TISSUE AND PARALOGUE SPECIFIC FUNCTIONS

Biochemical Journal Immediate Publication. Published on 04 May 2011 as manuscript BJ20102099


    
      
    
  
  

sc rip

t




     

     !" # $%&    '()*+   &* ,-*)'   '  .,-*) / 01 2- !!   ,3)+  + ,3,-* ,3 4 " #-
 2& #- ,5

nu

 !"#$

# $%& !)6//!! .78988:;78.78988:;79?! '()*+   &* ,-*)' 

ce

pte d



Ma

(-88 8; 
  !  ))* "$5' * @5/&=5 * @5/&(=C  /*  *>* = G   55@ /& (=
  
   = 51   5@ 1 & (*= '
 H( /& /=  C  * @5 *= %5+  )*  *  = C#%7 ( )7 % I(( @ )=+55@D /@ 5= #C1     (= 51  (> ( )@- (= F1@1  F-  @ 1= G1     & *@  /& (=5J * & * =5  =J%@E )&&4) E=1 &)1(*=K# *&/!  "!+" %*  /*  )*  &  @ * &  /* - / /(**!
      ()%1@ *& >()&&)* /*  /  H* -   4 * @5  LDM!
    ( )   55@ /& ( AG B    & *  @/& (@D A1 @DB  (   ) 7 AC#%7  (> ( )@- ( A51B   I(( @  ) A%B - /&H(& ) (/ L;M!C &)* )  ( ) - / )  -/       
   - /4 )     (& & (* @  @/ A-4L)- 5( &**( ( -  )!  
   >( - 5= ) /  )   5@ (! 0 )   )  ( &(/ )( &&4)5@)*

 * >/  ( @   >( ( 
  ! 0 - /

@)@)  ) > )  )! 5

 &   ( *  - * /  (*(= 4- 4 )  )   ) 5@D    & *

- / (( ( &*/!0 4 4 &5@;4-E@>))*! 5F(    &

 /  5  & *- (

* * ( * /   (& E@>!

- * (  &&)5( &-)
  !  #"""&$5)
  

 Licenced copy. Copying is not permitted, except with prior permission and as allowed by law. © 2011 The Authors Journal compilation © 2011 Portland Press Limited



Biochemical Journal Immediate Publication. Published on 04 May 2011 as manuscript BJ20102099

sc rip

nu

Ma

pte d

ce

Ac

THIS IS NOT THE VERSION OF RECORD - see doi:10.1042/BJ20102099

t

- -*)/ H*- - H)- ((! ) (   /  ) )*     /* * @5 *  4  *H)))** @5L8M!(&H*  (   &  ) (    )*  -  / &* ) /* ) & * (  (( (        ( > (     (& ( /   ) & ) )*  -
@>! 5* @ 5*4/F(()*(&4/ L9M*  L?M )  - () ) LNM ) )&LOM )/)
  LD:M  )/ 

&))** @5 LDDM! C4-   /(*  (( ) )* *  5   )  *    &H(

 & )  H*- / )LD;M)  )- / *

 !
 )(

 * @5/&(A5B/ F  ( )* * @5  * @5@ H& H*     & * )LD;M!5) *(/ * @5/&(& * 5  &(#@ * @5 /& A5'B4

!(*( / 54&

*) /- - )/ H(/&/A'
BLD(D:'() N9 4  H( ** / /)  H J &  1  //-(  

LD7M!5'D & &   / )  

 * ( >   /  / (* * * & *-*LD8M! @   4  5'D  ) ) P@   4 )    4 (@4@4@(  > /  LD9M!  & *   )@   ) &  /4 @    ()

*  /& ) )* * @5 4 &))*A((> *D+BLD?M! 5 & /  5( * 

) (&&   LDNM /((-/ )



 (

   */ !&)5'D/( (@(  /*  *   LDOM   4    )  (( 

  --   &4   

  L;:M       L;DM! '(  ) * @5 /& ( A5/DB      -&4 (/&

)/ *  - ) -*@ &  )*      (& ( L;;@;

 Licenced copy. Copying is not permitted, except with prior permission and as allowed by law. © 2011 The Authors Journal compilation © 2011 Portland Press Limited



Biochemical Journal Immediate Publication. Published on 04 May 2011 as manuscript BJ20102099

sc rip

nu

Ma

pte d

ce

Ac

THIS IS NOT THE VERSION OF RECORD - see doi:10.1042/BJ20102099

t

 & * ( *   ( * @5 ) * *    ((  /* )) ) * @5   -* ) H*  & * @5 />*   * @5 *        *  5.   *  )  @( * ) )**A-4LD; D8MB!
(44->))>5( &)& )*  > 
  ! 0   *  )   * @5 /& (  ( *   >( (   - () ) 

(   " & "#    0 4   &   L;OM!  )

4&  4 (-/*
   J.0 @*(#; 1D797  !"#$)

4&4(-/*# )  >(  5  Q#
  R  $(. #%&'('$   &#)"!$ !#""$!5

 4 - #; (!04(;:S#J+(  48: ! *   +        

  4   /* & 
     /* & 4 * @(   ,2@ &!    !#$   

 4)/*1&(8T@J5JJJJ5JJ5J@ B--  - 4 & & J(  -! 8 AJ( )4   $

   ) ,5B!
 2  6      51 (* 4 ()  //* !;:D:L& &'* L*  ACB   / ) )-   N: Z! /F *   )*  * A%5+ B4>/*)>A:!8BC;AD!8B! &(4))( - )#;!  (  4  -  > A7:@8: WB   %5+  4  *H /* & &(*   (  O::; F(( 4  '@05\   A5&   &    ) ,5B!%5+ 4)/*(  ) % A+ `  4B!(4 ()/*&'T@! .     ( 4 /))LD:+@C (C?!8  7:+# MA;::WB*(,'@ ;::A'& &  &B!5 /))A;::WB'A:!DXB

 Licenced copy. Copying is not permitted, except with prior permission and as allowed by law. © 2011 The Authors Journal compilation © 2011 Portland Press Limited



Biochemical Journal Immediate Publication. Published on 04 May 2011 as manuscript BJ20102099

sc rip

nu

Ma

pte d

ce

Ac

THIS IS NOT THE VERSION OF RECORD - see doi:10.1042/BJ20102099

t

4 ( 4 /@-@7 Z ) !( 4 ( DN::: & ) 8   7 Z  (  4  &  [/ [@5*_&)A
-&  /  )  ,5B! 9 2   .  2     F )  ( &)4

* &&(&  \-D!N!  !&"
#
  ,+*-!+" & +%&)".(#+#  /+-+"! 
   &  - & * - ( &  * @5 /&!5 &)5)
  ( &4 5'D  * 5/D A%&! DB   5@D & @9  +55@D A+/@5@DB

F)(/ *

& /& L ) )*  L