Nephrol Dial Transplant (2010) 25: 3593–3599 doi: 10.1093/ndt/gfq262 Advance Access publication 25 May 2010
The relationship between serum uric acid and chronic kidney disease among Appalachian adults Loretta Cain1, Anoop Shankar1, Alan M. Ducatman1 and Kyle Steenland2 1
Department of Community Medicine, West Virginia University School of Medicine, 1 Medical Center Drive, Morgantown, WV 26506-9190, USA and 2Department of Environmental and Occupational Health, Rollins School of Public Health, 1518 Clifton Road, Atlanta, GA 30322, USA Correspondence and offprint requests to: Anoop Shankar; E-mail:
[email protected]
Abstract Background. Higher serum uric acid (SUA) levels have been shown to be associated with cardiovascular disease. SUA levels are also associated with hypertension, a strong risk factor for chronic kidney disease (CKD). However, it is unclear whether SUA is independently associated with CKD. We examined the hypothesis that higher SUA levels are positively associated with CKD. Methods. We analysed data from the C8 Health Study, a population-based study of Appalachian adults aged ≥18 years and free of cardiovascular disease (n = 49,295, 53% women). SUA was examined as genderspecific quartiles. The outcome of interest was CKD (n = 2,980), defined as an estimated glomerular filtration rate of
