Article DOI: 10.1002/bkcs.11467
B. T. Ramanjaneyulu et al.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
Towards Versatile Continuous-Flow Chemistry and Process Technology Via New Conceptual Microreactor Systems Bandaru T. Ramanjaneyulu,† Niraj K. Vishwakarma,† Shinde Vidyacharan,† Praveen Reddy Adiyala,† and Dong-Pyo Kim* Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea. *E-mail:
[email protected] Received December 26, 2017, Accepted April 9, 2018 In the past decade, microreaction technology has been attracted much attention to the scientific community as one of the subareas in chemical synthesis. The microreactor improves the yield with higher selectivity, and also facilitates the reactions by simple, safe, fast, and green approaches. This review gives an overview on our contributions to develop versatile continuous-flow syntheses and process technology by exampling gas–liquid binary phase in modified PDMS microreactors, and process intensification for safe operation of toxic/hazardous chemistry by generating hazardous chemicals to end utilization via various separation techniques in newly devised systems as well as ordinary capillary reactors. Furthermore, it covers process technology for ultrafast organic synthesis such as submillisecond control of short-lived intermediates in a polyimide chip reactor. These works provide outlooks for integrated and automated flow chemistry via one-flow/feed to end concept, i.e., useful in pharmaceutical industry, toward enabling new and innovative chemistry beyond limits of a batch reactor. Keywords: Continuous-flow chemistry, Microreactor, Integrated process
Introduction In the past few years, microreaction technology (MRT) as a synonym of continuous-flow technology and microfluidic chemistry has been well exploring to conduct chemistry with potential advantages. In general, microreactor is a device composed of confined channel with small width (
