17:316A, 1998. Institute for Prostate Cancer Research and the Daniel Freeman Marina Hospital, Marina del. Rey, CA. Proc Amer Soc Clin Oncol 17:316A, 1998.
Strum SB, Scholz MC, McDermed JE: The Androgen Deprivation Syndrome: the incidence and severity in prostate cancer patients receiving hormone blockade. Proc Amer Soc Clin Oncol 17:316A, 1998. Institute for Prostate Cancer Research and the Daniel Freeman Marina Hospital, Marina del Rey, CA. Proc Amer Soc Clin Oncol 17:316A, 1998. We report the incidence and severity of common ADS symptoms in 77 hormone-naïve PC pts treated consecutively with a LHRH agonist and an anti-androgen. ADS was graded as absent(0), occasional(1), frequent/bothersome(2) or requiring drug treatment(3). Our findings are listed below: Signs and symptoms Hot flushes Mental/emotional changes Weakness Bone and joint pain Anemia Hypercholesterolemia Gynecomastia
Onset (mo.) 1-2 1-2+ 1-4+ 2-6+ 2-12 4-6 >12
Incidence and grade of severity #pts(% pts with ADS/total pts) 0-1 2-3 Total 18(23%) 19(26%) 37(48%) 2(3%) 11(13%) 13(17%) 39(51%) 4(5%) 43(56%) 20(26%) 3(4%) 23(30%) 25(32%) 10(13%) 35(45%) 14(18%) 26(34%) (52%) 14(18%) 15(19%) 29(38%)
Grade 2-3 anemia was more common in pts receiving flutamide v bicalutamide(P15mo v
