RESEARCH ARTICLE
The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life Annalisa Deodati1☯, Josepmarı´a Argemı´2☯, Daniela Germani3, Antonella Puglianiello1, Anna Alisi4, Cristiano De Stefanis4, Roberto Ferrero2, Valerio Nobili4, Toma´s Arago´n2‡, Stefano Cianfarani1,5‡*
a1111111111 a1111111111 a1111111111 a1111111111 a1111111111
1 Dipartimento Pediatrico Universitario Ospedaliero, ‘Bambino Gesu`’ Children’s Hospital–University of Rome Tor Vergata, Rome, Italy, 2 Division of Hepatology and Gene Therapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain, 3 Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy, 4 Hepatometabolic Unit, ‘Bambino Gesu`’ Children’s Hospital, Rome, Italy, 5 Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden ☯ These authors contributed equally to this work. ‡ These authors are joint senior authors on this work. *
[email protected]
Abstract OPEN ACCESS Citation: Deodati A, Argemı´ J, Germani D, Puglianiello A, Alisi A, De Stefanis C, et al. (2018) The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life. PLoS ONE 13(6): e0198490. https://doi.org/10.1371/journal. pone.0198490 Editor: Arun Rishi, Wayne State University, UNITED STATES Received: February 21, 2018 Accepted: May 18, 2018 Published: June 13, 2018 Copyright: © 2018 Deodati et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: The authors received no specific funding for this work. Competing interests: The authors have declared that no competing interests exist.
Early life events are associated with the susceptibility to chronic diseases in adult life. Perturbations of endoplasmic reticulum (ER) homeostasis activate the unfolded protein response (UPR), which contributes to the development of metabolic alterations. Our aim was to evaluate liver UPR in an animal model of intrauterine growth restriction (IUGR). A significantly increased expression of X-box binding protein-1 spliced (XBP1s) mRNA (p