butyrate were measured by the procedures of Mellanby and William- son (16) and ..... Adam, P. A. J., and Haynes, R. C., Jr. (1969) J. Bwl. Chem. 244,. 12.
Vol. 259, No. 12, Issue of June 25, pp. 7525-7531,1984 Printed in U.S.A.
THEJOURNAL OF BIOLOGICAL CHEMISTRY Q
1984 by The American Society of Biological Chemists, Inc.
The Stimulation of Hepatic Gluconeogenesisby Acetoacetate Precursors A ROLE FOR THE MONOCARBOXYLATE TRANSLOCATOR* (Received for publication, May 3,1983)
Tarun B. Patel$, Lynn L. Barron, and MerleS . Olson From the Department of Biochemistry, The University of Texas Health Science Center, SanAntonio, Texas 78284
Stimulation of the rate of entry of monocarboxylates such The regulation of the gluconeogenic pathway from the 3-carbon precursors pyruvate, lactate, and alanine as pyruvate into the mitochondrial compartment due to exwasinvestigatedintheisolatedperfusedrat liver. change with mitochondrially generated acetoacetate results Usingpyruvate (
