Apr 13, 2011 - determine optimal timing of ART initiation in relation to TB treatment. Acid-fast ..... analysis of hospitalised Thai patients receiving both ART and ...
NIH Public Access Author Manuscript N Engl J Med. Author manuscript; available in PMC 2011 April 13.
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Published in final edited form as: N Engl J Med. 2010 February 25; 362(8): 697–706. doi:10.1056/NEJMoa0905848.
Timing of Initiation of Antiretroviral Drugs during Tuberculosis Therapy Salim S. Abdool Karim1,2, Kogieleum Naidoo1, Anneke Grobler1, Nesri Padayatchi1, Cheryl Baxter1, Andrew Gray1, Tanuja Gengiah1, Gonasagrie Nair1, Sheila Bamber1, Aarthi Singh1, Munira Khan1, Jacqueline Pienaar1, Wafaa El-Sadr2,3, Gerald Friedland4, and Quarraisha Abdool Karim1,2 1 Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa 2
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA
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3
International Center for AIDS Care and Treatment Programs (ICAP), Yale University School of Medicine, New Haven, USA 4
Department of Internal Medicine and Epidemiology, Yale University School of Medicine, New Haven, USA
Abstract Despite high mortality rates in tuberculosis patients with HIV co-infection, there is continued controversy on when to initiate antiretroviral therapy (ART) in these patients. Methods—We conducted an open-label randomized controlled trial in Durban, South Africa to determine optimal timing of ART initiation in relation to TB treatment. Acid-fast bacilli (AFB) smear positive tuberculosis patients with HIV infection and CD4+ counts
