Accepted Manuscript The impact of serum trans fatty acids concentration on plaque vulnerability in patients with coronary artery disease: Assessment via optical coherence tomography Yoshinori Nagasawa, Toshiro Shinke, Ryuji Toh, Tatsuro Ishida, Hiromasa Otake, Tomofumi Takaya, Daisuke Sugiyama, Takayosi Toba, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Natsuko Tahara, Yuto Shinkura, Kenzo Uzu, Daiji Kashiwagi, Koji Kuroda, Yuichiro Nagano, Hiroyuki Yamamoto, Kenichi Yanaka, Yoshiro Tsukiyama, Ken-ichi Hirata PII:
S0021-9150(17)31171-1
DOI:
10.1016/j.atherosclerosis.2017.06.922
Reference:
ATH 15121
To appear in:
Atherosclerosis
Received Date: 1 March 2017 Revised Date:
18 June 2017
Accepted Date: 27 June 2017
Please cite this article as: Nagasawa Y, Shinke T, Toh R, Ishida T, Otake H, Takaya T, Sugiyama D, Toba T, Kuroda M, Takahashi H, Terashita D, Tahara N, Shinkura Y, Uzu K, Kashiwagi D, Kuroda K, Nagano Y, Yamamoto H, Yanaka K, Tsukiyama Y, Hirata K-i, The impact of serum trans fatty acids concentration on plaque vulnerability in patients with coronary artery disease: Assessment via optical coherence tomography, Atherosclerosis (2017), doi: 10.1016/j.atherosclerosis.2017.06.922. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
The Impact of serum trans fatty acids concentration on plaque vulnerability in patients with coronary artery disease: Assessment via
RI PT
optical coherence tomography
Yoshinori Nagasawaa, Toshiro Shinkea*, Ryuji Toha, Tatsuro Ishidaa, Hiromasa
SC
Otakea, Tomofumi Takayaa, Daisuke Sugiyamab, Takayosi Tobaa, Masaru
Kurodaa, Hachidai Takahashia, Daisuke Terashitaa, Natsuko Taharaa, Yuto
M AN U
Shinkuraa, Kenzo Uzua, Daiji Kashiwagia, Koji Kurodaa, Yuichiro Naganoa, Hiroyuki Yamamotoa, Kenichi Yanakaa, Yoshiro Tsukiyamaa, Ken-ichi Hirataa
a
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe
TE D
University Graduate School of Medicine, Kobe, Japan b
Department of Preventive medicine and Public Health, School of Medicine, Keio
EP
University, Tokyo, Japan
AC C
*Address for Correspondence: Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine. 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
E-mail address:
[email protected] (T. Shinke)
ACCEPTED MANUSCRIPT
Abstract Background and aims: Recent epidemiological studies have showed that
development
of
coronary
artery
disease
(CAD)
RI PT
excessive intake of trans fatty acids (TFA) can be a residual risk for the even
under
medical
SC
management, including statins. This study aimed at investigating the association
M AN U
between lipid profile, including serum TFA concentration, and plaque vulnerability using optical coherence tomography (OCT).
Methods: Level of serum elaidic acid, a major TFA component, was measured using gas chromatography in 161 consecutively enrolled patients with CAD
TE D
under guideline-directed risk factor management. OCT was performed to evaluate morphological features of angiographic intermediate stenosis (30%
