The effect of allopurinol on lowering blood pressure in hemodialysis ...
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Original Article
The effect of allopurinol on lowering blood pressure in hemodialysis patients with hyperuricemia Mojgan Jalalzadeh, Zeinalabedin Nurcheshmeh1, Ramin Mohammadi2, Nouraddin Mousavinasab3, Mohammad Hassan Ghadiani4
Departments of Nephrology of Imam Hossein Hospital of Shahid Beheshti University of Medical Sciences, 1Internal Medicine, Military hospital of Orumiyeh, 2Departments of Nephrology of Vali-e-Asr hospital of Zanjan University of Medical Sciences, 3Social Medicine, Zanjan University of Medical Sciences, 4Departments of Nephrology of Taleghani hospital of Shahid Beheshti University of Medical Sciences, Iran
Background: Hyperuricemia has been associated with the development of high blood pressure (BP). We studied the effects of allopurinol therapy in hyperuricemic hemodialysis (HD) patients with high BP. Materials and Methods: This single-blind, randomized cross-over clinical study involved 55 HD patients with serum uric acid level > 6.5 (men) and > 5.5 mg/dL (women). They were randomly divided in two groups, each of which went through two phases. Group-1 in phase-1 received 100 mg/day orally of allopurinol for three months; while Group-2 was given whatever medication they received prior to the study. After two months of washing period, the groups were crossed-over. The BP levels were measured before and after HD during the eight months study period. Results: Fifty-three patients completed the study (33 men and 20 women, with mean age of 55.8 years). Uric acid levels decreased significantly during the12 weeks of allopurinol therapy (7.71 ± 1.53 to 5.2 ± 1.2 P
