efficacy and safety of valproic acid (VPA) treatment in patients with retinitis pigmentosa. Methods or Study Design: Prospective evaluation of 48 eyes of.
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The Efficacy and Safety of Valproic Acid in the Treatment of Retinitis Pigmentosa Yüksel Totan, Emre Güler, Aslihan Yüce, Mehmet Serdar Dervisogullari Turgut Özal University Medical Faculty Department of Ophthalmology, Ankara, Turkey
Introduction: The purpose of this study was to determine the efficacy and safety of valproic acid (VPA) treatment in patients with retinitis pigmentosa. Methods or Study Design: Prospective evaluation of 48 eyes of 24 patients (13 male, 11 female) with a diagnosis of retinitis pigmentosa prescribed VPA was performed. The length of VPA treatment was 6 to 12 months. Parameters evaluated were best corrected visual acuity (BCVA) (LogMAR), visual field analyses (VFA) with Humprey automated perimetry, multifocal electroretinography (ERG) with Roland-RETI scan and VPA side effects. Results: Mean age of the patients was 34.3 ± 10.3 years (range 18–56 years). Eleven of the patients (22 eyes) had two ERG and VFA tracings allowing comparison between baseline and followup (range 6–12 months). Mean BCVA before and after VPA therapy was 0.36 ± 0.38 and 0.36 ± 0.37, respectively, and was not different statistically (p = 0.32). Quantitative perimetric indices including mean deviation (MD) and pattern standard deviation (PSD) were not significantly changed after VPA therapy (p > 0.05). P1 amplitudes (in terms of nV/deg2 and mV) of ERG waves and their P1 latencies were not significantly changed in all the rings after VPA therapy (p > 0.05). Similarly, there was no significant change in N1 amplitudes and N1 latencies after VPA therapy in any of the rings (p > 0.05). Conclusions: In this prospective study, no significant difference was observed in BCVA, VFA and ERG parameters following VPA therapy, yet requires to be verified by the future larger studies. Keywords: Valproic Acid, Retinitis Pigmentosa, Visual Field Analyses, Multifocal Electroretinography.
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Complex Estimation of Efficiency Treatment Optic Neuritis on Neuroimaging Techniques Halidjan Mahamadjanovich Kamilov, Munirahon Sadikjanovna Kasimova, Gavhar Khusanovna Khamraeva Tashkent Institute of Postgraduate Medical Education, Tashkent, Uzbekistan
Introduction: Tractography allows obtaining more detailed information about the orientation and curvature of the white matter pathways in passing through the entire brain. On tractography changes point to defeat fiber optic tract extending from the beginning of optic tracts to the cerebral cortex and reflects the degree of damage to different levels of the visual system. The aim of this study was to investigate the effectiveness of complex treatment optic neuritis with the use neuroprotectors by magnetic resonance tractography.
Abstracts
Methods or Study Design: The object of the study was 23 patients (23 eyes) with optic neuritis. Depending on the kind of treatment were allocated two groups of patients. The control group consisted of 11 patients (11 eyes), who received standard treatment: anti-inflammatory, decongestants, desensitizing therapy. Patients on main group (12 patients, 12 eyes), taken a course gliatilin (choline alfosterat) on tablets of 0.4 g 3 times a day during 2 months. All patients were performed by standard ophthalmic techniques and special methods of investigation. MR tractography conducted on magnetic – resonance imaging BRIVO-355/1.5 Tesla GE (USA). Results: After a course of treatment in the control group, 7 patients been preserved thinning fiber optic radiations, at 3 – was observed a few filaments of fibers the break occipital forceps on place of attachment to the beam of optic radiations. In the main group of 8 patients after treatment with neuroprotective therapy relationship fibers of the optic tract was restored. Thinning of fiber occipital forceps on the site of attachment to the beam optic radiation after treatment was visualized within the norm. Conclusions: changes on magnetic resonance tractography in patients with optic neuritis may serve as objective criteria for evaluation of effectiveness of the treatment. Keywords: Magnetic Resonance Tractography, Optic Neuritis.
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Early Retinal Vascular Caliper Changes After Intravitreal Ranibizumab in Eyes with Diabetic Macular Edema Murat Aslankurt, Muhammet Mustafa Kurt, Osman Cekic, Burak Erden, Cetin Akpolat, Mustafa Elcioglu Department of Ophthalmology, Okmeydani Training and Research Hospital, Istanbul, Turkey
Introduction: This study investigated alterations in retinal vessel calipers following intravitreal ranibizumab injection for diabetic macular edema. Methods or Study Design: Thirty eyes of 30 patients (16 male, 14 female, mean age: 60.9 years) underwent intravitreal injection of ranibizumab (0.5 mg/0.05 cc). Central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE) and artery/vein ratio (AVR) were determined by using a software on color fundus photographs at baseline and one week after injection. Wilcoxon signed rank test and Spearman correlation test were applied for statistical comparisons. Results: At post-injection seventh day, retinal vessel analysis showed a reduction of mean (± standard deviation) CRAE from 175.4 ± 51.4 μm (baseline) to 169.0 ± 30.9 μm (P < 0.05). CRVE also constricted from 235.3 ± 40.2 μm to 216.9 ± 38.1 μm (P < 0.05). Similarly, AVR reduced to 0.781 from 0.749 (P < 0.05). Central macular thickness determined by optical coherence tomography did not correlate neither with CRAE nor with CRVE (rho: 0.348, P > 0.05; and rho: 0.134, P > 0.05, respectively). Conclusions: Intravitreal ranibizumab may affect retinal vessel diameters in eyes with diabetic macular edema. Keywords: Retinal Vessel Diameter, Diabetic Macular Edema, Ranibizumab.
Ophthalmologica 2014;232(suppl 2):1–98 DOI: 10.1159/000368726
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