Thymic Stromal Lymphopoietin (TSLP) - Clinical and Translational ...
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Thymic Stromal Lymphopoietin (TSLP) - Clinical and Translational ...
Jun 26, 2015 - 2St. PaulLs Hospital, University of British Columbia, Vancouver, British ... Full list of author information is available at the end of the article.
Denburg et al. Clinical and Translational Allergy 2015, 5(Suppl 4):O3 http://www.ctajournal.com/content/5/S4/O3
ORAL PRESENTATION
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Thymic Stromal Lymphopoietin (TSLP) promotes human eosinophil-basophil in situ hemopoieisis, and its secretion from human nasal epithelium is a function of TSLP genotype Judah Denburg1*, Claudia Hui1, Helen Neighbour1, Delia Heroux1, Loubna Akhabir2, Andrew Sandford2 From The 10th Symposium of Experimental Rhinology and Immunology of the Nose (SERIN 2015) Stockholm, Sweden. 19-21 February 2015 Background Allergic diseases are characterized by tissue eosinophilic and basophilic inflammation. There is substantial evidence that this particular inflammatory profile results from the migration to tissues of a common eosinophil-basophil (Eo/B) progenitor that undergoes a differentiative process regulated by local cytokines, termed in situ hemopoiesis. We therefore investigated the role and mechanisms of TSLP involvement in human Eo/B in situ hemopoiesis in relation to atopy. Also, since candidate gene and genomewide association studies have identified ‘protective’ associations between the single nucleotide polymorphism (SNP) rs1837253 in the TSLP gene and risk for allergy, asthma and airway hyper-responsiveness, we evaluated the secretion of TSLP protein from primary nasal epithelial cells (NEC) in relation to rs1837253 genotype. Methods Peripheral blood CD34+ cells derived from atopic and nonatopic individuals were stimulated with and/or IL-3, IL-5, or GM-CSF and assessed for Eo/B colony forming units (CFU) in both methylcellulose and nasal epithelial/ CD34+ cell air-liquid interface (ALI) co-cultures, and cytokine surface receptor expression by flow cytometry. Genotyping was performed using a commercially available TaqMan® genotyping assay. Results ∘ TSLP preferentially enhanced IL-3/TNFa-dependent Eo/B CFU from CD34+ cells;
∘ Eo/B CFU and TSLPR expression were significantly increased in atopic-derived CD34+ cells post TSLP(p
