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Sep 26, 2016 - Silicone breast implants have been used for breast augmentation and reconstructive surgery for the past 40 years. Capsular contrac- ture is a ...
ORIGINAL ARTICLE

https://doi.org/10.14730/aaps.2016.22.3.129 Arch Aesthetic Plast Surg 2016;22(3):129-134 pISSN: 2234-0831  eISSN: 2288-9337

aaps Archives of Aesthetic Plastic Surgery

The Effects of Vascular Endothelial Growth Factor on Capsule Formation around Silicone Implant in Rats Da Han Kim1, You Seong Song2, Seung Yong Song3, Chung Hun Kim2 Yonsei E1 Plastic Surgery Clinic, Anyang; Department of Plastic and Reconstructive Surgery, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam; 3Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine, Seoul, Korea 1 2

No potential conflict of interest relevant to this article was reported.

Background The purpose of this study was to examine the effects of a single administration of vascular endothelial growth factor (VEGF) in promoting the angiogenesis and thereby reducing the formation of capsular contracture. Methods We treated 24 female Sprague-Dawley rats with (1) 5 mM Tris Buffer and 150 mM NaCl 0.1 cc, (2) VEGF 15 μg/0.1 cc, (3) VEGF 150 μg/0.1 cc during placement of the implant, or (4) VEGF 150 μg/0.1 cc and VEGF 300 μg/0.2 cc. We histopathologically measured the thickness of the capsule and the number of blood vessels. Results All experimental groups had a significant difference in the thickness of the capsule compared to the control group (P

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