Clinical Trial published: 13 November 2017 doi: 10.3389/fimmu.2017.01528
Edited by: Valentin A. Pavlov, Northwell Health, United States Reviewed by: Sergio Iván Valdés-Ferrer, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico Rui Li, University of Pennsylvania, United States *Correspondence: Miles Berger
[email protected] MAD-PIA Investigators also include Senthil Radhakrishnan, James H. Carter, Jr., Shivanandan Lad, Ali Zomorodi, John Sampson, Takanori Fukushima, Owoicho Adogwa, Karen Clemmons, Carlos Conde, Omowunmi Olaleye, Naraida Balajonda, Jhoanna Aquino, Bonita Funk, Yi-Ju Li, William D. White. †
The Effect of Propofol vs. isoflurane anesthesia on Postoperative Changes in Cerebrospinal Fluid Cytokine levels: results from a randomized Trial Miles Berger1*, Vikram Ponnusamy 2, Nathaniel Greene1, Mary Cooter 1, Jacob W. Nadler3, Allan Friedman 4, David L. McDonagh 5, Daniel T. Laskowitz1,6,7, Mark F. Newman1,8, Leslie M. Shaw 9, David S. Warner1,7,10, Joseph P. Mathew1, and Michael L. James1,6 For the MAD-PIA Investigators† 1 Department of Anesthesiology, Duke University Medical Center, Durham, NC, United States, 2 University of Missouri School of Medicine, Columbia, MO, United States, 3 Neurosurgical Anesthesiology, Postanesthesia Care Unit, Department of Anesthesiology, University of Rochester, Rochester, NY, United States, 4 Department of Neurosurgery, Duke University Medical Center, Durham, NC, United States, 5 Department of Anesthesiology & Pain Management, Neurological Surgery, Neurology and Neurotherapeutics, University of Texas, Southwestern, Dallas, TX, United States, 6 Department of Neurology, Duke University Medical Center, Durham, NC, United States, 7 Department of Neurobiology, Duke University Medical Center, Durham, NC, United States, 8 Private Diagnostic Clinic, Duke University Medical Center, Durham, NC, United States, 9 Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 10 Department of Surgery, Duke University Medical Center, Durham, NC, United States
I
Specialty section: This article was submitted to Inflammation, a section of the journal Frontiers in Immunology Received: 15 August 2017 Accepted: 27 October 2017 Published: 13 November 2017 Citation: Berger M, Ponnusamy V, Greene N, Cooter M, Nadler JW, Friedman A, McDonagh DL, Laskowitz DT, Newman MF, Shaw LM, Warner DS, Mathew JP and James ML (2017) The Effect of Propofol vs. Isoflurane Anesthesia on Postoperative Changes in Cerebrospinal Fluid Cytokine Levels: Results from a Randomized Trial. Front. Immunol. 8:1528. doi: 10.3389/fimmu.2017.01528
Frontiers in Immunology | www.frontiersin.org
1
November 2017 | Volume 8 | Article 1528
Berger et al.
Anesthetic Effects on CSF Inflammatory Markers
Discussion: These data clarify the magnitude of neuroinflammation after intracranial surgery, and raise the possibility that a coordinated neuroinflammatory response may play a role in neural injury after surgery. Keywords: anesthesia, cerebrospinal fluid, cytokine, inflammation, isoflurane, propofol, surgery, neuroinflammation
INTRODUCTION
lumbar CSF drain placement were enrolled in the Markers of AD after Propofol vs. Isoflurane Anesthesia (MAD-PIA) trial (20). MAD-PIA was a prospective randomized trial registered with http://www.clinicaltrials.gov (NCT01640275) on June 20, 2012 by Miles Berger, the study PI. Patients were excluded if they were (1) unable to provide informed consent, (2)
