------------TPIKH IFPHQFINLRSNNSATIIVPYVNAVPMD-----------------SMLRH IFPHQWINLRTNNCATIVMPYINSVPMD-----------------NMFRH IFPHQFINLRTNNTATIIVPYINSVPMD-----------------SMTRH IYPHQWINLRTNNSATLILPYVNAIPMD-----------------SAIRH IFPHQFINLRSNNSATIIVPYVNAVPMD-----------------SMLRH VFPHQIINLRTNNSATIVYPYTNCTPAG-----------------FGLAH IFPHQWINLRTNNSATIVLPWMNAAPMD-----------------FPLRH LYPHQMINLRTNNSATLILPYVSASPAE-----------------SPLTH IFPHQFINLRTNNTATIIVPYINSVPID-----------------SMTRH LFPHQLINPKDNNIATVRVPYVNIAPTS-----------------DTTVH IYPHQWINLRTNNSATIVMPYINSVPMD-----------------NMFRH IFPHQWINLRTNNSATIMLPWMNCAPMD-----------------FALRH IYPHQWINLRTNNCATIVLPYVNNVPSD-----------------CALKH IFPHQFINLRSNNSATLILPYVNAVPMD-----------------SMLRH IFPHQFINLRSNNSATLIVPYVNAVPMD-----------------SMLRH IFPHQFINLRTNNTATIVIPYINSVPID-----------------SMTRH IYPHQLINPKDTNIASVEVPYVNCAPTS-----------------DPMIH IFPHQWINLRTNNCATIVMPYINSVPMD-----------------NMFRH IFPHQFINLRSNNSATIIVPYVNAVPMD-----------------SMLRH IFPHQWINLRTNNSATIVIPYINSVPMD-----------------NMFRH IYPHQWINLRTNNSATIVMPYINSVPMD-----------------TMYRH VYPHQLINLRTNNSATIIVPYVNAVPMD-----------------SMVRH IFPHQFINLRTNNAATLILPYVNATPMD-----------------SMLRH IFPHQWINLRTNNSATIIVPYINSVPMD-----------------NMYRH IFPHQFINLRSNNSATIIVPYVNAVPMD-----------------SMLRH IFPHQFINLRTNNTATIVVPYINSVPID-----------------SMTRH

2016/02/23, 3:10 PM


UniRef90_G8IJH5_80_318 UniRef90_B9V435_80_318 UniRef90_Q8V398_80_292 UniRef90_Q82081_159_315 UniRef90_Q6W9F6_159_316 UniRef90_Q03053_159_316 UniRef90_A5GZD6_131_315 UniRef90_Q2YEN8_80_316 UniRef90_G8HH17_117_311 UniRef90_A7KC08_80_331 UniRef90_Q6W9G1_131_314 UniRef90_G8IQ64_80_315 UniRef90_I0IY47_80_323 UniRef90_G5DC75_80_317 UniRef90_Q05ED2_80_316 UniRef90_Q5VAK8_80_316 UniRef90_A7KC11_80_330 UniRef90_B5BSU6_131_316 UniRef90_Q05ED0_80_316 UniRef90_Q5VAL5_159_315 UniRef90_A4UHT9_129_315 UniRef90_H8Y6P9_127_322 UniRef90_P29813_80_316 UniRef90_P32537_131_305 UniRef90_G5D5E2_159_315 UniRef90_Q9YLG5_80_319 UniRef90_B8XTQ3_70_330 UniRef90_A7KC13_88_321 UniRef90_O41174_80_282 UniRef90_A5GZF9_80_318 UniRef90_G8IJE5_80_295 UniRef90_Q9QCF0_72_316 UniRef90_G5DC71_157_324 UniRef90_A8S330_157_325 UniRef90_Q9WN78_80_316 UniRef90_A0MHB7_86_316 UniRef90_O89280_159_323 UniRef90_G8IJG2_80_318 UniRef90_F6M9Y3_80_316 UniRef90_A5GZE0_80_317 UniRef90_Q7T7N9_80_323 UniRef90_A7YF31_159_315 UniRef90_H9X8D4_80_317 UniRef90_G9K146_80_316 UniRef90_G9K138_159_330 UniRef90_G0YPI0_80_292 UniRef90_O91734_159_316 UniRef90_B9V473_80_315 UniRef90_Q9WHH4_131_316 UniRef90_Q2L970_80_316 UniRef90_Q80GI2_159_316 UniRef90_Q05ED1_131_316 UniRef90_B9V440_80_317 UniRef90_G1CSA8_80_313 UniRef90_B1PZZ4_80_316 UniRef90_B9V457_80_316 UniRef90_D8VCT6_80_323 UniRef90_G8IRN4_129_324 UniRef90_Q80GI1_159_316 UniRef90_I1XV41_80_323 UniRef90_P21404_159_316 UniRef90_P23008_135_293 UniRef90_A5GZE2_80_315 UniRef90_Q6W9F4_159_316 UniRef90_B3SRP0_80_317 UniRef90_Q6JKS0_159_312 UniRef90_G8IJG6_157_325 UniRef90_D4AH62_131_316 UniRef90_A5GZD9_129_321 UniRef90_Q66331_80_318 UniRef90_Q6W9E8_159_323 UniRef90_P04936_159_330 UniRef90_A7KC07_80_326

16 of 20


IFPHQFINLRSNNSATIIVPYVNAVPMD-----------------SMLSH IYPHQFINLRSNNSATIIVPYVNAVPMD-----------------SMLRH VFPHQWINLRTNNSATIIVPYINNIPAD-----------------SPVRH IFPHQFINMRTNNTATIVVPYINSVPID-----------------SMTRH IFPHQWINLRTNNSATIVMPYINSVPMD-----------------NMYRH IFPHQWINLRTNNSATIVMPYINSVPMD-----------------NMFRH IFPHQFINLRTNNTATIIVPYMNSVPMD-----------------SMTRH IYPHQWINLRTNNCATIVMPYINSVPMD-----------------NMFRH IFPHQFINLRTNNSSTLILPYVNATPAE-----------------NALTH IFPHQFINLRSNNSATIIVPYVNAVPMD-----------------SMLRH IFPHQWINLRTNNSATIVMPYINSVPMD-----------------NMYRH IFPHQFINLRTNNTATIVVPYINSVPID-----------------SMTRH VYPHQIINLRTNNCATLVLPYVNSTSTD-----------------SMVKH IFPHQFINLRSNNSATIIVPYVNAVPMD-----------------SMLRH IYPHQWINLRTNNSATIVMPYINSVPMD-----------------NMYRH IFPHQWINLRTNNSATIVMPYINSVPMD-----------------NMYRH IFPHQYINLRSNNSATLILPYVNAVPMD-----------------SMLRH IYPHQWINLRTNNCATIVMPYINCVPMD-----------------NMNRH IFPHQWINLRTNNCATIVMPYINSVPMD-----------------NMFRH IFPHQWINLRTNNSATIVIPYINSVPMD-----------------NMFRH IFPHQLINLRTNNSSTIVVPYINCTPMD-----------------SMLRH AYPHQLINLRTNNSCTIVVPYINAVPMD-----------------NMLRH IYPHQWINLRTNNCATIVMPYINNVPMD-----------------NMFRH VYPHQWINLRTNNSATIVLPWMNSAPMD-----------------FALRH IFPHQFINLRTNNTATLVVPYINSVPID-----------------SMTRH IFPHQWINLRTNNSATIVMPYINSVPMD-----------------SMIRH LFPHQLINPKDTNVATVRVPYVNVAPTS-----------------DPRVH IFPHQFINLRTNNTATIVTPYINSVPMD-----------------SMTRH IYPHQWINLRTNNSATLVLPYANAIPMD-----------------SPIRH IFPHQFINLRSNNSATIIVPYVNAVPMD-----------------SMLRH IFPHQFINLRSNNSATIIVPYVNAVPMD-----------------SMLRH IFPHQWINLRTNNSATIVMPYINSVPMD-----------------NMFRH IFPHQLINLRTNNSSTIVVPYINCVPMD-----------------SMLRH IFPHQLINLRTNNSATIVVPYINCVPMD-----------------SMLRH IYPHQWINLRTNNSATIVMPYINSVPMD-----------------NMYRH IFPHQLINLRTNNSSSIVVPYINCTPMD-----------------SMLRH IFPHQWINLRTNNSATIVMPYINSVPMD-----------------NMFRH VYPHQYINLRSNNSATLILPYVNAVPMD-----------------SMVRH IYPHQFINLRSNNSATLILPYVNAVPMD-----------------SMLRH IFPHQFINLRSNNSATIIVPYVNAVPMD-----------------SMLRH VFPHQIINLRTNNCATLVLPYVNSVVTD-----------------SMAKH IFPHQWINLRTNNSATIVIPYINSVPMD-----------------NMFRH IFPHQFINLRSNNSATIIVPYVNAVPMD-----------------SMLRH IYPHQLINLRSNNSATIIVPYVNAVPMD-----------------SMLRH IFPHQFINLRSNNSATIIVPYVNAVPMD-----------------SMLRH IFPHQWINLRTNNCATIIMPYINAVPFD-----------------SAINH IFPHQWINLRTNNSATIVMPYVNSVPMD-----------------NMYRH IFPHQFINLRSNNSATLILPYVNAVPMD-----------------SMIRH IFPHQWINLRTNNSATIVMPYINCVPMD-----------------NMFRH IFPHQWINLRTNNCATIVMPYINSVPMD-----------------NMFRH IFPHQWITSRTNNCATIVMPYINCVPMD-----------------TMYRH IYPHQWINLRTNNSATIVMPYINCVPMD-----------------NMFRH IFPHQFINIRSNNSATLILPYVNAVPMD-----------------SMLRH IAPHQWINLRTNNCATIVMPYINAVPYD-----------------SALNH IFPHQWINLRTNNCATIVMPYINNVPMD-----------------NMFRH IYPHQFINLRSNNSATLILPYVNAVPMD-----------------SMLRH VFPHQIINLRTNNCATLVLPYVNSSATD-----------------SMAKH IFPHQLINLRTNNSSTIVVPYINCVPMD-----------------SMLRH VFPHQWINLRTNNCATIVMPYINSIPMD-----------------NMFRH VFPHQIINLRTNNCATLVLPYVNSTSTD-----------------SMAKH IYPHQWINLRTNNSATIVMPYINSVPMD-----------------NMFRH IFPHQFINLRSNNSATLIVPYVNAVPMD-----------------SMLRH IFPHQFINLRSNNSATLIVPYVNAVPMD-----------------SMLRH IYPHQWINLRTNNCATIVMPYINCVPMD-----------------NMFRH IYPHQWINLRTNNCATIVMPYINCLPFD-----------------SALNH VFPHQWINLRTNNCATIIVPYINAVPFD-----------------SAINH IFPHQLINLRTNNSSTIVVPYINCTPMD-----------------NMLRH IFPHQWINLRTNNSATIVMPYINSVPMD-----------------NMFRH IFPHQFINLRTNNTATIVVPYINSVPMD-----------------SMTRH IFPHQWINLRTNNSATIVMPYTNSVPMD-----------------NMFRH IYPHQWINLRTNNSATIVMPYINSVPMD-----------------NMHRH IFPHQFINLRSNNSATIIAPYVNAVPMD-----------------SMRSH IFPHQFINLRTNNSATLILPYMNCVSMD-----------------SMLRH

2016/02/23, 3:10 PM


17 of 20


UniRef90_Q66806_80_316 UniRef90_A5GZF5_80_318 UniRef90_Q05ED4_159_315 UniRef90_G8IRN3_129_329 UniRef90_Q82122_80_315 UniRef90_Q8V601_80_317 UniRef90_B9V433_129_314 UniRef90_G5EN04_80_318 UniRef90_Q8V613_159_316 UniRef90_Q6W9F9_80_316 UniRef90_H9C6N7_159_315 UniRef90_B9V434_80_314 UniRef90_A5GZF6_80_318 UniRef90_A5GZF2_80_318 UniRef90_C7DUC8_80_317 UniRef90_G5CZJ4_127_322 UniRef90_B9V477_80_318 UniRef90_G8IJH3_88_314 UniRef90_Q8UY33_159_317 UniRef90_P07210_80_318 UniRef90_Q66577_131_323 UniRef90_G8IJF0_127_318 UniRef90_E7CRL8_159_323 UniRef90_Q995Z1_80_314 UniRef90_C6ZEZ9_129_315 UniRef90_Q5G9Z5_159_312

IYPHQWINLRTNNCATIVMPYINSVPMD-----------------NMFRH IFPHQFINLRSNNSATLILPYVNAVPMD-----------------SMLRH IFPHQWINLRTNNSATIVMPYINSVPMD-----------------NMFRH IFPHQLINLRTNNSSTIVVPYINCVPMD-----------------NMLKH IFPHQFINLRSNNSATLIVPYVNAVPMD-----------------SMVRH IYPHQWINLRTNNCATIVMPYINCLPFD-----------------SALNH IFPHQFINLRTNNTATIVVPYINSVPMD-----------------SMTRH VFPHQWINLRTNNCATIIMPYVNALPFD-----------------SALNH IYPHQWINLRTNNSATIVMPYINCVPMD-----------------NMQRH IYPHQWINLRTNNSATIVMPYINSVPMD-----------------NMYRH IFPHQFINLRSNNSATLILPYVNAVPMD-----------------SMVRH IFPHQFINLRTNNAATLILPYVNATPMD-----------------FMLRH VYPHQYINLRSNNSATLILPYVNAVPMD-----------------SMVRH IYPHQYINLRTNNSATLILPYINAVPMD-----------------SMLRH IFPHQFINLRSNNSATLIVPYVNAVPMD-----------------SMLRH IFPHQMINLRTNNSATIVVPYINCLPMD-----------------NMLRH IFPHQFINLRSNNSATLILPYVNAVPMD-----------------SMLRH IFPHQFINLRTNNTATLVMPYINSVPMD-----------------SMTRH IYPHQWINLRTNNCATIVMPYINAVPYD-----------------SALNH IYPHQYINLRTNNSATLILPYVNAVPMD-----------------SMLRH IFPHQWINLRRNNSATIVIPYINCVPMD-----------------NMFRH IFPHQIINLRTNNSSTIIVPYINCTPMD-----------------SMLKH VYPHQIINLRTNNSATIVLPYVNAMAID-----------------SMVKH IFPHQWINLRTNNSATIVMPYINAVPMD-----------------NMYRH LYPHQMINLRTNNSATIVIPYINCVPMD-----------------NMLRH IFPHQWINLRTNNCATIVMPYINAVPYD------------

2WZR2 UniRef90_F1AW55_285_503 UniRef90_Q6PMU0_285_503 UniRef90_Q8V0G8_86_304 UniRef90_Q6PMU2_285_503 UniRef90_Q6PMT8_285_503 UniRef90_A2I8Z5_287_504 UniRef90_Q1L754_86_304 UniRef90_B8Y0J7_285_503 UniRef90_Q1L757_86_304 UniRef90_P49303_287_504 UniRef90_A6XP89_287_504 UniRef90_Q6PMT3_285_502 UniRef90_Q1L752_86_304 UniRef90_Q1L748_86_303 UniRef90_P15072_287_504 UniRef90_Q8JVD0_86_303 UniRef90_H9AY35_273_496 UniRef90_B0Z3W9_300_527 UniRef90_Q91LX8_289_537 UniRef90_Q66776_291_513 UniRef90_Q100Y4_72_320 UniRef90_Q2XP17_290_516 UniRef90_P12296_138_384 UniRef90_Q02472_148_405 UniRef90_A4ZKN2_144_403 UniRef90_C3U5A3_174_435 UniRef90_P08544_148_405 UniRef90_E3TMG9_144_405 UniRef90_G9FTJ7_144_402 UniRef90_B3VTU7_149_406 UniRef90_Q155Z9_151_421 UniRef90_G1C9J1_14_204 UniRef90_I1YLT5_69_326 UniRef90_G0Y2E2_141_365 UniRef90_G0Y2E0_150_361 UniRef90_Q8B552_195_378 UniRef90_B5A1N0_195_378 UniRef90_Q2LKZ0_129_301 UniRef90_Q65481_129_301 UniRef90_G1DFA4_229_430 UniRef90_H9LG14_129_301 UniRef90_H6VLP2_125_335

K K K K K Q K Q Q Q K K K Q K R K N S C C C N A A A A A A A A N N N N N N N N K C N N

A A A P A A P A A A P P A A A P A A V P P P P S N N N N N N N S Y V N N F F N N P N F

W W W W W W W W W W W W W W W W W Y W W W W W W W W W W W W W W W W W W V V W W W W W

T T T T T S T S S S T T T S T T T T S T T T T T A T T T T V T T T S T T T T T T T T T

L L L L L L L L L L L L L L L L L L L L L L I L L I L L L L L L L V V I L L L L L L V

V V V V V V A V V V V V V V V V V V V L V M V V V V V V V V V L A I Y Y V I S A V A F

V V V V V V V V V V V V V V V V V L V I I I I I V V V V I V V V I V V I I V V V F V I

M M M M M M M M M M M M A M A M A V G M V M L A A A A A A A A M L M T T R R I I M I T

V V V V V V V V V V V V V V V V V V V V V V I V V V V V V V V V V Y P I V P P V P P

L V V V V L V L L L V V M L M V L I V I V V L V L L L L L L L L I I V V V I L L V V

A A A A A T A T T T S A A T A A A S V S S T S A T S T S T S T V S V V V V V V T V V

P P P P P P P P P P P P P P P P P P P P P P E P P P P P P P P P P E P P P P D P D P

Y Y Y Y Y L L L L L L L L L L L L L M L L L L L L L L L L L L L L L L L L L L L

T T T T T T T T T T T T T T T T T T T R R T T Q Q Q Q Q Q Q D Q S D S S E A A S

N N N N N T V T T T T V T T T T T T I Y Y G Y Y Y C Y Y Y Y Y Y Y Y Y Y Y

D D D D D E E E E E P S M V S N Y Y Y N

Q Q Q Q Q A N A A A N K S A G N S S G S G S S A P A S S A K N N T T T A A A T

T T T T T Q N Q Q Q T T N Q T T N N A S Q T T A T T Q S A E G G G G G A D T G

I I I I I M E M M M V G M M M A M G G G G G G G G G G G G G A S S A A G G G A

G G G G G N G N N N S G G N G G G G G S A A A S S S S S S A A S S S S A S S T

S S S S S S A S S S A S Q S S A Q H S A A S A A A S A S A T P T T T -

T T N T S G P G G S G E D G D Q D A D P T T T T P P T P T T N T T T T T T T T

K L -

T T -

K K K K K T Q T T T Q Q N T N Q N V S D D T S D E D D T N D D E N Q Q Y F Y S

A A A A A V I V V V I I V V V I V V L V V V L V V V V I V V P V V V I V V V V I

E E E E E E K E E E K K E E E K R K D Q Q P D A D E Q E D Q E A P P P P P P P P

V V V V V V V V V V V V V V V V C V V L I V I I I I I I I I I M I V I I I I I V

Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y T K R T T T T T T T T T T T T T T T T T T T T T

V V V V V A A A A A A M A A A A Q V A M A M A V L A A A V A F L V I V V V V I V

N N N N N N N N N S N N N N N N T T S T T S S S S S S S S S S T S S S S T T T S

I I I I I I I I I I I A I I I I S V F I I V I L I I L I V I V I V I V V I I I I

A A A A A A A A A A A A A A A A P A T T T A Q Q Q Q Q Q Q Q R T A A A A A A A A

P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P

T T T T T T T T T T T T T T T T T V L T T I V V V V V V I V T I M -

N N N N N N N N N N H Y N N N N N D N D D D R N K K N K K K S D S -

V V V V V V V V V V V V V V V V V V V F F A P P P P P P P P P T C -

Y Y Y Y Y F H Y V F H H Y Y Y H Y K K V V M V V V V V V V V Y V S -

V V V V V V V V V V V V V V V V V V V A A V F F F F F F F F F F F -

A A A A A A A A A A A A A A S A A V A N N N N N N N N N N N N N S -

G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G -

E E E E E E E E E E E E E E E E E E P P -

K K K K R K L M L K L L R L K L K T M L -

P P P P P P P P P P P P P P P P P P P P -

V V A V A A S A G S S S S G A S T E N -

K K K K K K K K K K K K K K K K K R K -

Q Q Q Q E Q E Q Q Q E E Q Q Q E Q Q Q -

2016/02/23, 3:10 PM


UniRef90_B9VIN1_70_329 UniRef90_G1JYY8_171_367 UniRef90_Q8QUZ6_80_281 UniRef90_I1YLT7_70_335 UniRef90_F5B9S5_80_301 UniRef90_G0Y2E4_163_340 UniRef90_B8XTQ1_73_321 UniRef90_H9C6N6_131_322 UniRef90_I1YLT4_70_334 UniRef90_B8XTQ0_73_332 UniRef90_B9V442_80_329 UniRef90_D2IW00_80_316 UniRef90_Q2LL04_129_301 UniRef90_I1YLT6_69_335 UniRef90_G5DC73_80_330 UniRef90_A5GZE4_80_318 UniRef90_D9D8F3_70_328 UniRef90_G0ZNT5_127_322 UniRef90_B9V459_80_317 UniRef90_A8S322_129_323 UniRef90_C7DUC7_127_322 UniRef90_G8IJE2_80_317 UniRef90_Q2LKZ8_129_301 UniRef90_B8XTP8_70_327 UniRef90_H2E685_80_301 UniRef90_Q5YJ95_199_371 UniRef90_Q9IM09_80_305 UniRef90_A5GZE9_80_317 UniRef90_Q66790_80_316 UniRef90_A5GZD8_131_315 UniRef90_P12915_129_301 UniRef90_Q5XLP5_80_317 UniRef90_G0Z2U8_195_360 UniRef90_A1E4A3_131_303 UniRef90_G0Y2E3_141_369 UniRef90_B9V482_80_298 UniRef90_B8XTP9_157_328 UniRef90_F8V2V4_80_316 UniRef90_A1E4A2_131_303 UniRef90_Q8V5Z9_80_307 UniRef90_G8IJE1_80_316 UniRef90_P12916_80_317 UniRef90_P03303_80_315 UniRef90_B8XTQ4_69_329 UniRef90_Q9YLJ1_78_316 UniRef90_B9V466_80_318 UniRef90_Q05ED6_131_323 UniRef90_B5BSU7_131_316 UniRef90_A5GZF1_80_316 UniRef90_B9V453_80_313 UniRef90_Q05EE3_80_323 UniRef90_A5GZE7_80_317 UniRef90_B9V485_80_315 UniRef90_G8IJH5_80_318 UniRef90_B9V435_80_318 UniRef90_Q8V398_80_292 UniRef90_Q82081_159_315 UniRef90_Q6W9F6_159_316 UniRef90_Q03053_159_316 UniRef90_A5GZD6_131_315 UniRef90_Q2YEN8_80_316 UniRef90_G8HH17_117_311 UniRef90_A7KC08_80_331 UniRef90_Q6W9G1_131_314 UniRef90_G8IQ64_80_315 UniRef90_I0IY47_80_323 UniRef90_G5DC75_80_317 UniRef90_Q05ED2_80_316 UniRef90_Q5VAK8_80_316 UniRef90_A7KC11_80_330 UniRef90_B5BSU6_131_316 UniRef90_Q05ED0_80_316 UniRef90_Q5VAL5_159_315

18 of 20


N N S T N N T N T T N N S T N N T N N N N N S T S N N N Y N S N N N N N N N N N N N N N Y N Q Q N N Q N N N N N N H N N Y S N Y N N N Y H N Y Y Y

I F N V Y F V N V V N N N I N N V N N N N N N V N F V N N N N N F Q I N I N Q N N N N I N N N N N N N N N N N N N N N N N Y N N N N N N N N N N N

W F W W W V W V W W W W W W W W W L W L V W W W W V W W F V W W V W W I W F W W W W V W F W F F W W F W V W W W V F F V F W W F V W W F F W F F F

T S S T S S T S T T S S T T S S T T S S T S T T S T S S T S T S T T T S T T T T S S S T T S T T S S T S S S S T S T T S T T S T S G S T T S T T T

V L L A L L A L A A L I L A L L A L L L L L L A L L L L L L L L L L V L A L L L L L L A L L L L L L L L L L L L L L L L L L L L I L L L L L L L

V V M V L Y V L V V V V A V V V V L L V G V A V M V V L M L A L V A Y M V M A A V V M L M V M M V L M V L V V C M M M M M V M L V V M M V M M M

V I V V V I V V V V I I I V I I V I I I I I V V I I V I V V I I I I L V V I I V I I V V V I I I I I I I I I I V V I I V V I V V V I V V I V V I

M V M M I V M I M M I I I M I I M I I I I I I M I R I I I I I I R I V I M I I I I I I V I I I I I V I I I I I V V I I I I I I I M I I I I I I I

V P P V P P V P V V P P P V P P V P P P P P P V P V P P P P P P V P P P V P P P P P P V P P P P P P P P P P P P P P P P P P P P P P P P P P P P

L I V I V I L V I I I V V I I I I L V I L I V L I L V V F V V V L V V I V F V I I I I I F V F F I V F I I I I V I F F I F I F I F I F F I F F F

S A A A V V V V A V C S A C C C V V S V V C A V V V V S V V A S V V V V S A V S C S A A A S A V C S A S S C C V A A A A A C A A V S A V C V V A

P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P K P P P E P P P P P P P P P P P P K P P P P P P P P P

L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L L

Q N E K N T N N E Q K N E E Y R K R R E K N K R D K T V K E K E S D D N E R T Q A Q E T E R E K T E Q D N D S A D E S V D K N D E D E A

I Y F F N Y F S F T V Y T S A S T F Y S N A Y Y F Y T S V S A V V S V S A V S A F Y A Y N V A A Y Y T Y

G S H E S P V S D T Y S M S S G D A G M Y S S N Y D S P Y D N G A A V N Y N E P N S D S N L Q D P S S P A S P T S I P Y E S S Q S T S

S N A K E T T A G I A N S S A N N N S A S A D T A M V A T D T A T T T D G T T A Q N G A P A P T T G T T T T A T G T D N T S N M T

G G T G G G G G Q E A G T P G T Q G T T A G T G T S G G A S G R G G G S A G T G S G T G A S G G S N T T G G G G Q E S G E A N G Q G G G

A A G A A M A A T G D A I G A G A V G I E A G A G A G M E A A T A A A G G D S A A G G I A S D T A S G E S A A S A V N S G T T A D G G A

S S T S S S S S P T T S T S S G S R T T S T S A T S S T T S M S S S G A T S T S S S T S T T A S P T S S S T A S P L L A S T S T T T T

P P T P P P T P P T P T T T S P T T P T -

N T P T T T T T P P I N T T V T T P T P T T S T T P A P S T Q S T P N P T T V P N T A N N S P S T T E N N Q T V T T T P T

-

-

F T T Y L T S T R K T T L F F Q K Y I L I F M S Y M L T I S Y V S Q S A L T G T T Y Y T Y A S T K I F Y T Y Y Y

V V V I V I V V V V V V V I V L V V L V V V V V V V V I V V V V L V I V V V R L V V V V V V I V V L I I L V V L V V V L V V V V V V V V

Q G A P S P G S P P P N P P N P P P H P P S G P P P P P P P P P P G P P P P P P A P P P P P P P P P P P P P P P P P P P P P P P P P P P

M M V V I I M M I I I M I I M I I I I I I L I I I I I V I I I I I M I I I I I I M I I I I I I I I V I I V I I I V I I I I I I V I I I I

T V T T T T V T T T T T T T T T T T T T T T T T T T T T T T T T T V T T T T T T S T T T T T T T T T T T T T T T T T T T T T T T T T T T

L M V V M V M M I L V L I V M V I I V I V L V V I I V V V V V V V L V V I I V V M I I V V I V V I V V I V V V V V I V V L I I V I V V V

T T T S T T T S S S T T S S T T S S T S T T T S T S T T T S S S S T T S T S S T T T S T T S S T S T S S T T T T T S T T T S T T S T T T

L I I I I I I I I I I I I I I I I I I I I I I V M I I I I I V I V I V I I I I I V I I I V I I V I I I I I I V I I I V I V I V V I V I I

T T A S T A T A S S A T S S T A S A A S A T A A A S A A A S A A A T A A A S S A T A S A A S S A S A S S A A A A A S A A A S A A S A A A

P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P

T V M V L M V M V D D D I M M V V M M M M -

G N N N N C N C N K K K N C S N G D Q C Y -

S S T S S A S A S S S S S S C S A A A A A -

V V E V V E V E V E E E V M S V V E E E E -

F F F F F F F F F F F L F F F F F Y Y F F -

N N S N N S N S N S S S N A S N N N N S S -

G G G G G G G G G G G G G G G G G G G G G -

L L A L A A A A -

R R R R R R R R -

H H A Q A A A -

T T K Y R R R -

A A S A S S S -

Q Q Q Q Q Q Q -

2016/02/23, 3:10 PM


UniRef90_A4UHT9_129_315 UniRef90_H8Y6P9_127_322 UniRef90_P29813_80_316 UniRef90_P32537_131_305 UniRef90_G5D5E2_159_315 UniRef90_Q9YLG5_80_319 UniRef90_B8XTQ3_70_330 UniRef90_A7KC13_88_321 UniRef90_O41174_80_282 UniRef90_A5GZF9_80_318 UniRef90_G8IJE5_80_295 UniRef90_Q9QCF0_72_316 UniRef90_G5DC71_157_324 UniRef90_A8S330_157_325 UniRef90_Q9WN78_80_316 UniRef90_A0MHB7_86_316 UniRef90_O89280_159_323 UniRef90_G8IJG2_80_318 UniRef90_F6M9Y3_80_316 UniRef90_A5GZE0_80_317 UniRef90_Q7T7N9_80_323 UniRef90_A7YF31_159_315 UniRef90_H9X8D4_80_317 UniRef90_G9K146_80_316 UniRef90_G9K138_159_330 UniRef90_G0YPI0_80_292 UniRef90_O91734_159_316 UniRef90_B9V473_80_315 UniRef90_Q9WHH4_131_316 UniRef90_Q2L970_80_316 UniRef90_Q80GI2_159_316 UniRef90_Q05ED1_131_316 UniRef90_B9V440_80_317 UniRef90_G1CSA8_80_313 UniRef90_B1PZZ4_80_316 UniRef90_B9V457_80_316 UniRef90_D8VCT6_80_323 UniRef90_G8IRN4_129_324 UniRef90_Q80GI1_159_316 UniRef90_I1XV41_80_323 UniRef90_P21404_159_316 UniRef90_P23008_135_293 UniRef90_A5GZE2_80_315 UniRef90_Q6W9F4_159_316 UniRef90_B3SRP0_80_317 UniRef90_Q6JKS0_159_312 UniRef90_G8IJG6_157_325 UniRef90_D4AH62_131_316 UniRef90_A5GZD9_129_321 UniRef90_Q66331_80_318 UniRef90_Q6W9E8_159_323 UniRef90_P04936_159_330 UniRef90_A7KC07_80_326 UniRef90_Q66806_80_316 UniRef90_A5GZF5_80_318 UniRef90_Q05ED4_159_315 UniRef90_G8IRN3_129_329 UniRef90_Q82122_80_315 UniRef90_Q8V601_80_317 UniRef90_B9V433_129_314 UniRef90_G5EN04_80_318 UniRef90_Q8V613_159_316 UniRef90_Q6W9F9_80_316 UniRef90_H9C6N7_159_315 UniRef90_B9V434_80_314 UniRef90_A5GZF6_80_318 UniRef90_A5GZF2_80_318 UniRef90_C7DUC8_80_317 UniRef90_G5CZJ4_127_322 UniRef90_B9V477_80_318 UniRef90_G8IJH3_88_314 UniRef90_Q8UY33_159_317 UniRef90_P07210_80_318

19 of 20


N N H N N N N N S N N Y N N Y N N N N N N Y N N N N H N Q Y Y Y N C H N N N Y N Y N N Y C N N Y N N Y N N Y N Y N N C N S N Y N N N N N N N N C N

N N N N N N I N S N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N

V L F W V F W L W W W F V I F V F W W W W F W W W C F W F F F F W F F W W V F W F W W F F F V F L V F W W F W F L W F L F L F W W W W W L W L F W

S T T T S T T S S S S T S S T S T S S S G T S S S G T S T T T T S G T S G S T G T C S T G T S T S T T S S T S T T S G S G T T S S S S S T S S G S

L L L L L L A L L L L L L L L L L I I L I L L L L L L I L L L L L L L L I L L I L L L L L L L L L L L L L L L L L L L L L L L I L I L L L L L L L

V M M A M M V L L V V M V V M V M V V V V M V V V I M V M M M M V F M V V V M V M V V M V V L M M M M V L M V M V V I M V M M V L V V V L V L A V

I I I V I I I V V I I I V I V I I I I I V I I I I V I I L I V L I V I I I I V V V I I I V V I I V V I I I V I I I I V V V I I I I I I I I I V I I

I V I I I I M I I I I I I I I I I I I I I I I I I V I I I I I I I I I I L I I L I I I I I I I I I I I I I I I I V I I I I I I I V I I I I I I I I

P P P P P P V P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P

I I F V I F V V V I F I L F I F I V I F F I I I V F I F F F F I V F V F V F F F I I F V I I F I F F I V F V F L V V I I F F I I I I I I V V V I

C V V C A V T V V C V C V A C A S S C V A C C C A V S V A V A C A V S V C V V V S C V A S C A V V V C C A C A V C A V S V V S S S C C V C I A C

P P P P P P P P P E P P P K P K K P E K P S P P P P P P K K P P P P P P P P P K P Q P P P P K N P P P P Q P K P Q P D P E A P Q K P E K P P P P

L L L L L L L I L L L L L L L L L L L L L L L L L L L L M L L L L L L L L L L L L L L L L I L L L L L L L L L L I L L L L L L L L L L I L L

R K D A I D K T Q D R R E K A E D K A K R E E D E D D R K E N D A Q R D D D R E A A K R E T D D E Q D E D R Q A T K D D Q R V Q L R E T D Q

A P Y G V Y Y A V F K S H T Y C Y S S A F Y Y S Y T Y S V T Y A Y Y T V Y V Y F S A Y F V V H V A V

P G S G P V A N D T S G S P S T S D Y D E M N S A S A S S Q Y S S Y S V Y A E V E Y Y S V T C S S D A A T G N Y T Y S N A S E D G A T Y Q

A L S T T N D T T A G S P S D E T Q T T P G A D A D V G S S E G S D D T G M S C N S S P D S A P Q A N S S C A V S A T V S N P

T S D G N G G G G E N T Q G G G Q T N G S A V G N G G G G T D D E D N G S T T G G A T G G G G G A Q S G T S N S G N G N D G G S N T G G A G

A G S N A S A S V A V Q A A A G A A G A S S Q A V A S G G E G S S G A G G A S V G G G A A A S A I A A S A G I G T G A T I D G G A G S A G G

P S S T S S S P P S S T S P S T T A A T T T P S T S S T T G A S T A P T A S S S T A A P S A T S N T S E A S A T A T A A T T I S T E A A T

N P I T T S T T T T T T -

S P T T P P T P A T Q N T R T T G T P N T D S T T S T T D T R P P T N N T T T T S P T T R T Q S N N S P T T S D N A P A T Q H T Q

-

-

T S Y Y T Y S T Y T R Y T F I N T K Y I V Y P Y Y Y Y V A Y K A T Y N Y I T Y A A T V S Y Y T F H Y Y T I A S E F N P S Y T V T Y S A S

L L V V L I V I V V L L V L V V V V V V V V V V V V I V V V I V V I L V V V V V V I I L V I V V I V V V V L V I I V V V V I V V V L V V I I

P P P P P P Q P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P S P P P P P P P P P P P P P P P P P P P P P P P P

I I I I I I M V I I I I I I I I I I I I I I I I I I I I I I I V I I V I I I I I I I I I I I I I I I I I I I I I V I I I I I I I I I I I I I

T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T

I I V I V V L V I V I I V V V L I I V V V I I V I V V V I V V V I V I V V V V I V L V I V V V I I I V I V I V L I L V I I I I V I V I V V V

S T T S T T T T S T S S T S T S S S T T S S S T S T T T T S T T S T S T T T S S T S T S T T T T S S T S T S S S T T T T S S S S S T S T T S

I I V I I V I I I V I I V I I I I I I V I I I V I V V I I I I V I V I I I V I V I I I I I I I I I V I V I I I I I V V I I I I I I I I I I

A A A A A A T A S A A A A A A S S S A A S S S A S A A A A S A A S A A A A A S A A A A A A A A S S A S A A S A A A A A S S S S S A S A A S

P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P

N I M D D D M M D L L D M M M M D L L D M -

K D N K K R N C K N N K Y D C S K N N K N -

S T L S S A A S S S L A A A S S S S S -

E V E E E E E E E E E E E E E E E E E -

F F L F F Y F F F F L Y F F F F F F F -

S N S S S N S S A S S N S S S A S S A -

G G G G G G G G G G G G G G G G G G G -

A A A A A A A A -

R R R R K R R R -

A A Q -

K K K -

S R S -

Q Q Q -

2016/02/23, 3:10 PM



UniRef90_Q66577_131_323 UniRef90_G8IJF0_127_318 UniRef90_E7CRL8_159_323 UniRef90_Q995Z1_80_314 UniRef90_C6ZEZ9_129_315 UniRef90_Q5G9Z5_159_312

1

2 3 Variable

4

5 6 Average

N N N Y N

N N N N N

F V W F F

T S G T S

L L I L L

M V A M V

V I I I I

I I L I V

L P P P P

F I L F I

A V S A V

P P P K P

L L L L L

K R D E R

V Y P

S N F A G

S G A S N

G T Q G S

G G D S G

T P S S A

S -

N T V T P

-

-

Y T E V I

V I I V L

S P P P P

I I I I I

T T T T T

I V V V V

T S T T T

V V I V I

A A A A A

P P P P P

M -

D -

A -

E -

Y -

N -

G -

-

-

-

-

-

-

7 8 9 Conserved


20 of 20

2016/02/23, 3:10 PM



Figure 3S

ConSurf-DB Color-Coded MSA 2WZR3 UniRef90_F1AW55_504_724 UniRef90_Q6PMU0_504_724 UniRef90_Q6PMU2_504_724 UniRef90_Q8V0G8_305_525 UniRef90_Q6PMT3_503_723 UniRef90_Q1L748_304_524 UniRef90_Q6PMT8_504_725 UniRef90_B8Y0J7_504_725 UniRef90_Q1L757_305_524 UniRef90_Q1L752_305_526 UniRef90_Q1L754_305_526 UniRef90_P49303_505_725 UniRef90_Q6PMY9_505_723 UniRef90_A2I8Z5_505_724 UniRef90_P15072_505_723 UniRef90_Q8JVD0_304_524 UniRef90_H9AY35_497_713 UniRef90_B0Z3W9_528_746 UniRef90_Q2XP17_533_745 UniRef90_Q100Y4_324_550 UniRef90_Q91LX8_542_768 UniRef90_A4ZKN2_415_639 UniRef90_E3TMG9_417_639 UniRef90_P08544_417_642 UniRef90_B3VTU7_418_646 UniRef90_Q66776_543_769 UniRef90_G9FTJ7_414_638 UniRef90_Q02472_417_641 UniRef90_P12296_396_619 UniRef90_C3U5A3_447_672 UniRef90_G1DFA4_460_684 UniRef90_Q155Z9_448_665 UniRef90_B9VIN1_352_561 UniRef90_G8HZ08_715_947 UniRef90_B8XTQ3_353_566 UniRef90_D9D8F3_345_562 UniRef90_I1YLT4_348_565 UniRef90_B8XTP9_335_563 UniRef90_I1YLT7_349_565 UniRef90_I1YLT6_336_558 UniRef90_B8XTP8_334_562 UniRef90_B8XTQ0_353_567 UniRef90_Q5YJ95_381_603 UniRef90_B8XTQ4_341_566 UniRef90_I1YLT5_349_558 UniRef90_F6IA11_421_636 UniRef90_G0Z2U8_412_599 UniRef90_Q5YJA7_377_599 UniRef90_G0Y2E4_357_574 UniRef90_Q8B552_395_615 UniRef90_A7KC13_333_552 UniRef90_A5GZD6_337_514 UniRef90_G5CZJ8_367_551 UniRef90_G8HH17_373_575 UniRef90_G0Y2E3_380_601 UniRef90_B9V482_337_556 UniRef90_A5GZF6_334_555 UniRef90_A7KC10_335_556 UniRef90_G8IJG2_334_555 UniRef90_D2IW00_332_553 UniRef90_A5GZD9_331_550 UniRef90_A7KC07_334_555 UniRef90_Q672R3_805_1000 UniRef90_B5A1N0_416_617 UniRef90_B9V433_331_550 UniRef90_Q82081_333_552 UniRef90_Q5XLP5_336_557 UniRef90_B9V457_333_554

1 of 17

-----GILPVAVSDGYGGFQNTDPKTSDPVYGHVYNPARTLYPGRFTNLL -----GILPVAVSDGYGGFQNTDPKTSDPIYGHVYNPARTGYPGRYTNLL -----GILPVAVSHGYGGFQNTDPKTSDPVYGHVYNPARTGLPGRFSNLL -----GIVPVAVADGYGGFQNTDPKTSDPIYGHVYNAPRTGYPGRYTNLL -----GIFPVAAAAGYGGFQNTDPKTSDPIYGHVYNPARTGYPGRFTNLL -----GIIPVACNDGYGGFQNTDPKTADPIYGLVSNAPRTAFPGRFTNLL -----GIIPVACNDGYGGFQNTDPKTADPIYGLVVNPPRNAFPGRFTNLM -----GIIPVACSDGYGGFQNTDPKTADPIYGYVYNPSRNDCHGRYSNLL -----GIVPVAAADGYGGFQNTDPKTADPIYGYVYNPSRNDCHGRFSNLM -----GIVPVACADGYGGFQNTDPKTADPIYGHVYNPPRNDCCGRFTNFM -----GIVPVACSDGYGGFQNTDPKTADPIYGHVYTPSRQDCHGRFSNLL -----GILPVACADGYGGFQNTDPKTADPIYGHVYNPSRDGCHGRFSNLM -----GIVPVACSDGYGGLVTTDPKTADPVYGMVYNPPRTNYPGRFTNLL -----GIVPVACVDGYGNMVTTDPKTADPVYGKVFNPPRTNLPGRFTNFL -----GIFPVACSDGYGGLVTTDPKTADPVYGKVFNPPRNLLPGRFTNLL -----GIFPVACSDGYGNMVTTDPKTADPAYGKVYNPPRTALPGRFTNYL -----GIVPVACHDGYGGFQNTDPKTADPIYGLVSNPPRTAFPGRFTNLL -----GLVPLANHIGYGGFKTTAPLTADPVCGNVYNPPRQDMPGRFTNFM -----GIVPVAAKAGYSGFCTTSPITADPVYGKVVNPPRRHIPGRFTNFL ------------------FMSSVPDNSTPLYPKVVVPPRQ-VPGRFTNFI --AVSEGIPGT-QPYDRQFLSAEPSAPPPVYTPSWLPDRSFIPGKFTDFL ---VSEGIPGT-QPYDRQFLSTEPSAPPPLYTPSWLPDRSFIPGKFTDFL -------IPVTVREHAGTFYSTTPDNTVPVYGKTVATPSDYMCGEFTDLL -------FPVTVREHAGTFFSTTPDTTVPVYGNTISTPFDYMCGKFTDLL -------IPVTVREHKGCFYSTNPDTTVPIYGKTISTPSDYMCGEFSDLL -------IPVTVREHQGTFYSTNPDTTVPIYGKTIATPSDYMCGEFSDLI --AVAQGIPGT-QPYDRQFVSSEPSAPPPVYTPSWLPERSFIPGKFTDFL -------IPVTIREHAGTFYSTTPDTTVPIYGKTIATPSDYMCGEFDDLL -------VAVTVREHQGSFYSTNPDTTVPIYGKTIVTPSDYMCGEFTDLL -------IPVTIREHAGTWYSTLPDSTVPIYGKTPVAPANYMVGEYKDFL -------FPGTIREHAGTFYSTTPDTTVPVYGKTISTPANYMCGEFTDLL PQTITQGFAGHIRENQAMYASTIPDETTPVYGLGFNPNTDFVPGEVHNFL ------------------FLSTLPDDTVPAYGNVRTPPVNYLPGEITDLL ------------------FSSTVPDVTEPCYGMTVVPPKDFMPAPITDLV -------VPTFQVPGSGQFVSTLRNAGYPLYAHFEPTHSFENPGRFVNLL ------------------FSSTVPDVTEPCYGMTVNPPKDYMPEPVGDLV ---------------FDQFNTTVPLRTEPCYGMTVTPPVDYMPPPVEDLM ------------------FNTTVPLRTEPCYGMTLTPPLDYMPPPIEDLA -----GPIPTRPFHNFNQFNTTVPLRTEPCYGMTLTPPVDYMPKPIDDLV ------------------FNTTVPLITEPCYGMTLTPPTDYMPKPIEDLA -----GPIPVRTFHNSSQFATTVPLRAEPCYGMTVTPPTDYMPDPIDDLV -----GPIPVRPFHNFQQFSTTVPLRTEPCYGMTVTPPVDYMPLPITDLV ------------------FSTTVPLRTEPCYGMTVTPPVDYMPLPITDLV -------FPVRQVPGSQQFMTTQRDSGIPIYPEFEKTHGFKLPGRVTNLL -------IPVRMTQNSGQFSTTLPARMEPCYGLTPNPTRDFLPPVVEDLL ------------------FSSTVPDVTEPAYGMTVAPPRDYMPPPVDDLA -------VPTFDIPGSGQFCTTLANTGYPAFPIWTPSEGFPLPGRMTNLI ------------------------------------------PGRVTNLL -------FPIRQVPGSQQFMTTQRDSGIPIYPEFEKTHSFKLPGRVTNLL -------VPTFQIPGSGQFVTTIKNDGFPALPHYQETPLHFIPGEVTNLL -------IPVRQIPGSSQFLTVQRDAGVPLYPEFQKTARFTLPGRVTNYM -------LPTTLTPGSEQFLTTDDRQSPSALPNYEPTPLIHIPGRVTNLL -------LPTTTLPGSGQFLTTDDRQSPSALPNYEPTPKIHIPGEVKNLL ------------------------------------------PGRVVNLL ------------------------NPGYPLYPEYQKTPPHHIPGRVTNLM -------IPVFEVPGSGQFMTTLRNSGYPCLPDYEETPSHHIPGKVVNLL -------LPTTTLPGSGQFLTTDDRQSPSALPNYEPTPRIHIPGQVRNLL -------LPVMLTPGSEQFLTTDDAQSPSALPYFHPTKEIFIPGRVTNLS -------LPVMLTPGSEQFLTTDDNQSPSALPWFHPSKEIFIPGRVTNLA -------LPVMLTPGSAQFLTTDDAQSPSALPYFHPTKEIFIPGRVNNLS -------LPVMLTPGSGQFLTTDDAQSPSALPYFHPTKEIFIPGRVTNLS -------LPTVLTPGSEQFLTTDDRQSPSAMPNYEPTPLIHIPGEVRNLL -------LPVMITPGSGQFLTTDDAQSPSALPYFHPTKEIFIPGQVKNLI -------------------------------------HSFNLPGRVRNLL ----------------------------PVYPEFEKTHGFRLPGRVTNFL -------LPAVLTPGSEQFLTTDDRQSPSAMPNYEPTPLIHIPGEVKNLL -------LPTTTLPGSGQFLTTDDRQSPSALPSYEPTPRIHIPGKVRNLL -------LPVYMTPGSGQFLTTDDLQSPSALPWYHPTKEIFIPGQVRNLI -------LPVMLTPGSAQFLTTDDTQSPSALPYFHPTKEIFIPGKVSNLS

2016/02/23, 3:08 PM


UniRef90_G1JYY8_404_619 UniRef90_F6N707_334_556 UniRef90_G5D5D9_333_552 UniRef90_Q82122_332_553 UniRef90_G5D5E2_333_552 UniRef90_A5GZF5_335_556 UniRef90_G0Y2E2_378_600 UniRef90_P03303_333_552 UniRef90_P07210_338_559 UniRef90_F6M9Y3_333_554 UniRef90_B9V459_336_557 UniRef90_B9V477_333_554 UniRef90_H9C6N6_333_552 UniRef90_A5GZE7_336_557 UniRef90_B9V485_333_552 UniRef90_G0Y2E0_419_588 UniRef90_G9K138_332_516 UniRef90_A5GZE9_336_557 UniRef90_B9V434_332_553 UniRef90_P04936_332_552 UniRef90_C7DUC8_336_557 UniRef90_G8IQ74_332_548 UniRef90_I2CMI9_334_554 UniRef90_B9V466_338_522 UniRef90_A5GZF9_333_554 UniRef90_G8IJE2_332_552 UniRef90_H8Y6Q0_168_390 UniRef90_G0YPI0_327_543 UniRef90_B9V473_333_554 UniRef90_B5BSU6_368_556 UniRef90_A8S322_365_548 UniRef90_G8IQ62_334_555 UniRef90_B9V453_331_552 UniRef90_G9K146_333_520 UniRef90_F6M9Z0_330_551 UniRef90_P12916_334_555 UniRef90_G5EN04_327_500 UniRef90_C7DUC6_357_551 UniRef90_Q9WN78_367_554 UniRef90_G0YPI1_326_499 UniRef90_G0YPH9_326_499 UniRef90_Q8UY33_326_552 UniRef90_A5GZE0_334_555 UniRef90_G0ZNT7_334_555 UniRef90_A7KC11_332_515 UniRef90_G1JYY7_238_455 UniRef90_H6UKU5_326_499 UniRef90_Q03053_367_554 UniRef90_Q995Z1_365_551 UniRef90_B9V442_331_555 UniRef90_G1CSA8_329_506 UniRef90_A5GZE4_333_554 UniRef90_G8IJF4_357_552 UniRef90_A5GZF2_336_558 UniRef90_A5GZF1_333_554 UniRef90_Q5U904_326_555 UniRef90_Q6JKR7_325_551 UniRef90_G8IJF0_360_553 UniRef90_A1E4A3_319_512 UniRef90_Q8QUZ6_317_541 UniRef90_Q2LL04_324_545 UniRef90_F6M9Y7_364_585 UniRef90_Q8V601_326_552 UniRef90_Q6JKS0_326_499 UniRef90_B3SRP1_326_550 UniRef90_G5CZJ4_357_550 UniRef90_B5BSU7_367_555 UniRef90_G8IRN3_333_554 UniRef90_A5GZE2_333_554 UniRef90_A7KC08_333_554 UniRef90_H9BP13_325_500 UniRef90_Q80GI2_332_555 UniRef90_B9V435_333_554

2 of 17


-------IPVFQVPGSSQFLTTLRNDGYPIYPEFSTTHSYPLPGRVRNLL -------LPVMLTPGSAQFLTTDDTQSPSALPYFHPTKEIFIPGKVNNLS -------LPTTTLPGSGQFLTTDDRQSPSALPNYEPTPRIHIPGKVRNLL -------LPVYVTPGSGQFMTTDDMQSPCALPWYHPTKEIFIPGEVKNLI -------LPTTTLPGSGQFLTTDDRQSPSALPNYEPTPRIHIPGQVKNLL -------LPVFITPGSAQFLTTDDTQSPSALPYFHPTKEIFIPGEVKNLS -------VPVFEVPGSGQFVTTIRNSGFPILPDYEETPNHGIPGRVRNLM -------LPTTTLPGSGQFLTTDDRQSPSALPNYEPTPRIHIPGKVHNLL -------LPVMLTPGSGQFLTTDDTQSPSAFPYFHPTKEIFIPGQVRNLI -------LPVMLTPGSAQFLTTDDTQSPSALPYFHSTKEIFIPGKVSNLS -------LPVYVTPGSGQFMTTDDLQSPCALPWYHPTKEIFIPGEVRNLI -------LPVFLTPGSAQFLTTDDTQSPSALPYFHPTKEIFIPGEVKNLS -------LPTLTTPGSGQFLTTDDRQSPSAMPNYEPTPPIHIPGEVHNLL -------LPVYVTPGSGQFMTTDDLQSPSALPWYHPTKEILIPGEVKNLI -------LPTTTLPGSGQFLTTDDRQSPSALPCYEPTPKIHIPGEVKNLL ------------------------------------------PGRVTNLL -------LPVMVTPGSGQFMTTDDYQSPSALPWFHPTKEISIPGQVRNLI -------LPVYITPGSGQFMTTDDLQSPSALPWYHPTKEIFIPGEVKNLI -------LPVMLTPGSGQFLTTDDMQSPSVLPYFHPTQEIFIPGEVKNLV -------LPVFITPGSGQFLTTDDFQSPCALPWYHPTKEISIPGEVKNLV -------LPIYMTPGSGQFMTTDDFQSPSALPWYHPTKEILIPGEVKNLI -------LPVRMPSGSNQFMTTEDEQSPNILPSFHSTKQIHIPGQIKTVM -------LPVRMPSGSQQFMTTEDEQSPNMLPGYHSSKKIHIPGMITNVL -------LPTYITPGSGQFMTTDDFQSPSALPWYHPTKEILIPGEVKNLI -------IPTMLTPGSGQFMTTDDFQSPSALPWYHPTKEISIPGQVRNLI -------LPVLVTPGSGQFLTTDDYQSPCALPWYHPTKEIFIPGEVKNLV -------LPVRLASGTQQFMTTEDEQSANLLPGFHPTPVMHIPGEITNLM -------IPVEMKPGTNQFLTTDDGVSAPILPGFDPTPVIHIPGEVSSIL -------LPVMLTPGSAQFLTTDDAQSPSALPYFHPTKEIFIPGEVKNLS ------------------------------------------PGEVHNLM ------------------------------------------PGRITNIL -------IPTMLTPGSGQFMTTDDFQSPSALPWYHPTKEISIPGQVRNLI -------LPVMLTPGSGQFLTTDDMQSPSVLPYFHSTQEIFIPGEVKNLI -------LPVFITPGSGQFMTTDDFQSPSALPWFHPTREISIPGQVKNLV -------LPVMLTPGSGQFMTTDDFQSPCALPWYHPTKEISIPGQVRNLI -------LPVYITPGSGQFMTTDDMQSPCALPWYHPTKEISIPGEVKNLI -------FPTELKPGTNQFLTTDDGTSPPILPGFEPTPLIHIPGEFTSLL ---------------------------------FHPSKKIHIPGMITNIL ------------------------------------------PGQVRNLM -------LPVEIKPGSYQFLTTDDEVSAPILPGFQPTPEIHIPGEVRNLL -------VPVEMKPGTNQFLTTDDGTSAPILPGFHPTPTIHIPGEVHSLL -------IPVELKPGSNQFLTTDDEVSAPILPGFHPTPEIHIPGEVKNLL -------LPTLLTPGSGQFLTTDDYQSPSALPWYHPTKEISIPGQVQNLI -------LPVRMPSGAQQFMTTEDEQSPNILPGYHSSKKIHIPGKITSVL -------LPVLMTPGSGQFMTTDDYQSPSALPWFHPTKEIFIPGQVQNLS -------VPTFNVPGSGMFMTTLRNAGFPIYPEFSKTHSFPLPGRVRNLL -------VPMELKPGSNQFLTTDDEVSAPILPGFNATPNIYIPGEVTNLL ------------------------------------------PGQVNNLM ------------------------------------------PGEVKNLM -------LPVMLTPGSGQFMTTDDFQSPSALPWFHPTKEISIPGQVTNLI -------LPAELKPGTNQFLTTDNGVSAPILPGFHPTPAIHIPGEVHNLL -------LPTMMTPGSGQFMTTDDFQSPCALPWFHPTKEISIPGEVKNLI ---------------------------------FHPSKKIQIPGKITSVL -------LPVMLTPGSGQFLTTDDTQSPSAFPYFHPTKEIFIPGQVRNLI -------LPVFITPGSGQFMTTDDFQSPSALPWFHPTREISIPGQVKNFV -------LPAELKPGTNQFLTTDDGVSAPILPGFHPTPEMHIPGEVKNLL -------IPAELXPGTNQFLTTEDGTSAPILPGFHPTQVIHIPGEVRNLL ---------------------------------FHPSKKIHIPGMITNVM -------VPTYLLPGSGQFLTTDDHSSAPVLPCFNPTPEMHIPGQVRNML -------LPVTNTPGSYQFMTTDEDSSACVLPDFNPTQAIHIPGEVTNLQ ------------GPGSYQFMTSDEDSTPCILPDFQPTPEIFIPGEVTNLL -------LPAMLTPGSGQFMTTDDFQSPCALPWFHPTKEISIPGQVRNLI -------LPTELKPGTNQFLTTDDGVAAPILPGFHPTPEMFIPGEVKNLL -------IPVELKPGTNQFLTTDNEVSVPILPGFQPTPTIHIPGEVNNLL -------LPVELKPGSNQFLTTDDGVSAPILPGFHPTPLIHIPGEVNNLL ---------------------------------YSPTKEIHIPGKITNML ------------------------------------------PGEVKNLM -------LPVRLASGTQQFMTTEDEQSANLLPGFHPTPTMHIPGEITNIM -------LPVMMTPGSGQFMTTDDYQSPSALPWFHPTKEISIPGEVKNLV -------LPVMITPGSGQFLTTDDFQSPSALPWFHPTKEISIPGQVRNLV -------LPMELKPGTNQFLTTDDGVSAPILPGFHPTPVIHIPGEVRNLL -------LPVLNTPGSNQFLTTDDYQSPCAMPEYDVTPPLHIPGEVSNLM -------LPVLTTPGSGQFMTTDDFQSPSALPWFHPTKEISIPGQVRNLI

2016/02/23, 3:08 PM


3 of 17


UniRef90_Q5G9Z5_326_554 UniRef90_Q9YLG5_370_557 UniRef90_G8IJE5_332_553 UniRef90_Q8V614_326_499 UniRef90_Q5GA06_355_555 UniRef90_G8IJG6_332_548 UniRef90_Q05ED6_367_555 UniRef90_P23008_310_531 UniRef90_Q8JRP9_365_551 UniRef90_Q05EE3_367_555 UniRef90_Q8V604_326_552 UniRef90_C7DUC7_331_549 UniRef90_P12915_324_545 UniRef90_G8IJE1_331_509 UniRef90_A4UHT9_332_548 UniRef90_Q9QCF0_367_554 UniRef90_Q9QF31_325_500 UniRef90_Q65900_325_551 UniRef90_E5D8F2_334_553 UniRef90_A1E4A2_319_512 UniRef90_B9V440_332_553 UniRef90_Q6W9F4_332_507 UniRef90_G8IJH5_359_554 UniRef90_B1PZZ4_333_555 UniRef90_O89280_367_554 UniRef90_P32537_321_545 UniRef90_G0YPI2_326_499 UniRef90_Q9YLJ1_368_556 UniRef90_Q2YEN8_367_554 UniRef90_A7YF31_331_554 UniRef90_Q65481_317_544 UniRef90_Q2LKZ0_317_544 UniRef90_Q05ED0_367_555 UniRef90_Q8V5Z9_323_547 UniRef90_Q6W9F9_367_555 UniRef90_H8Y6P9_356_549 UniRef90_G5DC71_332_548 UniRef90_C6ZEZ9_341_560 UniRef90_Q05ED4_367_554 UniRef90_H6VBU4_358_522 UniRef90_Q8V398_325_495 UniRef90_D8VCT6_342_524 UniRef90_D9YV24_514_704 UniRef90_Q66577_367_555 UniRef90_A0MHB7_357_547 UniRef90_E9LS20_360_544 UniRef90_Q9WHH4_367_554 UniRef90_G0ZNT5_357_550 UniRef90_Q5YJA3_454_673 UniRef90_H9U0H0_456_678 UniRef90_Q6W9E8_367_554 UniRef90_Q80GI1_367_556 UniRef90_C7B298_377_565

-------LPAELKPGTNQFLTTDDGVSAPILPGFHPTPEIHIPGEVTNLL ------------------------------------------PGRVHNLM -------LPVLLTPGSGQFMTTDDFQSPSALPWYHPTKEISIPGQVRNLV -------LPVELKPGTNQFLTTDDDDAPPVLPGFQATPEMHIPGEVTNLL ---------------------------------YHPTQEIHIPGEVKNLL -------IPMRLPSGSNQFMTTEDEQSPNILPNFHPTKKIHIPGEIKTIM ------------------------------------------PGEVRNLM -------LPVYITPGSGQFMTTDDMQSPCALPWYHPTKEISIPGEVKNLI ------------------------------------------PGEVHNLM ------------------------------------------PGEVKNLM -------LPVVLTPGSTQFLTTNDGVSAPILPGFHPTPAIHIPGEVKNIL -------IPTRMPSGSQQFMTTEDEQSPNILPEYSPTKLMHIPGEITNVL ------------GPGSYQFMTTDEDCSPCILPDFQPTLEIFIPGKVNNLL -------LPVLMTPGSGQFMTTDDYQSPSALPWFHSTKEIFIPGQVHNLS -------LPVRMPSGANQFMTTEDEQSPNILPSFHSTKQIHIPGEIKTIM ------------------------------------------PGEVKNLM -------IPTELKPGTNQFLTTDDGVSAPILPGFHPTPPIHIPGEVHNLL -------IPTELKPGTNQFLTTDDGVSAPILPGFHPTPAIHIPGEVRNLL -------LPTRLPSGSQQFMTTEDEQSPNILPGFHPSKKIHIPGMITNVM -------VPTYLLPGSSQFMTTDDHSSAPAFPDFSPTPEIHIPGRVHNML -------LPVMITPGSGQFMTTDDYQSPSALPWFHSTKEISIPGQVRNLA -------LPVLATPGSDQFLTSDDYQSPCAMPEYDVTPPMRIPGEVRNLM ---------------------------------FHPTKEISIPGEVKNLI -------LPVMITPGSNQFLTSDDFQSPTAMPQFDVTPELNIPGEVQNLM ------------------------------------------PGQVNNLM -------VPTCLLPGSNQFLTTDDHSSAPAFPDFSPTPEMHIPGQVHSML -------IPAELRPGTNQFLTTDDDTAAPILPGFTPTPTIHIPGEVHSLL ------------------------------------------PGEVRNIM ------------------------------------------PGEVHNLM -------LPALLTPGSNQFLTSDDFQSPSAMPQFDPTPLMHIPGEVHNLM -------LPTMYTPGSGQFLTTDDFQSPSILPKFKATPEIEIPGRVLNIL -------IPTLYTPGSGQFLTTDDFQTPCMLPKFQPTPVIDIPGEVKNFL ------------------------------------------PGEVRNLM -------LPAQLTPGSTQFVTTDNDSSQPLIPNFDETTPIHIPGEVRNML ------------------------------------------PGEVRNLM ---------------------------------FSPTKQIHIPGKIDSIL -------IPTRMPSGSNQFMTTEDEQSPNILPSFHSTKQMHIPGQIKTIM -------IPTRIPAGSQQFMTTEDEQSPNILPEYSPTKEIHIPGKIDNML ------------------------------------------PGEVKNLM --------------------------------------------------------LPVKATPGSYQFLTTSDDCSEGLLPNFHSTPEIFIPGQVNNLL -------LPVLNTPGSNQFLTTDNFQSPCIVPNYDVTAPIHIPGEVRNMM -----------------------------------NPPTTYVPGRTTNYM ------------------------------------------PGEVHNLM ---------------------------------FSPTKQIHIPGQIKTIM ---------------------------------FHPTKKIHIPGLVTNIM ------------------------------------------PGEVKNLM ---------------------------------YTPTKQIFIPGEITNML ------------------FSSTQPYTAAPVYGKIPASNPSYMPGEFLDYV ------------------FSSTQPYQGPPVYGKISASDPSYMPGEFNDYV ------------------------------------------PGQVKNLM ------------------------------------------PGEVRNIM ------------------------------------------PGEVKNMM

2WZR3 UniRef90_F1AW55_504_724 UniRef90_Q6PMU0_504_724 UniRef90_Q6PMU2_504_724 UniRef90_Q8V0G8_305_525 UniRef90_Q6PMT3_503_723 UniRef90_Q1L748_304_524 UniRef90_Q6PMT8_504_725 UniRef90_B8Y0J7_504_725 UniRef90_Q1L757_305_524 UniRef90_Q1L752_305_526 UniRef90_Q1L754_305_526 UniRef90_P49303_505_725 UniRef90_Q6PMY9_505_723 UniRef90_A2I8Z5_505_724 UniRef90_P15072_505_723

DVAEACPTLLD----------------F-NG-VPYVQTQS-------NSG DVAEACPTFLD----------------F-NG-VPYVQTQN-------NSG DVAEACPTLLD----------------F-SG-RPYVITQA-------NSG DVAEACPTFLD----------------F-NG-VPYVTTQN-------NSG DVAEACPTLLD----------------F-NG-VPYVTTQN-------NSG DVAEACPTFLD----------------F-DG-TPYVKTRH-------NSG DVAEACPTFLD----------------F-DG-TPYVKTKH-------NSG DVAEACPTFLN----------------F-DG-KPYVVTK--------NNG DVAEACPTLLN----------------F-DG-KPYVVTR--------NSG DAAEACPTLLN----------------F-DG-KPYVVTK--------NNG DVAEACPTLLN----------------F-DG-KPYVVTK--------SSG DVAEACPTLLN----------------F-DG-KPYVVTG--------NSG DVAEACPTFLC----------------FDDG-KPYVVTR--------TDE DVAEACPTFLR----------------F-GE-VPFVKTV--------NSG DVAEACPTFLH----------------FDGD-VPYVTTK--------TDS DVAEACPTFLM----------------F-EN-VPYVSTR--------TDG

2016/02/23, 3:08 PM


UniRef90_Q8JVD0_304_524 UniRef90_H9AY35_497_713 UniRef90_B0Z3W9_528_746 UniRef90_Q2XP17_533_745 UniRef90_Q100Y4_324_550 UniRef90_Q91LX8_542_768 UniRef90_A4ZKN2_415_639 UniRef90_E3TMG9_417_639 UniRef90_P08544_417_642 UniRef90_B3VTU7_418_646 UniRef90_Q66776_543_769 UniRef90_G9FTJ7_414_638 UniRef90_Q02472_417_641 UniRef90_P12296_396_619 UniRef90_C3U5A3_447_672 UniRef90_G1DFA4_460_684 UniRef90_Q155Z9_448_665 UniRef90_B9VIN1_352_561 UniRef90_G8HZ08_715_947 UniRef90_B8XTQ3_353_566 UniRef90_D9D8F3_345_562 UniRef90_I1YLT4_348_565 UniRef90_B8XTP9_335_563 UniRef90_I1YLT7_349_565 UniRef90_I1YLT6_336_558 UniRef90_B8XTP8_334_562 UniRef90_B8XTQ0_353_567 UniRef90_Q5YJ95_381_603 UniRef90_B8XTQ4_341_566 UniRef90_I1YLT5_349_558 UniRef90_F6IA11_421_636 UniRef90_G0Z2U8_412_599 UniRef90_Q5YJA7_377_599 UniRef90_G0Y2E4_357_574 UniRef90_Q8B552_395_615 UniRef90_A7KC13_333_552 UniRef90_A5GZD6_337_514 UniRef90_G5CZJ8_367_551 UniRef90_G8HH17_373_575 UniRef90_G0Y2E3_380_601 UniRef90_B9V482_337_556 UniRef90_A5GZF6_334_555 UniRef90_A7KC10_335_556 UniRef90_G8IJG2_334_555 UniRef90_D2IW00_332_553 UniRef90_A5GZD9_331_550 UniRef90_A7KC07_334_555 UniRef90_Q672R3_805_1000 UniRef90_B5A1N0_416_617 UniRef90_B9V433_331_550 UniRef90_Q82081_333_552 UniRef90_Q5XLP5_336_557 UniRef90_B9V457_333_554 UniRef90_G1JYY8_404_619 UniRef90_F6N707_334_556 UniRef90_G5D5D9_333_552 UniRef90_Q82122_332_553 UniRef90_G5D5E2_333_552 UniRef90_A5GZF5_335_556 UniRef90_G0Y2E2_378_600 UniRef90_P03303_333_552 UniRef90_P07210_338_559 UniRef90_F6M9Y3_333_554 UniRef90_B9V459_336_557 UniRef90_B9V477_333_554 UniRef90_H9C6N6_333_552 UniRef90_A5GZE7_336_557 UniRef90_B9V485_333_552 UniRef90_G0Y2E0_419_588 UniRef90_G9K138_332_516 UniRef90_A5GZE9_336_557 UniRef90_B9V434_332_553 UniRef90_P04936_332_552

4 of 17


GRRCSVPNFLW----------------TSTG-HRTLRPST-------TVA HVAQVCPTFGR----------------IGSGSVPYFLTT--------QDS DVADACPTMAR----------------F-TS-KPSITTVS-------GAS DVAKQTYSFCS----------------ISGK-PYFEVTNT-------SGD QVAV-IPTLAE-------VSV-AS---YKPV-PSFSVSNV-------MQE QVAV-IPTMAE-------VSVGTN---HKPI-PSFSVGNT-------LED SLCK-IPTFLG-------NVSSTQ-----RL-PYFSATNT-------VPN SLCK-IPTFLG-------NLDSNK----KRI-PYFSATNS-------TPA ELCK-LPTFLG-------NP-NTN---NKRY-PYFSATNS-------VPA ELCK-LPTFLG-------NPANTSPP-GGRY-PYFSATNS-------VPI QVAV-IPTLAE-------VSV-QN---YKPV-PSFPVSNV-------LQT SLCK-IPTFLG-------NPATDQ-----RL-PYISASNT-------VGD ELCK-LPTFLG-------NLSNDT-----RV-PFFTATNS-------VPT EIAQ-IPTFIG-------NKVPNA------V-PYIEASNT-------AVK SLCK-IPTFVG-------NNLDSK-----WN-PYFSSTNS-------VNE EWTR-TPCLMS-------NVVDDTIR------GYFTASNT-------RSD QLAR-IPTLMAFERVPEPVPASDT-----YV-PYVAVPTQ-------FDD SLAK-VPTFCT-------V--------TENK-PYFEVNNN-------KSD EVAM-IGTFAD------VGQTQA----ASEE-IPDGTAITTKMNAVVGNL SLAK-VGSLVT-------VSYPS----NSDQ-PYFEISNT-------KKD SLAQ-VPCFLS-------VAFSDNSI--KGF-PYFAVSNT-------EQG DLVK-IPSFCS-------VSFTESSSDEKGF-PYFSVSNG-------TQG SLVK-VPSFIT-------NSGSDTPT-GRSF-PYFSVSSS-------TQG DLVR-VPSFCT-------VPF-RNTFRHKSF-PYFAVSNG-------DPG SVAK-VPSFVC-------I--------TDSI-PYFAVSNA-------TQG ELAK-VPSFVT-------VANSDTTS-ERSF-PYFSVSNT-------EQG SLSK-VPSFLT-------VAQGDTTK-QRN--PYFAVSNG-------TQG QVAQ-VGTFLK------FRNNVN----DASG-VYLNLDVT--------QG SIAK-VPCFLL-------ADEDT----TKQK-PYFLISNA-------SST SLAK-VPSFVT-------V--------TVDK-PYFEVTNA-------KST SVAR-IPTFLQ------GTGGNT----YGFS-VQNAIPAD---------QVAQ-VGTFLK------FSNNTN----NESG-VYLNLDIT--------QG QVAQ-VGTFLK------FSNNVN----DASR-VYLNLDIT--------QG EVCQ-IDTFAN------LGTS---------E-LSFTIDVS-------NQT QVAR-VPTLMK------MPNTMS----DGT---YLAVDVT--------QN ELVQ-VDTMIP------INNVTDL----DTI-EKYRIPLM-------QNQ EIIQ-VDTLIP------MNNTHTK----DEV-KSYLIPLV-------ANQ EIAQ-VDSLIP------INNIANN----DNL-ERYRIPLT-------PNV EVAE-VDTLCN------LSDT---------E-VLY-INAT-------GSA EVMS-VDTFCN------CSDS-D----TQTK-MYFTLNV---------NI EIIQ-VDTMIP------MNKTKVN----DEV-GNYLIPLI-------QGQ EICQ-IDSMIP------INNTHGV---KNTV-NMYTVQVQ-------EQT EICQ-VDTLIP------VNNVQAS---KNNV-SMYTVMLS-------TQT EICQ-IDSMIP------VNNTHAV---KNSV-NMYTVEVR-------SQA EICQ-VDSMIP------INNTVAS---HKRV-SMYAVRVG-------VQT EIAQ-VDTLIP------INNAEGI----TGL-ETYRIPLY-------QNR EMCQ-VDTLIP------VNNVQAS---KNNI-SMYTVQLT-------TQT EVAQ-IPTLVT------GLKEGT----EGWH-RPWLVNIE-------QSM EVAR-VGTIVA------MQSTSN----QSSQ-LYYTLDLT--------QN EIAQ-VDTLIP------LNNTTNT----TGL-GMYRIPLV-------QNM EIIQ-VGTLIP------MNNTGTN----DNV-TNYLIPLH-------ADR EMCQ-VDTMIP------INNTNER---IGNV-NMYTVSLT-------SQT EICQ-VDSMIP------VNNTTPV---NNSI-GMYTVRVE-------VQT EVAR-VGTFCD------FKGK-----------SSITIDVG-------K-EICQ-VDSMIP------INNIIAN---KNSI-NLYTVRVE-------VQT EIIQ-VDTLIP------MNNVHTS----DEV-NSYLIPLT-------ANR EMCQ-VDTLIP------INSTQSN---IGNV-SMYTVTLS-------PQT EIIQ-VDTLIP------MNNTHNR----DEV-KSYLIPLQ-------PNR EICQ-VDSMIP------INNVEQH---KNSV-DMYSVVLT-------KQT EVCG-VDTFCN------CATSTT----TDEQ-LSFSVSI---------ND EIIQ-VDTLIP------MNNTHTK----DEV-NSYLIPLN-------ANR EMCQ-VDTLIP------VNNTQEN---VRSV-NMYTVDLR-------TQV EICQ-VDSMIP------INNTIAM---NNKI-GMYTVEVG-------VQT EMCQ-VDTLIP------INNTFAN---LRNV-NKYAVSLF-------SQT EICQ-VDSMIP------VNNVQGN---KNSV-NMYSIILD-------KQT EIIQ-VDTLIP------MNNTGAR----DTM-DEYRIPLE-------VNK EMCQ-VDSLIP------INNTTAN---LRKV-NMYTIQLA-------NQT EMIQ-VDTLIP------MNNTTAT----DEV-GNYLIPLN-------VNK EVMQ-VDTFCN------PVNS------TNAA-VSFTLDVS-------NNS EMCQ-VDTLIP------INNLEQN---IRNV-NMYSVVLN-------QET EMCQ-VDTLIP------INNTASN---IRNV-SMYTVQLT-------SQV ELCQ-VDTMVP------LNNINAS---RNRI-DMYALPLT-------RQP EICQ-VDSLVP------INNTDTY---INSE-NMYSVVLQ-------SSI

2016/02/23, 3:08 PM


UniRef90_C7DUC8_336_557 UniRef90_G8IQ74_332_548 UniRef90_I2CMI9_334_554 UniRef90_B9V466_338_522 UniRef90_A5GZF9_333_554 UniRef90_G8IJE2_332_552 UniRef90_H8Y6Q0_168_390 UniRef90_G0YPI0_327_543 UniRef90_B9V473_333_554 UniRef90_B5BSU6_368_556 UniRef90_A8S322_365_548 UniRef90_G8IQ62_334_555 UniRef90_B9V453_331_552 UniRef90_G9K146_333_520 UniRef90_F6M9Z0_330_551 UniRef90_P12916_334_555 UniRef90_G5EN04_327_500 UniRef90_C7DUC6_357_551 UniRef90_Q9WN78_367_554 UniRef90_G0YPI1_326_499 UniRef90_G0YPH9_326_499 UniRef90_Q8UY33_326_552 UniRef90_A5GZE0_334_555 UniRef90_G0ZNT7_334_555 UniRef90_A7KC11_332_515 UniRef90_G1JYY7_238_455 UniRef90_H6UKU5_326_499 UniRef90_Q03053_367_554 UniRef90_Q995Z1_365_551 UniRef90_B9V442_331_555 UniRef90_G1CSA8_329_506 UniRef90_A5GZE4_333_554 UniRef90_G8IJF4_357_552 UniRef90_A5GZF2_336_558 UniRef90_A5GZF1_333_554 UniRef90_Q5U904_326_555 UniRef90_Q6JKR7_325_551 UniRef90_G8IJF0_360_553 UniRef90_A1E4A3_319_512 UniRef90_Q8QUZ6_317_541 UniRef90_Q2LL04_324_545 UniRef90_F6M9Y7_364_585 UniRef90_Q8V601_326_552 UniRef90_Q6JKS0_326_499 UniRef90_B3SRP1_326_550 UniRef90_G5CZJ4_357_550 UniRef90_B5BSU7_367_555 UniRef90_G8IRN3_333_554 UniRef90_A5GZE2_333_554 UniRef90_A7KC08_333_554 UniRef90_H9BP13_325_500 UniRef90_Q80GI2_332_555 UniRef90_B9V435_333_554 UniRef90_Q5G9Z5_326_554 UniRef90_Q9YLG5_370_557 UniRef90_G8IJE5_332_553 UniRef90_Q8V614_326_499 UniRef90_Q5GA06_355_555 UniRef90_G8IJG6_332_548 UniRef90_Q05ED6_367_555 UniRef90_P23008_310_531 UniRef90_Q8JRP9_365_551 UniRef90_Q05EE3_367_555 UniRef90_Q8V604_326_552 UniRef90_C7DUC7_331_549 UniRef90_P12915_324_545 UniRef90_G8IJE1_331_509 UniRef90_A4UHT9_332_548 UniRef90_Q9QCF0_367_554 UniRef90_Q9QF31_325_500 UniRef90_Q65900_325_551 UniRef90_E5D8F2_334_553 UniRef90_A1E4A2_319_512

5 of 17


EMCQ-VDTSIP------INNTTQN---LRKI-NMYTIQLE-------NQT DMAR-VDSFMP------INNIPSQ---IQKV-GIYNIQVS-------AAS HMAR-VDSFMP------INNIRTE---IGKV-SIYNIPIL-------RKT EMCQ-VDTLIP------INNTDNN---LRKV-NLYTVELT-------NQP ELCE-VDTLIP------INNTSEN---LKTT-NMYTVYLE-------RRS GICQ-VDSLIP------LVXXXXX---XTSE-AMYSIKLQ-------SSV HMAR-VDSFMP------INNISNH---INKV-PIYNVPIL-------KKS ELCQ-VETILE------VNNVTD----VQGV-SRLLIPVK-------AQE EICQ-VDSIIP------INNVEAR---KNSI-SMYTVEVG-------VKT EIAE-VDSVVP------VNNL-AGT--INTI-DAYGIPVS-------ASN HMAM-VDSFMP------LNNIETN---VGQI-SIYNVQVT-------KKT EMCE-VDTLIP------INNVGTN---VKNV-NMYTVLLE-------RQN ELCQ-VDTMVP------LNNLHIN---KNKI-GMYALPLT-------RQN ELCQ-VDTLIP------INSTTAN---NDNT-SIYTVTLE-------KQT ELCQ-VDTLIP------INNLEQN---VNNT-DMYSVVLN-------NET EMCQ-VDTLIP------VNNVGTN---VGNI-SMYTVQLG-------NQM DLCQ-IETILE------VNNTTS----TTGV-SRLLIPVR-------AQN HMAR-VDSFMP------INNIRNH---EGKI-SIYNITVV-------RKT EIAE-VDSVVP------VDNT-EEH--VNSI-EAYRIPVR-------PQT ELCQ-VETILE------VNNTTD----THGM-SRLLIPVS-------AQT ELCQ-IETMLE------VNNTTR----AVEL-DRLRIPVS-------AQS EIAQ-VESILE------VNNLKTNE--NDPM-RRLLIPVS-------VQS ELCQ-VATMIP------INNTNTN---IRDK-SMYTIRLG-------GET HMAR-VDSFMP------INNVESE---IGKV-SIYNVTVT-------KKA ELCQ-VDTIIP------INNISSN---TTSV-NMYSLVLT-------KER EVAQ-VGTFAS------FGKS-----------HKLVINVG-------KRT ELCQ-IETMLE------VNNVTD----VDGM-QRLLIPVS-------AQT EIAE-VDSVVP------VNNT-EGK--VSSI-EAYQIPVQ-------SNS EIAE-VDSLVP------VNNT-SRL--TRSI-EAYGIPVR-------TGL ELCQ-VDTLIP------VNNTETNG--VTNI-NMYTVTIN-------REV EIAQ-VESILE------VNNLTSLETPSTLM-QRLLIPVE-------AKS ELCQ-VDTMIP------INNVGNN---TKSV-DMYTVVLQ-------RQD HMAR-VDSFMP------INNIKAQ---EGSV-NMYHITVT-------RKG EMCQ-VDTLIP------INNTGNN---VRSA-NMYTVDLT-------TQELCQ-IDTLIP------INSVTGN---TNNT-SIYTVTLT-------RET EICQ-VESILE------VNNLTTNKAASQLM-TRLLIPVE-------AQT ELCQ-VETMLE------VNNLESNE--NDPM-QRLLIPVQ-------SQS HMAR-VDSFIP------LNNIEGE---TTKP-SVYCVTVP-------KKT EVVQ-VESMME------INNTEN----AVGM-ERLKVDIS-------ALT ALCQ-VESMLE------INNTPD----QQRN-GRLWLTVG-------AQS QIAQ-VESIVE------ANNVAD----ATGV-ERYVIPVS-------VQD ELCQ-VDTLIP------INNLQAN---VTNL-DMYSVVLN-------REI EIAQ-VESILE------VNNLTTNE--TNPM-ERLLIPVS-------VQS ELCQ-VESILE------VNNVTG----QEGI-NRLLIPVS-------TQS QLCQ-IESILE------VNNVPS----ASQM-QRLLIPVS-------VQS HIAQ-VESFLP------LNNIDRH---VGSI-DIYGVTIT-------GTS EIAE-VDSLVP------VNNV-PEK--VNSL-EAFQIPVS-------TGS HMAR-VDSFMP------INNTSER---VD-V-PIYNITVT-------RKS EMCQ-VDTLIP------INNTPGN---VNTI-NMYTVLLE-------RKD ELCQ-VDTLIP------IDSVEAN---IKST-NMYTVTLT-------RET ELCQ-IDTIME------VNNLTTNE--ATPM-ERLRIPVQ-------VQT EIAE-VDSVVP------VNNL-NDK--VNTI-ETFGIPVS-------ASD EMCQ-VDTIIP------INNTGTN---TTSI-NMYTVQLE-------RTA EICQ-VESIIE------VNNLSTLETSSTAM-QRLSFEVS-------VQS EIAE-VDSVVP------LNNI-QDN--LRKM-DIYRVQVS-------SQT ELCQ-VDTLIP------INNTEAN---IRNK-NMYTVQLG-------GEP ELCQ-VESILE------VNNTTT----ATGV-ERLLIPVS-------VQS EICR-VESILE------VNNLTTNE--ANPM-ERLLIPVS-------VQS DMAR-VDSFMP------INNIQSQ---LQDV-SVYNVQVT-------PQA EIAE-VDSVVP------VNNL-SKN--VNTM-EAYQIPVN-------TGN EMCQ-VDTLIP------VNNVGNN---VGNV-SMYTVQLG-------NQT EIAE-VDSLVP------VNNT-ARN--TRSI-EAYGIPVR-------AGV EVAE-VDSVVP------VNNN-PRD--VNSI-RAYQIPVS-------TGT EIMQ-VESILE------VNNLNSNE--STPM-NRLVIPVS-------VQS HMAQ-VEPFIP------INNIQAQ---IGRI-SMYTIPVT-------RKA EIAQ-VESILE------ANNREG----VEGV-ERYVIPVS-------VQD ELCQ-VDTIIP------INYTSAN---TTSV-NMYTVVLD-------KGE DMAR-VDSFMP------INNV-NQ---SHTL-GVYYITIS-------NVS EIAE-VDSVVP------VNNT-QDS--VYNM-DVYKIPVS-------GGN EICR-VETILE------VNNLKTNE--TTPM-QRLCFPVS-------VQS EICR-VETILE------VNNLQSNE--TTPM-QRLCFPVS-------VQS HMAR-VDSFIP------INNIQGE---VGKV-SMYYITVT-------KKT ELVQ-VESMME------INNVAD----ASGM-ERLRVEIS-------VQT

2016/02/23, 3:08 PM


6 of 17


UniRef90_B9V440_332_553 UniRef90_Q6W9F4_332_507 UniRef90_G8IJH5_359_554 UniRef90_B1PZZ4_333_555 UniRef90_O89280_367_554 UniRef90_P32537_321_545 UniRef90_G0YPI2_326_499 UniRef90_Q9YLJ1_368_556 UniRef90_Q2YEN8_367_554 UniRef90_A7YF31_331_554 UniRef90_Q65481_317_544 UniRef90_Q2LKZ0_317_544 UniRef90_Q05ED0_367_555 UniRef90_Q8V5Z9_323_547 UniRef90_Q6W9F9_367_555 UniRef90_H8Y6P9_356_549 UniRef90_G5DC71_332_548 UniRef90_C6ZEZ9_341_560 UniRef90_Q05ED4_367_554 UniRef90_H6VBU4_358_522 UniRef90_Q8V398_325_495 UniRef90_D8VCT6_342_524 UniRef90_D9YV24_514_704 UniRef90_Q66577_367_555 UniRef90_A0MHB7_357_547 UniRef90_E9LS20_360_544 UniRef90_Q9WHH4_367_554 UniRef90_G0ZNT5_357_550 UniRef90_Q5YJA3_454_673 UniRef90_H9U0H0_456_678 UniRef90_Q6W9E8_367_554 UniRef90_Q80GI1_367_556 UniRef90_C7B298_377_565

ELCQ-VDTIIP------INHTTAT---TSSV-NMYTVVLD-------KKT EIAE-VDSVIP------INNV-SDN--LQST-RVYQIPVS-------AAN ELCQ-VDSMIP------INNVTDK---IRSV-DMYTVVLQ-------RQD EIAE-VDSVVP------VNNV-EGK--LDTM-DIYRIPVQ-------SGN EIAE-VDSVVP------VNNT-ETN--VNGM-DAYRIPVQ-------SNM EIVQ-IESMME------INNVND----ASGV-ERLRVQIS-------AQS ELCR-VETILE------VNNTTE----ATGL-TRLLIPVS-------SQN EIAE-VDSVVP------VNNM-SSK--VKTI-EAYQIPVS-------VGT EIAE-VDSVVP------VNNT-QNN--LQSM-EAYHIEVN-------TGN EIAE-VDSVIP------INNT-TGK--CKTM-EAYQVAVR-------ANN EIVQ-VESLVE------INNVDQ----VNGV-ARYRIPLS-------VQD EVVQ-VESLVE------INNVES----AEGV-ARYRIPLN-------VQD EIAE-VDSVVP------MNNI-PAN--EKKM-ETYQIWVE-------ARD EICQ-VESILE------VNNVTG----VNGM-SRLLIPIS-------VQS EIAE-VDSVMP------INNI-EGN--LRNM-KAYRVQVS-------TGN HMAM-IESFIP------INNIPDH---IGKV-AIYSIQIT-------RKV DMAR-VDSFMP------INNIPSQ---IQEV-GVYNITVS-------GTS HIAM-VDSLIP------INNQRSH---TGQV-AMYNVQVS-------KKS EIAE-VDSVVP------VNNT-ARN--IHSM-EAYRIPVQ-------CFN -------------------------------------------------ELVQ-IETMMT------INNVAAQ---SAGV-ERISIPVS-------VQS ELAE-IDSVIP------MNAV-AGK--VNTM-EAYPIPLN-------QGT GLAN-QPGLMA------------------------LVDIG-------MDS EIAE-VDSVVP------VNNT-STH--MEGT-DAFQIKVT-------AGN DMAR-VDSFMP------INNLQSQ---LQDV-GVYNITLT-------GTS HIAR-VDSFIP------LNNIEGQ---VGRV-SMYYVPVT-------KKV EIAE-VDSVVP------INNV-EAA--ISSM-EAYRVEVN-------TSK HIAQ-VESFIP------LNNTEGH---LGKM-DIYRVTVT-------QKA QLAQ-IPSLVK----------------NREI-RVSSVDKT---------QLAQ-IPSLVK----------------NREI-RVSSVEQT---------EIAE-VDSVVP------LNNI-GSA--VNTL-EAYRVAVA-------SMA EIAE-IDSVVP------VNNVDEDK--VKSI-EAYRIPMN-------VVG EIAE-VDSLIP------MNAV-PGK--ANTM-DMYRIGLD-------SNA

2WZR3 UniRef90_F1AW55_504_724 UniRef90_Q6PMU0_504_724 UniRef90_Q6PMU2_504_724 UniRef90_Q8V0G8_305_525 UniRef90_Q6PMT3_503_723 UniRef90_Q1L748_304_524 UniRef90_Q6PMT8_504_725 UniRef90_B8Y0J7_504_725 UniRef90_Q1L757_305_524 UniRef90_Q1L752_305_526 UniRef90_Q1L754_305_526 UniRef90_P49303_505_725 UniRef90_Q6PMY9_505_723 UniRef90_A2I8Z5_505_724 UniRef90_P15072_505_723 UniRef90_Q8JVD0_304_524 UniRef90_H9AY35_497_713 UniRef90_B0Z3W9_528_746 UniRef90_Q2XP17_533_745 UniRef90_Q100Y4_324_550 UniRef90_Q91LX8_542_768 UniRef90_A4ZKN2_415_639 UniRef90_E3TMG9_417_639 UniRef90_P08544_417_642 UniRef90_B3VTU7_418_646 UniRef90_Q66776_543_769 UniRef90_G9FTJ7_414_638 UniRef90_Q02472_417_641 UniRef90_P12296_396_619 UniRef90_C3U5A3_447_672 UniRef90_G1DFA4_460_684 UniRef90_Q155Z9_448_665 UniRef90_B9VIN1_352_561 UniRef90_G8HZ08_715_947 UniRef90_B8XTQ3_353_566

-----SKVLACFDLA-FG-HKNMKNTY--MSGLAQYFAQYSGTLNLHFMY -----SKVLTCFDLA-FG-HKNFKNTF--MSGLAQYYTQYSGTLNLHFMY -----SKVLTLFDLA-FG-HKNLKNTF--MSGLAQYYTQYSGTLNLHFMY -----SKVMACFDLA-FG-HKNLKNTF--LSGLAQYYTQYSGTLNLHFMY -----SKVLTCFDLA-FG-HKNMKNTY--LSGLAQYYAQYSGTLNLHFMY -----SKILAHIDLA-FG-HKSFKNTY--LAGLAQYYAQYSGSINLHFMY -----SKIMTHIDLA-FG-HKSFKNTY--LAGLAQYFAQYSGTLNLHFMY -----DKVMTYFDVA-FT-HKVHKNTF--LAGLADYYTQYQGSLNYHFMY -----DKVMTAFDVA-FT-HKVHKNTF--LAGLADYYTQYSGSLNYHFMY -----DKVMTRFDVA-FT-HKVHKNTF--LAGLADYYTQYSGSLNYHFMY -----DKVMAAFDVA-FT-HKVHKNTF--LAGLADYYTQYTGSLNYHFMY -----NKVMTAFDVA-FT-HKVHRNTF--LAGLADYYTQYSGSLNYHFMY -----QRLLAKFDLS-LA-AKHMSNTY--LSGIAQYYAQYSGTINLHFMF -----DRLLAKFDMS-LA-AGHMSNTY--LAGLAQYYTQYSGTMNIHFMF -----DRVLAQFDLS-LA-AKHMSNTF--LAGLAQYYAQYSGTINLHFMF -----QRLLAKFDVS-LA-AKHMSNTY--LAGLAQYYTQYTGTINLHFMF -----ARYSHTLTWH-LG-TRSFKNTY--VAGLAQYYAQYSGSLNLHFMY -----DELLSTIDVS-FT-SFEMSSTF--LAGLAQFYAQYRGTINVHFTF -----ERLLATIDVS-LV-SHEMSFTY--LAGLSSLYAQYRGSINMHCIY ------EPLFQMDVS-LS-AAELHGTY--VASLSSFFAQYRGSLNFNFIF ------KPLVNTDLT-FT-SMTFRNTY--LASLAQHFTQYRGSLCLDLLF ------RPLLNTDLT-FT-SMTFRNTY--LSALALNYTQYRGSICVDFLF -----N-ALVTYQVS-LS-CSCMANSM--LASVARNFNQYRGSLNYLFVF -----T-PLVTYQVT-LS-CSCMANSM--LAAVARNFNQYRGSLNYLFVF -----T-SMVDYQVA-LS-CSCMANSM--LAAVARNFNQYRGSLNFLFVF -----T-ALASYQVA-LS-CSCMSNSM--LAAVARNFNQYRGSLNFLFVF ------KPLVNTDLT-FT-SMTFRNTY--VSALSLQYTQYRGSICMDLLF -----Q-PLATYQVT-LS-CSCMANSM--LAAVSRNFNQYRGSLNYLFVF -----E-SLVEYQVT-LS-CSCMSNSM--LASVARNFNQYRGSLNFLFVF -----TQPLAVYQVT-LS-CSCLANTF--LAALSRNFAQYRGSLVYTFVF -----NVSLVTYQVT-LS-SINLANTM--LSSVARNFNQYRGSLNFLFVF ------EPLLQMDVT-LA-SDHMRYTA--LGQMSFRYAQYRGSINVMLTF ------RPLISFPIT-LS-DPVYQNTL--VGAISSNFANYRGCIQITLTF ------APVFQSNVV-LS-DPHYAHTL--VAGLGRYFGNYRGSLQFTLIS VT---KTKVFSLDIS-LS-AKYLANTY--VGMLAKMFQQYRGSLKYTFTY ------TPLFKCNVL-LS-DPHFQHTL--VSNLGKYFANYRGSLQFSFIS

2016/02/23, 3:08 PM


UniRef90_D9D8F3_345_562 UniRef90_I1YLT4_348_565 UniRef90_B8XTP9_335_563 UniRef90_I1YLT7_349_565 UniRef90_I1YLT6_336_558 UniRef90_B8XTP8_334_562 UniRef90_B8XTQ0_353_567 UniRef90_Q5YJ95_381_603 UniRef90_B8XTQ4_341_566 UniRef90_I1YLT5_349_558 UniRef90_F6IA11_421_636 UniRef90_G0Z2U8_412_599 UniRef90_Q5YJA7_377_599 UniRef90_G0Y2E4_357_574 UniRef90_Q8B552_395_615 UniRef90_A7KC13_333_552 UniRef90_A5GZD6_337_514 UniRef90_G5CZJ8_367_551 UniRef90_G8HH17_373_575 UniRef90_G0Y2E3_380_601 UniRef90_B9V482_337_556 UniRef90_A5GZF6_334_555 UniRef90_A7KC10_335_556 UniRef90_G8IJG2_334_555 UniRef90_D2IW00_332_553 UniRef90_A5GZD9_331_550 UniRef90_A7KC07_334_555 UniRef90_Q672R3_805_1000 UniRef90_B5A1N0_416_617 UniRef90_B9V433_331_550 UniRef90_Q82081_333_552 UniRef90_Q5XLP5_336_557 UniRef90_B9V457_333_554 UniRef90_G1JYY8_404_619 UniRef90_F6N707_334_556 UniRef90_G5D5D9_333_552 UniRef90_Q82122_332_553 UniRef90_G5D5E2_333_552 UniRef90_A5GZF5_335_556 UniRef90_G0Y2E2_378_600 UniRef90_P03303_333_552 UniRef90_P07210_338_559 UniRef90_F6M9Y3_333_554 UniRef90_B9V459_336_557 UniRef90_B9V477_333_554 UniRef90_H9C6N6_333_552 UniRef90_A5GZE7_336_557 UniRef90_B9V485_333_552 UniRef90_G0Y2E0_419_588 UniRef90_G9K138_332_516 UniRef90_A5GZE9_336_557 UniRef90_B9V434_332_553 UniRef90_P04936_332_552 UniRef90_C7DUC8_336_557 UniRef90_G8IQ74_332_548 UniRef90_I2CMI9_334_554 UniRef90_B9V466_338_522 UniRef90_A5GZF9_333_554 UniRef90_G8IJE2_332_552 UniRef90_H8Y6Q0_168_390 UniRef90_G0YPI0_327_543 UniRef90_B9V473_333_554 UniRef90_B5BSU6_368_556 UniRef90_A8S322_365_548 UniRef90_G8IQ62_334_555 UniRef90_B9V453_331_552 UniRef90_G9K146_333_520 UniRef90_F6M9Z0_330_551 UniRef90_P12916_334_555 UniRef90_G5EN04_327_500 UniRef90_C7DUC6_357_551 UniRef90_Q9WN78_367_554 UniRef90_G0YPI1_326_499

7 of 17


------RKLFSSGVV-LS-DPHYQHTL--LSNLARFFCNYRGSIQFDFVA ------TQLFISGVV-LS-DPHYQHTL--LSNMAQFFCNYRGSIQFDFVA ------EKLFSSGVV-LS-DKHYQHTL--LSNLADFFCNYRGSLQFDLVA ------TNVFMASVV-LS-DPHYQHTL--LSNMAQYFCNYRGSLQFDFVA ------SKLIRMNVV-LS-DPHFQHTL--LASLAEHFCNYRGSLQVTLLS ------RNLFKSSVV-LS-DLHYQHTL--VANLARYFCNYRGSLQFDFIA ------SVLFSTGVI-LS-DPHYQHTL--VSNIAKYFCNYRGSIQFDFVA NQ---TARIAAIDVS-MI-SPHLATTY--LSRLAQMYANYRGSVVFEFMF -----QTAVFEMNVI-LS-EYALQRTF--VSMFGKFFCNYRGSIQITAWA ------GPLFKSNVV-LS-DLHYQHTL--VSQIGTFFGNYRGSLQFDLIA -----NTTLYSLDVS-LL-ATEMEKTY--IGRLARMFAFYKGSIVLRFTY NQ---TARIAAIDVS-MK-AGHLITTY--LSRLARMYANYRGSIVFEFMF AQ---TARIAAIDVS-MV-STHLSTTY--LSRLAQMYANYRGSIVFEFMF SV---GGKIKDFDMS-LN-STVLSTTY--LSKCARWYTHYRGSVNLTFMF IR---TQAIGKWDMS-LI-GDLFKPTY--LGRLAKMYANYRGSVIIEFMF ----QEQQVFGFSLF-LG-GGVLKTTL--LGEIAQYYTHWAGSIRISFMY ----QNQKIFGTDLY-IG-DGVFKTTL--LGEIAQYYTHWSGSLKISLMY ----QEKQVFGFSIF-LG-GTVLKTTL--LGEIAQYYTHWAGSLRISFMY PL---GENLGTWDLS-LQ-GNLLSPTY--LGRLSRFYTHYRGSINLTFMF TE---DKPIRAWDMD-LA-SKLFTTTY--IGRVTKWFSQHRGSIRLTFLY ----KNEQIFGTNLY-IG-DGVFKTTL--LGEIVQYYTHWSGSLRISLMY -T--PAKEVFAIPVD-VA-SQPLATTL--IGEIASYYTHWTGSVRFSFMF -Q--TAQEIFAIPVD-VA-SQPLATTL--IGEIASYYTHWTGSLRFSFMF -S--LAAEVFAIPVD-IA-SQPLATTL--IGEIASYYTHWTGSLRFSFMF -A--PAREVFAIPVD-VA-SQPLATTL--IGEIASYYTHWTGSIRFSFMF ----QGQQVFGFRLY-LG-DGVLKTTM--LGEICQYFTHWAGSLRLSFMY -D--VAKEVFAIPVD-VA-SQPLATTM--LGELSSYFTHWTGSLRFSFMF NS---GAQIFQMDMS-LM-SVNFESTY--LGQLARMYAQYRGDVIITLTF IQ---TTVLQTIDVS-LL-SDQMQTTY--LSRLAKQYANYRGSILLEFIF ----QGEQVFGFRLY-LG-DGVLKTTL--LGELCQYFTHWAGSLRLSFMY ----QNEQIFGTKLY-IG-DGVFKTTL--LGEIAQYYTHWSGSLRISLMY -NT--AEQIFAIKVD-IA-SQPLSSTL--IGEIASYYTHWTGSLRFSFMF -D--FKKEIFAIPVD-VA-SQPLSTTL--IGEIANYYTHWTGSLRFSFMF AD---ENPIINWNLD-LN-GNELKDTY--LGRLCTMYANFRGSIRLSFTF GN--LATEIFAIPVD-IA-AQPLATTL--IGEIASYYTHWTGSIRFSFMF ----QNDQIFGTKLF-IG-DGVFKTTL--LGEIAQYYTHWSGSLRISLMY -KL--AEEIFAIKVD-IA-SHPLATTL--IGEIASYFTHWTGSLRFSFMF ----QGEMVFGTKLF-IG-DGVFKTTL--LGEIVQYYTHWAGSLRFSLMY -N--PAEEIFAIPVD-VA-SQPLATTL--IGEIASYYTHWTGSIRISFMF SG---DGPIMEWDMD-LS-AVLFNTTY--LGRCSRWFSQHRGSIRLTFMF ----QNEQVFGTNLF-IG-DGVFKTTL--LGEIVQYYTHWSGSLRFSLMY -D--LAKEVFSIPVD-IA-SQPLATTL--IGELASYYTHWTGSLRFSFMF -E--LKAEIFAIPVD-VA-SQPLATTL--IGEIASYYTHWTGSLRFSFMF -DF--AKEIFAIKVD-VA-SQPLSSTL--LGEICSYYTHWTGSLRFSFMF -T--SAGEVFAIPVD-IA-SQPLATTL--IGEIASYYTHWTGSIRFSFMF ----VNEQIFGTRLF-IG-DGVFKTTL--FGEIAQYYTHWSGSIRISLMY -NM--AEEIFAIKVD-IA-SQPLSNTI--IGEIASYFTHWTGSLRFSFMF ----QNEQIFGTNLF-IG-DGVFKTTL--LGEIAQYYTHWAGSLRFSLMY VS---NAAIAHWDMD-MG-SVLFSTTY--MARCAKWYSQHRGGIRVTFMF -TT--AKEIFAIKVD-IA-SQPLATTM--IGEIASYFTHWTGSLRFSFLF -NL--AQEIFAIKVD-VA-SQPLSSTL--LGEICSYYTHWTGSLRFSFMF -QS--AVKLFTIPID-IA-SPPLNTTL--LGEIASYYTHWTGSIRLSFMF -NA--PDKIFSIRTD-VA-SQPLATTL--IGEISSYFTHWTGSLRFSFMF -EM--AKEIFAIKVD-IA-SQPLANTM--IGEIASYFTHWAGSLRFSFMF ---T-GK-ILTLPLD-MS-HTVFATTL--LGEVLNYFSNWSGSVKLTFFC --NN-DGLILSIPLD-MS-NSLFATTL--LGEVLNYFTNWSGSITLTFMC -TP--AQKIFSIKVD-IA-SQPLANTM--LGQIASYYTHWTGSLRFSFMF -DL--AQEIFAIRVD-IA-SQPLATTL--IGEIASYYTHWTGSLRFSFMF -DP--DLKIFSLRTD-IA-SQPLATTL--IGEISNYFTHWTGSLRFSFMF SGTQ-PDLILTIPLK-MD-DTLFSTTL--LGEVLSYFSNWSGSITLSFMC TV---DTLCASFQVD-PGRDGPWQSTL--IGQLCRYYTQWSGSLEITFMF -T--LAEEVFAIPVD-VA-SQPLATTL--IGEISSYYTHWTGSIRFSFMF TSR--DEAIFAFQLD-PGHSSVLSRTL--LGEILNYYAHWSGSLKFTFLF ---A-DKPIVVIPMD-IS-NTLFSTTL--LGEVLNYFANWSGSISITFMC -DL--AQEIFAIRVD-IA-SQPLATTL--IGEIASYYTHWTGSLRFSFMF -TP--AAELFAMPVD-IT-SSPLATTL--LGEIASYYTNWTGSIRLSFMF -SL--AQEIFAIKVD-IA-SNPLATTL--IGEIASYFTHWTGSVRFSFLF -EL--AKEIFAIKVD-IA-SQPLATTL--IGEIASYYTHWTGSLRFSFLF -DM--AQEVFAIKVD-IT-SQPLATTL--IGEIASYYTHWTGSLRFSFMF NV---DQLCASFQVD-PGRNGPWQSTM--VGQICRYYTQWSGSLKVTFMF --NN-GGLILTIPLE-MN-NTLFSTTL--LGEVLNYFTNWSGSITLTFMC NSG--EQ-VFGFQLQ-PGYDSVLKHTL--LGEILNYYANWSGSMKLTFMY AA---DKLCASFRVD-PGRSGPWESTL--LGQICRYYTQWSGSLEVTFMF

2016/02/23, 3:08 PM


UniRef90_G0YPH9_326_499 UniRef90_Q8UY33_326_552 UniRef90_A5GZE0_334_555 UniRef90_G0ZNT7_334_555 UniRef90_A7KC11_332_515 UniRef90_G1JYY7_238_455 UniRef90_H6UKU5_326_499 UniRef90_Q03053_367_554 UniRef90_Q995Z1_365_551 UniRef90_B9V442_331_555 UniRef90_G1CSA8_329_506 UniRef90_A5GZE4_333_554 UniRef90_G8IJF4_357_552 UniRef90_A5GZF2_336_558 UniRef90_A5GZF1_333_554 UniRef90_Q5U904_326_555 UniRef90_Q6JKR7_325_551 UniRef90_G8IJF0_360_553 UniRef90_A1E4A3_319_512 UniRef90_Q8QUZ6_317_541 UniRef90_Q2LL04_324_545 UniRef90_F6M9Y7_364_585 UniRef90_Q8V601_326_552 UniRef90_Q6JKS0_326_499 UniRef90_B3SRP1_326_550 UniRef90_G5CZJ4_357_550 UniRef90_B5BSU7_367_555 UniRef90_G8IRN3_333_554 UniRef90_A5GZE2_333_554 UniRef90_A7KC08_333_554 UniRef90_H9BP13_325_500 UniRef90_Q80GI2_332_555 UniRef90_B9V435_333_554 UniRef90_Q5G9Z5_326_554 UniRef90_Q9YLG5_370_557 UniRef90_G8IJE5_332_553 UniRef90_Q8V614_326_499 UniRef90_Q5GA06_355_555 UniRef90_G8IJG6_332_548 UniRef90_Q05ED6_367_555 UniRef90_P23008_310_531 UniRef90_Q8JRP9_365_551 UniRef90_Q05EE3_367_555 UniRef90_Q8V604_326_552 UniRef90_C7DUC7_331_549 UniRef90_P12915_324_545 UniRef90_G8IJE1_331_509 UniRef90_A4UHT9_332_548 UniRef90_Q9QCF0_367_554 UniRef90_Q9QF31_325_500 UniRef90_Q65900_325_551 UniRef90_E5D8F2_334_553 UniRef90_A1E4A2_319_512 UniRef90_B9V440_332_553 UniRef90_Q6W9F4_332_507 UniRef90_G8IJH5_359_554 UniRef90_B1PZZ4_333_555 UniRef90_O89280_367_554 UniRef90_P32537_321_545 UniRef90_G0YPI2_326_499 UniRef90_Q9YLJ1_368_556 UniRef90_Q2YEN8_367_554 UniRef90_A7YF31_331_554 UniRef90_Q65481_317_544 UniRef90_Q2LKZ0_317_544 UniRef90_Q05ED0_367_555 UniRef90_Q8V5Z9_323_547 UniRef90_Q6W9F9_367_555 UniRef90_H8Y6P9_356_549 UniRef90_G5DC71_332_548 UniRef90_C6ZEZ9_341_560 UniRef90_Q05ED4_367_554 UniRef90_H6VBU4_358_522

8 of 17


AV---DTLCAAFRVD-PGRDGPWQSTM--VGQLCRYYTQWSGSLKITFMF AV---DQLCASFRVD-PGRAGPWEATL--VGQLCRYYTQWSGSLEVTFMF -DI--KEAIFAMRVD-IA-SQPLATTL--IGEIASYYTHWTGSLRFSFMF P-NS-DGLILSIPLD-MS-NSLFSTTL--LGEILNYFTNWSGSITLTFMC -P---GHEVFAMKVD-IA-SQPLATTI--IGEISSYYTHWTGSLRFSFMF SD---TDPITTWDLN-LA-GDSLRDTY--LGRLVKHYTNFRGSLVCSFIY EA---DKLCASFKVD-PGRDGPWEATT--VGQICRYYTQWSGSLEVTFMF TNG--SQ-VFGFPLI-PGASSVLNRTL--LGEILNYYTHWSGSIKLTFMF VS---QQ-VFGFKLQ-PGYDSVFKHTL--LGEILNYYANWSGSIKLTFMF -NITPAKEIFAIKVD-IA-SQPLATTL--IGEIANYYTHWTGSIRFSFLF SP---DTLCASFKVD-PGRDGPWQSTL--VGQICKYYTQWSGSLEVTFMF -QL--MQEVFAIRVD-VA-SQPLATTL--IGEISSYYTQWTGSLRFSFMF --TN-NGLILTIPLE-MS-NTLFSTTL--LGEILNYFTNWSGSVTLTFMC -DHPYAQEVFAIPVD-VA-SHPLATTY--LGEMSSCFTHWTGSLRFSFMF -SL--AQEIFAIKVD-IA-SDPLATTL--IGEIASYYTHWTGSIRFSFLF AV---DALCAAFKVD-PGRDGPWQSTL--VGQICRYYTQWSGSLEVTFMF EK---GKLCAVFRAD-PGLDGPWQSTL--LGQLCRYYTQWSGSLKLTFMF ---N-DNVILVLPLE-MD-NTLFSTTL--LGEILNYFANWSGSITITFMC DV---DQLLFNIPLD-IQLDGPLRNTL--VGNISRYYTHWSGSLEMTFMF NP---DQQLFALEVT-FADGSIMSKTL--CGIITSYYTQWSGSLEFTFMF AL---DSQIYVLKLE-LGGSGPLSSTL--LGTLAKHFTQWSGSVEITCMF -DP--AKEVFAIKVD-IA-SQPLATTL--IGEISSYYTHWTGSLRFSFLF EV---DKLCASFRTD-PGRDGPWQSTL--VGQLCRYYTQWSGSLEVTFMF DK---DTLCASLRVD-PGRDGPWQSTL--VGQICRYYTQWSGSLEITFMF SV---DQLCASFRVD-PGRDGPWQSTI--VGQLCRYYTQWSGSLEVTFMF ---D-NKLIVAIPLQ-MD-NTLFATTL--LGEVLNYYANWSGSVRVTFMC HSG--EGAIFAFQLD-PGSGSVLKHTL--LGEILNYYAHWSGSLRFTFLF SSRQ-EDLILVLPLK-MD-DTVFATTL--LGEVLNYFSNWSGSITLSFIC -DL--MQEVFSIRVD-IA-SQPLATTM--IGEIASYYTHWTGSLRFSFMF -DS--AKEIFAIKVD-IA-SHPLATTL--IGEIASYYTHWTGSLRFSFLF QS---GELCAAFKAD-PGLDGPWQSTM--VGQLCRYYTQWSGSLKITFMF SAQ--TTAIFTFQLD-PGHSPVLRRTL--LGEVLNYYAHWSGSIKLTFLF -DL--MSEVFAINVD-IA-SHPLATTM--LGEIASYYTHWTGSLRFSFMF AV---DQLCAAFRVD-PGRDGPWQSTL--VGQICKYYTQWSGSLEVTFMF SQG--AQ-VFGFSLQ-PGASSVLQRTL--LGEILNYYTHWSGSLKLTFVF -DP--TTPVFTIRVD-IA-SQPLATTL--IGEISSYYTHWTGSVRFSFMF NV---DELCCAFRVD-PGRNGPWESTI--IGQICRYYSQWSGSLEITFMF AV---DSLCAAFRVD-PGRDGPWQSTL--LGQLCRYYTQWSGSLEITFMF ---E-GK-ILVIPLD-MS-NTLFATTL--LGEVLNYYSNWSGSIKLSFMC HPK--TKAIFSFPLD-PGNSSVMNRTL--LGEILNYYAHWSGSIKITFMF -GM--AQKVFSIKVD-IT-STPLATTL--IGEIASYYTHWTGSLRFSFMF TS---QQ-VFGFRVQ-PGYDSVFKHTL--LGEVLNYYANWSGSIKLTFMF HAS--SKAIFSFELD-PGNGTVLSKTL--LGEILNYYAHWSGSVKFTFLF SV---DQLCASFRVD-PGRAGPWESTL--VGQYCKYYTQWSGSLEVTFMF ---S-NDLIVVIPLQ-MD-NTLFATTL--LGEILNYYANWSGSIRVTFMC AL---DAQIYALRLE-LGGSGPLSSSL--LGTLAKHYTQWSGSVEITCMF -P---GREVFAMRVD-IA-THPLATTL--IGEIANYYTHWTGSLRFSLMF ---S-ERKILAIPLD-MS-NTLFSTTL--MGEVLNYYSNWSGSIKLTFFC QLS--TQ-VFGFQMQ-PGLNSVFKRTL--LGEILNYYAHWSGSVKLTFVF KT---GELCAAFRAD-PGRDGPWQSTI--LGQLCRYYTQWSGSLEVTFMF KT---GELCAVFRAD-PGRNGPWQSTI--LGQLCRYYTQWSGSLEVTFMF ---V-TERILVLPLE-MS-NTLFATTL--LGEVLNYYANWSGSITITFMC DM---DALLFNIPLD-IQLDGPLRSTL--LANIARYYTHWSGSMEMTFMF -SL--AEEVFAIKVD-IA-SQPLATTL--IGEMSSYYTHWTGSLRFSFMF SSQ--TESVFAFQLD-PGHGSVLNRTL--LGEILNYYAHWSGSLKFTFLF -EL--MQEVFAIRVD-VA-SQPLATTL--IGEISSYYTQWTGSXRFSFMF HQS--TQ-VFGFQVQ-PGLDNVFKHTL--LGEILNYYAHWSGSIKLTFVF DTG--GQ-VFGFPLQ-PGASSVFQRTL--LGEILNYYTHWSGSIKLTFMF DM---DQLLFNIPLD-IQLEGPLRNTL--LGNISRYYTHWSGSLEMTFMF KA---DELCAAFMVD-PGRIGPWQSTL--VGQICRYYTQWSGSLKVTFMF TVR--GDAIFSFQLN-PGNSPVLNRTL--LGEIINYYAHWSGSIKLTFLF HQG--DK-IFAFQIQ-PGLDSVFKRTL--LGEVLNYYAHWSGSIKLTFTF SRS--KDPIFSFQVD-PGFSEVLNRTL--LGEMLNYYAHWSGSIKLTFLF DM---DQQVMALRVD-PGTSGPLQSTL--LGVFSRYYTQWSGSIEFTFMF AM---DGQIMALRVD-PGIDGPMQSTL--LGVLHRYYAQWSGSLDFTFMF HET--TEAVFKFQLD-PGNDSVLNRTL--LGEILNYYAHWSGSIKFTFLF DL---DQQIASFRVD-PGADGPWQSTL--LGNICRYYNQWSGSLEITFMF HSG--TEPIFSFQMD-PGSSTVMRHTL--TGEMLNYYAHWSGSVKLTFLF ---N-DRNLLILPLE-MD-NTLFSCTL--LGEVLNYFSNWSGSITITFMC ---T-ER-ILTIPLD-IS-NTIFSTTL--LGEVLNYFSNWSGSIKLTFFC ---D-TDLILAMPLQ-MD-NTLFATTL--LGEVLNYFGNWSGSIKVTFMC TQG--GQ-VFGFEMQ-PGKETVFKRTL--VGEILNYYAHWSGSLKLTLTF --------LYAFPVR-LG-NSALRTTY--LGNMARFFSQYTGELKFSLMC

2016/02/23, 3:08 PM


9 of 17


UniRef90_Q8V398_325_495 UniRef90_D8VCT6_342_524 UniRef90_D9YV24_514_704 UniRef90_Q66577_367_555 UniRef90_A0MHB7_357_547 UniRef90_E9LS20_360_544 UniRef90_Q9WHH4_367_554 UniRef90_G0ZNT5_357_550 UniRef90_Q5YJA3_454_673 UniRef90_H9U0H0_456_678 UniRef90_Q6W9E8_367_554 UniRef90_Q80GI1_367_556 UniRef90_C7B298_377_565

DV---DAQIAAFAVN-PGGDGVFQSTY--LGQICRYFNNWSGSIEITFMF PTK--DQSIFSLSLS-PASDERLSRTL--LGEILNYYTHWAGSIKFTFLF PV---GTKLLCQKIDPISLTTPISGTLTPLGQTLTHFSQWRGTLDIDLVF VQD--KSAIFSFQLN-PGNSTVLRRTL--LGEILNYYAHWSGSIKLTFLF ---N-NR-ILAIPLD-MS-NTLFSTTL--MGEILNYFSNWSGSIKLTFLC ---N-DERILVLPLE-MN-NTLFSTTL--LGEVLNYFTNWSGSITITFMC HAG--DQ-VFGFKLG-PGSDAVLNRTL--LGEIMNYYTHWSGSIKLTFVF ---D-NGLIVVIPLQ-MD-NTLFATTL--LGEVLNYYGNWSGSVRITFMC ------GPIFQMPLR-PV-NEETTNTM--LGSVTRMFAQWRGSLVIRCVF ------NHIFSMPLR-PV-CEETMNTM--LGSVTRMFSQWRGSMVIRCVF SSG--QQ-VFGFQLQ-PGSSSVLMRTL--LGEILNYYTHWSGSIKLTFVF DSE--TSALFSFQLD-PGRSTVLQRTL--LGEILNYYAHWSGSIKFTFMF SDL--NNPIFCLSLS-PASDQRLQFT

2WZR3 UniRef90_F1AW55_504_724 UniRef90_Q6PMU0_504_724 UniRef90_Q6PMU2_504_724 UniRef90_Q8V0G8_305_525 UniRef90_Q6PMT3_503_723 UniRef90_Q1L748_304_524 UniRef90_Q6PMT8_504_725 UniRef90_B8Y0J7_504_725 UniRef90_Q1L757_305_524 UniRef90_Q1L752_305_526 UniRef90_Q1L754_305_526 UniRef90_P49303_505_725 UniRef90_Q6PMY9_505_723 UniRef90_A2I8Z5_505_724 UniRef90_P15072_505_723 UniRef90_Q8JVD0_304_524 UniRef90_H9AY35_497_713 UniRef90_B0Z3W9_528_746 UniRef90_Q2XP17_533_745 UniRef90_Q100Y4_324_550 UniRef90_Q91LX8_542_768 UniRef90_A4ZKN2_415_639 UniRef90_E3TMG9_417_639 UniRef90_P08544_417_642 UniRef90_B3VTU7_418_646 UniRef90_Q66776_543_769 UniRef90_G9FTJ7_414_638 UniRef90_Q02472_417_641 UniRef90_P12296_396_619 UniRef90_C3U5A3_447_672 UniRef90_G1DFA4_460_684 UniRef90_Q155Z9_448_665 UniRef90_B9VIN1_352_561 UniRef90_G8HZ08_715_947 UniRef90_B8XTQ3_353_566 UniRef90_D9D8F3_345_562 UniRef90_I1YLT4_348_565 UniRef90_B8XTP9_335_563 UniRef90_I1YLT7_349_565 UniRef90_I1YLT6_336_558 UniRef90_B8XTP8_334_562 UniRef90_B8XTQ0_353_567 UniRef90_Q5YJ95_381_603 UniRef90_B8XTQ4_341_566 UniRef90_I1YLT5_349_558 UniRef90_F6IA11_421_636 UniRef90_G0Z2U8_412_599 UniRef90_Q5YJA7_377_599 UniRef90_G0Y2E4_357_574 UniRef90_Q8B552_395_615 UniRef90_A7KC13_333_552 UniRef90_A5GZD6_337_514 UniRef90_G5CZJ8_367_551 UniRef90_G8HH17_373_575 UniRef90_G0Y2E3_380_601

TGPTNNKAKYMVAYIPPG--THPLPETPEMASHCYHAEWDTGLNSTFTFT TGPTNNKAKYMVAYIPPG--TTPLPGTPETASHCYHAEWDTGLNSTFTFT TGPTNNKAKYMVAYIPPG--THPLPETPEMASHCYHAEWDTGLNSTFTFT SGPTNNKAKYMVAYIPPG--THPLPNTPEQASHCYHAEWDTGLNSTFTFT TGPTNNKAKYMVAYIPPS--TNPLPTTPEAASHCYHAEWDTGLNSTFTFT TGPTQSKARFMVAYIPPG--TSPVPDTPEKAAHCYHSEWDTGLNSKFTFT TGPTQSKARFMVVYVPPG--TEPVPNTPEKAAHCYHSEWDTGLNSKFTFT TGPTHHKAKFMVAYIPPGIETDKLPKTPEDAAHCYHSEWDTGLNSQFTFA TGPTHHKAKFMVAYVPPGVSTEQLPKTPEDAAHCYHAEWDTGLNSSFSFA TGPTHHKAKFMVAYIPPG--TDPLPETPEDAAHCHHAEWDTGLNSTFTFA TGPTHHKAKFMVAYVPPGIAVAQLPKTPEDASHCYHSEWDTGLNSSFTFA TGPTHHKAKFMVAYVPPGISASALPRTPEDAAHCYHSEWDTGLNSQFTFA TGSTDSKARYMVAYVPPG--VETPPDTPEKAAHCIHAEWDTGLNSKFTFS TGPTDAKARYMVAYIPPG--MT-PPTDPERAAHCIHSEWDTGLNSKFTFS TGPTDAKARYMAAYAPPG--ME-PPKTPEAAAHCIHAEWDTGLNSKFTFS TGPTDAKARYMVAYVPPG--MD-APDNPEEAAHCIHAEWDTGLNSKFTFS TGPTQSKARFMVAYIPPG--TD-LFRHSRGSSTLLHSEWDTGLNSKFTFT TGPVNEKARFRVVFVPPG--TT-TPNTAADASLLIHSDWDSGLNSEFVFP TGFVSDKAKFLLVFVPPG--AD-PPTTLSEAQHCITLEWDTGLNSETVFN TGAAATKAKFLVAFVPPH--TA-APKTRDEAMACIHAVWDVGLNSAFSFN TGSAMAQGKFVVCYVPPG--R--EPTSLDEAMQGTYSIWDLGLNSSFKFV TGTAMAQGKFVVAYTPPG--R--EPKTLDEAMQGTYAIWDLGLNSSFKFV TGSAMTKGKFLISYTPPG--AG-KPTTRDQAMQATYAIWDLGLNSSYNFT TGSAMTKGKFLISYTPPG--AG-EPKTLDQAMQATYAIWDLGLNSSYNFT TGAAMVKGKFLIAYTPPG--AG-KPTTRDQAMQSTYAIWDLGLNSSFNFT TGTAVTKGKFLIAYTPPG--AG-KPTTREQAMQATYAIWDLGLNSSYNFT TGSAMCQGKFVVCYVPPG--R--EPQSLDEAMQGTYSIWDLGLNSSFKFV TGSAMAKGKFLISYTPPG--AG-KPKDREQAMQATYAIWDLGLNSSYNFT TGSAMTKGKFLIAYTPPG--AG-KPTTRDQAXQSTYAIWDLGLNSSYNFT TGTAMMKGKFLIAYTPPG--AG-KPTSRDQAMQATYAIWDLGLNSSYSFT TGSAMVKGKFLISXTPPG--AD-KPKNRNQAMQATYAIWDLGLNSSYNFT TGAAMVKGKFLLAYTPPG--AE-RPSTIEEAMQATYAIWDLGLQSSYDFT CGPMMARGKFLLSYSPPN--GT-QPQTLSEAMQCTYSIWDIGLNSSWTFV ATTSMTRGKLLCCYTPPG--AD-KPTTVEQAMMSTYAIWDLGLQSTFEFV CGSSMVTGKLLIAYTPPG--GT-EPTDREQAMLGTHMVWDIGLQSSVSFT ATTGMTKGKLLLSYTPPG--SG-APTTLEQAMNGTYSIWDIGLQSTFNFV ATTALTRGKLLIAYSPPG--AN-EPTSIDQAMMGTYAIWDLGLQSTFNFV ATTAMTRGKLLLSYTPPG--AG-KPTTIDQAMMGTYSIWDLGLQSTFNFV VTTAMTRGKLLLAYTPPG--AG-EPTTIDQAMMGTYTIWDLGLQSTVNFV ATTAMTRGKLLISYTPPG--AN-QPESIDQAMMGTYSIWDLGLQSTFNFV CCTAMTRGKLLVAYTPPG--AG-APESIDQAMQGTYTIWDLGLQSSLNFT ATTAMTRGKLLISYTPPG--AG-EPQSIDQAMMGTYAIWDLGLQSTFNFV ATTAMTRGKLLMAYTPPG--AN-KPTTIDQAMMGTFSIWDLGLQSTFNFV CGSQMATGKLLIAYTPPG--GS-SPTTRTDAMLATHVIWDIGLQSTCKLV AVTAMTRGKLLFSYTPPG--AG-KPQNIKQAMMGTYTIWDLGLQSTLNFT CTTAMTRGKLLLAYTPPG--AN-APETIEQAMMATYSIWDLGLQSTFSFV TGPKQSSGKLLIAYTPPG--GA-RPTSREEAMLGTNIIWDFGLQSTCTFV CGSQMATGKLLIAYTPPG--GS-SPTTRTDAMLATHVIWDIGLQSTCKLV CGSQMATGKLLIAYTPPG--GS-SPATRTDAMLATHVVWDLGLQSTCKLV CGSAMATGKILIAYTPPG--GD-APATRKDAMLATHVVWDLGLQSSVTFT CGSKMATGKFLVAYTPPG--GS-SPATREEAMLGTHVIWDIGLQSTCKFV TGPALSSAKLLLAYTPPG--AP-GPTNRKDAMLGTHIIWDIGLQSTIVMN TGPALSSAKLILAYTPPG--AP-GPETRKDAMLGTHVVWDIGLQSTIVMT TGPALSSAKLLLAYTPPG--AP-GPKTRKDAMLGTHLVWDIGLQSTVVMN CGSAMATGKFLISYTPPG--GD-APRTRQDAMLATHVVWDVGLQSSCSLV TGSAMSTGKLLIAYTPPG--GS-EPKTRKDAMLGTHVVWDIGLQSSITMV

2016/02/23, 3:08 PM


UniRef90_B9V482_337_556 UniRef90_A5GZF6_334_555 UniRef90_A7KC10_335_556 UniRef90_G8IJG2_334_555 UniRef90_D2IW00_332_553 UniRef90_A5GZD9_331_550 UniRef90_A7KC07_334_555 UniRef90_Q672R3_805_1000 UniRef90_B5A1N0_416_617 UniRef90_B9V433_331_550 UniRef90_Q82081_333_552 UniRef90_Q5XLP5_336_557 UniRef90_B9V457_333_554 UniRef90_G1JYY8_404_619 UniRef90_F6N707_334_556 UniRef90_G5D5D9_333_552 UniRef90_Q82122_332_553 UniRef90_G5D5E2_333_552 UniRef90_A5GZF5_335_556 UniRef90_G0Y2E2_378_600 UniRef90_P03303_333_552 UniRef90_P07210_338_559 UniRef90_F6M9Y3_333_554 UniRef90_B9V459_336_557 UniRef90_B9V477_333_554 UniRef90_H9C6N6_333_552 UniRef90_A5GZE7_336_557 UniRef90_B9V485_333_552 UniRef90_G0Y2E0_419_588 UniRef90_G9K138_332_516 UniRef90_A5GZE9_336_557 UniRef90_B9V434_332_553 UniRef90_P04936_332_552 UniRef90_C7DUC8_336_557 UniRef90_G8IQ74_332_548 UniRef90_I2CMI9_334_554 UniRef90_B9V466_338_522 UniRef90_A5GZF9_333_554 UniRef90_G8IJE2_332_552 UniRef90_H8Y6Q0_168_390 UniRef90_G0YPI0_327_543 UniRef90_B9V473_333_554 UniRef90_B5BSU6_368_556 UniRef90_A8S322_365_548 UniRef90_G8IQ62_334_555 UniRef90_B9V453_331_552 UniRef90_G9K146_333_520 UniRef90_F6M9Z0_330_551 UniRef90_P12916_334_555 UniRef90_G5EN04_327_500 UniRef90_C7DUC6_357_551 UniRef90_Q9WN78_367_554 UniRef90_G0YPI1_326_499 UniRef90_G0YPH9_326_499 UniRef90_Q8UY33_326_552 UniRef90_A5GZE0_334_555 UniRef90_G0ZNT7_334_555 UniRef90_A7KC11_332_515 UniRef90_G1JYY7_238_455 UniRef90_H6UKU5_326_499 UniRef90_Q03053_367_554 UniRef90_Q995Z1_365_551 UniRef90_B9V442_331_555 UniRef90_G1CSA8_329_506 UniRef90_A5GZE4_333_554 UniRef90_G8IJF4_357_552 UniRef90_A5GZF2_336_558 UniRef90_A5GZF1_333_554 UniRef90_Q5U904_326_555 UniRef90_Q6JKR7_325_551 UniRef90_G8IJF0_360_553 UniRef90_A1E4A3_319_512 UniRef90_Q8QUZ6_317_541

10 of 17


TGPALSSAKLILAYTPPG--AQ-GPTTKKDAXLGTHVVWDIGLQSTIVMT CGTANTSLKLLIAYTPPG--VP-KPTSRKDAMLSTHVVWDVGLQSTMSMV CGTANTTLKLLIAYTPPG--VP-KPDTRKKAMLGTHLVWDVGLQSTVSLV CGTANTSLKLLIAYTPPG--VP-KPDSRQKAMLSTHVVWDVGLQSTVSLV CGTANTSLKLLVAYTPPG--VP-KPDSRTKAMLGTHVVWDVGLQSTVSMV TGPALSSAKLLIAYTPPG--TA-GPADRRTAMLGTHVVWDIGLQSTVVLN CGTANTTLKLLIAYTPPG--VP-KPDTRKKAMLGTHLVWDVGLQSTVSMI CGTAMTTGKILIAYTPPG--AN-PPADRTEAMLGTHVVWDIGLQSSVTMA CGSQMATGKLLIAYTPPG--GS-RPTTRQEASLGTNIIWDLGLQSTCKFP TGPALSSAKLLIAYTPPG--AQ-GPTKRKEAMLGTHVVWDIGLQSTVVLN TGPALSSAKIILAYTPPG--TR-GPEDRKKAMLGTHVVWDIGLQSTIVMT CGTANTTLKLLLAYTPPG--ID-KPTTRKQAMLGTHIVWDVGLQSTVSLV CGTASTSLKLLIAYTPPG--VD-KPNTRTKAMLGTHVVWDVGLQSTVSMV AGSHMATGKLLLCYSPPG--AN-PPKTRDEAMLGTSLLWDIGLQSTVNFV CGTANTKVKLLIAYTPPG--VE-KPTSRTKAMLGTHLVWDVGLQSTVSMV TGPALSSAKLILAYTPPG--AQ-GPTNRKDAMLGTHVVWDIGLQSTIVMT CGTANTTLKVLLAYTPPG--IG-KPRSRKEAMLGTHVVWDVGLQSTVSLV TGPALSSAKLILSYTPPG--AN-GPTTRKEAMLGTHVVWDIGLQSTIVMT CGSANTSLKLLIAYTPPG--VP-KPTSRKEAMLGTHLVWDVGLQSTASMV CGSAMTTGKLLLAYTPPG--GA-APATRKEAMLGTHVVWDIGLQSSITMV TGPALSSAKLILAYTPPG--AR-GPQDRREAMLGTHVVWDIGLQSTIVMT CGSASSTLKLLIAYTPPG--VG-KPKSRREAMLGTHLVWDVGLQSTASLV CGTANTSLKLLIAYTPPG--VA-KPTTRTMAMLGTHLVWDVGLQSTVSMV CGTANTTLKVLIAYTPPG--IK-KPETRKQAMLGTHIVWDVGLQSTVSLV CGSANTSLKLLIAYTPPG--VP-KPTSRREAMLGTHLVWDVGLQSTASMV TGPALSSAKLILAYTPPG--TE-GPKTRREAMLGTHVVWDVGLQSTVVMN CGTANTTLKLLLAYTPPG--IK-KPTNRKQAMLGTHIVWDIGLQSTVSLV TGPALSSAKLILAYTPPG--VA-GPKNRKEAMLGTHVVWDIGLQSTIIMN CGSAMATGKLLLAFTPPG--GS-APATRRDAMLGTHEIWDLGLQSSITLV CGTANTTLKLLVAYTPPG--IE-KPQNRKDAMLGTHVVWDVGLQSTISMV CGTANTTLKLLLAYTPPG--IK-KPENRKQAMLGTHIVWDVGLQSTISLV CGSANSSLKLLIAYTPPG--AP-EPTKRKEAMLGTHIVWDVGLQSTCSLI CGTANTTVKLLLAYTPPG--IA-EPTTRKDAMLGTHVIWDVGLQSTISMV CGTANTTLKLLLAYTPPG--IG-KPRDRKQAMLGTHIVWDVGLQSTVSLV VCNSFSTGKFLIAYTPPG--AG-IPETRKDAMLGTHVVWDLGLQSSCHLI VCDSFSTGKFLLAYTPPG--GA-HPANRKQAMLGVHVVWDLGLQSSCTMV CGTANTTLKLLLAYTPPG--IG-EPRDRKQAMLGTHIVWDVGLQSTVSLV CGSASATLKLLLAYTPPG--IA-KPTTRKQAMLGTHVVWDVGLQSTISMI CGTANTTVKLLLAYTPPG--ID-EPRTRKDAMLGTHVIWDIGLQSTISMV VCDSFSTGKFLIAYTPPG--GG-HPSDRKEAMLGVHVIWDLGLQSTCTMV TGSFMATGKMLIAYTPPG--SA-QPTTRELAMLGTHIIWDFGLQSSVTLV CGTANTSLKLLIAYTPPG--VG-KPQNRTQAMLGTHMIWDVGLQSTVSMV CGSAMATGKILLSYSPPG--AK-VPEKRKDAMLGTHIIWDLGLQSSCVLC VCDSFSTGKFLLAYTPPG--AA-LPPDRKTAMLGVHVIWDLGLQSSCTIV CGSASTTLKLLLAYTPPG--IA-KPTTRKDAMLGTHVVWDVGLQSTISMI CGSANTSLKLLLAYTPPG--VS-KPTSRREAMLGTHLVWDVGLQSTCSLV CGTANTTLKLLVAYTPPG--IR-KPTSRKEAMLGTHVVWDVGLQSTMSMV CGSANTTLKLLIAYTPPG--IS-KPTKRKEAMLGTHVVWDVGLQSTMSMV CGTANTTLKLLLAYTPPG--ID-KPATRKDAMLGTHVVWDVGLQSTISLV TGSFMATGKMLIAYTPPG--SA-QPATREAAMLGTHIVWDFGLQSSVTLV VCDSFSTGKFLLAYTPPG--GA-HPKDRKEAMLGVHVIWDLGLQSSCTMV CGAAMATGKFLIAYSPPG--AG-VPGSRKDAMLGTHVIWDVGLQSSCVLC TGSFMATGKMLIAYTPPG--GE-QPKTRDVAMLGTHVIWDFGLQSSVTLV TGSFMATGKMLVAYTPPG--GA-QPASRELAMLGTHVIWDFGLQSSVTLV TGSFMATGKMLIAYTPPG--GA-QPTSREVAMLGTHVIWDFGLQSSVTMI CGSAFTTLKLLIAYTPPG--ID-VPSTRKQAMLGTHVIWDVGLQSTVSMV VCDSFSTGKFLLAYTPPG--GA-HPKTRKEAMLGVHVIWDLGLQSSCTMV CGSAGTTLKLLIAYTPPG--ID-KPTKRKDAMLGTHVVWDVGLQSTISMI TGSAMSTGKILVCYSPPG--AG-VPQSRTEAMLGTNVLWDLGLQSTLEFN TGSFMATGKMLIAYTPPG--GQ-QPATRDIAMLGTHVIWDFGLQSSVTLV CGSAMATGKFLLAYSPPG--AG-APTTRKEAMLGTHVIWDVGLQSSCVLC CGSAMTTGKLILAYSPPG--AG-VPGTRKDAILGTHVVWDLGLQSSCVLC CGTANTTLKLLVAYTPPG--IK-KPENRKDAMLGTHVVWDVGLQSTISMV TGSFMATGKMLIAYTPPG--GA-QPTTRDLAMLGTHVIWDFGLQSSITLV CGTANTTLKLLIAYTPPG--IV-KPRNRKEAMLGTHIVWDVGLQSTISMI VCDSFSTGKFLLAYTPPG--GA-HPKNRKEAMLGVHIIWDLGLQSSCTMV CGSACTTLKLLIAYTPPG--IA-KPTSRKEAMLGTHLVWDVGLQSTASLV CGSANTTLKLLIAYTPPG--IR-KPKNRKEAMLGTHVVWDVGLQSTISMV TGSFMATGKMLIAYTPPG--AP-QPANRRIAMLGTHVIWDFGLQSSVTLV TGSFMATGKMLIAYTPPG--GV-TPASRMDAMLGTHIIWDFGLQSSVSLV VCDAFSTGKFLLAYTPPG--GR-LPLSRKEAMLGVHVIWDLGLQSSCTIV CGSFMATGKLILCYTPPG--GS-CPTTRETAMLGTHIVWDFGLQSSVTLI TGSFMTTGKLLLAYSPPG--GS-APTTRDDAMLGTHVVWDFGLQSSITLV

2016/02/23, 3:08 PM


11 of 17


UniRef90_Q2LL04_324_545 UniRef90_F6M9Y7_364_585 UniRef90_Q8V601_326_552 UniRef90_Q6JKS0_326_499 UniRef90_B3SRP1_326_550 UniRef90_G5CZJ4_357_550 UniRef90_B5BSU7_367_555 UniRef90_G8IRN3_333_554 UniRef90_A5GZE2_333_554 UniRef90_A7KC08_333_554 UniRef90_H9BP13_325_500 UniRef90_Q80GI2_332_555 UniRef90_B9V435_333_554 UniRef90_Q5G9Z5_326_554 UniRef90_Q9YLG5_370_557 UniRef90_G8IJE5_332_553 UniRef90_Q8V614_326_499 UniRef90_Q5GA06_355_555 UniRef90_G8IJG6_332_548 UniRef90_Q05ED6_367_555 UniRef90_P23008_310_531 UniRef90_Q8JRP9_365_551 UniRef90_Q05EE3_367_555 UniRef90_Q8V604_326_552 UniRef90_C7DUC7_331_549 UniRef90_P12915_324_545 UniRef90_G8IJE1_331_509 UniRef90_A4UHT9_332_548 UniRef90_Q9QCF0_367_554 UniRef90_Q9QF31_325_500 UniRef90_Q65900_325_551 UniRef90_E5D8F2_334_553 UniRef90_A1E4A2_319_512 UniRef90_B9V440_332_553 UniRef90_Q6W9F4_332_507 UniRef90_G8IJH5_359_554 UniRef90_B1PZZ4_333_555 UniRef90_O89280_367_554 UniRef90_P32537_321_545 UniRef90_G0YPI2_326_499 UniRef90_Q9YLJ1_368_556 UniRef90_Q2YEN8_367_554 UniRef90_A7YF31_331_554 UniRef90_Q65481_317_544 UniRef90_Q2LKZ0_317_544 UniRef90_Q05ED0_367_555 UniRef90_Q8V5Z9_323_547 UniRef90_Q6W9F9_367_555 UniRef90_H8Y6P9_356_549 UniRef90_G5DC71_332_548 UniRef90_C6ZEZ9_341_560 UniRef90_Q05ED4_367_554 UniRef90_H6VBU4_358_522 UniRef90_Q8V398_325_495 UniRef90_D8VCT6_342_524 UniRef90_D9YV24_514_704 UniRef90_Q66577_367_555 UniRef90_A0MHB7_357_547 UniRef90_E9LS20_360_544 UniRef90_Q9WHH4_367_554 UniRef90_G0ZNT5_357_550 UniRef90_Q5YJA3_454_673 UniRef90_H9U0H0_456_678 UniRef90_Q6W9E8_367_554 UniRef90_Q80GI1_367_556 UniRef90_C7B298_377_565

TGTFMTTGKVLLAYTPPG--GD-MPRNREEAMLGTHVIWDFGLQSSITLV CGSANTTLKLLVAYTPPG--IA-KPTDRKAAMLGTHVVWDVGLQSTISMV TGSFMATGKLLIAYTPPG--AP-QPATRAQAMLGTHIVWDFGLQSSATLV TGSFMATGKMLIAYSPPG--SA-QPTTRDLAMLGTHVVWDFGLQSSITLV TGSFMATGKLLIAYTPPG--GT-QPTSRAVAMLGTHVIWDFGLQSSITLV VCDSFSTGKFLLAYTPPG--GR-LPRDRKEAMLGTHVVWDLGLQSSCTMV CGTAMTTGKLLIAYSPPG--AN-VPENRKDAMLGTHMVWDVGLQSSCVLC VCDSFSTGKFLIAYTPPG--GA-LPTDRKDAMLGVHVIWDLGLQSTCTIA CGTANTTLKLLLAYTPPG--IA-KPSNRKEAMLGTHVVWDVGLQSTISMI CGTACTTLKLLIAYTPPG--IR-KPENRREAMLGTHVVWDVGLQSTISMV TGSFMATGKMLIAYTPPG--GS-LPANRMQAMLGTHVIWDFGLQSSVTLV CGSAMATGKILLAYSPPG--AG-VPTKRKDAMLGTHVIWDIGLQSSCVLC CGSASTTLKLLLAYTPPG--IA-KPISRRDAMLGTHVVWDVGLQSTISMV TGSFMATGKMLIAYTPPG--GP-KPANRETAMLGTHVIWDFGLQSSVTLV CGSAMATGKFLLAYSPPG--AG-VPPDRKKAMLGTHVIWDVGLQSSCVLC CGSALTTLKLLIAYTPPG--IR-VPRNRKEAMLGTHLIWDVGLQSTVSMV TGSFMATGKMLIAYTPPG--GA-QPSNRTTAMLGTHVIWDFGLQSSVTLV TGSFMATGKMLIAYTPPG--GA-QPTSRSLAMLGTHVIWDFGLQSSVTLV VCDSFSTGKFLIAYTPPG--AG-LPTDRKQAMLGVHTIWDLGLQSTCNMV CGTAMATGKILLSYSPPG--AS-VPESRTQAMLGTHVIWDLGLQSSCVLC CGTANTTLKLLLAYTPPG--ID-EPTTRKDAMLGTHVVWDVGLQSTISLV CGSAMTTGKLILAYSPPG--AG-VPDSRKNAMLGTHVVLDLGLQSSCVLC CGSAMATGKILLAYSPPG--AS-VPKDRKQAMLGTHVIWDLGLQSSCVLC TGSFMATGKMLIAYTPPG--GA-QPANRRTAMLGTHVIWDFGLQSSVTLV VCDSFGTGKSLMAYTPPG--GK-LPTSRKEAMLGVHVIWDLGLQSSCTMV TGTFMTTGKVLLAYTPPG--GD-MPRNREEAMLGTHVVWDFGLQSSITLV CGTAGTTLKLLVAYTPPG--IA-KPTNRKDAMLGTHVVWDVGLQSTISMI VCDSFSTGKFLIAYTPPG--AD-IPESRRDAMLGTHVVWDLGLQSSCHLV CGSAMALAKFLLAYSPPG--AD-PPKSRKEAMLGTHVIWDIGLQSSCVLC AGSFMATGKMLIAYTPPG--GN-VPADRITAMLGTHVIWDFGLQSSVTLV AGSFMATGKMLIAYTPPG--GG-VPADRLTAMLGTHVIWDFGLQSSVTLV VCDAFSTGKFLVAYTPPG--GK-LPEDRKQAMLGVHIIWDLGLQSSCTIV CGSFMATGKVILCYTPPG--GS-CPTDRESAMLGTHIVWDFGLQSSITLV CGTAGTTLKLLLAYTPPG--IA-KPQKRKDAMLGTHVVWDVGLQSTISMI CGSAMATGKLLLAYSPPG--AD-VPKSRKDAMLGTHIVWDLGLQSSCVLC CGTANTTLKLLIAYTPPG--IA-KPKSRKEAMLGTHIVWDVGLQSTISMI CGSAMATGKFLLAYAPPG--AN-APKSRKDAMLGTHIIWDVGLQSSCVLC CGSAMATGKFLLAYSPPG--AG-APKSRKDAMLGTHVIWDVGLQSSCVLC CGSFMTTGKLIICYTPPG--GS-SPTDRMQAMLATHVVWDFGLQSSITII TGSFMATGKMLVAYSPPG--SA-QPANRETAMLGTHVIWDFGLQSSVSLV CGSAMATGKLLLAYSPPG--AS-VPTSRKDAMLGTHIIWDLGLQSSCVLC CGSAMATGKLLLAYSPPG--AD-VPASRKQAMLGTHIIWDIGLQSSCVLC CGSAMATGKLLLAYSPPG--AS-VPTTRKDAMLGTHIIWDLGLQSSCVLC CGTFMSTGKVIIAYTPPG--GT-APTSRREAMLGTHIVWDFGLQSSITLV CGTFMTTGKVIIAYTPPG--GD-QPTARRQAMLGTHVVWDFGLQSSITLV CGSAMATGKLLIAYSPPG--AN-PPTDRKQAMLGTHIIWDLGLQSSCVLC TGSFMATGKILIGYSPPG--GS-QPATREDAMLGTYVVWDFGLQSSVTLA CGSAMATGKLLLAYSPPG--AS-VPTSRKDAMLGTHIIWDVGLQSSCVLC VCDSFSTGKFLVAYTPPG--GK-PPTDRKDAMLGVHIIWDLGLQSSCSIV VCDSFSTGKFLIAYTPPG--AD-IPTKRKDAMLGTHVIWDLGLQSSCHLV VCDSFSSGKFLVAYTPPG--GG-VPTNRKEAMLGTHLIWDLGLQSSCTLV CGSAMATGKFLVAYSPPG--AN-PPKNRKDAMLGTHIIWDVGLQSSCVLC CANSMTKGRLLISFLPGV--VT-RPNNINQAMLGSYVVYDVGLNSTFEFP CGSFMATGKILIAYTPPG--GS-APTDRKSAMLGTHIIWDFGLQSSATLV CGSMMATGKILISYSPPG--AA-PPTTRKDAMLGTHVIWDIGLQSSVTLV SGSQQNTGRILVSTTPPV--AG-CPATMEAAMRNTCYIWDLTTSASISIT CGSAMATGKLLLAYSHAG--AS-VPKSRRDAMLGTHVIWDVGLQSSCVLC VCDSFSTGKFLIAYTPPG--AS-IPANRTDAMLGTHIIWDLGLQSSCHMV VCDSFSTGKFLLAYTPPG--GA-HPKDRKQAMLGVHVIWDLGLQSSCTMV CGSAMTTGKFLLSYAPPG--AG-APTKRKDAMLGTHVVWDVGLQSSCVLC VCDSFSTGKFLMAYTPPG--GR-LPADRKEAMLGTHVVWDLGLQSSCSMV VGNQMQTCRLLVAWTPQGFNAPV-PSKMAEAMQGHYVIYDTGVDSSVDLV VGNQMQNCRLVMAWTPQGFGTTEAPRTMEQAMQGHYVIYDTGIDSSVDLV CGSAMATGKFLLAYSPPG--AG-KPMSRKDAMLGTHVVWDVGLQSSCVLC CGSAMATGKILLSYSPPG--AK-APSSRKDAMLGTHVIWDIGLQSSCVLC

2WZR3 UniRef90_F1AW55_504_724 UniRef90_Q6PMU0_504_724

VPYFSAADYA--YT-----------YADE---PEQASVQGWVGVYQITDT VPYVSAADFA--YT-----------YSNE---PEQTSVQGWVGVYQITDT VPYVSAADFA--YT-----------YSDE---PEQASVQGWVGVYQVTDT

2016/02/23, 3:08 PM


UniRef90_Q6PMU2_504_724 UniRef90_Q8V0G8_305_525 UniRef90_Q6PMT3_503_723 UniRef90_Q1L748_304_524 UniRef90_Q6PMT8_504_725 UniRef90_B8Y0J7_504_725 UniRef90_Q1L757_305_524 UniRef90_Q1L752_305_526 UniRef90_Q1L754_305_526 UniRef90_P49303_505_725 UniRef90_Q6PMY9_505_723 UniRef90_A2I8Z5_505_724 UniRef90_P15072_505_723 UniRef90_Q8JVD0_304_524 UniRef90_H9AY35_497_713 UniRef90_B0Z3W9_528_746 UniRef90_Q2XP17_533_745 UniRef90_Q100Y4_324_550 UniRef90_Q91LX8_542_768 UniRef90_A4ZKN2_415_639 UniRef90_E3TMG9_417_639 UniRef90_P08544_417_642 UniRef90_B3VTU7_418_646 UniRef90_Q66776_543_769 UniRef90_G9FTJ7_414_638 UniRef90_Q02472_417_641 UniRef90_P12296_396_619 UniRef90_C3U5A3_447_672 UniRef90_G1DFA4_460_684 UniRef90_Q155Z9_448_665 UniRef90_B9VIN1_352_561 UniRef90_G8HZ08_715_947 UniRef90_B8XTQ3_353_566 UniRef90_D9D8F3_345_562 UniRef90_I1YLT4_348_565 UniRef90_B8XTP9_335_563 UniRef90_I1YLT7_349_565 UniRef90_I1YLT6_336_558 UniRef90_B8XTP8_334_562 UniRef90_B8XTQ0_353_567 UniRef90_Q5YJ95_381_603 UniRef90_B8XTQ4_341_566 UniRef90_I1YLT5_349_558 UniRef90_F6IA11_421_636 UniRef90_G0Z2U8_412_599 UniRef90_Q5YJA7_377_599 UniRef90_G0Y2E4_357_574 UniRef90_Q8B552_395_615 UniRef90_A7KC13_333_552 UniRef90_A5GZD6_337_514 UniRef90_G5CZJ8_367_551 UniRef90_G8HH17_373_575 UniRef90_G0Y2E3_380_601 UniRef90_B9V482_337_556 UniRef90_A5GZF6_334_555 UniRef90_A7KC10_335_556 UniRef90_G8IJG2_334_555 UniRef90_D2IW00_332_553 UniRef90_A5GZD9_331_550 UniRef90_A7KC07_334_555 UniRef90_Q672R3_805_1000 UniRef90_B5A1N0_416_617 UniRef90_B9V433_331_550 UniRef90_Q82081_333_552 UniRef90_Q5XLP5_336_557 UniRef90_B9V457_333_554 UniRef90_G1JYY8_404_619 UniRef90_F6N707_334_556 UniRef90_G5D5D9_333_552 UniRef90_Q82122_332_553 UniRef90_G5D5E2_333_552 UniRef90_A5GZF5_335_556 UniRef90_G0Y2E2_378_600

12 of 17


VPYVSGADFA--YT-----------HADE---PEQASVQGWVGVYQITDT VPYISAADYA--YT-----------YADE---PEQASVQGWIGVYQVTDT VPYMSAADFA--YT-----------YCDE---PEQASAQGWVTLYQITDT VPYVSGADYA--YT-----------YCDE---PETTSAQGWVTLYQITDT VPYVSASDFS--YT-----------HTDT---PAMATTNGWVAVYQVTDT VPYISASDFT--YT-----------HTDT---PAMATTNGWVVVLQVTDT VPYMSASDYT--FT-----------HTDT---PAMATTNGWVAVYQVTDT VPYISSADFS--YT-----------HTDT---PAMATTNGWVVVLQVTDT VPYVSASDFS--YT-----------HTDT---PAMATTNGWVVVLQVTDT IPYVSAADYA--YT-----------ASDV---AETTNVQGWVCIYQITHG IPYLSAADYA--YT-----------ASDV---AETTSVQGWVCIYQITHG IPYLSAADYA--YT-----------ASDV---AETTNVQGWVCLFQITHG IPYISAADYA--YT-----------ASHE---AETTCVQGWVCVYQITHG GQPTWRADFA--YT-----------YCDE---PEQASAQGWVTVYQITDT VPYVSPTPYT--TT-----------HGTD---ADQATVNGWIQIYQL-DA IPYISQTYYT--ST-----------HSST---ADIGNVSGRVQIYQVT-A VPYSSPSDFM--AV-----------YS-A--DATVVNVSGWLQVYALTAL IPYISASAYR--FT-----------HEDD--RPSVVNAVGWLQIYQLTTL IPYISASAYR--FT-----------NEDD--RPSVVNAVGWLQVYQLTTL VPFISPTHYR--QT-----------SY-T--TPSITSVDGWLSVWQLTPL VPFISPTHYR--QT-----------SY-N--TPTITSVDGWLTVWQLTPL APFISPTHYR--QT-----------SY-T--SPTITSVDGWVTVWKLTPL VPFISPTHYR--QT-----------SY-T--STSITSVDGWLTVWQLTPL VPYISASAYR--FT-----------HEDD--QPSALNAVGWLQIYQLTNL VPFISPTHYR--QT-----------SY-T--TPSITSVDGWLSIWQLTPL VPFISPSHYR--QT-----------SY-T--SPSIAAVDGWLTVWQLTPL VPFISPTHFR--MV-----------GT-D--QANITNVDGWVTVWQLTPL VPFISPTHFR--QT-----------SY-T--TSTITSVDGWISVWQLTPL IPFISVSDFR--LT-----------AS-G--IPSTISVDGWFTVFQYTAL VPYISPSDYR--ET-----------RA-I--TNSVYSADGWFSLHKLTKI VPFISTVDFR--VN-----------VV-S--TSSAVNVDGWFSIFKLNAL VPYISVSQYR--MT-----------SG----ENTAISVCGWISMRYQTSF VPYISAVDFR--LC-----------AA-S--ASSVVNTDGWFTVWLLNSL VPFISATDFR--YN-----------QV-A--IASASNSDGWLTVWMLNPL VPFISASDFR--YN-----------SV-S--VSSALNSDGWLSVWLLNPL VPFISASDFR--YN-----------SV-S--VSSALNSDGWFTVWLLNPL VPFISACDFR--YN-----------TV-S--VSSALNSNGWISIWLMTPL IPFISAVDFR--LN-----------SS-A--RSSVLNSDGWFSVWLMSPL VPFISASDFR--FN-----------TS-S--VSNALNSDGWITVWLMNPL VPFISATDFR--YN-----------LV-S--VNSALNSDGWFTVWLLNPL VPYISSSQYR--QN-----------NV----DQTVLSYNGWVTVFQQTAL IPYISSVDFR--IN-----------SR-A--VASALNADGWLTIWILNPI VPFVSTVDFR--VN-----------NV-S--ISSAVNADGWFTIFLLNPL IPYISISSRR--FA-----------NT----TGTIFSYDGYVTVWYQTAV VPYISSSQYR--QN-----------NV----DQTTLSYNGWVTIFQQTAL VPYISSSQYR--QN-----------NL----TNTTLSYDGWVTIFQQTAL VPYISQSQYR--YN-----------NI----DGNIFSYDGFISMFYQTNI IPYISTSVYR--SS-----------ML----TNTTLSYDGWITMWYQTAI IPWTAGSQFR--YT-----------DPDT------YTHPGFISCWYQTSL IPWTSGVQFR--YT-----------DKD---------------------IPWTSGSQFR--YT-----------DPDT------YTHPGYISCWYQTSL IPYISQSQYR--FS-----------NI----SGNKLSYDGYITLWYQTAV VPWVSQTVYR--YN-----------HPK---EENALTYRGFVTVFYQTAL IPWTSGVQFR--YT-----------DKDT------YTSAGFLSCWYQTSL VPWVSASHYR--YT-----------TPDT------YSKAGYITCWYQTNF VPWVSASHFR--FT-----------TPDT------YSKAGYITCWYQTNF VPWISASHYR--YT-----------TPDT------YSKAGYITCWYQTNF VPWVSASHYR--LT-----------TPDT------YSKAGYITSWYQTNF IPWTSGVQFR--YT-----------DPDT------YTSAGFVSCWYQTSL VPWVSASHFR--FT-----------TPDT------YSKAGYITCWYQTNF IPFISTVQAR--YT-----------GV----EESTLSYCGYITAWLQTKL IPYISSSQYR--QT-----------NV----RETILSYNGWVTIWYQTAI IPWTSGVQYR--YT-----------DPDT------YTSAGFVSCWYQTSL IPWTSGVQFR--YT-----------DPDT------YTSAGYLSCWYLTSL VPWVSASHFR--YT-----------TPDT------YSMAGYITCWYQTNF VPWISASHYR--FT-----------TPDT------YSQAGYITCWYQTNF IPYISMSQFR--TT-----------VG----DTGFLSSSGTMTMWYQTSV VPWISASNYR--FT-----------TPDT------YSQAGYITCWYQTNF IPWTSGVQFR--YT-----------DPDT------YTSAGYLSCWYQTSL VPWISASQYR--FT-----------TPDT------YSSAGYITCWYQTNF IPWTSGVQFR--YT-----------DPDT------YTSAGFLSCWYQTSL IPWVSASHYR--FT-----------TPDI------YTLAGYVTCWYQTNL VPWVSQTVYR--YN-----------HPK---EENVLTYRGFLSVFHQTAL

2016/02/23, 3:08 PM


UniRef90_P03303_333_552 UniRef90_P07210_338_559 UniRef90_F6M9Y3_333_554 UniRef90_B9V459_336_557 UniRef90_B9V477_333_554 UniRef90_H9C6N6_333_552 UniRef90_A5GZE7_336_557 UniRef90_B9V485_333_552 UniRef90_G0Y2E0_419_588 UniRef90_G9K138_332_516 UniRef90_A5GZE9_336_557 UniRef90_B9V434_332_553 UniRef90_P04936_332_552 UniRef90_C7DUC8_336_557 UniRef90_G8IQ74_332_548 UniRef90_I2CMI9_334_554 UniRef90_B9V466_338_522 UniRef90_A5GZF9_333_554 UniRef90_G8IJE2_332_552 UniRef90_H8Y6Q0_168_390 UniRef90_G0YPI0_327_543 UniRef90_B9V473_333_554 UniRef90_B5BSU6_368_556 UniRef90_A8S322_365_548 UniRef90_G8IQ62_334_555 UniRef90_B9V453_331_552 UniRef90_G9K146_333_520 UniRef90_F6M9Z0_330_551 UniRef90_P12916_334_555 UniRef90_G5EN04_327_500 UniRef90_C7DUC6_357_551 UniRef90_Q9WN78_367_554 UniRef90_G0YPI1_326_499 UniRef90_G0YPH9_326_499 UniRef90_Q8UY33_326_552 UniRef90_A5GZE0_334_555 UniRef90_G0ZNT7_334_555 UniRef90_A7KC11_332_515 UniRef90_G1JYY7_238_455 UniRef90_H6UKU5_326_499 UniRef90_Q03053_367_554 UniRef90_Q995Z1_365_551 UniRef90_B9V442_331_555 UniRef90_G1CSA8_329_506 UniRef90_A5GZE4_333_554 UniRef90_G8IJF4_357_552 UniRef90_A5GZF2_336_558 UniRef90_A5GZF1_333_554 UniRef90_Q5U904_326_555 UniRef90_Q6JKR7_325_551 UniRef90_G8IJF0_360_553 UniRef90_A1E4A3_319_512 UniRef90_Q8QUZ6_317_541 UniRef90_Q2LL04_324_545 UniRef90_F6M9Y7_364_585 UniRef90_Q8V601_326_552 UniRef90_Q6JKS0_326_499 UniRef90_B3SRP1_326_550 UniRef90_G5CZJ4_357_550 UniRef90_B5BSU7_367_555 UniRef90_G8IRN3_333_554 UniRef90_A5GZE2_333_554 UniRef90_A7KC08_333_554 UniRef90_H9BP13_325_500 UniRef90_Q80GI2_332_555 UniRef90_B9V435_333_554 UniRef90_Q5G9Z5_326_554 UniRef90_Q9YLG5_370_557 UniRef90_G8IJE5_332_553 UniRef90_Q8V614_326_499 UniRef90_Q5GA06_355_555 UniRef90_G8IJG6_332_548 UniRef90_Q05ED6_367_555

13 of 17


IPWTSGVQFR--YT-----------DPDT------YTSAGFLSCWYQTSL VPWVSASHFR--FT-----------TPDT------YSSAGYITCWYQTNF VPWVSASHYR--FT-----------TPDT------YSQAGYITCWYQTNF VPWVSASHFR--YT-----------TPDT------YSAAGYITCWYQTNF VPWVSASHYR--FT-----------TPDM------YSLAGYITCWYQTNL IPWTSGVQFR--YT-----------DPDT------YTSAGHLSCWYQTSL VPWVSASHFR--YT-----------TPDT------YSAAGYITCWYQTNF IPWTSGVQFR--YT-----------DPDT------YTSAGHLSCWYQTSL VPWISQTAYR--FN-----------QPSTSADGNVLTYRGYISVFYQTAV VPWVSASHYR--NT-----------TPDT------YSQA----------VPWVSASHFR--YT-----------TPDN------YSSAGFITCWYQTNF IPWVSASHFR--NT-----------TPDT------YSKAGFVTCWYQTNF VPWISASHYR--NT-----------SPGR-------STSGYITCWYQTRL VPWVSASHFR--YT-----------SRDE------HSAAGFITCWYQTNF VPWISSHFYR--RT-----------KRDD------YTDGGYVTLWLQTAF IPWISSGFYR--NT-----------KSDD------HTEAGYVSLWYQTDF VPWVSSSHFR--YT-----------SRDE------HSAA----------VPWVSASHFR--NT-----------TPDT------YSLAGYVTCWYQTNL VPWISASHYR--NT-----------SPDI-------SSSGYITCWYQTGL VPWISQGYYR--HT-----------KADK------YTEAGFVTLWYQTDF VPWISNTHFR--TV-----------KTGG---YLDYYATGVVTIWYQTNF VPWISASNYR--FT-----------TPDA------YSQAGFITCWYQTNF VPWISQSHYR--LV-----------QQDE------YSAAGFISGWYQTNI VPWMSGTFHR--RT-----------KADN------YTQAGYVSLWYQTDF VPWVSASHFR--NT-----------TPDT------YSLAGYITCWYQTNL IPWISASHFR--NT-----------TPDT------YSKAGYVTCWYQTNF VPWVSASHFR--NT-----------TPDT------YSLAGYV-------VPWVSASHFR--NT-----------TPDK------YSLAGYITCWYQTNL VPWVSASHFR--LT-----------ANDK------YSMAGYITCWYQTNL IPWISNTHF----------------------------------------IPWMSSGFYR--RT-----------KSDE------YTHAGYVSLWYQTDF VPWISQTNYR--YV-----------TRDA------YTDAGYITCWYQTSI IPWISNSHY----------------------------------------VPWISNTHY----------------------------------------IPWISNTHYR--TQ-----------ATNN---YFEYYTSGIVTLWYQTNY VPWVSASHYR--NT-----------TPDT------YSSAGYITCWYQTNL VPWISSGFYR--NT-----------KSDN------HTEAGFVSLWHQTDF VPWVSASHYR--NT-----------TPDK------FSQA----------IPFISMSQYR--TT-----------TN----TTGFLSSAGTLSLWYQTSI IPWISNTHY----------------------------------------IPWISQTHYR--YV-----------VVDE------YTAGGYITCWYQTNI VPWISQTHYR--YV-----------QSDT------YTDAGFVTCWYQTSI VPWISASHYR--NT-----------TPDK------YSSAGYITCWYQTNL IPWISNSHF----------------------------------------VPWVSASHFR--NT-----------TPDT------YSLAGFITCWYQTNL VPWLSSGFYR--RT-----------ESDD------YTHAGYVSLWHQTDF VPWVSASHFR--FT-----------TPDT------YSAAGYITCWYQTNF VPWVSASHFR--NT-----------TPDT------YSLAGYVTCWYQTNL IPWISNTHYR--AM-----------GSND---YFDYYSAGIVTIWYQTNF IPWISNTHYR--AQ-----------SKNQ---YFDYYSSGIISIWYQTNF VPWISSNFYR--RT-----------KSDS------YTEAGYVSLWYQTDF IPWISGSHYR--MF-----------NNDA---KSTNANVGYVTCF----VPWISGGYFR--GV-----------ARTE---GYSYYNAGYITGWYQTNL VPWISASHFR--GV-----------SVDDTL-NYQYYAAGYVTMWYQTNM VPWVSASHFR--NT-----------TPDT------YSLAGYITCWYQTNL IPWISNTHFR--GT-----------STNG---VYNYYSSGIVTIWYQTNF IPWISNTHF----------------------------------------IPWISNTHFR--TN-----------ASGT---YFDYYTAGIVTIWYQTNF APWISSTFFR--RT-----------KADK------YSSGGIITLWHQTAF VPWISQTHYR--QV-----------KTDV------YTSAGYISGWYQTSI VPWIAQGYYR--HT-----------KSNH------YTEAGYITLWYQTDF VPWVSASHFR--NT-----------TPDT------FSSAGYISCWYQTNL VPWVSASHFR--NT-----------TPDK------YSLAGYITCWYQTNL VPWISNTHY----------------------------------------VPWISQTHYR--LV-----------DQDE------YTAAGFVSGWYQTNL VPWVSASHFR--NT-----------TPDK------YSLAGFITCWYQTNL IPWISNTHFR--TQ-----------ATGG---YFDYYTAGIVTIWYQTNF VPWISQTHYR--YT-----------VKDE------YTDSGYITCWYQTNV VPWVSASHYR--NT-----------TPDT------YSLAGFITCWYQTKL VPWISNTHF----------------------------------------IPWISNTHYR--AH-----------GDGG---YFDYYSTGIVTIWYQTNY IPWISAHNYR--RT-----------KADK------FTEGGYVSVWYQTTF VPWISQTHYR--FV-----------HEDV------YTSAGYVTAWYQTTI

2016/02/23, 3:08 PM


14 of 17


UniRef90_P23008_310_531 UniRef90_Q8JRP9_365_551 UniRef90_Q05EE3_367_555 UniRef90_Q8V604_326_552 UniRef90_C7DUC7_331_549 UniRef90_P12915_324_545 UniRef90_G8IJE1_331_509 UniRef90_A4UHT9_332_548 UniRef90_Q9QCF0_367_554 UniRef90_Q9QF31_325_500 UniRef90_Q65900_325_551 UniRef90_E5D8F2_334_553 UniRef90_A1E4A2_319_512 UniRef90_B9V440_332_553 UniRef90_Q6W9F4_332_507 UniRef90_G8IJH5_359_554 UniRef90_B1PZZ4_333_555 UniRef90_O89280_367_554 UniRef90_P32537_321_545 UniRef90_G0YPI2_326_499 UniRef90_Q9YLJ1_368_556 UniRef90_Q2YEN8_367_554 UniRef90_A7YF31_331_554 UniRef90_Q65481_317_544 UniRef90_Q2LKZ0_317_544 UniRef90_Q05ED0_367_555 UniRef90_Q8V5Z9_323_547 UniRef90_Q6W9F9_367_555 UniRef90_H8Y6P9_356_549 UniRef90_G5DC71_332_548 UniRef90_C6ZEZ9_341_560 UniRef90_Q05ED4_367_554 UniRef90_H6VBU4_358_522 UniRef90_Q8V398_325_495 UniRef90_D8VCT6_342_524 UniRef90_D9YV24_514_704 UniRef90_Q66577_367_555 UniRef90_A0MHB7_357_547 UniRef90_E9LS20_360_544 UniRef90_Q9WHH4_367_554 UniRef90_G0ZNT5_357_550 UniRef90_Q5YJA3_454_673 UniRef90_H9U0H0_456_678 UniRef90_Q6W9E8_367_554 UniRef90_Q80GI1_367_556 UniRef90_C7B298_377_565

VPWVSASHFR--LT-----------ADNK------YSMAGYITCWYQTNL IPWISQTHYR--YV-----------QSDA------YTDAGFVTCWYQTSI VPWISQTHYR--FV-----------HDNP------YTSAGYITAWYQTTM IPWISNTHYR--TQ-----------ATNN---YFEYYSSGIVTIWYQTNY APWISSTYFR--RT-----------KADK------YSSGGIISLWYQTDF IPWISASHFR--GV-----------SNDDVL-NYQYYAAGHVTIWYQTNM VPWVSASHFR--NT-----------TPD---------------------VPWISSHFFR--RT-----------RKDN------YTESGFVTLWHQTAF VPWISQTHYR--LV-----------QQDE------YTSAGYVTCWYQTSL VPWISNTHY----------------------------------------IPWISNTHYR--AH-----------AKDG---YFDYYTTGTITIWYQTNY VPWISSGFYR--RT-----------KADS------FTHGGYVSLWYQTAF IPWISGSHFR--MF-----------NSDA---KSINANVGYVTCF----VPWVSASHYR--NT-----------TPDT------FSLAGYITCWYQTNL VPWISQTHY----------------------------------------VPWVSASHFR--NT-----------TPDT------YSLAGFITCWYQTNL IPWISQTHYR--LV-----------QQDE------YTSAGNVTCWYQTGI IPWISQTHYR--FV-----------VADE------YTAGGFITCWYQTNV IPWISGSHYR--MF-----------NTDA---KAINANVGYVTCFMQTNL IPWISNTHF----------------------------------------VPWISQTHYR--MV-----------QQDE------YSAAGYITCWYQTNI IPWISQTHYR--LV-----------QQDE------YTSAGNVTCWYQTGI VPWISQSHYR--MV-----------HKDA------YTTAGYVTCWYQTNI VPWISSGHFR--AA-----------DINATLFKYKYYEAGFVTMWYQTNL VPWISSGHFR--GT-----------TLENTIYKYRYYERGYITMWYQTNM VPWISQTHYR--LV-----------KQDQ------YSAAGFITCWYQTNI IPWISNVMFR--NL-----------QSIA---GQPYFYAGIVTMWYQTNF VPWISQTHYR--LV-----------EHDE------YTSAGYVTCWYQTSI VPWMSAGFFR--HT-----------MKDK------YSSGGYITLWRQTDF IPWISSHYYR--RT-----------KKDS------YTEGGFVTLWHQTAF APWMSSTFYR--RT-----------KGDA------YTSGGYITLWYQTDF VPWISQTHYR--LV-----------DQDA------YTDAGNVTCWYQTGV IPYISPTYWR--PTLGFGNHNVRDNTNQPKPAQTTLDSLGVVSVWVYTRF IPWIS--------------------------------------------APWISNTDYR--RS-----------TKDD--------------------IPYFSSTPWK--TL-----------SRSTSLSLSVNQLAGWLGLYVYSPL VPWISQTHYR--LV-----------AQDE------YTSAGYITCWYQTNI IPWISSHFFR--RT-----------RKDN------FTEGGFVTLWHQTAF VPWISSGFYR--RT-----------KADN------YTEGGYVSLWYQTDF IPWISQAHYR--FV-----------EKDP------YSAAGYVTCWYQTGV APWISSTFFR--RT-----------KSDE------YTSGGIISLWHQTDF VPYVSPYDFSPVQTPYTKTDFPLVSTNVPITVDTPYWSKGYVTIWQYTNL VPYVSPYDFTPVRTSYTRTEIPPVQTTPKVLVDTPYWSKGYVSVWQYTNL VPWISQTHYR--FV-----------KEDS------YTDAGFITCWYQTSI VPWISHTHYR--LV-----------ERDE------YSAAGFITAWYQTNI

2WZR3 UniRef90_F1AW55_504_724 UniRef90_Q6PMU0_504_724 UniRef90_Q6PMU2_504_724 UniRef90_Q8V0G8_305_525 UniRef90_Q6PMT3_503_723 UniRef90_Q1L748_304_524 UniRef90_Q6PMT8_504_725 UniRef90_B8Y0J7_504_725 UniRef90_Q1L757_305_524 UniRef90_Q1L752_305_526 UniRef90_Q1L754_305_526 UniRef90_P49303_505_725 UniRef90_Q6PMY9_505_723 UniRef90_A2I8Z5_505_724 UniRef90_P15072_505_723 UniRef90_Q8JVD0_304_524 UniRef90_H9AY35_497_713 UniRef90_B0Z3W9_528_746 UniRef90_Q2XP17_533_745 UniRef90_Q100Y4_324_550 UniRef90_Q91LX8_542_768 UniRef90_A4ZKN2_415_639

H H H H H H H H H H H H K K K K H T P T T T T

S -

T F Y Y

D P P P

I A A V

A D N G

V V T C

E E E E E D D S S N S S A A A A D A S N P P P

K K K K K P P A A A A A E E D D P A S S T H T

D D D D D D D E E E E E Q G G A D N T K Q L N

G G G G G S S A A A A A D D D D S L S G A S S

A A A A A A A A A A A A T A A A A A E R D D D

V V V L V V V V V V V V L L L L V V L V I I I

I I V I V L L V V V V V V V V V L A L L L V L

V V V V V V V V V V V V V V V V V V V V V V T

T S S T S S S S S S S S S S L S S A L A F F L

V V V V V V V V V V V V V V A A V F F V L V V

S S S S S S S S S S S S S S S S S S S S S S S

A A A A A A A A A A A A A A A A A A S A A A G

G G G G G G G G G G G G G G G G G G G G G G G

P P P P P A T P P P P P K K K K A P R P L K D

D D D D D D D D D D D D D D D D D D D D D D D

F F F L L F L L L L L L F F F F L M F F F F F

E E E E E E E E E E E E E E D E E E Q S C S T

F F F F F L F F F F F F L F L L F F L L L L L

R R R R R R R R R R R R R R R R R R R R R R R

M M M L L L L F F F F F L L L L L F C H F F M

P P P P P P P P P P P P P P P P P P P P P P P

I L I I I I I I I I I I I V V V I C V V I I I

S S S S S N N D D D D D D D D D N E E D D D S

P P P P P P P P P P P P P A A A P P P L P

S S S S S A A V V V V V R R R R V V P T

R R R R R T P R R R R R S R T Q A K D K

Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q K -

Q -

2016/02/23, 3:08 PM


UniRef90_E3TMG9_417_639 UniRef90_P08544_417_642 UniRef90_B3VTU7_418_646 UniRef90_Q66776_543_769 UniRef90_G9FTJ7_414_638 UniRef90_Q02472_417_641 UniRef90_P12296_396_619 UniRef90_C3U5A3_447_672 UniRef90_G1DFA4_460_684 UniRef90_Q155Z9_448_665 UniRef90_B9VIN1_352_561 UniRef90_G8HZ08_715_947 UniRef90_B8XTQ3_353_566 UniRef90_D9D8F3_345_562 UniRef90_I1YLT4_348_565 UniRef90_B8XTP9_335_563 UniRef90_I1YLT7_349_565 UniRef90_I1YLT6_336_558 UniRef90_B8XTP8_334_562 UniRef90_B8XTQ0_353_567 UniRef90_Q5YJ95_381_603 UniRef90_B8XTQ4_341_566 UniRef90_I1YLT5_349_558 UniRef90_F6IA11_421_636 UniRef90_G0Z2U8_412_599 UniRef90_Q5YJA7_377_599 UniRef90_G0Y2E4_357_574 UniRef90_Q8B552_395_615 UniRef90_A7KC13_333_552 UniRef90_A5GZD6_337_514 UniRef90_G5CZJ8_367_551 UniRef90_G8HH17_373_575 UniRef90_G0Y2E3_380_601 UniRef90_B9V482_337_556 UniRef90_A5GZF6_334_555 UniRef90_A7KC10_335_556 UniRef90_G8IJG2_334_555 UniRef90_D2IW00_332_553 UniRef90_A5GZD9_331_550 UniRef90_A7KC07_334_555 UniRef90_Q672R3_805_1000 UniRef90_B5A1N0_416_617 UniRef90_B9V433_331_550 UniRef90_Q82081_333_552 UniRef90_Q5XLP5_336_557 UniRef90_B9V457_333_554 UniRef90_G1JYY8_404_619 UniRef90_F6N707_334_556 UniRef90_G5D5D9_333_552 UniRef90_Q82122_332_553 UniRef90_G5D5E2_333_552 UniRef90_A5GZF5_335_556 UniRef90_G0Y2E2_378_600 UniRef90_P03303_333_552 UniRef90_P07210_338_559 UniRef90_F6M9Y3_333_554 UniRef90_B9V459_336_557 UniRef90_B9V477_333_554 UniRef90_H9C6N6_333_552 UniRef90_A5GZE7_336_557 UniRef90_B9V485_333_552 UniRef90_G0Y2E0_419_588 UniRef90_G9K138_332_516 UniRef90_A5GZE9_336_557 UniRef90_B9V434_332_553 UniRef90_P04936_332_552 UniRef90_C7DUC8_336_557 UniRef90_G8IQ74_332_548 UniRef90_I2CMI9_334_554 UniRef90_B9V466_338_522 UniRef90_A5GZF9_333_554 UniRef90_G8IJE2_332_552 UniRef90_H8Y6Q0_168_390

15 of 17


T T T T T T T T T T T V T T T T T T T T V T T V V V V V V I V I I I V I V V V V V V I V V I V I V I V V I V V V I I V I V V V V V V V V V V

-

Y Y Y F Y F Y Y Y L Y Y Y Y Y Y Y Y Y Y V Y Y F V V V V L L T V L V V V V L V H V L L F T I V L V L V I L V V F V L F L V F T I F S T V I A

P P P P P P P P P P P P P P P P P P P P P P P A P P P P P P P P P P P P P P P P P P P P P P P P P P A P P P P P A P P P P P A P P P P -

L S A P A A P A A P A P P P P P P P P P P P P P P P P P P P P A P P P P P P P A P P P P P V P P P P P A P D P P P P P P V P P P P P P P G

G G N N N N G N N D N G G N Q G N N S S G Q N N G G G N D E N D E S G N C Q G G G Q Q N S G Q N N D N S E S N N N D N Q G N D Q N T N E S

V T T V T V C T T C T T T T T S T T T T A T T C A A A C T T C T T T T T T V T V A T T T T A T T T T T V T T T T T T T T A T A T T N T T T T

P P P P P P P P P P P P P P P P P P P P P P P P P P P P N N P P S P P P P E P P P Q S P P P P T P P P P T P P P P A P S P P P P D A P P T

N T P T Q P T T Q Q P T P P P P P P P P T P P S S T S S Q Q N H G N N N K Q N T S Q G N K A R G N N T H G D T N S G S G S T P N T G P P G

D N N R S S S H R S N T T T T T T T T T T Q T S T T T T K T Q T T S T S T T S T T T Q N Y T H Q T E T S Q N T S T T T T S T T R V Q N T Q

S S A A A S A S S P Q S Q Q Q Q Q Q Q Q C Q Q A C C C C V V C A V A A A A V A S C V V A A C A V A V A A V A A A A V A A A A A A G G A A G

H D D D D D K D D C H Q N Q Q Q Q Q Q Q Q A H V Q Q Q Q F Y A S Y D N N D Y N P Q Y Y N D Q D H E Y R E Y K N D R Y D Y D D R D A A K R A

I I I V I I I I V I I I V I I I I I I I L I I V L L I I I L L V L I M I I M M I L M L M I V I L M M M I L M I M M L M L M I L M I I M L I

L L L L L L L L L L L I V V V V V V L A V L V L V V V I I L V C L I L I I L L V V L L I I F I L L L I C L V I L I L L L L I L L M L L L L

T T T V T T T T V F V T V M M V M M M V V L L V V V L G G G C V S C C C C G C V C G S C C C C S C S C V S C C C C A C S C C C C V V C C V

L L L F L L M L F F M T M M M M M M L M T M M T T T L L F F F L F F F F F F F Y L F F F F T F F F F F L F M F F F F F F F L F F T T F F T

V V V F V V V V I A L V L L L L L L M M I A L A A V V V V I A A V V V V V V V A A I I V V V V I V I V C I V V V V I V I V V V V C C V V C

S S S S S S S S S S S A S S S S S S S S S S A A S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S

G A A A G A A G S A G A A A G A G A A A A A G A A A A A A A A V A G G A G A A A A A A G G A G A G A G A A A G A G A A A A A G A A G G A A

G G G G G G G G G G G G G G G G G G G G A G G G A A A S C C C T C C C C C C C S S C C C C C C C C C C T C C C C C C C C C C C C C C C C C

D D D S D N K D Q E S E E K A E S D S A D S Q E D D K D P P K S P K K K K P K N D P P K K D K P K P K S P K K K K P K P K K K K P P K K P

D D D D D D D D D D D D D D D D D D D D N D D D N N D N D D D D D D D D D D D N N D D D D N D D D D D D D D D D D D D D D D D D D D D D D

F F F F F F F F M Y F F F F F F F F F F F F F L F F F F F F F F F F F F F F F F F F F F F F F F F F F F F F F F F F F F F F F F M I F F M

T T T C T T S T C T S Q S S T S T S S S V S S E V V T V K K E V K C C C C K C T V K K C C C C K C K C V K C C C C K C K C C C C A S C C A

L L L L L L L L F L Y F Y F Y Y Y Y Y L L Y Y Y L L L F L L M M L L L L L L L F F L L L L F L L L L L M L L L L L L L L L L L L V V L L V

R R R R R R K R R R R R R R R R R R R R R R R R R R R R R R R R R R R R R R K R R R R R R R R R R R R R R R R R R R R R R R R R R R R R

M M M F M M M M L L V N L L L L L L L I L L I V L I L L L V L M M M M L M C I L L M M I M L M L M C L L M M M L M L M M M M M M M M M

P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P -

V I I V V I I V V I M I I I I I I I I I I V I -

T S S D T S S T D A D S S S S P H S S N S D D -

P P P P P P P P P P P P P P P P P -

T T S T A T P A P N P P P -

K K K K K -

-

-

2016/02/23, 3:08 PM


UniRef90_G0YPI0_327_543 UniRef90_B9V473_333_554 UniRef90_B5BSU6_368_556 UniRef90_A8S322_365_548 UniRef90_G8IQ62_334_555 UniRef90_B9V453_331_552 UniRef90_G9K146_333_520 UniRef90_F6M9Z0_330_551 UniRef90_P12916_334_555 UniRef90_G5EN04_327_500 UniRef90_C7DUC6_357_551 UniRef90_Q9WN78_367_554 UniRef90_G0YPI1_326_499 UniRef90_G0YPH9_326_499 UniRef90_Q8UY33_326_552 UniRef90_A5GZE0_334_555 UniRef90_G0ZNT7_334_555 UniRef90_A7KC11_332_515 UniRef90_G1JYY7_238_455 UniRef90_H6UKU5_326_499 UniRef90_Q03053_367_554 UniRef90_Q995Z1_365_551 UniRef90_B9V442_331_555 UniRef90_G1CSA8_329_506 UniRef90_A5GZE4_333_554 UniRef90_G8IJF4_357_552 UniRef90_A5GZF2_336_558 UniRef90_A5GZF1_333_554 UniRef90_Q5U904_326_555 UniRef90_Q6JKR7_325_551 UniRef90_G8IJF0_360_553 UniRef90_A1E4A3_319_512 UniRef90_Q8QUZ6_317_541 UniRef90_Q2LL04_324_545 UniRef90_F6M9Y7_364_585 UniRef90_Q8V601_326_552 UniRef90_Q6JKS0_326_499 UniRef90_B3SRP1_326_550 UniRef90_G5CZJ4_357_550 UniRef90_B5BSU7_367_555 UniRef90_G8IRN3_333_554 UniRef90_A5GZE2_333_554 UniRef90_A7KC08_333_554 UniRef90_H9BP13_325_500 UniRef90_Q80GI2_332_555 UniRef90_B9V435_333_554 UniRef90_Q5G9Z5_326_554 UniRef90_Q9YLG5_370_557 UniRef90_G8IJE5_332_553 UniRef90_Q8V614_326_499 UniRef90_Q5GA06_355_555 UniRef90_G8IJG6_332_548 UniRef90_Q05ED6_367_555 UniRef90_P23008_310_531 UniRef90_Q8JRP9_365_551 UniRef90_Q05EE3_367_555 UniRef90_Q8V604_326_552 UniRef90_C7DUC7_331_549 UniRef90_P12915_324_545 UniRef90_G8IJE1_331_509 UniRef90_A4UHT9_332_548 UniRef90_Q9QCF0_367_554 UniRef90_Q9QF31_325_500 UniRef90_Q65900_325_551 UniRef90_E5D8F2_334_553 UniRef90_A1E4A2_319_512 UniRef90_B9V440_332_553 UniRef90_Q6W9F4_332_507 UniRef90_G8IJH5_359_554 UniRef90_B1PZZ4_333_555 UniRef90_O89280_367_554 UniRef90_P32537_321_545 UniRef90_G0YPI2_326_499

16 of 17


V V I V V I I V I V V I I V V V V V I V V V V I V V I V V V V V V V I V V I V V V V V V V V V V V V V V V V V I V -

-

V V V V T A V P T V I A V V V V V P V V V V P V I A V V S V P V V V V V A V V S V V V V V G I S V V P T F V V A -

P P P P A P P P P P P P P P P S P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P -

P P P S P P P P S P E P T P A T P P S P P S A S P P T D A G P G P P P A D A P I P P V P D G P P I P P P A L V -

D N K P N N N N S D G N T S D G N D S N N G E V N G N G G D K S N N N D G D N G Q S G K G S G G G V N D G G G -

T T T N T T T T Q I A A T C T V T T Q T T A T N F F A A A T T Q T T T T A A T A T T T V T A D F N A A S T T T A A -

P P P D P P P P T P P A T P Q V P P V P P P P A P P P P P A P G P P P P P L A P S P P V P P P P G P P G P P P Q A -

N K T G S P Q Q S T T P G Q S T T A T R T T T G T N Q T T N T G T T T T T S S T L T Q A T T T N T A T G S T T S D -

E T D I T T T T Q T S V Q T D Q S T G S T S T T S T T S S V E Q T T S T Q T T S A S T Q S S T S T T T T T S N Q -

A A C G A A A A G S A A G C C S A A G A A A A G A A A A A G C G A A C A A C A A G C A S C A G A G C A G A A C C C -

N N R T K D R D A T Y D A S K T K R A K K Y N T T G R Y Y T K A K K E N R Y D Y C K D T Y Y T G S G Y S R R S S Y -

I I V I M I M M I I I M I I I I M M I M M I I I I I M I L I I V M M I L I I M I I I M I I I I I I V I I M M I I I -

I I L V L I L L L L I I L L L L L L L V L I I I I I L I I L L L L L L L I M L I M L L L L I V I M L V L L L M L V -

A C C A C C C C V C A C V C C C C C V C C A V A A M C A A A C V C C C C A C C A V C C C C A A M V C A A C C C C G -

M F F T F L F F T F L F T K F F F F T M F L L T L L F L L T F T F F F F L M F L T F F F F L T M T L L T F F F F M -

G V V C V V V V C V G V C I V V V V C V V A G C M V V A G C V C V V V V G V V G C V V V V G C I C A A C V V V V V -

A S S S S S S S S S A S S A S S S S S S S A A S A A S A A S S S S S S S A S S A S S S S S A S A S S A S S S S S A -

G G A G G A A A G A A G G A A A G G G A G A A A A A A A A G A A G G A A A A G A A A A A A A G A A A A A G G A A A -

C C C C C C C C C Q C C G C C C C C C C Q Q C Q Q C Q Q C C C C C C C Q C C Q C C C C C Q C Q C C Q C C C C C K -

K N P K K K K P N P K P E N N K K P K K K P P P P K R P P N P K K N K K N K P P N K S N P P P S N D P K K N N K -

D D D D D D D D D N D D N D D D D D D D N N D N N D N N D D D D D D D N D D N D D D D D N D N D D N D D D D D D -

F F L F F F F L F F F I F F F F F L F F F F M F F F F F I F M F F F F F F F F M F F F F F I F M F F M F F F F F -

C S S C C C C S S S C S C S S C C S C C T T S S S C T T S S A C C S C T S C T A S C S S S S S S S T S C C S S N -

L V V L L L L V V L L V M V V L L V L L L M V C F L M M V V V L L V L L V L M V V L V V L V F V V M V L L V V L -

R R R R R R R R R K R R R R R R R R R R R R R R R R R R R R R R R R R R R R R R R R R R K R R R R K R R R R R R -

M M M M M M M M L L M M I M L M M M L M L L M V I M L L M L M M M M M L M M L M M M L M L M I M M L M M M L M L -

P P -

-

-

-

-

-

-

-

2016/02/23, 3:08 PM



UniRef90_Q9YLJ1_368_556 UniRef90_Q2YEN8_367_554 UniRef90_A7YF31_331_554 UniRef90_Q65481_317_544 UniRef90_Q2LKZ0_317_544 UniRef90_Q05ED0_367_555 UniRef90_Q8V5Z9_323_547 UniRef90_Q6W9F9_367_555 UniRef90_H8Y6P9_356_549 UniRef90_G5DC71_332_548 UniRef90_C6ZEZ9_341_560 UniRef90_Q05ED4_367_554 UniRef90_H6VBU4_358_522 UniRef90_Q8V398_325_495 UniRef90_D8VCT6_342_524 UniRef90_D9YV24_514_704 UniRef90_Q66577_367_555 UniRef90_A0MHB7_357_547 UniRef90_E9LS20_360_544 UniRef90_Q9WHH4_367_554 UniRef90_G0ZNT5_357_550 UniRef90_Q5YJA3_454_673 UniRef90_H9U0H0_456_678 UniRef90_Q6W9E8_367_554 UniRef90_Q80GI1_367_556 UniRef90_C7B298_377_565

1

2 3 Variable

4

5 6 Average

I V V V V I V V V V I V Q S V V I V V A A V I

T -

V V V V V V V V P S P V P C V S P S T S S T V

P P P P P P P P P S P P P P P P P

P P S P P P D P G S P A A P S A G P P P P

D G G S N D G E S S N N F E N G S N G S G

T T T F F T A T S A S T N N T N G N T S S T A

P P P P P P P P N G G P T P P G T Q T P P Q S

T N T N N T T T G V G T V D S Q S P T S S S P

D K E Q H R S H V V V Q P Q D V A K V Q Q K H

C C C A A C A C G G G C I A C G G C G A A C C

I V V A S A D D Y A T T D T V S S Y T D D F Y

V V V I I M I I I I I I F I V I I I I F F I T

L L L L L L I L L M L L I A L M V M L L L M L

C C G M M C A G A V A C P V C V A C A V L C C

F F F F F F L F T T T F F F F T T F T F F L F

V V V V V V G I C C C V L I V C C V C V V V A

S S S A A S S S S S S S S R S S S S S F F S S

A A A A A A A A G A A A A G A A A G A A A A

C C C Q Q C Q C C C C C G G C C C C G G C C

N N N P P N S N P S P N K A N S N P E K N N

D D D N N D N D D D D D G D D D D D D D D D

F F F F F F F F L M L F F F F M F I Y Y F F

S S S S S S S S S S S S S E S S S S V V S S

V V V M L V L V V V V V F A V V V V L L V V

R R R R R R R R R R R R R R R R R R K K R R

M M L I I M L M M M M L L I M M L M G G L M

P P P P -

T S -

A S -

P -

T -

-

-

-

7 8 9 Conserved


17 of 17

2016/02/23, 3:08 PM

Supplementary Tables: Table S1

Supplementary References: 1 Goldenberg, O., Erez, E., Nimrod, G. & Ben-Tal, N. The ConSurf-DB: precalculated evolutionary conservation profiles of protein structures. Nucleic Acids Research 37, D323-D327, (2009). 2 Angermüller, C., Biegert, A. & Söding, J. Discriminative modelling of context-specific amino acid substitution probabilities. Bioinformatics 28, 3240-3247, (2012). 3 Biegert, A. & Söding, J. Sequence context-specific profiles for homology searching. Proceedings of the National Academy of Sciences 106, 37703775, (2009). 4 Katoh, K., Misawa, K., Kuma, K.-i. & Miyata, T. MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Nucleic Acids Research 30, 3059-3066, (2002). 5 Pupko, T., Bell, R. E., Mayrose, I., Glaser, F. & Ben-Tal, N. Rate4Site: an algorithmic tool for the identification of functional regions in proteins by surface mapping of evolutionary determinants within their homologues. Bioinformatics 18, S71-S77, (2002).