two main outcomes of interest were TB infection and. TB disease. Analysis of risk factors for TB infection compared TB exposed uninfected children to those with.
Golla et al. BMC Infectious Diseases (2017) 17:593 DOI 10.1186/s12879-017-2668-2
RESEARCH ARTICLE
Open Access
The impact of drug resistance on the risk of tuberculosis infection and disease in child household contacts: a cross sectional study Vera Golla1, Kathryn Snow2, Anna M. Mandalakas3, Simon H. Schaaf1, Karen Du Preez1, Anneke C. Hesseling1* and James A. Seddon1,4*
Abstract Background: The relative fitness of organisms causing drug-susceptible (DS) and multidrug-resistant (MDR) tuberculosis (TB) is unclear. We compared the risk of TB infection and TB disease in young child household contacts of adults with confirmed DS-TB and MDR-TB. Methods: In this cross-sectional analysis we included data from two community-based contact cohort investigation studies conducted in parallel in Cape Town, South Africa. Children 18 months) or DNA polymerase chain reaction (PCR; children
